Development Level

Tbio 40 | 10,625
Tchem 13 | 1,890
Tclin 2 | 602

Collection

GPCR: IDG Consortium (Targets) 1 | 127
Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 8 | 633
embryonic lethality prior to t... 3 | 187
abnormal embryo size 2 | 112
abnormal eye morphology 2 | 38
decreased startle reflex 2 | 48
hydrops fetalis 2 | 22
impaired glucose tolerance 2 | 52
increased body weight 2 | 42
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
abnormal QRS complex 1 | 25
abnormal bone mineralization 1 | 55
abnormal embryo development 1 | 2
abnormal embryo turning 1 | 15
abnormal eye size 1 | 11
abnormal forebrain development 1 | 18
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal limb bud morphology 1 | 15
abnormal liver size 1 | 4
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pericardium morpholog... 1 | 11
abnormal placenta size 1 | 10
abnormal response to tactile s... 1 | 16
abnormal spinal cord morpholog... 1 | 8
abnormal startle reflex 1 | 14
abnormal stomach morphology 1 | 4
absent heartbeat 1 | 6
anophthalmia 1 | 20
cataract 1 | 26
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
decreased total body fat amoun... 1 | 186
enlarged lymph nodes 1 | 27
increased B cell number 1 | 23
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased heart rate variabili... 1 | 4
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
limb grasping 1 | 35
microphthalmia 1 | 15
pale liver 1 | 5
pale yolk sac 1 | 12
pallor 1 | 13
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
syndactyly 1 | 4

Disease

psoriasis 29 | 6,685
Cancer 28 | 2,346
ovarian cancer 27 | 8,491
osteosarcoma 25 | 7,933
atypical teratoid / rhabdoid tumor 24 | 4,369
Breast cancer 16 | 3,098
glioblastoma 16 | 5,572
interstitial cystitis 16 | 2,299
medulloblastoma, large-cell 15 | 6,234
ependymoma 14 | 2,514
lung cancer 14 | 4,473
oligodendroglioma 13 | 2,849
malignant mesothelioma 12 | 3,163
pediatric high grade glioma 12 | 2,712
sonic hedgehog group medulloblastoma 12 | 1,482
Carcinoma 11 | 2,147
breast carcinoma 10 | 1,614
invasive ductal carcinoma 10 | 2,950
pilocytic astrocytoma 10 | 3,086
Cleft palate 9 | 125
Osteoporosis 9 | 259
astrocytoma 9 | 1,493
cystic fibrosis 9 | 1,670
ductal carcinoma in situ 9 | 1,745
group 3 medulloblastoma 9 | 2,254
lung carcinoma 9 | 2,844
non-small cell lung cancer 9 | 2,798
primitive neuroectodermal tumor 9 | 3,031
Cleft Lip 8 | 91
colon cancer 8 | 1,475
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
pancreatic cancer 8 | 2,300
posterior fossa group A ependymoma 8 | 1,511
Colonic Neoplasms 7 | 126
Colorectal Neoplasms 7 | 217
Holoprosencephaly 7 | 52
Nevoid basal cell carcinoma syndrome 7 | 9
Polydactyly 7 | 93
cutaneous lupus erythematosus 7 | 1,056
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
lung adenocarcinoma 7 | 2,714
non primary Sjogren syndrome sicca 7 | 840
Basal cell carcinoma 6 | 31
Familial adenomatous polyposis 6 | 33
Mammary Neoplasms 6 | 410
Pick disease 6 | 1,893
astrocytic glioma 6 | 2,241
esophageal adenocarcinoma 6 | 737
group 4 medulloblastoma 6 | 1,875
subependymal giant cell astrocytoma 6 | 2,287
Liver carcinoma 5 | 217
Parkinson's disease 5 | 364
Prostatic Neoplasms 5 | 471
Rheumatoid Arthritis 5 | 1,170
Robinow syndrome 5 | 12
Synostosis 5 | 18
adrenocortical carcinoma 5 | 1,427
diabetes mellitus 5 | 1,663
medulloblastoma 5 | 1,524
primary pancreatic ductal adenocarcinoma 5 | 1,271
spina bifida 5 | 1,064
ulcerative colitis 5 | 2,087
Adenocarcinoma 4 | 115
Adenoma 4 | 165
Ameloblastoma 4 | 25
Amyotrophic Lateral Sclerosis 4 | 432
Atopic dermatitis 4 | 944
Basal Cell Nevus Syndrome 4 | 4
Carcinoma of colon 4 | 32
Endometriosis 4 | 535
Lung Neoplasms 4 | 171
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 4 | 12
Obesity 4 | 616
Skin Neoplasms 4 | 49
Stomach Neoplasms 4 | 282
Tooth agenesis 4 | 38
acute myeloid leukemia 4 | 785
fibroadenoma 4 | 557
glioblastoma multiforme 4 | 347
hepatocellular carcinoma 4 | 550
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
pituitary cancer 4 | 1,972
posterior fossa group B ependymoma 4 | 1,530
tuberculosis 4 | 1,563
Alobar Holoprosencephaly 3 | 14
Kidney disease 3 | 397
Liver cancer 3 | 31
Lobar Holoprosencephaly 3 | 14
Pancreatic Neoplasm 3 | 79
Peripheral Neuropathy 3 | 303
SOLITARY MEDIAN MAXILLARY CENTRAL INCISOR 3 | 14
Schizophrenia 3 | 503
Semilobar Holoprosencephaly 3 | 14
Vascular disease 3 | 281
active Crohn's disease 3 | 918
atypical teratoid/rhabdoid tumor 3 | 1,095
gastric carcinoma 3 | 832
nasopharyngeal carcinoma 3 | 1,056
non-small cell lung carcinoma 3 | 413

Tissue

Digestive Tract 55 | 18,472
Endocrine System 55 | 18,511
Female tissues 55 | 18,646
Male tissues 55 | 17,968
Nervous System 55 | 18,560
Respiratory system 55 | 17,483
Skin and soft tissues 55 | 18,114
Urinary Tract 55 | 18,443
Blood and immune system 54 | 17,994
Liver and Pancreas 54 | 18,135
Cardiovascular System 53 | 17,957

Target Family

Non-IDG 34 | 11,969
GPCR 11 | 408
Transcription Factor 8 | 1,400
Kinase 2 | 634

KEGG Pathway

Basal cell carcinoma 55 | 55
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Frizzled-1 FZD1 Tbio GPCR -2.04125 74.3 233
Frizzled-4 FZD4 Tbio GPCR -2.00958 92.5 273
Frizzled-10 FZD10 Tbio GPCR -1.33529 23.5 156
Suppressor of fused homolog SUFU Tbio Non-IDG -2.28664 185.5 162
Transcription factor 7-like 2 TCF7L2 Tbio Transcription Factor -2.60797 439.7 281
Frizzled-3 FZD3 Tbio GPCR -1.73949 54.6 288
Frizzled-2 FZD2 Tchem GPCR -1.88197 74.4 226
Zinc finger protein GLI1 GLI1 Tchem Transcription Factor -2.99657 942.8 372
Segment polarity protein dishevelled homolog DVL-2 DVL2 Tbio Non-IDG -1.80293 59.3 265