Development Level

Tchem 51 | 1,890
Tbio 43 | 10,625
Tclin 12 | 602

IMPC Term

abnormal bone mineralization 6 | 55
preweaning lethality, complete... 5 | 633
abnormal bone structure 4 | 131
increased heart weight 4 | 37
abnormal behavior 3 | 226
decreased body weight 3 | 174
decreased bone mineral content 3 | 157
decreased mean corpuscular vol... 3 | 50
abnormal spleen morphology 2 | 36
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 24
decreased circulating creatini... 2 | 31
decreased circulating triglyce... 2 | 83
decreased lean body mass 2 | 195
increased circulating alkaline... 2 | 119
male infertility 2 | 62
vertebral fusion 2 | 23
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal glucose homeostasis 1 | 5
abnormal heart left ventricle ... 1 | 20
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal skin condition 1 | 6
abnormal vocalization 1 | 21
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased body length 1 | 108
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating phosphat... 1 | 15
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
decreased thermal nociceptive ... 1 | 4
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired righting response 1 | 19
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating LDL chol... 1 | 15
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased neutrophil cell numb... 1 | 15
increased thermal nociceptive ... 1 | 9
polydactyly 1 | 22
small superior vagus ganglion 1 | 20
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

Cancer 67 | 2,346
psoriasis 61 | 6,685
ovarian cancer 59 | 8,484
glioblastoma 57 | 5,572
lung cancer 45 | 4,466
lung carcinoma 43 | 2,844
osteosarcoma 42 | 7,933
medulloblastoma, large-cell 41 | 6,234
atypical teratoid / rhabdoid tumor 37 | 4,369
pilocytic astrocytoma 37 | 3,086
diabetes mellitus 30 | 1,663
tuberculosis 30 | 1,557
ulcerative colitis 30 | 2,087
Kidney disease 29 | 396
subependymal giant cell astrocytoma 29 | 2,287
Breast cancer 28 | 3,094
interstitial cystitis 27 | 2,299
Arthritis 26 | 248
invasive ductal carcinoma 26 | 2,950
Asthma 25 | 349
malignant mesothelioma 25 | 3,162
Multiple Sclerosis 24 | 498
Rheumatoid Arthritis 24 | 1,160
lung adenocarcinoma 23 | 2,713
Lung Neoplasms 22 | 171
Obesity 22 | 616
adult high grade glioma 22 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
non-small cell lung cancer 22 | 2,798
pancreatic cancer 22 | 2,300
Carcinoma 21 | 2,147
cystic fibrosis 21 | 1,665
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
pediatric high grade glioma 21 | 2,712
pituitary cancer 21 | 1,972
Hypersensitivity reaction type II disease 20 | 235
Lung disease 20 | 132
Vascular disease 20 | 281
astrocytoma 20 | 1,493
primitive neuroectodermal tumor 20 | 3,031
Reperfusion Injury 19 | 84
group 4 medulloblastoma 19 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
juvenile dermatomyositis 19 | 1,189
posterior fossa group A ependymoma 19 | 1,511
Inflammatory bowel disease 18 | 142
Liver disease 18 | 219
colon cancer 18 | 1,475
cutaneous lupus erythematosus 18 | 1,056
Atherosclerosis 17 | 275
Heart disease 17 | 279
Inflammation 17 | 109
Prostatic Neoplasms 17 | 471
Influenza 16 | 142
Mammary Neoplasms 16 | 410
Brain Ischemia 15 | 87
Meningitis 15 | 46
Pneumonia 15 | 133
ependymoma 15 | 2,514
oligodendroglioma 15 | 2,849
Allergic hypersensitivity disease 14 | 123
Alzheimer's disease 14 | 644
Malaria 14 | 140
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
Coronary artery disease 13 | 240
Pick disease 13 | 1,893
Pulmonary Fibrosis 13 | 66
Schizophrenia 13 | 501
Stomach Neoplasms 13 | 282
acute quadriplegic myopathy 13 | 1,157
adrenocortical carcinoma 13 | 1,427
group 3 medulloblastoma 13 | 2,254
medulloblastoma 13 | 1,524
Cardiomyopathies 12 | 90
Dermatitis 12 | 107
Human immunodeficiency virus infectious disease 12 | 92
Hyperglycemia 12 | 120
Hypertension 12 | 287
IGA Glomerulonephritis 12 | 454
Leishmaniasis 12 | 49
Peritonitis 12 | 37
Waldenstrons macroglobulinemia 12 | 765
dermatomyositis 12 | 933
periodontitis 12 | 269
Diabetes Mellitus, Experimental 11 | 106
Diabetes Mellitus, Non-Insulin-Dependent 11 | 157
Myocardial Ischemia 11 | 169
Neoplasm Metastasis 11 | 138
acute myeloid leukemia 11 | 780
astrocytic glioma 11 | 2,241
breast carcinoma 11 | 1,614
ductal carcinoma in situ 11 | 1,745
Cerebrovascular disease 10 | 231
Crohn Disease 10 | 97
Endometriosis 10 | 535
Eosinophilia 10 | 65
Hypertensive disease 10 | 193
Liver carcinoma 10 | 217
Toxic encephalopathy 10 | 131
primary Sjogren syndrome 10 | 789

Tissue

Blood and immune system 103 | 17,995
Digestive Tract 102 | 18,473
Urinary Tract 102 | 18,444
Endocrine System 101 | 18,512
Female tissues 101 | 18,647
Liver and Pancreas 101 | 18,136
Nervous System 101 | 18,561
Respiratory system 101 | 17,484
Male tissues 100 | 17,969
Cardiovascular System 99 | 17,958
Skin and soft tissues 98 | 18,115

Target Family

Non-IDG 55 | 11,971
Kinase 25 | 634
Enzyme 19 | 4,146
Transcription Factor 6 | 1,400
GPCR 1 | 406

KEGG Pathway

Chagas disease (American trypa... 106 | 106
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.27492 2052.7 1794
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform PPP2R2A Tchem Enzyme -1.29353 14.5 115
Complement C1q subcomponent subunit C C1QC Tbio Non-IDG -1.27032 17.5 141
Complement C1q subcomponent subunit B C1QB Tbio Non-IDG -1.63026 41.3 161
Complement C1q subcomponent subunit A C1QA Tbio Non-IDG -1.71898 50.3 208
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.58202 42.2 123