Development Level

Tbio 52 | 11,445
Tchem 39 | 1,598
Tclin 13 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal bone structure 6 | 187
increased startle reflex 5 | 112
abnormal behavior 4 | 298
increased heart weight 4 | 62
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased lymphocyte cell numb... 3 | 83
embryonic lethality prior to t... 3 | 278
hypoactivity 3 | 132
increased leukocyte cell numbe... 3 | 47
increased neutrophil cell numb... 3 | 46
preweaning lethality, incomple... 3 | 499
small superior vagus ganglion 3 | 74
abnormal embryo size 2 | 220
abnormal seminal vesicle morph... 2 | 114
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
increased circulating alkaline... 2 | 122
increased eosinophil cell numb... 2 | 11
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
male infertility 2 | 123
short tibia 2 | 97
vertebral fusion 2 | 23
abnormal bone mineralization 1 | 38
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased basophil cell number 1 | 7
increased bone mineral content 1 | 108
increased cardiac muscle contr... 1 | 8
increased circulating LDL chol... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
prolonged ST segment 1 | 36
thrombocytosis 1 | 27

Disease

Carcinoma 69 | 11,493
Cancer 68 | 2,499
glioblastoma 62 | 5,792
ovarian cancer 62 | 8,520
psoriasis 61 | 6,694
lung cancer 50 | 4,740
atypical teratoid / rhabdoid tumor 41 | 5,112
lung carcinoma 41 | 2,843
medulloblastoma, large-cell 41 | 6,241
osteosarcoma 40 | 7,950
Astrocytoma, Pilocytic 36 | 3,081
Schizophrenia 35 | 1,160
adult high grade glioma 34 | 3,801
tuberculosis 34 | 2,010
diabetes mellitus 33 | 1,728
Breast cancer 32 | 3,578
ependymoma 32 | 4,679
Arthritis 31 | 290
Kidney disease 28 | 430
malignant mesothelioma 28 | 3,232
Asthma 27 | 385
subependymal giant cell astrocytoma 27 | 2,287
ulcerative colitis 27 | 1,819
Rheumatoid arthritis 25 | 1,191
interstitial cystitis 25 | 2,312
Autosomal recessive predisposition 24 | 1,442
group 3 medulloblastoma 24 | 4,104
invasive ductal carcinoma 24 | 2,951
pancreatic cancer 24 | 2,398
Hypersensitivity reaction type II disease 23 | 253
Lung Neoplasms 23 | 232
Multiple Sclerosis 23 | 540
lung adenocarcinoma 23 | 2,716
Inflammatory bowel disease 22 | 151
Obesity 22 | 678
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
Hypertensive disease 21 | 292
Liver Cirrhosis, Experimental 21 | 769
Liver disease 21 | 237
cystic fibrosis 21 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
non-small cell lung cancer 21 | 2,890
pituitary cancer 21 | 1,972
Bipolar Disorder 20 | 666
Kidney cancer 20 | 2,613
Lung disease 20 | 142
primitive neuroectodermal tumor 20 | 3,035
Coronary artery disease 19 | 268
Reperfusion Injury 19 | 86
Vascular disease 19 | 319
group 4 medulloblastoma 19 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
juvenile dermatomyositis 19 | 1,187
Hypertension 18 | 396
colon cancer 18 | 1,478
cutaneous lupus erythematosus 18 | 1,057
Atherosclerosis 17 | 291
Depressive disorder 17 | 409
Heart disease 17 | 306
Inflammation 17 | 120
Meningitis 17 | 67
Pneumonia 17 | 174
Prostatic Neoplasms 17 | 495
Seizures 17 | 596
Breast Neoplasms 16 | 445
Epilepsy 16 | 792
Immunologic Deficiency Syndromes 16 | 113
Influenza 16 | 142
Malaria 16 | 160
Mammary Neoplasms 16 | 425
astrocytoma 16 | 1,146
Allergic hypersensitivity disease 15 | 126
Brain Ischemia 15 | 110
Hyperglycemia 15 | 137
astrocytic glioma 15 | 2,597
oligodendroglioma 15 | 2,850
Stomach Neoplasms 14 | 300
Vasculitis 14 | 80
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Alzheimer's disease 13 | 658
Cardiomyopathies 13 | 110
Cholestasis, Extrahepatic 13 | 25
Disease Models, Animal 13 | 155
Fever 13 | 138
Human immunodeficiency virus infectious disease 13 | 138
Hyperalgesia 13 | 83
Liver carcinoma 13 | 240
Melanoma 13 | 711
Pick disease 13 | 1,894
Pulmonary Fibrosis 13 | 106
acute quadriplegic myopathy 13 | 1,158
adrenocortical carcinoma 13 | 1,428
breast carcinoma 13 | 1,638
Arthritis, Rheumatoid 12 | 174
Endometriosis 12 | 540
Leishmaniasis 12 | 47
Major Depressive Disorder 12 | 301
Mental Depression 12 | 333
Waldenstrons macroglobulinemia 12 | 765
dermatomyositis 12 | 966

Tissue

Blood and immune system 101 | 16,909
Digestive Tract 100 | 17,369
Female tissues 100 | 17,400
Liver and Pancreas 100 | 16,750
Male tissues 100 | 17,142
Skin and soft tissues 100 | 17,230
Endocrine System 99 | 18,159
Respiratory system 99 | 16,393
Urinary Tract 99 | 16,678
Nervous System 98 | 16,725
Cardiovascular System 95 | 15,192

Target Family

Non-IDG 55 | 12,091
Kinase 24 | 634
Enzyme 18 | 4,145
Transcription Factor 6 | 1,400
GPCR 1 | 408

KEGG Pathway

Chagas disease (American trypa... 104 | 104
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
C-C motif chemokine 3-like 1 CCL3L1 Tbio Non-IDG -1.80717 51.3 142
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Guanine nucleotide-binding protein subunit alpha-14 GNA14 Tbio Non-IDG -0.78609 4.51 142
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.88444 66.2 265
Complement C1q subcomponent subunit A C1QA Tbio Non-IDG -1.73823 51.2 241
T-cell surface glycoprotein CD3 gamma chain CD3G Tclin Non-IDG -2.34430 223.5 239
Protein ALEX GNAS Tbio Non-IDG -2.63356 1389.7 509
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308