Development Level

Tbio 86 | 11,445
Tchem 32 | 1,598
Tclin 6 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 18 | 979
embryonic lethality prior to o... 11 | 239
embryonic lethality prior to t... 10 | 278
abnormal embryo size 7 | 220
preweaning lethality, incomple... 6 | 499
abnormal heart morphology 4 | 162
edema 4 | 59
abnormal lens morphology 3 | 81
abnormal testis morphology 3 | 43
cataract 3 | 92
small testis 3 | 58
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
decreased caudal vertebrae num... 2 | 53
decreased circulating glucose ... 2 | 126
decreased mean corpuscular hem... 2 | 50
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
female infertility 2 | 60
impaired glucose tolerance 2 | 75
increased circulating HDL chol... 2 | 80
male infertility 2 | 123
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal joint morphology 1 | 23
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating insulin ... 1 | 76
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hyperactivity 1 | 148
increased circulating alanine ... 1 | 13
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small kidney 1 | 16
small seminal vesicle 1 | 10
small spleen 1 | 19
small superior vagus ganglion 1 | 74
syndactyly 1 | 23
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 90 | 8,520
Cancer 85 | 2,499
Carcinoma 83 | 11,493
medulloblastoma, large-cell 75 | 6,241
glioblastoma 74 | 5,792
psoriasis 73 | 6,694
lung cancer 70 | 4,740
osteosarcoma 69 | 7,950
Breast cancer 68 | 3,578
atypical teratoid / rhabdoid tumor 65 | 5,112
group 3 medulloblastoma 64 | 4,104
malignant mesothelioma 58 | 3,232
primitive neuroectodermal tumor 54 | 3,035
adult high grade glioma 47 | 3,801
lung adenocarcinoma 46 | 2,716
non-small cell lung cancer 46 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,291
ependymoma 43 | 4,679
adrenocortical carcinoma 42 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,989
invasive ductal carcinoma 34 | 2,951
oligodendroglioma 33 | 2,850
ductal carcinoma in situ 32 | 1,745
colon cancer 31 | 1,478
pancreatic cancer 31 | 2,398
Astrocytoma, Pilocytic 29 | 3,081
Kidney cancer 29 | 2,613
nasopharyngeal carcinoma 29 | 1,058
Endometriosis 27 | 540
breast carcinoma 27 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
Atopic dermatitis 22 | 952
Multiple myeloma 21 | 1,332
astrocytic glioma 21 | 2,597
astrocytoma 20 | 1,146
Small head 19 | 374
acute quadriplegic myopathy 18 | 1,158
Schizophrenia 17 | 1,160
Short stature 17 | 531
Waldenstrons macroglobulinemia 17 | 765
subependymal giant cell astrocytoma 17 | 2,287
Intellectual disability 16 | 1,016
Prostatic Neoplasms 16 | 495
dermatomyositis 16 | 966
diabetes mellitus 16 | 1,728
Pick disease 15 | 1,894
pediatric high grade glioma 15 | 1,064
tuberculosis 15 | 2,010
Carcinoma, Hepatocellular 14 | 228
Liver carcinoma 14 | 240
Melanoma 14 | 711
Rheumatoid arthritis 14 | 1,191
Stomach Neoplasms 14 | 300
ulcerative colitis 14 | 1,819
Autosomal recessive predisposition 13 | 1,442
Bladder Neoplasm 13 | 112
Breast Neoplasms 13 | 445
Cognitive delay 13 | 608
Dull intelligence 13 | 645
Fetal Growth Retardation 13 | 189
Global developmental delay 13 | 608
Hypoplastic mandible condyle 13 | 275
Infant, Small for Gestational Age 13 | 176
Intrauterine retardation 13 | 176
Low intelligence 13 | 645
Mammary Neoplasms 13 | 425
Mandibular hypoplasia 13 | 275
Mental Retardation 13 | 645
Mental and motor retardation 13 | 608
Mental deficiency 13 | 645
Micrognathism 13 | 275
Poor school performance 13 | 645
Urinary Bladder Neoplasms 13 | 114
interstitial cystitis 13 | 2,312
juvenile dermatomyositis 13 | 1,187
pituitary cancer 13 | 1,972
Carcinoma, Squamous Cell 12 | 110
Cryptorchidism 12 | 296
Glaucoma 12 | 239
Liver Cirrhosis, Experimental 12 | 769
Squamous cell carcinoma 12 | 129
group 4 medulloblastoma 12 | 1,855
Delayed bone age 11 | 136
Lung Neoplasms 11 | 232
medulloblastoma 11 | 720
primary Sjogren syndrome 11 | 735
primary pancreatic ductal adenocarcinoma 11 | 1,109
Byzanthine arch palate 10 | 194
Esophageal Squamous Cell Carcinoma 10 | 77
Failure to gain weight 10 | 365
Immune system cancer 10 | 140
Low set ears 10 | 181
Lymphoid leukemia 10 | 160
Pancreatic Neoplasm 10 | 85
Pediatric failure to thrive 10 | 365
Squamous cell carcinoma of esophagus 10 | 77
esophageal adenocarcinoma 10 | 737
Bipolar Disorder 9 | 666
cystic fibrosis 9 | 1,696
lung carcinoma 9 | 2,843

Tissue

Blood and immune system 124 | 16,909
Digestive Tract 124 | 17,369
Endocrine System 124 | 18,159
Female tissues 124 | 17,400
Liver and Pancreas 124 | 16,750
Male tissues 124 | 17,142
Skin and soft tissues 124 | 17,230
Nervous System 123 | 16,725
Respiratory system 123 | 16,393
Urinary Tract 122 | 16,678
Cardiovascular System 118 | 15,192

Target Family

Non-IDG 62 | 12,091
Enzyme 26 | 4,145
Kinase 20 | 634
Transcription Factor 13 | 1,400
Epigenetic 4 | 242

KEGG Pathway

Cell cycle 125 | 125
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200
Origin recognition complex subunit 1 ORC1 Tbio Non-IDG -1.42573 28.0 148
Origin recognition complex subunit 2 ORC2 Tbio Non-IDG -0.68275 4.92 168
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase PKMYT1 Tchem Kinase -1.27237 19.2 364
Origin recognition complex subunit 5 ORC5 Tbio Non-IDG -1.50983 31.3 71
Structural maintenance of chromosomes protein 1B SMC1B Tbio Non-IDG -1.33220 21.7 87
Anaphase-promoting complex subunit 10 ANAPC10 Tbio Enzyme -1.23751 18.1 156