Development Level

Tbio 24 | 11,178
Tchem 18 | 1,885
Tclin 4 | 612
Tdark 2 | 6,569

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased circulating glucose ... 2 | 126
decreased circulating total pr... 2 | 49
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
hypoactivity 2 | 132
male infertility 2 | 123
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating potassiu... 1 | 29
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
short tibia 1 | 97
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

Carcinoma 30 | 11,192
psoriasis 26 | 6,514
ovarian cancer 23 | 8,297
medulloblastoma, large-cell 21 | 6,086
osteosarcoma 21 | 7,766
glioblastoma 18 | 5,635
lung cancer 16 | 4,607
ependymoma 15 | 4,559
atypical teratoid / rhabdoid tumor 14 | 4,971
group 3 medulloblastoma 14 | 4,002
invasive ductal carcinoma 14 | 2,867
lung adenocarcinoma 14 | 2,627
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,911
Intellectual disability 12 | 998
Liver Cirrhosis, Experimental 12 | 733
Autosomal recessive predisposition 11 | 1,407
Cancer 11 | 2,388
primitive neuroectodermal tumor 11 | 2,957
Dull intelligence 10 | 634
Low intelligence 10 | 634
Mental Retardation 10 | 634
Mental deficiency 10 | 634
Poor school performance 10 | 634
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,872
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,204
non-small cell lung cancer 10 | 2,799
interstitial cystitis 9 | 2,237
oligodendroglioma 9 | 2,768
pancreatic cancer 9 | 2,322
subependymal giant cell astrocytoma 9 | 2,230
Bipolar Disorder 8 | 646
Breast cancer 8 | 3,469
Cognitive delay 8 | 596
Global developmental delay 8 | 596
Mental and motor retardation 8 | 596
Schizophrenia 8 | 1,136
Seizures 8 | 584
adult high grade glioma 8 | 3,701
ductal carcinoma in situ 8 | 1,686
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,902
malignant mesothelioma 8 | 3,135
pediatric high grade glioma 8 | 1,035
pituitary cancer 8 | 1,915
Astrocytoma, Pilocytic 7 | 3,006
Depressive disorder 7 | 401
Epilepsy 7 | 775
Kidney disease 7 | 411
breast carcinoma 7 | 1,589
lung carcinoma 7 | 2,755
nephrosclerosis 7 | 314
Mood Disorders 6 | 181
Myocardial Infarction 6 | 142
Myopathy 6 | 185
Succinic semialdehyde dehydrogenase deficiency 6 | 16
astrocytic glioma 6 | 2,530
diabetes mellitus 6 | 1,683
esophageal adenocarcinoma 6 | 696
ulcerative colitis 6 | 1,765
Asthma 5 | 370
Autistic Disorder 5 | 358
Colonic Neoplasms 5 | 133
Duchenne muscular dystrophy 5 | 587
Hypertension 5 | 372
Muscle hypotonia 5 | 562
acute myeloid leukemia 5 | 760
acute quadriplegic myopathy 5 | 1,133
astrocytoma 5 | 1,113
colon cancer 5 | 1,428
cutaneous lupus erythematosus 5 | 1,016
cystic fibrosis 5 | 1,629
gastric carcinoma 5 | 781
tuberculosis 5 | 1,963
Alcohol dependence 4 | 107
Alcoholic Intoxication, Chronic 4 | 283
Atopic dermatitis 4 | 915
Coronary artery disease 4 | 253
Cutis Laxa 4 | 39
Delayed speech and language development 4 | 110
Dressler's syndrome 4 | 6
Enterocolitis, Necrotizing 4 | 17
Gyrate atrophy 4 | 7
Language Delay 4 | 110
Leishmaniasis 4 | 46
Mental Depression 4 | 325
Necrotizing Enterocolitis 4 | 17
Obesity 4 | 655
Primary hyperoxaluria 4 | 15
Secondary progressive multiple sclerosis 4 | 10
Speech Delay 4 | 110
Speech impairment 4 | 110
Status Epilepticus 4 | 96
dermatomyositis 4 | 941
fibroadenoma 4 | 538
juvenile dermatomyositis 4 | 1,147
primary pancreatic ductal adenocarcinoma 4 | 1,071
Attention deficit hyperactivity disorder 3 | 272
Endometriosis 3 | 521
Pick disease 3 | 1,856
Vascular disease 3 | 294
spina bifida 3 | 1,053

Tissue

Blood and immune system 48 | 16,909
Digestive Tract 48 | 17,369
Endocrine System 48 | 18,159
Liver and Pancreas 48 | 16,750
Nervous System 48 | 16,725
Urinary Tract 48 | 16,678
Female tissues 47 | 17,400
Skin and soft tissues 47 | 17,230
Male tissues 45 | 17,142
Respiratory system 45 | 16,393
Cardiovascular System 44 | 15,192

Target Family

Enzyme 44 | 4,145
Kinase 4 | 634

KEGG Pathway

Arginine and proline metabolis... 48 | 48
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Diamine acetyltransferase 1 SAT1 Tbio Enzyme -2.60045 409.5 159
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 Tbio Enzyme -1.74725 52.8 197
Nitric oxide synthase, endothelial NOS3 Tchem Enzyme -3.96497 9525.3 1195
Ornithine aminotransferase, mitochondrial OAT Tchem Enzyme -2.87569 729.0 148
Nitric oxide synthase, brain NOS1 Tchem Enzyme -3.27741 1885.8 661
Amine oxidase [flavin-containing] B MAOB Tclin Enzyme -3.40865 2530.3 252
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
Aspartate aminotransferase, cytoplasmic GOT1 Tbio Enzyme -2.25904 173.1 355
Hydroxyproline dehydrogenase PRODH2 Tbio Enzyme -0.72861 5.94 76
Carnosine synthase 1 CARNS1 Tbio Enzyme -0.64427 4.21 70