Development Level

Tclin 65 | 612
Tchem 62 | 1,885
Tbio 54 | 11,178
Tdark 2 | 6,569

Collection

Kinase: IDG Consortium (Target... 4 | 125
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 11 | 979
increased startle reflex 8 | 112
preweaning lethality, incomple... 7 | 499
abnormal bone structure 5 | 187
increased heart weight 5 | 62
abnormal behavior 4 | 298
abnormal embryo size 4 | 220
abnormal gait 4 | 69
decreased total body fat amoun... 4 | 207
embryonic lethality prior to t... 4 | 278
improved glucose tolerance 4 | 79
increased fasted circulating g... 4 | 76
increased total body fat amoun... 4 | 134
decreased body weight 3 | 161
decreased circulating triglyce... 3 | 79
decreased prepulse inhibition 3 | 82
increased circulating sodium l... 3 | 71
abnormal bone mineralization 2 | 38
abnormal seminal vesicle morph... 2 | 114
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating chloride... 2 | 30
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased heart weight 2 | 27
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased mean platelet volume 2 | 25
decreased threshold for audito... 2 | 26
edema 2 | 59
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
male infertility 2 | 123
small heart 2 | 10
small liver 2 | 8
abnormal digit morphology 1 | 10
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal locomotor behavior 1 | 24
abnormal pancreas morphology 1 | 13
abnormal placenta vasculature 1 | 2
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
absent vibrissae 1 | 12
cataract 1 | 92
convulsive seizures 1 | 13
cyanosis 1 | 7
decreased bone mineral content 1 | 151
decreased brain size 1 | 4
decreased cardiac stroke volum... 1 | 6
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased mature B cell number 1 | 7
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
hemorrhage 1 | 23
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased spleen weight 1 | 10
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2
short tibia 1 | 97
small lung 1 | 5
small spleen 1 | 19
small stomach 1 | 3
small superior vagus ganglion 1 | 74
small thymus 1 | 16
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

Carcinoma 147 | 11,192
psoriasis 92 | 6,514
medulloblastoma, large-cell 89 | 6,086
glioblastoma 86 | 5,635
osteosarcoma 82 | 7,766
ovarian cancer 77 | 8,297
ependymoma 76 | 4,559
atypical teratoid / rhabdoid tumor 72 | 4,971
adult high grade glioma 65 | 3,701
group 3 medulloblastoma 61 | 4,002
Astrocytoma, Pilocytic 60 | 3,006
primitive neuroectodermal tumor 59 | 2,957
oligodendroglioma 58 | 2,768
Kidney cancer 57 | 2,548
astrocytic glioma 57 | 2,530
lung cancer 53 | 4,607
Schizophrenia 52 | 1,136
Breast cancer 45 | 3,469
lung carcinoma 44 | 2,755
Cancer 43 | 2,388
subependymal giant cell astrocytoma 39 | 2,230
Bipolar Disorder 38 | 646
invasive ductal carcinoma 37 | 2,867
pancreatic cancer 37 | 2,322
interstitial cystitis 36 | 2,237
malignant mesothelioma 36 | 3,135
Depressive disorder 35 | 401
Pick disease 35 | 1,856
colon cancer 35 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,902
lung adenocarcinoma 35 | 2,627
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,204
non-small cell lung cancer 31 | 2,799
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,872
Epilepsy 29 | 775
pituitary cancer 29 | 1,915
ulcerative colitis 29 | 1,765
Autosomal recessive predisposition 25 | 1,407
Parkinson's disease 25 | 378
Hypertension 24 | 372
Major Depressive Disorder 24 | 293
tuberculosis 24 | 1,963
Melanoma 23 | 689
Mental Depression 23 | 325
Mood Disorders 23 | 181
cystic fibrosis 23 | 1,629
Liver cancer 22 | 589
group 4 medulloblastoma 22 | 1,806
Skin cancer 21 | 451
ductal carcinoma in situ 20 | 1,686
Asthma 19 | 370
Obesity 19 | 655
diabetes mellitus 19 | 1,683
Heart disease 18 | 288
Hypertensive disease 18 | 278
Alcoholic Intoxication, Chronic 17 | 283
Unipolar Depression 17 | 244
Substance Withdrawal Syndrome 15 | 53
breast carcinoma 15 | 1,589
Allergic rhinitis 14 | 93
Alzheimer's disease 14 | 640
Autistic Disorder 14 | 358
Hyperalgesia 14 | 80
Seizures 14 | 584
acute quadriplegic myopathy 14 | 1,133
cutaneous lupus erythematosus 14 | 1,016
Liver Cirrhosis, Experimental 13 | 733
Migraine 13 | 78
Rheumatoid arthritis 13 | 1,156
spina bifida 13 | 1,053
Attention deficit hyperactivity disorder 12 | 272
Common cold 12 | 66
Duchenne muscular dystrophy 12 | 587
Endometrial cancer 12 | 301
Hypertensive disorder 12 | 56
adrenocortical carcinoma 12 | 1,385
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,911
primary Sjogren syndrome 12 | 710
Cerebrovascular disease 11 | 223
Intellectual disability 11 | 998
Nasal congestion 11 | 23
Nasal discharge 11 | 25
Psychotic Disorders 11 | 150
Toxic encephalopathy 11 | 139
astrocytoma 11 | 1,113
gastric carcinoma 11 | 781
primary pancreatic ductal adenocarcinoma 11 | 1,071
Atopic dermatitis 10 | 915
Atrial Fibrillation 10 | 120
Cocaine-Related Disorders 10 | 90
Essential Hypertension 10 | 92
General anesthesia 10 | 53
Heart failure 10 | 157
Kidney disease 10 | 411
Pain 10 | 102
Polycystic ovary syndrome 10 | 348
chronic rhinosinusitis 10 | 505
medulloblastoma 10 | 702
nasopharyngeal carcinoma 10 | 1,024
Prostatic Neoplasms 9 | 472

Tissue

Endocrine System 179 | 18,159
Nervous System 173 | 16,725
Digestive Tract 172 | 17,369
Female tissues 172 | 17,400
Skin and soft tissues 169 | 17,230
Male tissues 167 | 17,142
Liver and Pancreas 165 | 16,750
Urinary Tract 163 | 16,678
Blood and immune system 162 | 16,909
Respiratory system 158 | 16,393
Cardiovascular System 148 | 15,192

Target Family

GPCR 51 | 408
Kinase 31 | 634
Enzyme 30 | 4,145
Ion Channel 29 | 344
Non-IDG 28 | 12,091
Transporter 14 | 473

KEGG Pathway

Calcium signaling pathway 183 | 183
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103
Prostaglandin E2 receptor EP1 subtype PTGER1 Tclin GPCR -2.64481 402.0 168
Adenylate cyclase type 3 ADCY3 Tbio Enzyme -2.31593 204.4 82
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 PLCB4 Tbio Enzyme -1.77110 57.7 19
Beta-2 adrenergic receptor ADRB2 Tclin GPCR -3.22695 1680.9 829
Receptor tyrosine-protein kinase erbB-4 ERBB4 Tclin Kinase -2.78704 558.2 1072
Thromboxane A2 receptor TBXA2R Tclin GPCR -2.17674 123.4 112
Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A Tchem Ion Channel -3.06226 1140.1 64
5-hydroxytryptamine receptor 7 HTR7 Tclin GPCR -4.15964 13643.7 259
Plasma membrane calcium-transporting ATPase 3 ATP2B3 Tbio Transporter -2.52332 332.0 52