Development Level

Tchem 29 | 1,598
Tbio 18 | 11,445
Tclin 18 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased body weight 3 | 161
abnormal gait 2 | 69
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased total body fat amoun... 2 | 207
increased circulating LDL chol... 2 | 13
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 96
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating triglyce... 1 | 79
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased eosinophil cell numb... 1 | 11
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Carcinoma 57 | 11,493
Cancer 46 | 2,499
ovarian cancer 43 | 8,520
lung cancer 36 | 4,740
osteosarcoma 35 | 7,950
glioblastoma 33 | 5,792
psoriasis 31 | 6,694
Breast cancer 29 | 3,578
atypical teratoid / rhabdoid tumor 27 | 5,112
medulloblastoma, large-cell 26 | 6,241
group 3 medulloblastoma 25 | 4,104
Kidney cancer 24 | 2,613
pancreatic cancer 22 | 2,398
astrocytic glioma 21 | 2,597
breast carcinoma 21 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
Cognitive delay 20 | 608
Epilepsy 20 | 792
Global developmental delay 20 | 608
Mental and motor retardation 20 | 608
Schizophrenia 20 | 1,160
ependymoma 20 | 4,679
invasive ductal carcinoma 20 | 2,951
malignant mesothelioma 20 | 3,232
oligodendroglioma 20 | 2,850
Autosomal recessive predisposition 19 | 1,442
Intellectual disability 19 | 1,016
Renal Cell Carcinoma 19 | 214
Seizures 19 | 596
non-small cell lung cancer 19 | 2,890
Dull intelligence 18 | 645
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
Stomach Neoplasms 18 | 300
Lung Neoplasms 17 | 232
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
Breast Neoplasms 16 | 445
Mammary Neoplasms 16 | 425
lung adenocarcinoma 16 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Orbital separation excessive 15 | 244
adult high grade glioma 15 | 3,801
diabetes mellitus 15 | 1,728
juvenile dermatomyositis 15 | 1,187
Blepharoptosis 14 | 231
Downward slant of palpebral fissure 14 | 158
Obesity 14 | 678
Squamous cell carcinoma 14 | 129
ductal carcinoma in situ 14 | 1,745
interstitial cystitis 14 | 2,312
tuberculosis 14 | 2,010
Astrocytoma, Pilocytic 13 | 3,081
Carcinoma, Hepatocellular 13 | 228
Carcinoma, Squamous Cell 13 | 110
Concave bridge of nose 13 | 195
Depressed nasal bridge 13 | 195
Depressed nasal root/bridge 13 | 195
Frontal bossing 13 | 157
Liver carcinoma 13 | 240
Short stature 13 | 531
subependymal giant cell astrocytoma 13 | 2,287
ulcerative colitis 13 | 1,819
Bipolar Disorder 12 | 666
Byzanthine arch palate 12 | 194
Hypoplastic mandible condyle 12 | 275
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
Muscle hypotonia 12 | 571
Ovarian Neoplasms 12 | 102
Prostatic Neoplasms 12 | 495
adrenocortical carcinoma 12 | 1,428
pituitary cancer 12 | 1,972
Acquired scoliosis 11 | 281
Big calvaria 11 | 147
Curvature of spine 11 | 282
High forehead 11 | 102
Increased head circumference 11 | 147
Increased size of cranium 11 | 147
Increased size of skull 11 | 147
Lymphoid leukemia 11 | 160
Pick disease 11 | 1,894
Strabismus 11 | 270
Tall forehead 11 | 102
Vascular disease 11 | 319
colon cancer 11 | 1,478
lung carcinoma 11 | 2,843
nasopharyngeal carcinoma 11 | 1,058
ovarian neoplasm 11 | 99
primitive neuroectodermal tumor 11 | 3,035
Adenoma 10 | 167
Immune system cancer 10 | 140
Melanoma 10 | 711
Pectus excavatum 10 | 100
Skin cancer 10 | 469
Splenomegaly 10 | 190
cutaneous lupus erythematosus 10 | 1,057
dermatomyositis 10 | 966

Tissue

Digestive Tract 64 | 17,369
Endocrine System 64 | 18,159
Nervous System 64 | 16,725
Skin and soft tissues 64 | 17,230
Urinary Tract 64 | 16,678
Blood and immune system 63 | 16,909
Female tissues 63 | 17,400
Liver and Pancreas 63 | 16,750
Male tissues 63 | 17,142
Respiratory system 62 | 16,393
Cardiovascular System 61 | 15,192

Target Family

Kinase 36 | 634
Enzyme 18 | 4,145
Transporter 5 | 473
Transcription Factor 3 | 1,400
Epigenetic 2 | 242
Non-IDG 1 | 12,091

KEGG Pathway

Central carbon metabolism in c... 65 | 65
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Large neutral amino acids transporter small subunit 1 SLC7A5 Tbio Transporter -1.90516 156.1 254
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Glutaminase liver isoform, mitochondrial GLS2 Tbio Enzyme -3.14287 1343.1 167
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Hexokinase-2 HK2 Tchem Kinase -2.64934 432.5 446
Glutaminase kidney isoform, mitochondrial GLS Tchem Enzyme -2.92171 795.3 268
Mast/stem cell growth factor receptor Kit KIT Tclin Kinase -3.80501 6371.9 4098