Development Level

Tbio 21 | 11,651
Tdark 5 | 6,593
Tclin 2 | 612

IMPC Phenotype

thin ventricular wall 2 | 24
abnormal body wall morphology 1 | 9
abnormal embryo size 1 | 220
anophthalmia 1 | 33
decreased heart left ventricle... 1 | 28
increased body length 1 | 32
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased mean corpuscular hem... 1 | 96
microphthalmia 1 | 26
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 23 | 11,493
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
ovarian cancer 11 | 8,520
Autosomal recessive predisposition 10 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
atypical teratoid / rhabdoid tumor 9 | 5,112
interstitial cystitis 9 | 2,312
medulloblastoma, large-cell 9 | 6,241
oligodendroglioma 9 | 2,850
psoriasis 9 | 6,694
adult high grade glioma 8 | 3,801
colon cancer 8 | 1,478
glioblastoma 8 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
osteosarcoma 8 | 7,950
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
Muscle hypotonia 7 | 571
ependymoma 7 | 4,679
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung carcinoma 7 | 2,843
Epilepsy 6 | 792
Pick disease 6 | 1,894
Seizures 6 | 596
astrocytic glioma 6 | 2,597
ductal carcinoma in situ 6 | 1,745
invasive ductal carcinoma 6 | 2,951
malignant mesothelioma 6 | 3,232
primitive neuroectodermal tumor 6 | 3,035
ulcerative colitis 6 | 1,819
Hypoglycemia 5 | 152
Intellectual disability 5 | 1,016
adrenocortical carcinoma 5 | 1,428
lung cancer 5 | 4,740
nephrosclerosis 5 | 333
Astrocytoma, Pilocytic 4 | 3,081
Bipolar Disorder 4 | 666
Dull intelligence 4 | 645
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Poor school performance 4 | 645
Succinic semialdehyde dehydrogenase deficiency 4 | 16
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
non-small cell lung cancer 4 | 2,890
Alcoholic Intoxication, Chronic 3 | 289
Autistic Disorder 3 | 364
Liver Cirrhosis, Experimental 3 | 769
Major Depressive Disorder 3 | 301
Medium chain acyl-CoA dehydrogenase deficiency 3 | 13
Multiple myeloma 3 | 1,332
Schizophrenia 3 | 1,160
Very long chain acyl-CoA dehydrogenase deficiency 3 | 10
astrocytoma 3 | 1,146
beta-ketothiolase deficiency 3 | 13
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
gastric carcinoma 3 | 807
lung adenocarcinoma 3 | 2,716
subependymal giant cell astrocytoma 3 | 2,287
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Breast cancer 2 | 3,578
Cardiomyopathy, Dilated 2 | 83
Cocaine-Related Disorders 2 | 92
Contracture 2 | 96
Contracture of joint 2 | 93
Curvature of spine 2 | 282
Delayed speech and language development 2 | 112
Failure to gain weight 2 | 365
Hepatomegaly 2 | 285
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hyperreflexia 2 | 209
Infantile onset 2 | 238
Language Delay 2 | 112
Maple syrup urine disease 2 | 24
Melanoma 2 | 711
Mood Disorders 2 | 184
Myocardial Ischemia 2 | 169
Myoglobinuria 2 | 15
Pediatric failure to thrive 2 | 365
Phenotypic variability 2 | 150
Psychotic Disorders 2 | 151
Speech Delay 2 | 112
Speech impairment 2 | 112
Unipolar Depression 2 | 250
Vomiting 2 | 116
chronic rhinosinusitis 2 | 512
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 559
medulloblastoma 2 | 720
nasopharyngeal carcinoma 2 | 1,058
pancreatic cancer 2 | 2,398
posterior fossa group B ependymoma 2 | 416

Tissue

Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Liver and Pancreas 28 | 16,750
Skin and soft tissues 28 | 17,230
Nervous System 27 | 16,725
Urinary Tract 27 | 16,678
Female tissues 26 | 17,400
Male tissues 26 | 17,142
Blood and immune system 25 | 16,909
Respiratory system 24 | 16,393
Cardiovascular System 23 | 15,192

Target Family

Enzyme 26 | 4,145
Non-IDG 2 | 12,091

KEGG Pathway

Butanoate metabolism 28 | 28
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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