Development Level

Tchem 42 | 1,890
Tbio 37 | 10,625
Tclin 24 | 602
Tdark 7 | 7,003

Collection

Kinase: IDG Consortium (Targets) 2 | 125
GPCR: IDG Consortium (Complete/Control) 1 | 26
Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

abnormal behavior 5 | 226
preweaning lethality, complete... 4 | 633
preweaning lethality, incomple... 4 | 260
abnormal embryo size 3 | 112
decreased body weight 3 | 174
hyperactivity 3 | 108
increased circulating alkaline... 3 | 119
abnormal bone mineralization 2 | 55
abnormal epididymis morphology 2 | 31
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal neural tube closure 2 | 37
abnormal spleen morphology 2 | 36
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
embryonic lethality prior to t... 2 | 187
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
thrombocytosis 2 | 23
abnormal facial morphology 1 | 9
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal midbrain development 1 | 22
abnormal placenta vasculature 1 | 2
abnormal respiratory quotient 1 | 9
abnormal vocalization 1 | 21
cyanosis 1 | 6
decreased body length 1 | 108
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating insulin ... 1 | 75
decreased circulating phosphat... 1 | 15
decreased circulating total pr... 1 | 41
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
edema 1 | 11
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
hemorrhage 1 | 12
hypoactivity 1 | 89
impaired righting response 1 | 19
increased circulating LDL chol... 1 | 15
increased circulating alanine ... 1 | 11
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
male infertility 1 | 62
prenatal lethality 1 | 16
respiratory system phenotype 1 | 2
small epididymis 1 | 3
small kidney 1 | 10
small superior vagus ganglion 1 | 20
sparse hair 1 | 6
straub tail 1 | 26
vertebral fusion 1 | 23

Disease

medulloblastoma, large-cell 59 | 6,234
ovarian cancer 57 | 8,491
glioblastoma 56 | 5,572
psoriasis 55 | 6,685
osteosarcoma 51 | 7,933
atypical teratoid / rhabdoid tumor 46 | 4,369
pilocytic astrocytoma 42 | 3,086
primitive neuroectodermal tumor 42 | 3,031
Carcinoma 33 | 2,147
lung cancer 33 | 4,473
oligodendroglioma 32 | 2,849
pediatric high grade glioma 32 | 2,712
subependymal giant cell astrocytoma 31 | 2,287
lung carcinoma 30 | 2,844
Breast cancer 28 | 3,098
Cancer 26 | 2,346
ependymoma 25 | 2,514
ulcerative colitis 24 | 2,087
Pick disease 23 | 1,893
astrocytic glioma 23 | 2,241
invasive ductal carcinoma 23 | 2,950
group 3 medulloblastoma 21 | 2,254
lung adenocarcinoma 21 | 2,714
malignant mesothelioma 21 | 3,163
medulloblastoma 21 | 1,524
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,289
Epilepsy 19 | 346
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
pituitary cancer 19 | 1,972
astrocytoma 18 | 1,493
adult high grade glioma 17 | 2,148
interstitial cystitis 17 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
non-small cell lung cancer 17 | 2,798
posterior fossa group A ependymoma 17 | 1,511
Schizophrenia 16 | 503
cystic fibrosis 16 | 1,670
group 4 medulloblastoma 16 | 1,875
juvenile dermatomyositis 16 | 1,189
pancreatic cancer 16 | 2,300
Obesity 14 | 616
Parkinson's disease 14 | 364
colon cancer 14 | 1,475
diabetes mellitus 14 | 1,663
Rheumatoid Arthritis 13 | 1,170
primary Sjogren syndrome 13 | 788
Alzheimer's disease 12 | 644
Substance Withdrawal Syndrome 12 | 55
ductal carcinoma in situ 12 | 1,745
Intellectual disability 11 | 573
Prostatic Neoplasms 10 | 471
breast carcinoma 10 | 1,614
posterior fossa group B ependymoma 10 | 1,530
Autistic Disorder 9 | 320
Long QT syndrome 9 | 53
Lung Neoplasms 9 | 171
Mammary Neoplasms 9 | 410
primary pancreatic ductal adenocarcinoma 9 | 1,271
Cocaine-Related Disorders 8 | 88
Seizures 8 | 95
Waldenstrons macroglobulinemia 8 | 764
dermatomyositis 8 | 966
sonic hedgehog group medulloblastoma 8 | 1,482
tuberculosis 8 | 1,563
Alcohol dependence 7 | 107
Atrial Fibrillation 7 | 110
Colorectal Neoplasms 7 | 217
Down syndrome 7 | 548
Heart disease 7 | 279
Multiple myeloma 7 | 1,327
Stomach Neoplasms 7 | 282
Toxic encephalopathy 7 | 131
Vascular disease 7 | 281
active Crohn's disease 7 | 918
adrenocortical carcinoma 7 | 1,427
atypical teratoid/rhabdoid tumor 7 | 1,095
cutaneous lupus erythematosus 7 | 1,056
sarcoidosis 7 | 368
spina bifida 7 | 1,064
Adenoma 6 | 165
Diabetes Mellitus, Non-Insulin-Dependent 6 | 161
Duchenne muscular dystrophy 6 | 602
Hypertensive disorder 6 | 58
Multiple Sclerosis 6 | 498
Nerve Degeneration 6 | 73
Neurodegenerative disease 6 | 383
Pain agnosia 6 | 99
Squamous cell carcinoma 6 | 96
acute quadriplegic myopathy 6 | 1,157
gastric cancer 6 | 436
non primary Sjogren syndrome sicca 6 | 840
non-small cell lung carcinoma 6 | 413
pancreatic carcinoma 6 | 567
tuberculosis and treatment for 6 months 6 | 686
Juvenile arthritis 5 | 124
acute myeloid leukemia 5 | 785
esophageal adenocarcinoma 5 | 737
hepatocellular carcinoma 5 | 550
nasopharyngeal carcinoma 5 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795

Tissue

Blood and immune system 110 | 17,994
Digestive Tract 110 | 18,472
Endocrine System 110 | 18,511
Female tissues 110 | 18,646
Liver and Pancreas 110 | 18,135
Nervous System 110 | 18,560
Skin and soft tissues 110 | 18,114
Urinary Tract 110 | 18,443
Cardiovascular System 109 | 17,957
Male tissues 107 | 17,968
Respiratory system 106 | 17,483

Target Family

Ion Channel 25 | 341
Kinase 24 | 634
Non-IDG 24 | 11,969
Enzyme 21 | 4,146
Transcription Factor 9 | 1,400
GPCR 5 | 408
Transporter 2 | 473

KEGG Pathway

Cholinergic synapse 110 | 110
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclic AMP-responsive element-binding protein 5 CREB5 Tbio Transcription Factor -0.80452 6.31 141
Neuronal acetylcholine receptor subunit beta-4 CHRNB4 Tclin Ion Channel -1.54794 32.2 109
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.86049 63.7 252
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.12726 13094.7 961
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.12987 136.7 95
Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C Tclin Ion Channel -2.72211 489.2 316
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
GTPase NRas NRAS Tchem Enzyme -2.98048 880.4 265
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.87621 876.7 339