Development Level

Tbio 100 | 10,625
Tchem 56 | 1,890
Tclin 13 | 602
Tdark 7 | 7,003

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 11 | 633
decreased lean body mass 6 | 195
abnormal bone structure 5 | 131
decreased bone mineral content 5 | 157
abnormal behavior 4 | 226
decreased body weight 4 | 174
decreased bone mineral density 4 | 126
increased body weight 4 | 42
abnormal spleen morphology 3 | 36
decreased lumbar vertebrae num... 3 | 62
embryonic lethality prior to t... 3 | 187
increased circulating iron lev... 3 | 25
increased lean body mass 3 | 107
limb grasping 3 | 35
preweaning lethality, incomple... 3 | 260
abnormal bone mineralization 2 | 55
abnormal gait 2 | 51
abnormal lens morphology 2 | 73
abnormal locomotor activation 2 | 26
abnormal retina morphology 2 | 100
cataract 2 | 26
decreased circulating creatini... 2 | 31
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased rib number 2 | 59
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
hyperactivity 2 | 108
impaired glucose tolerance 2 | 52
increased circulating alanine ... 2 | 11
increased circulating alkaline... 2 | 119
increased or absent threshold ... 2 | 128
male infertility 2 | 62
prenatal lethality prior to he... 2 | 64
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal embryo development 1 | 2
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal forelimb morphology 1 | 2
abnormal iris morphology 1 | 12
abnormal kidney morphology 1 | 30
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 11
abnormal respiratory quotient 1 | 9
abnormal response to new envir... 1 | 8
abnormal skin morphology 1 | 23
abnormal testis morphology 1 | 30
abnormal vocalization 1 | 21
corneal opacity 1 | 25
corneal vascularization 1 | 5
decreased B cell number 1 | 30
decreased T cell number 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glycerol... 1 | 19
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased hematocrit 1 | 25
decreased kidney weight 1 | 7
decreased macrophage cell numb... 1 | 4
decreased mature B cell number 1 | 25
decreased spleen weight 1 | 13
decreased startle reflex 1 | 48
enlarged adrenal glands 1 | 3
enlarged kidney 1 | 7
enlarged spleen 1 | 26
female infertility 1 | 34
hydrometra 1 | 13
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral content 1 | 92
increased circulating aspartat... 1 | 17
increased circulating free fat... 1 | 17
increased fasted circulating g... 1 | 68
increased heart rate variabili... 1 | 4
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
increased vertical activity 1 | 18
irregularly shaped pupil 1 | 7
long tibia 1 | 13
polycystic kidney 1 | 9
prenatal lethality 1 | 16
short tibia 1 | 82
small testis 1 | 37

