Development Level

Tbio 47 | 11,445
Tchem 30 | 1,598
Tclin 10 | 613

IMPC Phenotype

preweaning lethality, complete... 10 | 979
increased mean corpuscular hem... 4 | 96
decreased body weight 3 | 161
increased hemoglobin content 3 | 45
abnormal bone mineralization 2 | 38
abnormal heart morphology 2 | 162
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
hyperactivity 2 | 148
increased circulating LDL chol... 2 | 13
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 36
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
small testis 2 | 58
abnormal body wall morphology 1 | 9
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal response to tactile s... 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
male infertility 1 | 123
mammalian phenotype 1 | 17
microphthalmia 1 | 26
polydactyly 1 | 7
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
protruding tongue 1 | 3
short tibia 1 | 97
small seminal vesicle 1 | 10
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Cancer 73 | 2,499
Carcinoma 63 | 11,493
ovarian cancer 61 | 8,520
osteosarcoma 49 | 7,950
psoriasis 49 | 6,694
glioblastoma 47 | 5,792
medulloblastoma, large-cell 41 | 6,241
atypical teratoid / rhabdoid tumor 40 | 5,112
lung cancer 40 | 4,740
Breast cancer 37 | 3,578
ependymoma 36 | 4,679
group 3 medulloblastoma 34 | 4,104
malignant mesothelioma 28 | 3,232
Stomach Neoplasms 27 | 300
pancreatic cancer 27 | 2,398
Kidney cancer 26 | 2,613
diabetes mellitus 26 | 1,728
Schizophrenia 25 | 1,160
Prostatic Neoplasms 24 | 495
adult high grade glioma 23 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
primitive neuroectodermal tumor 22 | 3,035
Astrocytoma, Pilocytic 21 | 3,081
Breast Neoplasms 21 | 445
Colorectal Neoplasms 21 | 243
invasive ductal carcinoma 21 | 2,951
oligodendroglioma 21 | 2,850
Epilepsy 20 | 792
Intellectual disability 20 | 1,016
Lung Neoplasms 20 | 232
Mammary Neoplasms 20 | 425
Vascular disease 20 | 319
subependymal giant cell astrocytoma 20 | 2,287
Carcinoma, Hepatocellular 19 | 228
Liver carcinoma 19 | 240
Orbital separation excessive 19 | 244
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
tuberculosis 19 | 2,010
Adenoma 18 | 167
Colonic Neoplasms 18 | 142
breast carcinoma 18 | 1,638
pituitary cancer 18 | 1,972
Byzanthine arch palate 17 | 194
Seizures 17 | 596
astrocytic glioma 17 | 2,597
juvenile dermatomyositis 17 | 1,187
lung adenocarcinoma 17 | 2,716
Familial adenomatous polyposis 16 | 32
Muscle hypotonia 16 | 571
Rheumatoid arthritis 16 | 1,191
hepatocellular carcinoma 16 | 547
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
Acquired scoliosis 15 | 281
Curvature of spine 15 | 282
Dull intelligence 15 | 645
Hypertensive disease 15 | 292
Hypoplastic mandible condyle 15 | 275
Kidney disease 15 | 430
Low intelligence 15 | 645
Mandibular hypoplasia 15 | 275
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Micrognathism 15 | 275
Multiple myeloma 15 | 1,332
Neoplasm Metastasis 15 | 168
Obesity 15 | 678
Ovarian Neoplasms 15 | 102
Poor school performance 15 | 645
Squamous cell carcinoma 15 | 129
group 4 medulloblastoma 15 | 1,855
non-small cell lung cancer 15 | 2,890
Adenocarcinoma 14 | 122
Depressive disorder 14 | 409
Endometrial cancer 14 | 311
Melanoma 14 | 711
adrenocortical carcinoma 14 | 1,428
ductal carcinoma in situ 14 | 1,745
ovarian neoplasm 14 | 99
ulcerative colitis 14 | 1,819
Alzheimer's disease 13 | 658
Carcinoma, Squamous Cell 13 | 110
Cell Transformation, Neoplastic 13 | 97
Liver Neoplasms, Experimental 13 | 59
Parkinson's disease 13 | 392
Pick disease 13 | 1,894
Renal Cell Carcinoma 13 | 214
Waldenstrons macroglobulinemia 13 | 765
interstitial cystitis 13 | 2,312
lung carcinoma 13 | 2,843
Autosomal recessive predisposition 12 | 1,442
Cognitive delay 12 | 608
Cryptorchidism 12 | 296
Downward slant of palpebral fissure 12 | 158
Global developmental delay 12 | 608
High forehead 12 | 102
Mental and motor retardation 12 | 608
Short stature 12 | 531
Strabismus 12 | 270
Tall forehead 12 | 102
non-small cell lung carcinoma 12 | 317

Tissue

Blood and immune system 85 | 16,909
Digestive Tract 85 | 17,369
Endocrine System 85 | 18,159
Female tissues 85 | 17,400
Male tissues 85 | 17,142
Nervous System 85 | 16,725
Skin and soft tissues 85 | 17,230
Urinary Tract 85 | 16,678
Liver and Pancreas 84 | 16,750
Respiratory system 84 | 16,393
Cardiovascular System 83 | 15,192

Target Family

Non-IDG 36 | 12,091
Kinase 24 | 634
Enzyme 15 | 4,145
Transcription Factor 11 | 1,400
Epigenetic 1 | 242

KEGG Pathway

Colorectal cancer 87 | 87
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 Tbio Non-IDG -2.70122 462.2 347
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Bcl-2-binding component 3 BBC3 Tbio Non-IDG -2.02081 88.0 559
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Ral guanine nucleotide dissociation stimulator RALGDS Tbio Non-IDG -2.85677 683.6 102
DNA mismatch repair protein Msh6 MSH6 Tbio Epigenetic -2.72594 572.3 479