Development Level

Tchem 70 | 1,388
Tbio 55 | 11,651
Tclin 12 | 612
Tdark 1 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 5 | 499
decreased body weight 4 | 161
embryonic lethality prior to t... 4 | 278
increased mean corpuscular hem... 4 | 96
abnormal embryo size 3 | 220
embryonic growth retardation 3 | 106
increased hemoglobin content 3 | 45
abnormal neural tube closure 2 | 46
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 36
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
absent testes 1 | 6
cataract 1 | 92
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
enlarged heart 1 | 210
female infertility 1 | 60
increased basophil cell number 1 | 7
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
male infertility 1 | 123
pallor 1 | 34
premature death 1 | 5
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
small epididymis 1 | 3
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Cancer 99 | 2,499
Carcinoma 88 | 11,493
ovarian cancer 83 | 8,520
lung cancer 69 | 4,740
osteosarcoma 65 | 7,950
psoriasis 64 | 6,694
glioblastoma 63 | 5,792
medulloblastoma, large-cell 51 | 6,241
atypical teratoid / rhabdoid tumor 43 | 5,112
malignant mesothelioma 41 | 3,232
Breast cancer 40 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
ependymoma 37 | 4,679
pancreatic cancer 37 | 2,398
group 3 medulloblastoma 36 | 4,104
diabetes mellitus 35 | 1,728
lung carcinoma 35 | 2,843
Astrocytoma, Pilocytic 33 | 3,081
adult high grade glioma 33 | 3,801
subependymal giant cell astrocytoma 32 | 2,287
Schizophrenia 29 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,989
lung adenocarcinoma 29 | 2,716
non-small cell lung cancer 28 | 2,890
tuberculosis 28 | 2,010
Autosomal recessive predisposition 26 | 1,442
Mammary Neoplasms 26 | 425
primitive neuroectodermal tumor 26 | 3,035
ulcerative colitis 26 | 1,819
Breast Neoplasms 25 | 445
Kidney cancer 25 | 2,613
Vascular disease 25 | 319
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
invasive ductal carcinoma 25 | 2,951
oligodendroglioma 25 | 2,850
Epilepsy 24 | 792
Intellectual disability 24 | 1,016
Alzheimer's disease 23 | 658
Stomach Neoplasms 22 | 300
colon cancer 22 | 1,478
Lung Neoplasms 21 | 232
Prostatic Neoplasms 21 | 495
Rheumatoid arthritis 21 | 1,191
Seizures 21 | 596
interstitial cystitis 21 | 2,312
juvenile dermatomyositis 21 | 1,187
Multiple myeloma 20 | 1,332
adrenocortical carcinoma 20 | 1,428
cutaneous lupus erythematosus 20 | 1,057
Obesity 19 | 678
cystic fibrosis 19 | 1,696
Bipolar Disorder 18 | 666
Brain Ischemia 18 | 110
astrocytic glioma 18 | 2,597
breast carcinoma 18 | 1,638
group 4 medulloblastoma 18 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
pituitary cancer 18 | 1,972
Arthritis 17 | 290
Dull intelligence 17 | 645
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Neurodegenerative disease 17 | 414
Pick disease 17 | 1,894
Poor school performance 17 | 645
Toxic encephalopathy 17 | 141
Carcinoma, Hepatocellular 16 | 228
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Liver carcinoma 16 | 240
Melanoma 16 | 711
Mental and motor retardation 16 | 608
Splenomegaly 16 | 190
hepatocellular carcinoma 16 | 547
Parkinson's disease 15 | 392
Short stature 15 | 531
acute myeloid leukemia 15 | 783
acute quadriplegic myopathy 15 | 1,158
dermatomyositis 15 | 966
primary pancreatic ductal adenocarcinoma 15 | 1,109
Muscle hypotonia 14 | 571
Renal Cell Carcinoma 14 | 214
astrocytoma 14 | 1,146
gastric carcinoma 14 | 807
Colonic Neoplasms 13 | 142
Depressive disorder 13 | 409
Orbital separation excessive 13 | 244
primary Sjogren syndrome 13 | 735
Amyotrophic lateral sclerosis 12 | 451
Asthma 12 | 385
Atopic dermatitis 12 | 952
Heart disease 12 | 306
Hepatomegaly 12 | 285
Hypersensitivity reaction type II disease 12 | 253
Kidney disease 12 | 430
nasopharyngeal carcinoma 12 | 1,058
pancreatic carcinoma 12 | 562
spina bifida 12 | 1,074
Endometriosis 11 | 540

Tissue

Endocrine System 136 | 18,159
Blood and immune system 135 | 16,909
Female tissues 135 | 17,400
Skin and soft tissues 135 | 17,230
Male tissues 134 | 17,142
Digestive Tract 133 | 17,369
Liver and Pancreas 133 | 16,750
Nervous System 133 | 16,725
Cardiovascular System 132 | 15,192
Respiratory system 132 | 16,393
Urinary Tract 132 | 16,678

Target Family

Non-IDG 67 | 12,091
Enzyme 35 | 4,145
Kinase 26 | 634
Transcription Factor 7 | 1,400
Ion Channel 3 | 344

KEGG Pathway

Apoptosis 138 | 138
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive caspase-12 CASP12 Tbio Enzyme -2.64252 415.1 429
Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 Tbio Non-IDG -2.81111 643.5 577
Poly [ADP-ribose] polymerase 3 PARP3 Tclin Enzyme -1.66230 41.9 193
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Tubulin alpha-3C/D chain TUBA3C Tchem Non-IDG -1.55574 5.76 132
BH3-interacting domain death agonist BID Tbio Non-IDG -1.85313 58.9 981
Calpain-2 catalytic subunit CAPN2 Tchem Non-IDG -1.69585 48.5 220
p53-regulated apoptosis-inducing protein 1 TP53AIP1 Tbio Non-IDG -1.34343 17.8 97
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.32299 2090.2 2060
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.29568 193.3 384