Development Level

Tbio 25 | 10,625
Tchem 4 | 1,890
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 5 | 633
embryonic lethality prior to o... 2 | 148
abnormal QRS complex 1 | 25
abnormal coping response 1 | 12
abnormal kidney morphology 1 | 30
decreased IgM level 1 | 1
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased lean body mass 1 | 195
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
increased bone mineral content 1 | 92
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased lean body mass 1 | 107

Disease

ovarian cancer 22 | 8,484
psoriasis 16 | 6,685
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
Multiple myeloma 12 | 1,327
medulloblastoma, large-cell 11 | 6,234
osteosarcoma 11 | 7,933
glioblastoma 10 | 5,572
Breast cancer 8 | 3,094
astrocytic glioma 8 | 2,241
lung cancer 8 | 4,466
Lactic acidosis 7 | 42
Pick disease 7 | 1,893
atypical teratoid / rhabdoid tumor 7 | 4,369
malignant mesothelioma 7 | 3,162
Leigh disease 6 | 81
Obesity 6 | 616
invasive ductal carcinoma 6 | 2,950
lung adenocarcinoma 6 | 2,713
oligodendroglioma 6 | 2,849
pilocytic astrocytoma 6 | 3,086
primitive neuroectodermal tumor 6 | 3,031
ulcerative colitis 6 | 2,087
Cancer 5 | 2,346
Degenerative polyarthritis 5 | 93
Hemangioma 5 | 35
Neoplastic Syndromes, Hereditary 5 | 48
Waldenstrons macroglobulinemia 5 | 765
adult high grade glioma 5 | 2,148
ductal carcinoma in situ 5 | 1,745
ependymoma 5 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
medulloblastoma 5 | 1,524
Carcinoma 4 | 2,147
Chondroma 4 | 12
Gastrointestinal stromal tumor 4 | 61
Liver carcinoma 4 | 217
Persistent generalized lymphadenopathy 4 | 15
Phaeochromocytoma 4 | 20
Pyruvate decarboxylase deficiency 4 | 15
breast carcinoma 4 | 1,614
group 4 medulloblastoma 4 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
non primary Sjogren syndrome sicca 4 | 840
non-small cell lung cancer 4 | 2,798
pituitary cancer 4 | 1,972
Carney Triad 3 | 3
Disease Progression 3 | 125
Gastrointestinal Stromal Tumors 3 | 8
Hamartoma Syndrome, Multiple 3 | 9
Methylmalonic acidemia 3 | 39
Mitochondrial complex II deficiency 3 | 5
Neurofibromatosis 3 | 37
PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA 3 | 3
Paraganglioma 3 | 12
Sideroblastic anemia with spinocerebellar ataxia 3 | 6
Stomach Neoplasms 3 | 282
adrenocortical carcinoma 3 | 1,427
aldosterone-producing adenoma 3 | 664
astrocytoma 3 | 1,493
atypical teratoid/rhabdoid tumor 3 | 1,095
colon cancer 3 | 1,475
extra-adrenal pheochromocytoma 3 | 7
group 3 medulloblastoma 3 | 2,254
hereditary spastic paraplegia 3 | 313
lung carcinoma 3 | 2,844
nephrosclerosis 3 | 329
pediatric high grade glioma 3 | 2,712
posterior fossa group A ependymoma 3 | 1,511
tuberculosis 3 | 1,557
Anoxia 2 | 33
Atopic dermatitis 2 | 944
Cholangiocarcinoma 2 | 32
Cowden disease 2 | 16
DOID:2627 2 | 14
Dystonia 2 | 77
Hyperglycemia 2 | 120
Hypoglycemia 2 | 81
Immune system cancer 2 | 38
Inflammatory dermatosis 2 | 38
Liver Cirrhosis, Experimental 2 | 108
Mitochondrial myopathy 2 | 23
Myelofibrosis 2 | 11
Myocardial Ischemia 2 | 169
Ollier disease 2 | 15
Papilloma 2 | 27
Parkinson's disease 2 | 364
Pheochromocytoma 2 | 22
Renal Cell Carcinoma 2 | 199
Thyroid cancer 2 | 25
Tropical spastic paraparesis 2 | 17
acute quadriplegic myopathy 2 | 1,157
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
dermatomyositis 2 | 933
diabetes mellitus 2 | 1,663
fibroadenoma 2 | 557
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
pancreatic cancer 2 | 2,300
pancreatic carcinoma 2 | 567
sonic hedgehog group medulloblastoma 2 | 1,482
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Blood and immune system 30 | 17,995
Cardiovascular System 30 | 17,958
Digestive Tract 30 | 18,473
Endocrine System 30 | 18,512
Female tissues 30 | 18,647
Liver and Pancreas 30 | 18,136
Male tissues 30 | 17,969
Nervous System 30 | 18,561
Respiratory system 30 | 17,484
Urinary Tract 30 | 18,444
Skin and soft tissues 29 | 18,115

Target Family

Enzyme 28 | 4,146
Kinase 2 | 634

KEGG Pathway

Citrate cycle (TCA cycle) 30 | 30
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

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