Development Level

Tbio 96 | 11,445
Tchem 36 | 1,598
Tclin 25 | 613
Tdark 1 | 6,588

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 13 | 979
abnormal embryo size 7 | 220
abnormal bone structure 6 | 187
abnormal heart morphology 6 | 162
decreased total body fat amoun... 6 | 207
decreased vertical activity 6 | 208
enlarged heart 6 | 210
increased startle reflex 6 | 112
preweaning lethality, incomple... 6 | 499
abnormal behavior 5 | 298
embryonic lethality prior to t... 4 | 278
increased heart weight 4 | 62
increased total body fat amoun... 4 | 134
abnormal spleen morphology 3 | 55
cataract 3 | 92
decreased bone mineral density 3 | 126
edema 3 | 59
embryonic lethality prior to o... 3 | 239
increased circulating choleste... 3 | 66
increased lean body mass 3 | 172
microphthalmia 3 | 26
small superior vagus ganglion 3 | 74
abnormal eye morphology 2 | 68
abnormal facial morphology 2 | 17
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
abnormal vocalization 2 | 21
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating insulin ... 2 | 76
decreased circulating phosphat... 2 | 27
decreased circulating total pr... 2 | 49
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
enlarged spleen 2 | 41
hydrometra 2 | 53
hyperactivity 2 | 148
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased fasted circulating g... 2 | 76
male infertility 2 | 123
polydactyly 2 | 7
prenatal lethality 2 | 28
short tibia 2 | 97
small heart 2 | 10
abnormal body wall morphology 1 | 9
abnormal brain morphology 1 | 13
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal hindbrain development 1 | 16
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal pancreas morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased cardiac muscle contr... 1 | 11
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
female infertility 1 | 60
hemorrhage 1 | 23
hydroencephaly 1 | 14
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
prolonged PQ interval 1 | 5
small kidney 1 | 16
small seminal vesicle 1 | 10
small testis 1 | 58
syndactyly 1 | 23
vertebral fusion 1 | 23

Disease

Carcinoma 123 | 11,493
ovarian cancer 81 | 8,520
psoriasis 76 | 6,694
osteosarcoma 73 | 7,950
glioblastoma 70 | 5,792
Cancer 69 | 2,499
atypical teratoid / rhabdoid tumor 68 | 5,112
medulloblastoma, large-cell 64 | 6,241
Breast cancer 56 | 3,578
ependymoma 53 | 4,679
group 3 medulloblastoma 51 | 4,104
lung cancer 51 | 4,740
adult high grade glioma 49 | 3,801
Astrocytoma, Pilocytic 41 | 3,081
primitive neuroectodermal tumor 41 | 3,035
Kidney cancer 39 | 2,613
malignant mesothelioma 38 | 3,232
oligodendroglioma 36 | 2,850
astrocytic glioma 33 | 2,597
pancreatic cancer 33 | 2,398
invasive ductal carcinoma 30 | 2,951
non-small cell lung cancer 30 | 2,890
pituitary cancer 29 | 1,972
lung adenocarcinoma 28 | 2,716
Adenoma 27 | 167
Autosomal recessive predisposition 27 | 1,442
ductal carcinoma in situ 27 | 1,745
subependymal giant cell astrocytoma 27 | 2,287
breast carcinoma 26 | 1,638
lung carcinoma 26 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
Osteoporosis 24 | 363
Pick disease 24 | 1,894
interstitial cystitis 24 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
Obesity 23 | 678
Schizophrenia 23 | 1,160
adrenocortical carcinoma 23 | 1,428
Melanoma 22 | 711
colon cancer 22 | 1,478
cystic fibrosis 22 | 1,696
diabetes mellitus 22 | 1,728
Bipolar Disorder 21 | 666
Hypertensive disease 21 | 292
Depressive disorder 20 | 409
Liver cancer 20 | 604
Prostatic Neoplasms 20 | 495
Short stature 19 | 531
group 4 medulloblastoma 19 | 1,855
ulcerative colitis 19 | 1,819
Cushing's syndrome 18 | 48
Epilepsy 17 | 792
Intellectual disability 17 | 1,016
astrocytoma 17 | 1,146
tuberculosis 17 | 2,010
Mental Depression 16 | 333
Breast Neoplasms 15 | 445
Carcinoma, Hepatocellular 15 | 228
Dull intelligence 15 | 645
Hypertension 15 | 396
Liver carcinoma 15 | 240
Low intelligence 15 | 645
Major Depressive Disorder 15 | 301
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Polycystic ovary syndrome 15 | 360
Poor school performance 15 | 645
Skin cancer 15 | 469
Vascular disease 15 | 319
Cognitive delay 14 | 608
Global developmental delay 14 | 608
Mammary Neoplasms 14 | 425
Mental and motor retardation 14 | 608
Muscle hypotonia 14 | 571
cutaneous lupus erythematosus 14 | 1,057
primary pancreatic ductal adenocarcinoma 14 | 1,109
Rheumatoid arthritis 13 | 1,191
Stomach Neoplasms 13 | 300
Unipolar Depression 13 | 250
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
pediatric high grade glioma 13 | 1,064
Acromegaly 12 | 51
Carney complex 12 | 25
Cryptorchidism 12 | 296
Failure to gain weight 12 | 365
Increase in blood pressure 12 | 119
Lung Neoplasms 12 | 232
Pediatric failure to thrive 12 | 365
Substance Withdrawal Syndrome 12 | 55
acute myeloid leukemia 12 | 783
Adrenal cortical adenoma 11 | 19
Cleft Palate 11 | 271
Congenital adrenal hyperplasia 11 | 73
Mood Disorders 11 | 184
Multiple Endocrine Neoplasia Type 1 11 | 29
Seizures 11 | 596
Stomach cancer 11 | 30
spina bifida 11 | 1,074
Orbital separation excessive 10 | 244

Tissue

Endocrine System 152 | 18,159
Digestive Tract 151 | 17,369
Female tissues 150 | 17,400
Male tissues 147 | 17,142
Nervous System 147 | 16,725
Skin and soft tissues 147 | 17,230
Urinary Tract 143 | 16,678
Blood and immune system 142 | 16,909
Liver and Pancreas 141 | 16,750
Respiratory system 141 | 16,393
Cardiovascular System 124 | 15,192

Target Family

Non-IDG 54 | 12,091
Enzyme 34 | 4,145
Transcription Factor 21 | 1,400
Kinase 17 | 634
GPCR 14 | 408
Ion Channel 14 | 344
Epigenetic 2 | 242
Nuclear Receptor 2 | 48

KEGG Pathway

Cushing's syndrome 158 | 158
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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