Development Level

Tbio 42 | 11,445
Tchem 26 | 1,598
Tclin 25 | 613
Tdark 6 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

increased startle reflex 6 | 112
preweaning lethality, incomple... 6 | 499
abnormal bone structure 5 | 187
increased heart weight 5 | 62
preweaning lethality, complete... 5 | 979
abnormal behavior 4 | 298
hyperactivity 4 | 148
enlarged heart 3 | 210
abnormal bone mineralization 2 | 38
abnormal spleen morphology 2 | 55
decreased bone mineral content 2 | 151
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
enlarged spleen 2 | 41
increased bone mineral content 2 | 108
small superior vagus ganglion 2 | 74
abnormal coat-hair pigmentatio... 1 | 64
abnormal duodenum morphology 1 | 4
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal gallbladder morpholog... 1 | 1
abnormal heart morphology 1 | 162
abnormal locomotor behavior 1 | 24
abnormal pancreas morphology 1 | 13
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal urinary bladder morph... 1 | 11
abnormal vocalization 1 | 21
decreased body weight 1 | 161
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
increased vertical activity 1 | 24
limb grasping 1 | 41
male infertility 1 | 123
mammalian phenotype 1 | 17
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small epididymis 1 | 3
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8

Disease

Carcinoma 71 | 11,493
glioblastoma 60 | 5,792
medulloblastoma, large-cell 60 | 6,241
atypical teratoid / rhabdoid tumor 54 | 5,112
ependymoma 53 | 4,679
ovarian cancer 50 | 8,520
psoriasis 48 | 6,694
osteosarcoma 45 | 7,950
primitive neuroectodermal tumor 45 | 3,035
group 3 medulloblastoma 44 | 4,104
adult high grade glioma 43 | 3,801
Astrocytoma, Pilocytic 40 | 3,081
Kidney cancer 36 | 2,613
Breast cancer 35 | 3,578
lung carcinoma 34 | 2,843
Schizophrenia 33 | 1,160
lung cancer 32 | 4,740
oligodendroglioma 32 | 2,850
subependymal giant cell astrocytoma 32 | 2,287
astrocytic glioma 31 | 2,597
Pick disease 28 | 1,894
Epilepsy 24 | 792
Depressive disorder 22 | 409
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
lung adenocarcinoma 22 | 2,716
non-small cell lung cancer 22 | 2,890
pancreatic cancer 22 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
pituitary cancer 21 | 1,972
Bipolar Disorder 20 | 666
invasive ductal carcinoma 20 | 2,951
malignant mesothelioma 20 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
Mental Depression 18 | 333
Substance Withdrawal Syndrome 18 | 55
Liver cancer 17 | 604
colon cancer 17 | 1,478
Major Depressive Disorder 16 | 301
diabetes mellitus 16 | 1,728
ulcerative colitis 16 | 1,819
Intellectual disability 15 | 1,016
Cancer 14 | 2,499
Toxic encephalopathy 14 | 141
Hypertension 13 | 396
Parkinson's disease 13 | 392
group 4 medulloblastoma 13 | 1,855
interstitial cystitis 13 | 2,312
Alzheimer's disease 12 | 658
breast carcinoma 12 | 1,638
Melanoma 11 | 711
Obesity 11 | 678
Unipolar Depression 11 | 250
cystic fibrosis 11 | 1,696
Alcoholic Intoxication, Chronic 10 | 289
Cocaine-Related Disorders 10 | 92
Hypertensive disease 10 | 292
Rheumatoid arthritis 10 | 1,191
Skin cancer 10 | 469
astrocytoma 10 | 1,146
ductal carcinoma in situ 10 | 1,745
Autosomal recessive predisposition 9 | 1,442
General anesthesia 9 | 53
Heart disease 9 | 306
Hyperalgesia 9 | 83
Local anesthesia 9 | 40
juvenile dermatomyositis 9 | 1,187
tuberculosis 9 | 2,010
Autistic Disorder 8 | 364
Cerebrovascular disease 8 | 238
Dull intelligence 8 | 645
Endometrial cancer 8 | 311
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Mood Disorders 8 | 184
Poor school performance 8 | 645
Seizures 8 | 596
pediatric high grade glioma 8 | 1,064
primary Sjogren syndrome 8 | 735
Amyotrophic lateral sclerosis 7 | 451
Hypertensive disorder 7 | 56
Kidney disease 7 | 430
Neurodegenerative disease 7 | 414
Osteoporosis 7 | 363
adrenocortical carcinoma 7 | 1,428
aldosterone-producing adenoma 7 | 665
gastric carcinoma 7 | 807
primary pancreatic ductal adenocarcinoma 7 | 1,109
Acquired metabolic disease 6 | 336
Adenoma 6 | 167
Attention deficit hyperactivity disorder 6 | 278
Crohn's disease 6 | 321
Duchenne muscular dystrophy 6 | 601
Increase in blood pressure 6 | 119
Lennox-Gastaut syndrome 6 | 34
Polycystic ovary syndrome 6 | 360
Waldenstrons macroglobulinemia 6 | 765
acute quadriplegic myopathy 6 | 1,158
chronic rhinosinusitis 6 | 512
substance-related disorder 6 | 162

Tissue

Endocrine System 96 | 18,159
Blood and immune system 93 | 16,909
Digestive Tract 93 | 17,369
Nervous System 93 | 16,725
Female tissues 91 | 17,400
Male tissues 91 | 17,142
Skin and soft tissues 91 | 17,230
Liver and Pancreas 90 | 16,750
Urinary Tract 87 | 16,678
Respiratory system 86 | 16,393
Cardiovascular System 80 | 15,192

Target Family

Non-IDG 36 | 12,091
Ion Channel 23 | 344
Enzyme 20 | 4,145
Kinase 15 | 634
GPCR 3 | 408
Transcription Factor 2 | 1,400

KEGG Pathway

Circadian entrainment 99 | 99
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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