Development Level

Tbio 88 | 10,625
Tchem 21 | 1,890
Tdark 4 | 7,003
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 11 | 633
decreased body weight 3 | 174
decreased bone mineral content 3 | 157
decreased total body fat amoun... 3 | 186
abnormal embryo size 2 | 112
abnormal heart left ventricle ... 2 | 20
abnormal kidney morphology 2 | 30
abnormal lens morphology 2 | 73
decreased lean body mass 2 | 195
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
increased bone mineral content 2 | 92
increased lean body mass 2 | 107
prenatal lethality prior to he... 2 | 64
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal body wall morphology 1 | 7
abnormal bone mineralization 1 | 55
abnormal coping response 1 | 12
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal glucose homeostasis 1 | 5
abnormal retina morphology 1 | 100
abnormal retinal inner nuclear... 1 | 5
abnormal skin appearance 1 | 8
abnormal tail movements 1 | 12
abnormal vitreous body morphol... 1 | 7
abnormal vocalization 1 | 21
anophthalmia 1 | 20
craniofacial phenotype 1 | 9
decreased IgM level 1 | 1
decreased NK T cell number 1 | 28
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating calcium ... 1 | 33
decreased circulating serum al... 1 | 79
decreased spleen weight 1 | 13
herniated abdominal wall 1 | 4
hydrops fetalis 1 | 22
increased NK T cell number 1 | 11
increased body weight 1 | 42
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating fructosa... 1 | 11
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased heart rate variabili... 1 | 4
increased marginal zone B cell... 1 | 3
increased or absent threshold ... 1 | 128
increased rib number 1 | 41
microphthalmia 1 | 15
pale yolk sac 1 | 12
small adrenal glands 1 | 15
thrombocytopenia 1 | 46

Disease

ovarian cancer 65 | 8,484
psoriasis 49 | 6,685
pancreatic ductal adenocarcinoma liver metastasis 48 | 1,795
osteosarcoma 45 | 7,933
lung cancer 38 | 4,466
glioblastoma 37 | 5,572
medulloblastoma, large-cell 36 | 6,234
atypical teratoid / rhabdoid tumor 29 | 4,369
non-small cell lung cancer 28 | 2,798
Multiple myeloma 27 | 1,327
invasive ductal carcinoma 27 | 2,950
Breast cancer 25 | 3,094
adrenocortical carcinoma 24 | 1,427
lung adenocarcinoma 24 | 2,713
pancreatic cancer 23 | 2,300
malignant mesothelioma 22 | 3,162
ductal carcinoma in situ 21 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
astrocytic glioma 20 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,988
primitive neuroectodermal tumor 20 | 3,031
oligodendroglioma 19 | 2,849
Cancer 18 | 2,346
Waldenstrons macroglobulinemia 18 | 765
colon cancer 18 | 1,475
ulcerative colitis 18 | 2,087
adult high grade glioma 16 | 2,148
ependymoma 15 | 2,514
pilocytic astrocytoma 14 | 3,086
tuberculosis 14 | 1,557
Obesity 13 | 616
Pick disease 13 | 1,893
acute quadriplegic myopathy 13 | 1,157
group 3 medulloblastoma 13 | 2,254
posterior fossa group B ependymoma 13 | 1,530
group 4 medulloblastoma 12 | 1,875
lung carcinoma 12 | 2,844
medulloblastoma 12 | 1,524
pediatric high grade glioma 12 | 2,712
astrocytoma 11 | 1,493
breast carcinoma 11 | 1,614
diabetes mellitus 11 | 1,663
primary pancreatic ductal adenocarcinoma 11 | 1,271
subependymal giant cell astrocytoma 11 | 2,287
Degenerative polyarthritis 10 | 93
Liver carcinoma 10 | 217
atypical teratoid/rhabdoid tumor 10 | 1,095
interstitial cystitis 10 | 2,299
Stomach Neoplasms 9 | 282
aldosterone-producing adenoma 9 | 664
posterior fossa group A ependymoma 9 | 1,511
sonic hedgehog group medulloblastoma 9 | 1,482
Carcinoma 8 | 2,147
Leigh disease 8 | 81
Methylmalonic acidemia 8 | 39
Myocardial Ischemia 8 | 169
cystic fibrosis 8 | 1,665
dermatomyositis 8 | 933
nephrosclerosis 8 | 329
Alzheimer's disease 7 | 644
Down syndrome 7 | 548
Drug-Induced Liver Injury 7 | 118
Hypoglycemia 7 | 81
Lactic acidosis 7 | 42
Liver Cirrhosis, Experimental 7 | 108
Mammary Neoplasms 7 | 410
Osteoporosis 7 | 257
nasopharyngeal carcinoma 7 | 1,056
non-small cell lung carcinoma 7 | 413
pituitary cancer 7 | 1,972
Atopic dermatitis 6 | 944
Congenital hemolytic anemia 6 | 30
Glycogen storage disease 6 | 37
Hemangioma 6 | 35
Kidney disease 6 | 396
Neoplasm Invasiveness 6 | 127
Pyruvate decarboxylase deficiency 6 | 15
Rheumatoid Arthritis 6 | 1,160
active ulcerative colitis 6 | 477
acute myeloid leukemia 6 | 780
fibroadenoma 6 | 557
gastric carcinoma 6 | 832
non primary Sjogren syndrome sicca 6 | 840
pancreatic carcinoma 6 | 567
Animal Mammary Neoplasms 5 | 136
Anoxia 5 | 33
Atherosclerosis 5 | 275
Diabetes Mellitus, Experimental 5 | 106
Mammary Neoplasms, Experimental 5 | 150
Neoplastic Syndromes, Hereditary 5 | 48
Neurodegenerative disease 5 | 383
Persistent generalized lymphadenopathy 5 | 15
Phaeochromocytoma 5 | 20
Polycystic Ovary Syndrome 5 | 332
Prostatic Neoplasms 5 | 471
active Crohn's disease 5 | 918
esophageal adenocarcinoma 5 | 737
Disease Progression 4 | 125
tuberculosis and treatment for 3 months 4 | 327

Tissue

Blood and immune system 114 | 17,995
Cardiovascular System 114 | 17,958
Digestive Tract 114 | 18,473
Endocrine System 114 | 18,512
Female tissues 114 | 18,647
Liver and Pancreas 114 | 18,136
Male tissues 114 | 17,969
Nervous System 114 | 18,561
Respiratory system 114 | 17,484
Urinary Tract 114 | 18,444
Skin and soft tissues 112 | 18,115

Target Family

Enzyme 89 | 4,146
Kinase 18 | 634
Non-IDG 7 | 11,971

KEGG Pathway

Carbon metabolism 114 | 114
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
Glutamate dehydrogenase 2, mitochondrial GLUD2 Tbio Enzyme -1.13407 13.6 143
NADP-dependent malic enzyme ME1 Tchem Non-IDG -1.96870 90.3 172
Phosphoglycerate kinase 1 PGK1 Tchem Kinase -2.77086 576.3 300
Glycine dehydrogenase (decarboxylating), mitochondrial GLDC Tbio Enzyme -1.68278 53.7 117
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM Tbio Enzyme -2.58670 387.0 269