Development Level

Tbio 24 | 11,445
Tchem 17 | 1,598
Tclin 2 | 613
Tdark 2 | 6,588

IMPC Phenotype

decreased total body fat amoun... 4 | 207
preweaning lethality, complete... 4 | 979
decreased bone mineral density 3 | 126
increased bone mineral content 3 | 108
increased lean body mass 3 | 172
abnormal behavior 2 | 298
abnormal retina morphology 2 | 71
decreased bone mineral content 2 | 151
decreased circulating HDL chol... 2 | 68
decreased circulating glucose ... 2 | 126
decreased lean body mass 2 | 135
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
absent pinna reflex 1 | 23
brachydactyly 1 | 19
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased food intake 1 | 13
decreased granulocyte number 1 | 6
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased grip strength 1 | 41
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
small testis 1 | 58
syndactyly 1 | 23

Disease

Carcinoma 31 | 11,493
ovarian cancer 22 | 8,520
medulloblastoma, large-cell 18 | 6,241
osteosarcoma 17 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
psoriasis 16 | 6,694
Cancer 15 | 2,499
invasive ductal carcinoma 12 | 2,951
lung cancer 12 | 4,740
Autosomal recessive predisposition 10 | 1,442
Schizophrenia 10 | 1,160
group 3 medulloblastoma 10 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
non-small cell lung cancer 10 | 2,890
atypical teratoid / rhabdoid tumor 9 | 5,112
ependymoma 9 | 4,679
glioblastoma 9 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
lung adenocarcinoma 9 | 2,716
malignant mesothelioma 9 | 3,232
Breast cancer 8 | 3,578
Intellectual disability 8 | 1,016
primitive neuroectodermal tumor 8 | 3,035
tuberculosis 8 | 2,010
ulcerative colitis 8 | 1,819
Dull intelligence 7 | 645
Hyperhomocysteinemia 7 | 37
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Prostatic Neoplasms 7 | 495
adrenocortical carcinoma 7 | 1,428
astrocytic glioma 7 | 2,597
interstitial cystitis 7 | 2,312
oligodendroglioma 7 | 2,850
pancreatic cancer 7 | 2,398
Breast Neoplasms 6 | 445
Down syndrome 6 | 499
Homocystinuria 6 | 21
Hypermethioninemia 6 | 11
Mammary Neoplasms 6 | 425
Multiple myeloma 6 | 1,332
Myocardial Infarction 6 | 151
gastric carcinoma 6 | 807
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
lung carcinoma 6 | 2,843
Bipolar Disorder 5 | 666
Epilepsy 5 | 792
Kidney cancer 5 | 2,613
Liver Cirrhosis, Experimental 5 | 769
Pick disease 5 | 1,894
adult high grade glioma 5 | 3,801
ductal carcinoma in situ 5 | 1,745
subependymal giant cell astrocytoma 5 | 2,287
Anemia 4 | 365
Astrocytoma, Pilocytic 4 | 3,081
Atherosclerosis 4 | 291
Cleft Lip 4 | 141
Cleft Palate 4 | 271
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Hypertension 4 | 396
Melanoma 4 | 711
Mood Disorders 4 | 184
Seizures 4 | 596
Waldenstrons macroglobulinemia 4 | 765
atypical teratoid/rhabdoid tumor 4 | 357
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
hepatocellular carcinoma 4 | 547
medulloblastoma 4 | 720
primary pancreatic ductal adenocarcinoma 4 | 1,109
progressive supranuclear palsy 4 | 676
spina bifida 4 | 1,074
Adenocarcinoma of lung 3 | 142
Aphasia 3 | 26
Atopic dermatitis 3 | 952
Cardiovascular system disease 3 | 246
Chemical and Drug Induced Liver Injury 3 | 195
Cognitive delay 3 | 608
Coronary artery disease 3 | 268
Dementia 3 | 175
Depressive disorder 3 | 409
Disease Models, Animal 3 | 155
Dystonia 3 | 164
Failure to gain weight 3 | 365
Global developmental delay 3 | 608
Hypertensive disease 3 | 292
MYELODYSPLASTIC SYNDROME 3 | 53
Mental and motor retardation 3 | 608
Pediatric failure to thrive 3 | 365
Tall stature 3 | 34
acute quadriplegic myopathy 3 | 1,158
dermatomyositis 3 | 966
immunodeficiency-centromeric instability-facial anomalies syndrome 3 | 16
pituitary cancer 3 | 1,972

Tissue

Digestive Tract 45 | 17,369
Female tissues 45 | 17,400
Liver and Pancreas 45 | 16,750
Skin and soft tissues 45 | 17,230
Urinary Tract 45 | 16,678
Endocrine System 44 | 18,159
Nervous System 44 | 16,725
Blood and immune system 43 | 16,909
Male tissues 42 | 17,142
Respiratory system 42 | 16,393
Cardiovascular System 40 | 15,192

Target Family

Enzyme 42 | 4,145
Epigenetic 2 | 242
Non-IDG 1 | 12,091

KEGG Pathway

Cysteine and methionine metabo... 45 | 45
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
L-amino-acid oxidase IL4I1 Tbio Enzyme -2.79074 622.3 53
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ADI1 Tbio Enzyme -2.05198 103.3 194
Methylthioribose-1-phosphate isomerase MRI1 Tbio Enzyme -2.37285 221.6 146
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
S-adenosylmethionine decarboxylase proenzyme AMD1 Tchem Enzyme -3.21826 1586.8 141
DNA (cytosine-5)-methyltransferase 1 DNMT1 Tclin Enzyme -3.21333 1562.7 1125
Cystathionine beta-synthase-like protein CBS Tbio Non-IDG -3.25635 3246.1 0
Spermine synthase SMS Tchem Enzyme -1.50353 28.6 215
Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 Tbio Enzyme -1.47858 32.0 77
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.25018 186.1 256