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Development Level

Tbio 94 | 11,651
Tchem 17 | 1,388
Tdark 3 | 6,593
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 19 | 979
increased bone mineral content 3 | 108
abnormal QT variability 2 | 10
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal kidney morphology 2 | 65
anophthalmia 2 | 33
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased circulating alkaline... 2 | 122
increased lean body mass 2 | 172
microphthalmia 2 | 26
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal craniofacial morpholo... 1 | 33
abnormal digit morphology 1 | 10
abnormal eye morphology 1 | 68
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal retinal vasculature m... 1 | 27
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
absent testes 1 | 6
brachydactyly 1 | 19
decreased IgM level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
edema 1 | 59
increased basophil cell number 1 | 7
increased body length 1 | 32
increased body temperature 1 | 9
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
long tibia 1 | 25
pale yolk sac 1 | 25
pallor 1 | 34
small adrenal glands 1 | 16
syndactyly 1 | 23
thrombocytopenia 1 | 56

Disease

Carcinoma 85 | 11,493
ovarian cancer 65 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,962
psoriasis 49 | 6,694
Autosomal recessive predisposition 45 | 1,442
osteosarcoma 45 | 7,950
lung cancer 39 | 4,740
glioblastoma 38 | 5,792
atypical teratoid / rhabdoid tumor 36 | 5,112
medulloblastoma, large-cell 36 | 6,241
Cognitive delay 31 | 608
Global developmental delay 31 | 608
Mental and motor retardation 31 | 608
Seizures 30 | 596
Epilepsy 29 | 792
ependymoma 29 | 4,679
group 3 medulloblastoma 28 | 4,104
non-small cell lung cancer 28 | 2,890
Multiple myeloma 27 | 1,332
invasive ductal carcinoma 27 | 2,951
Breast cancer 26 | 3,578
Muscle hypotonia 25 | 571
Intellectual disability 24 | 1,016
adrenocortical carcinoma 24 | 1,428
adult high grade glioma 24 | 3,801
lung adenocarcinoma 24 | 2,716
Dull intelligence 23 | 645
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
pancreatic cancer 23 | 2,398
malignant mesothelioma 22 | 3,232
Cancer 21 | 2,499
astrocytic glioma 21 | 2,597
ductal carcinoma in situ 21 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
primitive neuroectodermal tumor 20 | 3,035
oligodendroglioma 19 | 2,850
Waldenstrons macroglobulinemia 18 | 765
colon cancer 18 | 1,478
tuberculosis 17 | 2,010
ulcerative colitis 16 | 1,819
Astrocytoma, Pilocytic 15 | 3,081
Cerebellar Ataxia 15 | 304
Obesity 15 | 678
Failure to gain weight 14 | 365
Kidney cancer 14 | 2,613
Liver Cirrhosis, Experimental 14 | 769
Pediatric failure to thrive 14 | 365
breast carcinoma 14 | 1,638
Acidosis, Lactic 13 | 97
Lethargy 13 | 77
Pick disease 13 | 1,894
acute quadriplegic myopathy 13 | 1,158
Hypoglycemia 12 | 152
Lactic acidemia 12 | 95
Metabolic acidosis 12 | 90
Stomach Neoplasms 12 | 300
lung carcinoma 12 | 2,843
Chemical and Drug Induced Liver Injury 11 | 195
Dystonia 11 | 164
Dystonic disease 11 | 106
Osteoarthritis 11 | 184
Schizophrenia 11 | 1,160
diabetes mellitus 11 | 1,728
group 4 medulloblastoma 11 | 1,855
subependymal giant cell astrocytoma 11 | 2,287
Carcinoma, Hepatocellular 10 | 228
Degenerative polyarthritis 10 | 115
Infantile onset 10 | 238
Liver carcinoma 10 | 240
Short stature 10 | 531
astrocytoma 10 | 1,146
interstitial cystitis 10 | 2,312
Adenocarcinoma of lung 9 | 142
Disease Models, Animal 9 | 155
Hepatomegaly 9 | 285
Leigh disease 9 | 100
Nystagmus 9 | 317
Optic Atrophy 9 | 242
Osteoporosis 9 | 363
Small head 9 | 374
aldosterone-producing adenoma 9 | 665
cystic fibrosis 9 | 1,696
Alzheimer's disease 8 | 658
Bipolar Disorder 8 | 666
Cardiomyopathies 8 | 110
Lactic acidosis 8 | 51
Myocardial Ischemia 8 | 169
Peripheral Neuropathy 8 | 134
active ulcerative colitis 8 | 764
dermatomyositis 8 | 966
nephrosclerosis 8 | 333
primary pancreatic ductal adenocarcinoma 8 | 1,109
Down syndrome 7 | 499
nasopharyngeal carcinoma 7 | 1,058
pituitary cancer 7 | 1,972

Tissue

Endocrine System 115 | 18,159
Blood and immune system 112 | 16,909
Male tissues 112 | 17,142
Urinary Tract 112 | 16,678
Digestive Tract 111 | 17,369
Female tissues 111 | 17,400
Liver and Pancreas 111 | 16,750
Skin and soft tissues 111 | 17,230
Nervous System 110 | 16,725
Respiratory system 107 | 16,393
Cardiovascular System 102 | 15,192

Target Family

Enzyme 90 | 4,145
Kinase 18 | 634
Non-IDG 8 | 12,091

KEGG Pathway

Carbon metabolism 116 | 116
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275