Development Level

Tclin 63 | 602
Tchem 62 | 1,890
Tbio 54 | 10,625
Tdark 2 | 7,003

Collection

Eligible Kinase Proteins 6 | 134
Eligible non-olfactory GPCR Proteins 3 | 143
Eligible Ion Channel Proteins 2 | 117

IMPC Term

abnormal bone mineralization 7 | 55
preweaning lethality, complete... 7 | 633
abnormal behavior 5 | 226
abnormal bone structure 5 | 131
increased heart weight 5 | 37
decreased circulating triglyce... 4 | 83
embryonic lethality prior to t... 4 | 187
decreased body weight 3 | 174
increased blood urea nitrogen ... 3 | 44
increased fasted circulating g... 3 | 68
preweaning lethality, incomple... 3 | 260
abnormal embryo size 2 | 112
abnormal seminal vesicle morph... 2 | 47
abnormal spleen morphology 2 | 36
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 24
decreased circulating chloride... 2 | 32
decreased circulating glycerol... 2 | 19
decreased prepulse inhibition 2 | 52
increased circulating alkaline... 2 | 119
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased startle reflex 2 | 38
male infertility 2 | 62
small heart 2 | 8
small liver 2 | 8
abnormal epididymis morphology 1 | 31
abnormal facial morphology 1 | 9
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pancreas morphology 1 | 6
abnormal placenta vasculature 1 | 2
abnormal sensory capabilities/... 1 | 3
abnormal vibrissa morphology 1 | 17
abnormal vocalization 1 | 21
absent vibrissae 1 | 14
convulsive seizures 1 | 11
cyanosis 1 | 6
decreased B cell number 1 | 30
decreased bone mineral content 1 | 157
decreased brain size 1 | 4
decreased caudal vertebrae num... 1 | 49
decreased circulating alkaline... 1 | 41
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating phosphat... 1 | 15
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased mature B cell number 1 | 25
decreased mean corpuscular vol... 1 | 50
edema 1 | 11
enlarged spleen 1 | 26
hemorrhage 1 | 12
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased caudal vertebrae num... 1 | 8
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating choleste... 1 | 53
increased circulating phosphat... 1 | 24
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 57
no abnormal phenotype detected 1 | 3
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
respiratory system phenotype 1 | 2
short tibia 1 | 82
small epididymis 1 | 3
small lung 1 | 5
small spleen 1 | 11
small stomach 1 | 3
small thymus 1 | 11
straub tail 1 | 26
thrombocytopenia 1 | 46
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

