Development Level

Tbio 107 | 11,651
Tchem 48 | 1,388
Tclin 14 | 612
Tdark 5 | 6,593

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, complete... 13 | 979
preweaning lethality, incomple... 9 | 499
abnormal behavior 5 | 298
abnormal bone structure 5 | 187
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 5 | 278
decreased body weight 4 | 161
increased lean body mass 4 | 172
increased total body fat amoun... 4 | 134
abnormal retina morphology 3 | 71
abnormal spleen morphology 3 | 55
cataract 3 | 92
decreased bone mineral content 3 | 151
decreased circulating triglyce... 3 | 79
decreased hematocrit 3 | 46
hyperactivity 3 | 148
increased body weight 3 | 25
increased circulating alkaline... 3 | 122
limb grasping 3 | 41
abnormal bone mineralization 2 | 38
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal locomotor activation 2 | 16
abnormal skin morphology 2 | 50
decreased bone mineral density 2 | 126
decreased circulating creatini... 2 | 39
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased erythrocyte cell num... 2 | 62
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
enlarged heart 2 | 210
enlarged kidney 2 | 14
enlarged uterus 2 | 11
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
increased circulating iron lev... 2 | 30
increased circulating triglyce... 2 | 42
increased monocyte cell number 2 | 63
increased startle reflex 2 | 112
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal forelimb morphology 1 | 2
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal response to new envir... 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
anophthalmia 1 | 33
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
edema 1 | 59
enlarged adrenal glands 1 | 3
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating glucose ... 1 | 24
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased spleen weight 1 | 10
long tibia 1 | 25
mammalian phenotype 1 | 17
polycystic kidney 1 | 15
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 143 | 11,493
ovarian cancer 103 | 8,520
osteosarcoma 101 | 7,950
glioblastoma 96 | 5,792
atypical teratoid / rhabdoid tumor 90 | 5,112
medulloblastoma, large-cell 88 | 6,241
psoriasis 80 | 6,694
ependymoma 73 | 4,679
lung cancer 72 | 4,740
Kidney cancer 71 | 2,613
Breast cancer 70 | 3,578
Cancer 69 | 2,499
adult high grade glioma 64 | 3,801
Astrocytoma, Pilocytic 59 | 3,081
oligodendroglioma 55 | 2,850
group 3 medulloblastoma 54 | 4,104
malignant mesothelioma 52 | 3,232
lung carcinoma 48 | 2,843
astrocytic glioma 47 | 2,597
invasive ductal carcinoma 47 | 2,951
primitive neuroectodermal tumor 45 | 3,035
subependymal giant cell astrocytoma 43 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,291
pancreatic cancer 42 | 2,398
non-small cell lung cancer 41 | 2,890
lung adenocarcinoma 39 | 2,716
group 4 medulloblastoma 36 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,955
breast carcinoma 35 | 1,638
cystic fibrosis 34 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
Schizophrenia 33 | 1,160
interstitial cystitis 32 | 2,312
Pick disease 30 | 1,894
pituitary cancer 30 | 1,972
ductal carcinoma in situ 27 | 1,745
primary pancreatic ductal adenocarcinoma 27 | 1,109
tuberculosis 27 | 2,010
ulcerative colitis 25 | 1,819
Intellectual disability 19 | 1,016
astrocytoma 18 | 1,146
cutaneous lupus erythematosus 18 | 1,057
juvenile dermatomyositis 18 | 1,187
spina bifida 18 | 1,074
colon cancer 17 | 1,478
Liver cancer 16 | 604
Rheumatoid arthritis 16 | 1,191
pediatric high grade glioma 16 | 1,064
Alzheimer's disease 15 | 658
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
medulloblastoma 15 | 720
Blastic phase chronic myeloid leukemia 14 | 58
Breast Neoplasms 14 | 445
Chronic Myelocytic Leukemia Accelerated Phase 14 | 59
Chronic phase chronic myeloid leukemia 14 | 45
Mammary Neoplasms 14 | 425
Melanoma 14 | 711
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 14 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 14 | 47
Prostatic Neoplasms 14 | 495
Skin cancer 14 | 469
Waldenstrons macroglobulinemia 14 | 765
diabetes mellitus 14 | 1,728
Bipolar Disorder 13 | 666
Endometriosis 13 | 540
Epilepsy 13 | 792
Liver Cirrhosis, Experimental 13 | 769
Short stature 13 | 531
adrenocortical carcinoma 13 | 1,428
esophageal adenocarcinoma 13 | 737
Hypertension 12 | 396
Muscle hypotonia 12 | 571
Orbital separation excessive 12 | 244
Stomach Neoplasms 12 | 300
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Atopic dermatitis 11 | 952
Cognitive delay 11 | 608
Downward slant of palpebral fissure 11 | 158
Endometrial cancer 11 | 311
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
Neoplasm Invasiveness 11 | 161
Renal Cell Carcinoma 11 | 214
Squamous cell carcinoma 11 | 129
fibroadenoma 11 | 559
Byzanthine arch palate 10 | 194
Depressive disorder 10 | 409
Hypoplastic mandible condyle 10 | 275
Mandibular hypoplasia 10 | 275
Micrognathism 10 | 275
Seizures 10 | 596
Strabismus 10 | 270
active Crohn's disease 10 | 922
acute quadriplegic myopathy 10 | 1,158
aldosterone-producing adenoma 10 | 665
primary Sjogren syndrome 10 | 735

Tissue

Endocrine System 172 | 18,159
Nervous System 171 | 16,725
Digestive Tract 170 | 17,369
Female tissues 170 | 17,400
Skin and soft tissues 170 | 17,230
Male tissues 168 | 17,142
Liver and Pancreas 166 | 16,750
Respiratory system 166 | 16,393
Blood and immune system 165 | 16,909
Urinary Tract 165 | 16,678
Cardiovascular System 156 | 15,192

Target Family

Non-IDG 85 | 12,091
Kinase 50 | 634
Enzyme 28 | 4,145
Ion Channel 5 | 344
GPCR 3 | 408
Transcription Factor 3 | 1,400

KEGG Pathway

Axon guidance 174 | 174
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Ephrin type-A receptor 6 EPHA6 Tchem Kinase -1.34848 21.8 266
LIM domain kinase 2 LIMK2 Tchem Kinase -1.65006 41.3 405
Semaphorin-3C SEMA3C Tbio Non-IDG -1.95299 88.1 184
Roundabout homolog 1 ROBO1 Tbio Non-IDG -2.15518 129.8 261
Short transient receptor potential channel 5 TRPC5 Tchem Ion Channel -2.25002 172.0 220
Protein patched homolog 1 PTCH1 Tbio Non-IDG -3.04637 1057.4 452
Leucine-rich repeat-containing protein 4C LRRC4C Tbio Non-IDG -2.22551 163.3 161
Short transient receptor potential channel 3 TRPC3 Tchem Ion Channel -2.46704 294.6 217