Development Level

Tbio 49 | 11,445
Tchem 12 | 1,598
Tclin 2 | 613

Collection

GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 12 | 979
abnormal heart morphology 5 | 162
embryonic lethality prior to t... 5 | 278
enlarged heart 4 | 210
decreased vertical activity 3 | 208
abnormal embryo development 2 | 7
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
impaired glucose tolerance 2 | 75
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
microphthalmia 2 | 26
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal brain morphology 1 | 13
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye size 1 | 7
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal liver size 1 | 5
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal response to tactile s... 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
hydroencephaly 1 | 14
hydrometra 1 | 53
hydrops fetalis 1 | 1
increased B cell number 1 | 9
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating insulin ... 1 | 3
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
limb grasping 1 | 41
mammalian phenotype 1 | 17
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
polydactyly 1 | 7
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
protruding tongue 1 | 3
short tibia 1 | 97
small heart 1 | 10
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
syndactyly 1 | 23

Disease

Carcinoma 50 | 11,493
Cancer 36 | 2,499
psoriasis 33 | 6,694
ovarian cancer 32 | 8,520
osteosarcoma 30 | 7,950
atypical teratoid / rhabdoid tumor 26 | 5,112
ependymoma 22 | 4,679
glioblastoma 21 | 5,792
Breast cancer 19 | 3,578
lung cancer 19 | 4,740
medulloblastoma, large-cell 18 | 6,241
group 3 medulloblastoma 17 | 4,104
malignant mesothelioma 17 | 3,232
interstitial cystitis 16 | 2,312
oligodendroglioma 13 | 2,850
pancreatic cancer 13 | 2,398
Cleft Lip 12 | 141
Cleft Palate 12 | 271
breast carcinoma 12 | 1,638
Astrocytoma, Pilocytic 11 | 3,081
Kidney cancer 11 | 2,613
Orbital separation excessive 11 | 244
non-small cell lung cancer 11 | 2,890
primitive neuroectodermal tumor 11 | 3,035
Cognitive delay 10 | 608
Colonic Neoplasms 10 | 142
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
astrocytic glioma 10 | 2,597
ductal carcinoma in situ 10 | 1,745
invasive ductal carcinoma 10 | 2,951
lung carcinoma 10 | 2,843
spina bifida 10 | 1,074
Abnormally small eyeball 9 | 97
Decreased size of eyeball 9 | 97
Intellectual disability 9 | 1,016
Microphthalmos 9 | 100
Osteoporosis 9 | 363
Polydactyly 9 | 107
Prostatic Neoplasms 9 | 495
colon cancer 9 | 1,478
cystic fibrosis 9 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Autosomal recessive predisposition 8 | 1,442
Big calvaria 8 | 147
Breast Neoplasms 8 | 445
Cryptorchidism 8 | 296
Frontal bossing 8 | 157
Gastrointestinal Stromal Tumors 8 | 48
Increased head circumference 8 | 147
Increased size of cranium 8 | 147
Increased size of skull 8 | 147
Nevoid basal cell carcinoma syndrome 8 | 16
Short stature 8 | 531
Stomach Neoplasms 8 | 300
adult high grade glioma 8 | 3,801
cutaneous lupus erythematosus 8 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
lung adenocarcinoma 8 | 2,716
medulloblastoma 8 | 720
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis 8 | 2,010
Basal cell carcinoma 7 | 54
Brachydactyly 7 | 156
Broad flat nasal bridge 7 | 236
Carcinoma, Hepatocellular 7 | 228
Colorectal Neoplasms 7 | 243
Dull intelligence 7 | 645
Highly variable severity 7 | 157
Holoprosencephaly 7 | 56
Hypoplastic mandible condyle 7 | 275
Hypotrophic malar bone 7 | 129
Liver carcinoma 7 | 240
Low intelligence 7 | 645
Malar flattening 7 | 129
Mammary Neoplasms 7 | 425
Mandibular hypoplasia 7 | 275
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Micrognathism 7 | 275
Nasal bridge wide 7 | 236
Obesity 7 | 678
Pick disease 7 | 1,894
Poor school performance 7 | 645
Rheumatoid arthritis 7 | 1,191
Schizophrenia 7 | 1,160
Variable expressivity 7 | 157
Vascular disease 7 | 319
adrenocortical carcinoma 7 | 1,428
astrocytoma 7 | 1,146
non primary Sjogren syndrome sicca 7 | 891
pediatric high grade glioma 7 | 1,064
Cataract 6 | 297
Hydrocephalus 6 | 152
Lens Opacities 6 | 231
acute myeloid leukemia 6 | 783
esophageal adenocarcinoma 6 | 737
pituitary cancer 6 | 1,972
primary pancreatic ductal adenocarcinoma 6 | 1,109

Tissue

Female tissues 62 | 17,400
Digestive Tract 61 | 17,369
Endocrine System 61 | 18,159
Nervous System 61 | 16,725
Male tissues 60 | 17,142
Skin and soft tissues 60 | 17,230
Blood and immune system 59 | 16,909
Urinary Tract 59 | 16,678
Liver and Pancreas 57 | 16,750
Respiratory system 55 | 16,393
Cardiovascular System 49 | 15,192

Target Family

Non-IDG 41 | 12,091
GPCR 11 | 408
Transcription Factor 8 | 1,400
Enzyme 2 | 4,145
Kinase 1 | 634

KEGG Pathway

Basal cell carcinoma 63 | 63
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hedgehog-interacting protein HHIP Tbio Non-IDG -1.83526 65.4 193
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Protein patched homolog 2 PTCH2 Tbio Non-IDG -1.80541 50.4 92
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
Protein Wnt-7b WNT7B Tbio Non-IDG -1.76807 52.2 46
Protein Wnt-2b WNT2B Tbio Non-IDG -1.76988 58.0 172
DNA polymerase kappa POLK Tbio Enzyme -2.42142 256.3 224
Protein Wnt-10a WNT10A Tbio Non-IDG -2.66153 436.3 118
Bone morphogenetic protein 2 BMP2 Tbio Non-IDG -3.65728 4647.9 684