psoriasis 91 | 6,685
medulloblastoma, large-cell 88 | 6,234
osteosarcoma 81 | 7,933
glioblastoma 80 | 5,572
ovarian cancer 71 | 8,484
atypical teratoid / rhabdoid tumor 60 | 4,369
pilocytic astrocytoma 59 | 3,086
primitive neuroectodermal tumor 58 | 3,031
Carcinoma 57 | 2,147
oligodendroglioma 57 | 2,849
lung cancer 48 | 4,466
lung carcinoma 44 | 2,844
pediatric high grade glioma 44 | 2,712
astrocytic glioma 42 | 2,241
Cancer 41 | 2,346
ependymoma 41 | 2,514
subependymal giant cell astrocytoma 38 | 2,287
invasive ductal carcinoma 37 | 2,950
Breast cancer 36 | 3,094
interstitial cystitis 36 | 2,299
colon cancer 35 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,988
lung adenocarcinoma 35 | 2,713
Pick disease 34 | 1,893
malignant mesothelioma 34 | 3,162
Schizophrenia 33 | 501
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,289
medulloblastoma 33 | 1,524
pancreatic cancer 33 | 2,300
ulcerative colitis 33 | 2,087
adult high grade glioma 30 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,956
non-small cell lung cancer 29 | 2,798
pituitary cancer 29 | 1,972
astrocytoma 26 | 1,493
Parkinson's disease 25 | 364
group 3 medulloblastoma 24 | 2,254
group 4 medulloblastoma 24 | 1,875
Epilepsy 23 | 346
Obesity 22 | 616
cystic fibrosis 21 | 1,665
Asthma 20 | 349
ductal carcinoma in situ 20 | 1,745
posterior fossa group A ependymoma 19 | 1,511
posterior fossa group B ependymoma 19 | 1,530
atypical teratoid/rhabdoid tumor 17 | 1,095
Heart disease 16 | 279
tuberculosis 16 | 1,557
Hypertension 15 | 287
Hypertensive disease 15 | 193
breast carcinoma 15 | 1,614
diabetes mellitus 15 | 1,663
Allergic rhinitis 14 | 91
Alzheimer's disease 14 | 644
Autistic Disorder 14 | 320
Bipolar Disorder 14 | 266
acute quadriplegic myopathy 14 | 1,157
cutaneous lupus erythematosus 14 | 1,056
sonic hedgehog group medulloblastoma 14 | 1,482
Hyperalgesia 13 | 71
Migraine 13 | 79
primary pancreatic ductal adenocarcinoma 13 | 1,271
spina bifida 13 | 1,064
Common cold 12 | 63
Duchenne muscular dystrophy 12 | 602
Hypertensive disorder 12 | 58
Rheumatoid Arthritis 12 | 1,160
Substance Withdrawal Syndrome 12 | 52
adrenocortical carcinoma 12 | 1,427
gastric carcinoma 12 | 832
primary Sjogren syndrome 12 | 789
Kidney cancer 11 | 118
Major Depressive Disorder 11 | 106
Nasal congestion 11 | 24
Nasal discharge 11 | 26
Atopic dermatitis 10 | 944
Atrial Fibrillation 10 | 110
Cerebrovascular disease 10 | 231
Cocaine-Related Disorders 10 | 88
General anesthesia 10 | 53
Kidney disease 10 | 396
chronic rhinosinusitis 10 | 512
nasopharyngeal carcinoma 10 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
Adenoma 9 | 165
Diabetes Mellitus, Experimental 9 | 106
Essential Hypertension 9 | 82
Irritable bowel syndrome 9 | 59
Neurodegenerative disease 9 | 383
Pain 9 | 70
Parkinsonism 9 | 19
Prostatic Neoplasms 9 | 471
Renal Cell Carcinoma 9 | 199
Toxic encephalopathy 9 | 131
Vascular disease 9 | 281
aldosterone-producing adenoma 9 | 664
non-small cell lung carcinoma 9 | 413
progressive supranuclear palsy 9 | 674
Attention deficit hyperactivity disorder 8 | 156
Multiple myeloma 8 | 1,327

Tissue

Digestive Tract 179 | 18,473
Female tissues 179 | 18,647
Liver and Pancreas 179 | 18,136
Endocrine System 178 | 18,512
Nervous System 178 | 18,561
Urinary Tract 178 | 18,444
Cardiovascular System 177 | 17,958
Male tissues 177 | 17,969
Respiratory system 176 | 17,484
Skin and soft tissues 176 | 18,115
Blood and immune system 174 | 17,995

Target Family

GPCR 51 | 406
Kinase 31 | 634
Enzyme 30 | 4,146
Ion Channel 29 | 341
Non-IDG 26 | 11,971
Transporter 14 | 473

KEGG Pathway

Calcium signaling pathway 181 | 181
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Sodium/calcium exchanger 2 SLC8A2 Tbio Transporter -1.56223 31.9 51
Inositol-trisphosphate 3-kinase B ITPKB Tbio Kinase -1.40405 29.1 141
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
5-hydroxytryptamine receptor 6 HTR6 Tchem GPCR -2.29395 203.8 55
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 PLCD1 Tchem Enzyme -2.16125 137.5 96
Calcium uniporter protein, mitochondrial MCU Tbio Ion Channel -2.59256 408.9 18