Disease

osteosarcoma 103 | 7,933
ovarian cancer 103 | 8,484
glioblastoma 89 | 5,572
medulloblastoma, large-cell 88 | 6,234
atypical teratoid / rhabdoid tumor 80 | 4,369
psoriasis 80 | 6,685
Carcinoma 68 | 2,147
lung cancer 68 | 4,466
Cancer 66 | 2,346
pilocytic astrocytoma 62 | 3,086
Breast cancer 60 | 3,094
oligodendroglioma 55 | 2,849
lung carcinoma 50 | 2,844
invasive ductal carcinoma 49 | 2,950
malignant mesothelioma 48 | 3,162
pediatric high grade glioma 45 | 2,712
primitive neuroectodermal tumor 45 | 3,031
subependymal giant cell astrocytoma 45 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,289
pancreatic cancer 41 | 2,300
astrocytic glioma 40 | 2,241
lung adenocarcinoma 39 | 2,713
non-small cell lung cancer 39 | 2,798
adult high grade glioma 36 | 2,148
ependymoma 36 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,956
cystic fibrosis 34 | 1,665
interstitial cystitis 34 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,988
breast carcinoma 33 | 1,614
medulloblastoma 31 | 1,524
Pick disease 30 | 1,893
pituitary cancer 30 | 1,972
sonic hedgehog group medulloblastoma 29 | 1,482
posterior fossa group A ependymoma 28 | 1,511
primary pancreatic ductal adenocarcinoma 28 | 1,271
ulcerative colitis 28 | 2,087
ductal carcinoma in situ 27 | 1,745
group 4 medulloblastoma 27 | 1,875
group 3 medulloblastoma 26 | 2,254
astrocytoma 24 | 1,493
Schizophrenia 23 | 501
posterior fossa group B ependymoma 22 | 1,530
tuberculosis 19 | 1,557
cutaneous lupus erythematosus 18 | 1,056
juvenile dermatomyositis 18 | 1,189
spina bifida 18 | 1,064
colon cancer 17 | 1,475
Rheumatoid Arthritis 16 | 1,160
atypical teratoid/rhabdoid tumor 16 | 1,095
non-small cell lung carcinoma 15 | 413
Alzheimer's disease 14 | 644
Blastic phase chronic myeloid leukemia 14 | 58
Chronic Myelocytic Leukemia Accelerated Phase 14 | 59
Chronic phase chronic myeloid leukemia 14 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 14 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 14 | 47
Waldenstrons macroglobulinemia 14 | 765
diabetes mellitus 14 | 1,663
Mammary Neoplasms 13 | 410
Prostatic Neoplasms 13 | 471
adrenocortical carcinoma 13 | 1,427
esophageal adenocarcinoma 13 | 737
primary Sjogren syndrome 13 | 789
Endometriosis 12 | 535
Atopic dermatitis 11 | 944
fibroadenoma 11 | 557
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
Hypertension 10 | 287
Neoplasm Invasiveness 10 | 127
active Crohn's disease 10 | 918
acute quadriplegic myopathy 10 | 1,157
aldosterone-producing adenoma 10 | 664
mucosa-associated lymphoid tissue lymphoma 10 | 480
Kidney disease 9 | 396
Lung Neoplasms 9 | 171
Multiple myeloma 9 | 1,327
Neoplasm Metastasis 9 | 138
Parkinson's disease 9 | 364
Stomach Neoplasms 9 | 282
dermatomyositis 9 | 933
glioblastoma multiforme 9 | 347
hereditary spastic paraplegia 9 | 313
interstitial lung disease 9 | 291
nasopharyngeal carcinoma 9 | 1,056
Autistic Disorder 8 | 320
Liver carcinoma 8 | 217
Multiple Sclerosis 8 | 498
Noonan Syndrome 8 | 33
Renal Cell Carcinoma 8 | 199
Squamous cell carcinoma 8 | 94
gastric carcinoma 8 | 832
progressive supranuclear palsy 8 | 674
Craniofrontonasal syndrome 7 | 13
Down syndrome 7 | 548
Heart disease 7 | 279
Intellectual disability 7 | 573
Obesity 7 | 616
Vascular disease 7 | 281
tuberculosis and treatment for 6 months 7 | 686

Tissue

Blood and immune system 176 | 17,995
Cardiovascular System 176 | 17,958
Digestive Tract 176 | 18,473
Endocrine System 176 | 18,512
Female tissues 176 | 18,647
Liver and Pancreas 176 | 18,136
Male tissues 176 | 17,969
Nervous System 176 | 18,561
Urinary Tract 176 | 18,444
Respiratory system 175 | 17,484
Skin and soft tissues 175 | 18,115

Target Family

Non-IDG 85 | 11,971
Kinase 51 | 634
Enzyme 29 | 4,146
Ion Channel 5 | 341
GPCR 3 | 406
Transcription Factor 3 | 1,400

KEGG Pathway

Axon guidance 176 | 176
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Protein phosphatase Slingshot homolog 1 SSH1 Tbio Enzyme -1.41770 25.0 106
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.59340 415.3 337
Semaphorin-3E SEMA3E Tbio Non-IDG -1.51645 40.3 201
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Slit homolog 1 protein SLIT1 Tbio Non-IDG -1.66562 42.1 104
Protein phosphatase Slingshot homolog 2 SSH2 Tchem Enzyme -0.70039 3.84 25
Netrin receptor UNC5B UNC5B Tbio Non-IDG -1.68718 46.2 106