Development Level

Tbio 44 | 11,445
Tchem 43 | 1,598
Tclin 15 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 8 | 499
preweaning lethality, complete... 4 | 979
abnormal bone structure 3 | 187
decreased body weight 3 | 161
decreased circulating choleste... 3 | 93
decreased mean corpuscular vol... 3 | 79
increased total body fat amoun... 3 | 134
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal bone mineralization 2 | 38
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased hematocrit 2 | 46
decreased mean corpuscular hem... 2 | 50
increased circulating alkaline... 2 | 122
increased circulating glucose ... 2 | 24
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased neutrophil cell numb... 2 | 46
abnormal clavicle morphology 1 | 6
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal sensory capabilities-... 1 | 8
abnormal skin condition 1 | 6
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
impaired righting response 1 | 26
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
prenatal lethality 1 | 28
small epididymis 1 | 3
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 67 | 11,493
Cancer 63 | 2,499
psoriasis 59 | 6,694
ovarian cancer 53 | 8,520
osteosarcoma 52 | 7,950
lung cancer 49 | 4,740
glioblastoma 47 | 5,792
medulloblastoma, large-cell 37 | 6,241
Breast cancer 33 | 3,578
atypical teratoid / rhabdoid tumor 33 | 5,112
ependymoma 32 | 4,679
malignant mesothelioma 31 | 3,232
subependymal giant cell astrocytoma 29 | 2,287
adult high grade glioma 28 | 3,801
Kidney cancer 27 | 2,613
tuberculosis 27 | 2,010
Astrocytoma, Pilocytic 26 | 3,081
Schizophrenia 26 | 1,160
lung carcinoma 26 | 2,843
diabetes mellitus 25 | 1,728
pancreatic cancer 24 | 2,398
ulcerative colitis 24 | 1,819
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
non-small cell lung cancer 23 | 2,890
primitive neuroectodermal tumor 23 | 3,035
interstitial cystitis 22 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
invasive ductal carcinoma 22 | 2,951
oligodendroglioma 22 | 2,850
Arthritis 21 | 290
group 3 medulloblastoma 21 | 4,104
Rheumatoid arthritis 20 | 1,191
Asthma 19 | 385
Lung Neoplasms 19 | 232
Breast Neoplasms 18 | 445
Heart disease 18 | 306
Mammary Neoplasms 18 | 425
Stomach Neoplasms 18 | 300
lung adenocarcinoma 18 | 2,716
Inflammatory bowel disease 16 | 151
Multiple Sclerosis 16 | 540
Pick disease 16 | 1,894
astrocytic glioma 16 | 2,597
Alzheimer's disease 15 | 658
Autosomal recessive predisposition 15 | 1,442
Epilepsy 15 | 792
Obesity 15 | 678
Seizures 15 | 596
breast carcinoma 15 | 1,638
cystic fibrosis 15 | 1,696
juvenile dermatomyositis 15 | 1,187
Bipolar Disorder 14 | 666
Hypertension 14 | 396
Kidney disease 14 | 430
Multiple myeloma 14 | 1,332
Vascular disease 14 | 319
dermatomyositis 14 | 966
group 4 medulloblastoma 14 | 1,855
Liver carcinoma 13 | 240
Lung disease 13 | 142
cutaneous lupus erythematosus 13 | 1,057
Carcinoma, Hepatocellular 12 | 228
Prostatic Neoplasms 12 | 495
Toxic encephalopathy 12 | 141
Waldenstrons macroglobulinemia 12 | 765
pancreatic carcinoma 12 | 562
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Brain Ischemia 11 | 110
Crohn's disease 11 | 321
Depressive disorder 11 | 409
Fever 11 | 138
Hyperglycemia 11 | 137
Immunologic Deficiency Syndromes 11 | 113
Parkinson's disease 11 | 392
Reperfusion Injury 11 | 86
acute quadriplegic myopathy 11 | 1,158
astrocytoma 11 | 1,146
colon cancer 11 | 1,478
ductal carcinoma in situ 11 | 1,745
mucosa-associated lymphoid tissue lymphoma 11 | 484
pituitary cancer 11 | 1,972
primary pancreatic ductal adenocarcinoma 11 | 1,109
Anemia 10 | 365
Atopic dermatitis 10 | 952
Dermatitis 10 | 157
Diarrhea 10 | 253
Disease Models, Animal 10 | 155
Dull intelligence 10 | 645
Hyperalgesia 10 | 83
Intellectual disability 10 | 1,016
Liver Cirrhosis, Experimental 10 | 769
Low intelligence 10 | 645
Melanoma 10 | 711
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Neoplasm Metastasis 10 | 168
Pneumonia 10 | 174
Poor school performance 10 | 645
Squamous cell carcinoma 10 | 129

Tissue

Blood and immune system 103 | 16,909
Digestive Tract 103 | 17,369
Endocrine System 103 | 18,159
Female tissues 103 | 17,400
Liver and Pancreas 103 | 16,750
Skin and soft tissues 103 | 17,230
Male tissues 101 | 17,142
Respiratory system 101 | 16,393
Urinary Tract 100 | 16,678
Cardiovascular System 97 | 15,192
Nervous System 97 | 16,725

Target Family

Non-IDG 36 | 12,091
Kinase 29 | 634
Enzyme 21 | 4,145
Transcription Factor 15 | 1,400
Ion Channel 3 | 344

KEGG Pathway

C-type lectin receptor signali... 104 | 104
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
C-type lectin domain family 4 member D CLEC4D Tbio Non-IDG -1.43609 25.1 193
Nuclear factor of activated T-cells, cytoplasmic 4 NFATC4 Tbio Transcription Factor -1.93766 88.3 358
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.29685 1936.6 519
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.53531 28.2 147
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Rho guanine nucleotide exchange factor 12 ARHGEF12 Tbio Non-IDG -2.63794 448.3 88