Development Level

Tbio 52 | 11,651
Tchem 29 | 1,388
Tclin 25 | 612
Tdark 5 | 6,593

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

abnormal behavior 7 | 298
preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 6 | 499
hyperactivity 5 | 148
abnormal embryo size 3 | 220
decreased body weight 3 | 161
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating triglyce... 2 | 42
increased lean body mass 2 | 172
increased startle reflex 2 | 112
prenatal lethality 2 | 28
short tibia 2 | 97
small superior vagus ganglion 2 | 74
thrombocytosis 2 | 27
abnormal bone mineralization 1 | 38
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal gallbladder morpholog... 1 | 1
abnormal glucose homeostasis 1 | 4
abnormal hair growth 1 | 10
abnormal hindbrain development 1 | 16
abnormal locomotor behavior 1 | 24
abnormal neural tube closure 1 | 46
abnormal placenta vasculature 1 | 2
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
cyanosis 1 | 7
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydrometra 1 | 53
hypoactivity 1 | 132
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2
small epididymis 1 | 3
small kidney 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 86 | 11,493
glioblastoma 62 | 5,792
medulloblastoma, large-cell 59 | 6,241
ovarian cancer 57 | 8,520
psoriasis 55 | 6,694
osteosarcoma 52 | 7,950
atypical teratoid / rhabdoid tumor 50 | 5,112
ependymoma 47 | 4,679
primitive neuroectodermal tumor 42 | 3,035
Astrocytoma, Pilocytic 41 | 3,081
adult high grade glioma 41 | 3,801
group 3 medulloblastoma 39 | 4,104
Breast cancer 37 | 3,578
lung cancer 36 | 4,740
Schizophrenia 34 | 1,160
Kidney cancer 32 | 2,613
oligodendroglioma 32 | 2,850
subependymal giant cell astrocytoma 31 | 2,287
lung carcinoma 30 | 2,843
astrocytic glioma 29 | 2,597
Epilepsy 28 | 792
Cancer 27 | 2,499
Depressive disorder 24 | 409
Bipolar Disorder 23 | 666
Pick disease 23 | 1,894
invasive ductal carcinoma 23 | 2,951
ulcerative colitis 22 | 1,819
Seizures 21 | 596
lung adenocarcinoma 21 | 2,716
malignant mesothelioma 21 | 3,232
group 4 medulloblastoma 20 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
Intellectual disability 19 | 1,016
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
pituitary cancer 19 | 1,972
non-small cell lung cancer 18 | 2,890
pancreatic cancer 18 | 2,398
Mental Depression 17 | 333
interstitial cystitis 17 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
Autosomal recessive predisposition 16 | 1,442
cystic fibrosis 16 | 1,696
diabetes mellitus 16 | 1,728
juvenile dermatomyositis 16 | 1,187
tuberculosis 16 | 2,010
Melanoma 15 | 711
Parkinson's disease 14 | 392
Skin cancer 14 | 469
colon cancer 14 | 1,478
Alcoholic Intoxication, Chronic 13 | 289
Major Depressive Disorder 13 | 301
Obesity 13 | 678
Rheumatoid arthritis 13 | 1,191
breast carcinoma 13 | 1,638
primary Sjogren syndrome 13 | 735
Alzheimer's disease 12 | 658
Dull intelligence 12 | 645
Liver cancer 12 | 604
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
Substance Withdrawal Syndrome 12 | 55
Unipolar Depression 12 | 250
astrocytoma 12 | 1,146
ductal carcinoma in situ 12 | 1,745
Cognitive delay 11 | 608
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
Mood Disorders 11 | 184
Prostatic Neoplasms 11 | 495
Endometrial cancer 10 | 311
Attention deficit hyperactivity disorder 9 | 278
Big calvaria 9 | 147
Breast Neoplasms 9 | 445
Increased head circumference 9 | 147
Increased size of cranium 9 | 147
Increased size of skull 9 | 147
Long QT syndrome 9 | 39
Lung Neoplasms 9 | 232
Mammary Neoplasms 9 | 425
Muscle hypotonia 9 | 571
Orbital separation excessive 9 | 244
Stomach Neoplasms 9 | 300
primary pancreatic ductal adenocarcinoma 9 | 1,109
Autistic Disorder 8 | 364
Byzanthine arch palate 8 | 194
Cocaine-Related Disorders 8 | 92
Colorectal Neoplasms 8 | 243
Hypertensive disease 8 | 292
Hypoplastic mandible condyle 8 | 275
Liver Cirrhosis, Experimental 8 | 769
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Myopia 8 | 176
Vascular disease 8 | 319
Waldenstrons macroglobulinemia 8 | 765
dermatomyositis 8 | 966
pediatric high grade glioma 8 | 1,064
Multiple myeloma 7 | 1,332

Tissue

Endocrine System 110 | 18,159
Digestive Tract 109 | 17,369
Female tissues 108 | 17,400
Nervous System 108 | 16,725
Skin and soft tissues 106 | 17,230
Liver and Pancreas 105 | 16,750
Male tissues 104 | 17,142
Blood and immune system 103 | 16,909
Urinary Tract 100 | 16,678
Respiratory system 99 | 16,393
Cardiovascular System 94 | 15,192

Target Family

Ion Channel 25 | 344
Kinase 24 | 634
Non-IDG 24 | 12,091
Enzyme 22 | 4,145
Transcription Factor 9 | 1,400
GPCR 5 | 408
Transporter 2 | 473

KEGG Pathway

Cholinergic synapse 111 | 111
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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