Development Level

Tbio 78 | 11,651
Tchem 40 | 1,388
Tclin 9 | 612
Tdark 1 | 6,593

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 13 | 979
preweaning lethality, incomple... 6 | 499
decreased body weight 5 | 161
embryonic lethality prior to t... 3 | 278
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
abnormal behavior 2 | 298
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
decreased blood urea nitrogen ... 2 | 51
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased total body fat amoun... 2 | 207
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal glucose homeostasis 1 | 4
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged spleen 1 | 41
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating serum al... 1 | 22
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
male infertility 1 | 123
premature death 1 | 5
prenatal lethality 1 | 28
short tibia 1 | 97
small epididymis 1 | 3
small testis 1 | 58
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 89 | 11,493
ovarian cancer 88 | 8,520
osteosarcoma 70 | 7,950
Cancer 60 | 2,499
psoriasis 57 | 6,694
medulloblastoma, large-cell 52 | 6,241
glioblastoma 51 | 5,792
atypical teratoid / rhabdoid tumor 41 | 5,112
lung cancer 39 | 4,740
Breast cancer 33 | 3,578
ependymoma 32 | 4,679
subependymal giant cell astrocytoma 30 | 2,287
Kidney cancer 28 | 2,613
malignant mesothelioma 28 | 3,232
adult high grade glioma 27 | 3,801
diabetes mellitus 24 | 1,728
invasive ductal carcinoma 23 | 2,951
group 3 medulloblastoma 22 | 4,104
juvenile dermatomyositis 22 | 1,187
lung adenocarcinoma 22 | 2,716
oligodendroglioma 22 | 2,850
Intellectual disability 21 | 1,016
astrocytic glioma 21 | 2,597
group 4 medulloblastoma 21 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
Dull intelligence 19 | 645
Low intelligence 19 | 645
Mental Retardation 19 | 645
Mental deficiency 19 | 645
Multiple myeloma 19 | 1,332
Poor school performance 19 | 645
Schizophrenia 19 | 1,160
Vascular disease 19 | 319
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
Prostatic Neoplasms 18 | 495
breast carcinoma 18 | 1,638
Cognitive delay 17 | 608
Epilepsy 17 | 792
Global developmental delay 17 | 608
Mental and motor retardation 17 | 608
acute quadriplegic myopathy 17 | 1,158
pancreatic cancer 17 | 2,398
primitive neuroectodermal tumor 17 | 3,035
tuberculosis 17 | 2,010
Renal Cell Carcinoma 16 | 214
lung carcinoma 16 | 2,843
Astrocytoma, Pilocytic 15 | 3,081
Pick disease 15 | 1,894
Seizures 15 | 596
cystic fibrosis 15 | 1,696
dermatomyositis 15 | 966
Breast Neoplasms 14 | 445
Lung Neoplasms 14 | 232
Mammary Neoplasms 14 | 425
Orbital separation excessive 14 | 244
astrocytoma 14 | 1,146
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
spina bifida 14 | 1,074
Alzheimer's disease 13 | 658
Autosomal recessive predisposition 13 | 1,442
Obesity 13 | 678
Short stature 13 | 531
Stomach Neoplasms 13 | 300
non-small cell lung cancer 13 | 2,890
ulcerative colitis 13 | 1,819
Byzanthine arch palate 12 | 194
Carcinoma, Hepatocellular 12 | 228
Concave bridge of nose 12 | 195
Depressed nasal bridge 12 | 195
Depressed nasal root/bridge 12 | 195
Downward slant of palpebral fissure 12 | 158
Liver carcinoma 12 | 240
Muscle hypotonia 11 | 571
Parkinson's disease 11 | 392
pituitary cancer 11 | 1,972
primary pancreatic ductal adenocarcinoma 11 | 1,109
Acquired scoliosis 10 | 281
Big calvaria 10 | 147
Curvature of spine 10 | 282
High forehead 10 | 102
Hyperglycemia 10 | 137
Hypertension 10 | 396
Hypoplastic mandible condyle 10 | 275
Increased head circumference 10 | 147
Increased size of cranium 10 | 147
Increased size of skull 10 | 147
Mandibular hypoplasia 10 | 275
Micrognathism 10 | 275
Neurodegenerative disease 10 | 414
Ovarian Neoplasms 10 | 102
Pectus excavatum 10 | 100
Rheumatoid arthritis 10 | 1,191
Squamous cell carcinoma 10 | 129
Tall forehead 10 | 102
Waldenstrons macroglobulinemia 10 | 765
colon cancer 10 | 1,478
interstitial cystitis 10 | 2,312
pediatric high grade glioma 10 | 1,064

Tissue

Endocrine System 127 | 18,159
Digestive Tract 126 | 17,369
Female tissues 126 | 17,400
Male tissues 126 | 17,142
Nervous System 126 | 16,725
Skin and soft tissues 126 | 17,230
Blood and immune system 125 | 16,909
Liver and Pancreas 125 | 16,750
Respiratory system 125 | 16,393
Urinary Tract 125 | 16,678
Cardiovascular System 123 | 15,192

Target Family

Non-IDG 60 | 12,091
Kinase 40 | 634
Enzyme 25 | 4,145
Transcription Factor 2 | 1,400
Ion Channel 1 | 344

KEGG Pathway

Autophagy - animal 128 | 128
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 Tbio Non-IDG -2.81111 643.5 577
Vesicle-associated membrane protein 8 VAMP8 Tbio Non-IDG -1.79654 64.6 107
WD repeat domain phosphoinositide-interacting protein 2 WIPI2 Tbio Non-IDG -1.16004 13.0 195
5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 Tchem Kinase -1.42705 21.1 603
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
WD repeat domain phosphoinositide-interacting protein 1 WIPI1 Tbio Non-IDG -1.64159 43.5 192
Ubiquitin-like protein ATG12 ATG12 Tbio Non-IDG -2.17958 122.1 528
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765