Development Level

Tbio 51 | 11,445
Tclin 11 | 613
Tchem 6 | 1,598
Tdark 4 | 6,588

Collection

Ion Channel: IDG Consortium (T... 14 | 99

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal embryo size 3 | 220
decreased circulating glucose ... 3 | 126
embryonic lethality prior to t... 3 | 278
increased startle reflex 3 | 112
corneal opacity 2 | 32
decreased prepulse inhibition 2 | 82
hemorrhage 2 | 23
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
prenatal lethality 2 | 28
prolonged PR interval 2 | 15
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal placenta vasculature 1 | 2
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal startle reflex 1 | 15
cataract 1 | 92
corneal vascularization 1 | 6
cyanosis 1 | 7
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased cardiac muscle contr... 1 | 11
decreased circulating alkaline... 1 | 46
decreased circulating free fat... 1 | 31
decreased coping response 1 | 8
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased total body fat amoun... 1 | 207
dilated heart left ventricle 1 | 11
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
narrow eye opening 1 | 12
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
respiratory system phenotype 1 | 2
syndactyly 1 | 23
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 64 | 11,493
glioblastoma 42 | 5,792
osteosarcoma 39 | 7,950
atypical teratoid / rhabdoid tumor 38 | 5,112
ovarian cancer 38 | 8,520
psoriasis 35 | 6,694
medulloblastoma, large-cell 33 | 6,241
ependymoma 31 | 4,679
Kidney cancer 28 | 2,613
Astrocytoma, Pilocytic 27 | 3,081
lung cancer 27 | 4,740
lung carcinoma 27 | 2,843
primitive neuroectodermal tumor 27 | 3,035
adult high grade glioma 25 | 3,801
pancreatic cancer 24 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
non-small cell lung cancer 23 | 2,890
Autosomal recessive predisposition 22 | 1,442
Breast cancer 21 | 3,578
lung adenocarcinoma 21 | 2,716
malignant mesothelioma 21 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
invasive ductal carcinoma 19 | 2,951
oligodendroglioma 19 | 2,850
Cancer 18 | 2,499
group 3 medulloblastoma 18 | 4,104
Cardiomyopathy 16 | 116
Schizophrenia 16 | 1,160
colon cancer 16 | 1,478
interstitial cystitis 16 | 2,312
pituitary cancer 16 | 1,972
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
cystic fibrosis 14 | 1,696
group 4 medulloblastoma 14 | 1,855
Bipolar Disorder 13 | 666
Pick disease 13 | 1,894
ductal carcinoma in situ 13 | 1,745
pediatric high grade glioma 13 | 1,064
primary pancreatic ductal adenocarcinoma 13 | 1,109
astrocytic glioma 12 | 2,597
tuberculosis 12 | 2,010
subependymal giant cell astrocytoma 11 | 2,287
Dilated cardiomyopathy 10 | 56
Intellectual disability 10 | 1,016
Muscular dystrophy 10 | 75
breast carcinoma 10 | 1,638
Arrhythmogenic right ventricular cardiomyopathy 9 | 30
Cardiomyopathy, Dilated 9 | 83
Creatine phosphokinase serum increased 9 | 110
Elevated creatine kinase 9 | 110
Epilepsy 9 | 792
Liver cancer 9 | 604
Myopathy 9 | 185
Rheumatoid arthritis 9 | 1,191
Skin cancer 9 | 469
acute quadriplegic myopathy 9 | 1,158
dermatomyositis 9 | 966
diabetes mellitus 9 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
ulcerative colitis 9 | 1,819
Duchenne muscular dystrophy 8 | 601
Dull intelligence 8 | 645
Low intelligence 8 | 645
Melanoma 8 | 711
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Muscle biopsy shows dystrophic changes 8 | 39
Muscle hypotonia 8 | 571
Poor school performance 8 | 645
astrocytoma 8 | 1,146
cutaneous lupus erythematosus 8 | 1,057
Alopecia 7 | 115
Cardiac Arrhythmia 7 | 103
Endometrial cancer 7 | 311
Gliosis 7 | 56
Heart failure 7 | 162
Neoplasm Invasiveness 7 | 161
Seizures 7 | 596
Sudden Cardiac Death 7 | 29
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
gastric carcinoma 7 | 807
limb-girdle muscular dystrophy 7 | 37
medulloblastoma 7 | 720
posterior fossa group A ependymoma 7 | 468
Autistic Disorder 6 | 364
Cardiomyopathy, right ventricular 6 | 7
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Heart disease 6 | 306
Hypertensive disease 6 | 292
Liver Cirrhosis, Experimental 6 | 769
Mental and motor retardation 6 | 608
Osteoporosis 6 | 363
Stomach Neoplasms 6 | 300
Syncope 6 | 22
Type 2 diabetes mellitus 6 | 272
Ventricular arrhythmia 6 | 27
adrenocortical carcinoma 6 | 1,428
nasopharyngeal carcinoma 6 | 1,058
pancreatic carcinoma 6 | 562

Tissue

Endocrine System 71 | 18,159
Nervous System 70 | 16,725
Digestive Tract 69 | 17,369
Male tissues 68 | 17,142
Blood and immune system 67 | 16,909
Skin and soft tissues 67 | 17,230
Female tissues 66 | 17,400
Urinary Tract 66 | 16,678
Respiratory system 65 | 16,393
Liver and Pancreas 64 | 16,750
Cardiovascular System 59 | 15,192

Target Family

Non-IDG 44 | 12,091
Ion Channel 21 | 344
Transcription Factor 4 | 1,400
Transporter 2 | 473
Enzyme 1 | 4,145

KEGG Pathway

Arrhythmogenic right ventricul... 72 | 72
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 Tbio Ion Channel -1.46356 25.4 471
Emerin EMD Tbio Non-IDG -2.80459 640.6 299
Actin, cytoplasmic 2 ACTG1 Tbio Non-IDG -2.50312 297.3 225
Integrin alpha-7 ITGA7 Tbio Non-IDG -1.63563 42.4 193
Desmoplakin DSP Tbio Non-IDG -2.95735 853.9 198
Voltage-dependent calcium channel gamma-7 subunit CACNG7 Tdark Ion Channel -0.50762 2.36 68