Development Level

Tbio 35 | 11,445
Tclin 17 | 613
Tchem 14 | 1,598

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

abnormal bone structure 6 | 187
increased startle reflex 5 | 112
abnormal behavior 4 | 298
abnormal embryo size 4 | 220
increased heart weight 4 | 62
preweaning lethality, incomple... 4 | 499
decreased total body fat amoun... 3 | 207
increased circulating choleste... 3 | 66
increased total body fat amoun... 3 | 134
abnormal vocalization 2 | 21
decreased circulating phosphat... 2 | 27
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased fasted circulating g... 2 | 76
preweaning lethality, complete... 2 | 979
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal gallbladder morpholog... 1 | 1
abnormal hindbrain development 1 | 16
abnormal locomotor behavior 1 | 24
abnormal male genitalia morpho... 1 | 3
abnormal neural tube closure 1 | 46
abnormal pancreas morphology 1 | 13
abnormal placenta vasculature 1 | 2
abnormal spleen morphology 1 | 55
absent external male genitalia 1 | 1
cardiovascular system phenotyp... 1 | 36
cyanosis 1 | 7
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased circulating unsatura... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased prepulse inhibition 1 | 82
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
male infertility 1 | 123
oligodactyly 1 | 1
polydactyly 1 | 7
prenatal lethality 1 | 28
prolonged PQ interval 1 | 5
prolonged PR interval 1 | 15
prolonged QT interval 1 | 38
respiratory system phenotype 1 | 2
short tibia 1 | 97
small epididymis 1 | 3
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small superior vagus ganglion 1 | 74
vertebral fusion 1 | 23

Disease

Carcinoma 55 | 11,493
osteosarcoma 33 | 7,950
ovarian cancer 33 | 8,520
psoriasis 31 | 6,694
glioblastoma 27 | 5,792
atypical teratoid / rhabdoid tumor 25 | 5,112
Kidney cancer 24 | 2,613
lung cancer 23 | 4,740
adult high grade glioma 22 | 3,801
medulloblastoma, large-cell 22 | 6,241
ependymoma 20 | 4,679
Cancer 19 | 2,499
Astrocytoma, Pilocytic 18 | 3,081
Breast cancer 18 | 3,578
group 3 medulloblastoma 18 | 4,104
lung carcinoma 17 | 2,843
Autosomal recessive predisposition 16 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
pancreatic cancer 16 | 2,398
pituitary cancer 16 | 1,972
primitive neuroectodermal tumor 16 | 3,035
astrocytic glioma 15 | 2,597
Hypertensive disease 14 | 292
invasive ductal carcinoma 14 | 2,951
lung adenocarcinoma 14 | 2,716
Obesity 13 | 678
Polycystic ovary syndrome 13 | 360
group 4 medulloblastoma 13 | 1,855
non-small cell lung cancer 13 | 2,890
Bipolar Disorder 12 | 666
Cushing's syndrome 12 | 48
Liver cancer 12 | 604
subependymal giant cell astrocytoma 12 | 2,287
ulcerative colitis 12 | 1,819
Adenoma 11 | 167
Congenital adrenal hyperplasia 11 | 73
Depressive disorder 11 | 409
Epilepsy 11 | 792
Hypertension 11 | 396
Osteoporosis 11 | 363
Schizophrenia 11 | 1,160
adrenocortical carcinoma 11 | 1,428
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
malignant mesothelioma 11 | 3,232
oligodendroglioma 11 | 2,850
colon cancer 10 | 1,478
ductal carcinoma in situ 10 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
Melanoma 9 | 711
Pick disease 9 | 1,894
breast carcinoma 9 | 1,638
diabetes mellitus 9 | 1,728
interstitial cystitis 9 | 2,312
Carney complex 8 | 25
Hyperaldosteronism 8 | 35
Hypogonadism 8 | 173
Increase in blood pressure 8 | 119
Mental Depression 8 | 333
Primary pigmented nodular adrenocortical disease 8 | 13
Skin cancer 8 | 469
Substance Withdrawal Syndrome 8 | 55
cystic fibrosis 8 | 1,696
Hyperandrogenism 7 | 34
Prostatic Neoplasms 7 | 495
cutaneous lupus erythematosus 7 | 1,057
Adrenal hyperplasia 6 | 13
Angina Pectoris 6 | 32
Atrial Fibrillation 6 | 124
Conn's syndrome 6 | 22
Gynecomastia 6 | 64
Hypertensive disorder 6 | 56
Hypothyroidism 6 | 122
Infertility 6 | 188
Kidney disease 6 | 430
Major Depressive Disorder 6 | 301
McCune Albright syndrome 6 | 19
Mood Disorders 6 | 184
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primary pancreatic ductal adenocarcinoma 6 | 1,109
tuberculosis 6 | 2,010
Acquired metabolic disease 5 | 336
Acromegaly 5 | 51
Adrenal cortical adenoma 5 | 19
Delayed bone age 5 | 136
Endometrial cancer 5 | 311
Fibrous dysplasia 5 | 15
Hypokalemia 5 | 52
Hypospadias 5 | 53
Hypotension 5 | 82
Increased circulating ACTH level 5 | 8
Low to undetectable plasma cortisol 5 | 12
Penile hypospadias 5 | 106
Pituitary adenoma 5 | 38
Pseudohermaphroditism 5 | 16
Pseudohypoparathyroidism 5 | 18
Seizures 5 | 596
Short stature 5 | 531
Small testicle 5 | 75
Unipolar Depression 5 | 250
progressive supranuclear palsy 5 | 676

Tissue

Endocrine System 63 | 18,159
Digestive Tract 62 | 17,369
Female tissues 61 | 17,400
Male tissues 60 | 17,142
Respiratory system 59 | 16,393
Skin and soft tissues 59 | 17,230
Nervous System 58 | 16,725
Urinary Tract 58 | 16,678
Blood and immune system 57 | 16,909
Liver and Pancreas 57 | 16,750
Cardiovascular System 50 | 15,192

Target Family

Enzyme 22 | 4,145
Ion Channel 14 | 344
Transcription Factor 12 | 1,400
Non-IDG 11 | 12,091
Kinase 3 | 634
GPCR 2 | 408
Nuclear Receptor 2 | 48

KEGG Pathway

Cortisol synthesis and secreti... 66 | 66
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adrenocorticotropic hormone receptor MC2R Tclin GPCR -2.22640 172.4 223
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1 Tchem Enzyme -2.62147 370.7 267
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G Tclin Ion Channel -2.16668 140.8 217
Scavenger receptor class B member 1 SCARB1 Tchem Non-IDG -2.93920 915.7 378
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.88444 66.2 265
Adenylate cyclase type 6 ADCY6 Tchem Enzyme -2.05332 113.7 111