Development Level

Tbio 53 | 11,445
Tchem 14 | 1,598
Tclin 3 | 613
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal behavior 3 | 298
abnormal QT variability 2 | 10
decreased bone mineral density 2 | 126
increased bone mineral content 2 | 108
abnormal craniofacial morpholo... 1 | 33
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal tail movements 1 | 12
anophthalmia 1 | 33
brachydactyly 1 | 19
cataract 1 | 92
decreased IgM level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased granulocyte number 1 | 6
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
edema 1 | 59
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased body temperature 1 | 9
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
long tibia 1 | 25
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small adrenal glands 1 | 16
syndactyly 1 | 23
thrombocytopenia 1 | 56

Disease

Carcinoma 54 | 11,493
ovarian cancer 35 | 8,520
psoriasis 33 | 6,694
Autosomal recessive predisposition 30 | 1,442
medulloblastoma, large-cell 28 | 6,241
osteosarcoma 28 | 7,950
lung adenocarcinoma 23 | 2,716
atypical teratoid / rhabdoid tumor 22 | 5,112
ependymoma 22 | 4,679
lung cancer 22 | 4,740
non-small cell lung cancer 22 | 2,890
Cancer 21 | 2,499
Epilepsy 21 | 792
Seizures 21 | 596
glioblastoma 20 | 5,792
pancreatic cancer 20 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
Intellectual disability 19 | 1,016
adult high grade glioma 19 | 3,801
Cognitive delay 18 | 608
Dull intelligence 18 | 645
Global developmental delay 18 | 608
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental and motor retardation 18 | 608
Mental deficiency 18 | 645
Poor school performance 18 | 645
group 3 medulloblastoma 18 | 4,104
Breast cancer 16 | 3,578
invasive ductal carcinoma 16 | 2,951
Multiple myeloma 14 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
malignant mesothelioma 14 | 3,232
oligodendroglioma 14 | 2,850
adrenocortical carcinoma 13 | 1,428
astrocytic glioma 13 | 2,597
Astrocytoma, Pilocytic 12 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
primitive neuroectodermal tumor 12 | 3,035
Muscle hypotonia 11 | 571
ductal carcinoma in situ 11 | 1,745
Failure to gain weight 10 | 365
Pediatric failure to thrive 10 | 365
tuberculosis 10 | 2,010
Carcinoma, Hepatocellular 9 | 228
Liver Cirrhosis, Experimental 9 | 769
Liver carcinoma 9 | 240
Schizophrenia 9 | 1,160
Waldenstrons macroglobulinemia 9 | 765
breast carcinoma 9 | 1,638
colon cancer 9 | 1,478
lung carcinoma 9 | 2,843
primary pancreatic ductal adenocarcinoma 9 | 1,109
Adenocarcinoma of lung 8 | 142
Disease Models, Animal 8 | 155
Kidney cancer 8 | 2,613
acute quadriplegic myopathy 8 | 1,158
group 4 medulloblastoma 8 | 1,855
Cerebellar Ataxia 7 | 304
Down syndrome 7 | 499
Fetal Growth Retardation 7 | 189
Hyperammonemia 7 | 30
Osteoporosis 7 | 363
Vomiting 7 | 116
hepatocellular carcinoma 7 | 547
pituitary cancer 7 | 1,972
Acquired scoliosis 6 | 281
Argininosuccinic aciduria 6 | 17
Carcinoma, Non-Small-Cell Lung 6 | 107
Chemical and Drug Induced Liver Injury 6 | 195
Curvature of spine 6 | 282
Glycogen storage disease 6 | 39
Hypermethioninemia 6 | 11
Infant, Small for Gestational Age 6 | 176
Intrauterine retardation 6 | 176
Irritation - emotion 6 | 68
Neurodegenerative disease 6 | 414
Obesity 6 | 678
Osteoarthritis 6 | 184
Small head 6 | 374
active Crohn's disease 6 | 922
dermatomyositis 6 | 966
interstitial cystitis 6 | 2,312
nasopharyngeal carcinoma 6 | 1,058
non-small cell lung carcinoma 6 | 317
ulcerative colitis 6 | 1,819
Alzheimer's disease 5 | 658
Asthma 5 | 385
Atopic dermatitis 5 | 952
Bipolar Disorder 5 | 666
Cutis Laxa 5 | 39
Hepatomegaly 5 | 285
Polycystic ovary syndrome 5 | 360
Vascular disease 5 | 319
diabetes mellitus 5 | 1,728
gastric carcinoma 5 | 807
nephrosclerosis 5 | 333
pancreatic carcinoma 5 | 562
subependymal giant cell astrocytoma 5 | 2,287

Tissue

Endocrine System 73 | 18,159
Blood and immune system 71 | 16,909
Digestive Tract 70 | 17,369
Female tissues 70 | 17,400
Nervous System 70 | 16,725
Skin and soft tissues 70 | 17,230
Urinary Tract 70 | 16,678
Liver and Pancreas 69 | 16,750
Male tissues 69 | 17,142
Respiratory system 67 | 16,393
Cardiovascular System 63 | 15,192

Target Family

Enzyme 62 | 4,145
Kinase 10 | 634
Non-IDG 1 | 12,091

KEGG Pathway

Biosynthesis of amino acids 73 | 73
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.17330 1408.2 293
Aconitate hydratase, mitochondrial ACO2 Tbio Enzyme -2.21106 157.2 307
Arginase-2, mitochondrial ARG2 Tchem Enzyme -2.46702 275.2 245
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
Argininosuccinate lyase ASL Tbio Enzyme -2.13476 130.8 199
Cystathionine beta-synthase-like protein CBS Tbio Non-IDG -3.25635 3246.1 0
Pyrroline-5-carboxylate reductase 3 PYCR3 Tbio Enzyme 0.15 0.58 111
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Alanine aminotransferase 1 GPT Tbio Enzyme -2.47451 285.2 217