Development Level

Tbio 34 | 11,445
Tchem 32 | 1,598
Tclin 12 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased body weight 5 | 161
abnormal lens morphology 4 | 81
cataract 4 | 92
preweaning lethality, incomple... 4 | 499
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
abnormal locomotor activation 2 | 16
abnormal startle reflex 2 | 15
abnormal testis morphology 2 | 43
decreased circulating creatini... 2 | 39
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased prepulse inhibition 2 | 82
edema 2 | 59
increased blood urea nitrogen ... 2 | 48
increased circulating alkaline... 2 | 122
increased circulating amylase ... 2 | 25
increased circulating choleste... 2 | 66
increased hemoglobin content 2 | 45
increased startle reflex 2 | 112
limb grasping 2 | 41
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
cardiovascular system phenotyp... 1 | 36
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
female infertility 1 | 60
hyperactivity 1 | 148
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased heart left ventricle... 1 | 4
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
microphthalmia 1 | 26
prenatal lethality 1 | 28
short tibia 1 | 97
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Cancer 68 | 2,499
Carcinoma 59 | 11,493
ovarian cancer 59 | 8,520
osteosarcoma 47 | 7,950
glioblastoma 43 | 5,792
medulloblastoma, large-cell 37 | 6,241
lung cancer 36 | 4,740
psoriasis 34 | 6,694
Breast cancer 31 | 3,578
atypical teratoid / rhabdoid tumor 31 | 5,112
ependymoma 29 | 4,679
group 3 medulloblastoma 26 | 4,104
malignant mesothelioma 25 | 3,232
Kidney cancer 24 | 2,613
primitive neuroectodermal tumor 23 | 3,035
Orbital separation excessive 22 | 244
Breast Neoplasms 20 | 445
Lung Neoplasms 20 | 232
Mammary Neoplasms 20 | 425
Multiple myeloma 20 | 1,332
oligodendroglioma 20 | 2,850
Short stature 19 | 531
juvenile dermatomyositis 19 | 1,187
pancreatic cancer 19 | 2,398
subependymal giant cell astrocytoma 19 | 2,287
Acquired scoliosis 18 | 281
Astrocytoma, Pilocytic 18 | 3,081
Curvature of spine 18 | 282
Melanoma 18 | 711
Prostatic Neoplasms 18 | 495
adult high grade glioma 18 | 3,801
Byzanthine arch palate 17 | 194
Stomach Neoplasms 17 | 300
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
Dull intelligence 16 | 645
Hypoplastic mandible condyle 16 | 275
Intellectual disability 16 | 1,016
Low intelligence 16 | 645
Mandibular hypoplasia 16 | 275
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Micrognathism 16 | 275
Poor school performance 16 | 645
Schizophrenia 16 | 1,160
astrocytic glioma 16 | 2,597
lung adenocarcinoma 16 | 2,716
Adenoma 15 | 167
Blepharoptosis 15 | 231
Carcinoma, Hepatocellular 15 | 228
Cognitive delay 15 | 608
Epilepsy 15 | 792
Global developmental delay 15 | 608
Liver carcinoma 15 | 240
Mental and motor retardation 15 | 608
Seizures 15 | 596
Squamous cell carcinoma 15 | 129
astrocytoma 15 | 1,146
group 4 medulloblastoma 15 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Carcinoma, Squamous Cell 14 | 110
Cryptorchidism 14 | 296
Muscle hypotonia 14 | 571
Strabismus 14 | 270
dermatomyositis 14 | 966
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
invasive ductal carcinoma 14 | 2,951
Downward slant of palpebral fissure 13 | 158
High forehead 13 | 102
Pectus excavatum 13 | 100
Rheumatoid arthritis 13 | 1,191
Splenomegaly 13 | 190
Tall forehead 13 | 102
Vascular disease 13 | 319
adrenocortical carcinoma 13 | 1,428
Colonic Neoplasms 12 | 142
Concave bridge of nose 12 | 195
Congenital Epicanthus 12 | 177
Depressed nasal bridge 12 | 195
Depressed nasal root/bridge 12 | 195
Frontal bossing 12 | 157
Immune system cancer 12 | 140
Lymphoid leukemia 12 | 160
Short neck 12 | 140
acute quadriplegic myopathy 12 | 1,158
diabetes mellitus 12 | 1,728
ductal carcinoma in situ 12 | 1,745
Adenocarcinoma 11 | 122
Colorectal Neoplasms 11 | 243
Exophthalmos 11 | 112
Liver Neoplasms, Experimental 11 | 59
Neck webbing 11 | 35
Pancreatic Neoplasm 11 | 85
Pick disease 11 | 1,894
Prominent eyes 11 | 96
Prominent globes 11 | 96
Protruding eyes 11 | 96
cystic fibrosis 11 | 1,696
lung carcinoma 11 | 2,843
tuberculosis 11 | 2,010
Autosomal recessive predisposition 10 | 1,442

Tissue

Blood and immune system 76 | 16,909
Digestive Tract 76 | 17,369
Endocrine System 76 | 18,159
Female tissues 76 | 17,400
Liver and Pancreas 76 | 16,750
Male tissues 76 | 17,142
Nervous System 76 | 16,725
Respiratory system 76 | 16,393
Skin and soft tissues 76 | 17,230
Urinary Tract 76 | 16,678
Cardiovascular System 74 | 15,192

Target Family

Non-IDG 29 | 12,091
Kinase 22 | 634
Enzyme 12 | 4,145
Transcription Factor 12 | 1,400
Epigenetic 2 | 242
TF/Epigenetic 1 | 38

KEGG Pathway

Chronic myeloid leukemia 78 | 78
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
MDS1 and EVI1 complex locus protein MDS1 MECOM Tbio Non-IDG -1.84060 124.5 0
Breakpoint cluster region protein BCR Tclin Non-IDG -2.99605 934.2 437
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
SHC-transforming protein 2 SHC2 Tbio Non-IDG -2.47843 293.4 113
SHC-transforming protein 3 SHC3 Tbio Non-IDG -1.97665 99.4 137
Son of sevenless homolog 2 SOS2 Tbio Non-IDG -1.62118 35.9 134