Development Level

Tbio 89 | 11,445
Tchem 36 | 1,598
Tclin 20 | 613
Tdark 2 | 6,588

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 18 | 979
enlarged heart 6 | 210
abnormal embryo size 5 | 220
abnormal heart morphology 5 | 162
decreased vertical activity 5 | 208
embryonic lethality prior to t... 5 | 278
cataract 4 | 92
decreased body weight 4 | 161
increased lean body mass 4 | 172
increased total body fat amoun... 4 | 134
preweaning lethality, incomple... 4 | 499
decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
increased circulating choleste... 3 | 66
microphthalmia 3 | 26
abnormal body wall morphology 2 | 9
abnormal bone mineralization 2 | 38
abnormal eye morphology 2 | 68
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal retinal vasculature m... 2 | 27
corneal opacity 2 | 32
decreased bone mineral content 2 | 151
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
edema 2 | 59
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased bone mineral content 2 | 108
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
increased startle reflex 2 | 112
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal brain morphology 1 | 13
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
cleft palate 1 | 8
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating creatine... 1 | 4
decreased circulating serum al... 1 | 82
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased neutrophil cell numb... 1 | 42
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
hydroencephaly 1 | 14
hydrometra 1 | 53
impaired righting response 1 | 26
increased B cell number 1 | 9
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating creatine... 1 | 5
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
iris synechia 1 | 3
limb grasping 1 | 41
small seminal vesicle 1 | 10
syndactyly 1 | 23
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 104 | 11,493
Cancer 98 | 2,499
ovarian cancer 84 | 8,520
psoriasis 73 | 6,694
osteosarcoma 72 | 7,950
glioblastoma 66 | 5,792
Breast cancer 62 | 3,578
lung cancer 62 | 4,740
atypical teratoid / rhabdoid tumor 57 | 5,112
medulloblastoma, large-cell 57 | 6,241
Breast Neoplasms 49 | 445
Mammary Neoplasms 48 | 425
ependymoma 46 | 4,679
malignant mesothelioma 46 | 3,232
group 3 medulloblastoma 44 | 4,104
Kidney cancer 38 | 2,613
oligodendroglioma 35 | 2,850
primitive neuroectodermal tumor 33 | 3,035
Schizophrenia 31 | 1,160
invasive ductal carcinoma 31 | 2,951
Autosomal recessive predisposition 30 | 1,442
Lung Neoplasms 30 | 232
breast carcinoma 30 | 1,638
interstitial cystitis 30 | 2,312
Astrocytoma, Pilocytic 29 | 3,081
Prostatic Neoplasms 29 | 495
astrocytic glioma 29 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
non-small cell lung cancer 28 | 2,890
Orbital separation excessive 26 | 244
ductal carcinoma in situ 26 | 1,745
Hypoplastic mandible condyle 25 | 275
Liver carcinoma 25 | 240
Mandibular hypoplasia 25 | 275
Micrognathism 25 | 275
Short stature 25 | 531
astrocytoma 25 | 1,146
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
lung adenocarcinoma 25 | 2,716
Carcinoma, Hepatocellular 24 | 228
Intellectual disability 24 | 1,016
adult high grade glioma 24 | 3,801
diabetes mellitus 24 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
lung carcinoma 24 | 2,843
pituitary cancer 24 | 1,972
adrenocortical carcinoma 23 | 1,428
Dull intelligence 22 | 645
Low intelligence 22 | 645
Mental Retardation 22 | 645
Mental deficiency 22 | 645
Poor school performance 22 | 645
Vascular disease 22 | 319
cystic fibrosis 22 | 1,696
pancreatic cancer 22 | 2,398
tuberculosis 22 | 2,010
Cryptorchidism 21 | 296
Obesity 21 | 678
Osteoporosis 21 | 363
Downward slant of palpebral fissure 20 | 158
Stomach Neoplasms 20 | 300
colon cancer 20 | 1,478
juvenile dermatomyositis 20 | 1,187
Cognitive delay 19 | 608
Global developmental delay 19 | 608
Mental and motor retardation 19 | 608
pediatric high grade glioma 19 | 1,064
subependymal giant cell astrocytoma 19 | 2,287
Adenocarcinoma 18 | 122
Adenoma 18 | 167
Colonic Neoplasms 18 | 142
Pick disease 18 | 1,894
Rheumatoid arthritis 18 | 1,191
group 4 medulloblastoma 18 | 1,855
Big calvaria 17 | 147
Byzanthine arch palate 17 | 194
Increased head circumference 17 | 147
Increased size of cranium 17 | 147
Increased size of skull 17 | 147
Neoplasm Metastasis 17 | 168
Acquired scoliosis 16 | 281
Alzheimer's disease 16 | 658
Carcinoma, Squamous Cell 16 | 110
Cell Transformation, Neoplastic 16 | 97
Cleft Palate 16 | 271
Curvature of spine 16 | 282
Delayed bone age 16 | 136
Endometrial cancer 16 | 311
Epilepsy 16 | 792
Melanoma 16 | 711
Muscle hypotonia 16 | 571
Ovarian Neoplasms 16 | 102
Renal Cell Carcinoma 16 | 214
Seizures 16 | 596
Strabismus 16 | 270
Bipolar Disorder 15 | 666
Depressive disorder 15 | 409
acute myeloid leukemia 15 | 783
nasopharyngeal carcinoma 15 | 1,058
ulcerative colitis 15 | 1,819

Tissue

Endocrine System 144 | 18,159
Digestive Tract 142 | 17,369
Female tissues 140 | 17,400
Nervous System 140 | 16,725
Blood and immune system 139 | 16,909
Male tissues 138 | 17,142
Skin and soft tissues 138 | 17,230
Urinary Tract 137 | 16,678
Liver and Pancreas 135 | 16,750
Respiratory system 131 | 16,393
Cardiovascular System 123 | 15,192

Target Family

Non-IDG 78 | 12,091
Kinase 28 | 634
Transcription Factor 18 | 1,400
GPCR 10 | 408
Enzyme 8 | 4,145
Nuclear Receptor 3 | 48
Epigenetic 2 | 242

KEGG Pathway

Breast cancer 147 | 147
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.89822 84.6 146
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Delta-like protein 3 DLL3 Tbio Non-IDG -1.68978 48.6 214