Development Level

Tbio 72 | 11,445
Tchem 43 | 1,598
Tclin 15 | 613
Tdark 6 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 9 | 499
enlarged heart 5 | 210
decreased vertical activity 4 | 208
abnormal behavior 3 | 298
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased body weight 3 | 161
decreased circulating LDL chol... 3 | 38
decreased mean corpuscular vol... 3 | 79
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
enlarged spleen 3 | 41
increased lean body mass 3 | 172
increased startle reflex 3 | 112
male infertility 3 | 123
abnormal embryo size 2 | 220
abnormal gait 2 | 69
abnormal spleen morphology 2 | 55
decreased circulating choleste... 2 | 93
decreased mean platelet volume 2 | 25
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased mean platelet volume 2 | 45
increased red blood cell distr... 2 | 34
increased spleen weight 2 | 10
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal bone mineralization 1 | 38
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal thymus morphology 1 | 7
abnormal vocalization 1 | 21
absent seminal vesicle 1 | 4
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged thymus 1 | 5
female infertility 1 | 60
hydrometra 1 | 53
hypoactivity 1 | 132
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased glycosylated hemoglo... 1 | 1
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased respiratory quotient 1 | 2
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small epididymis 1 | 3
small kidney 1 | 16
small testis 1 | 58
small uterus 1 | 3
thrombocytosis 1 | 27

Disease

Carcinoma 92 | 11,493
ovarian cancer 78 | 8,520
glioblastoma 69 | 5,792
osteosarcoma 67 | 7,950
medulloblastoma, large-cell 61 | 6,241
psoriasis 60 | 6,694
ependymoma 53 | 4,679
atypical teratoid / rhabdoid tumor 52 | 5,112
Breast cancer 51 | 3,578
lung cancer 46 | 4,740
Cancer 45 | 2,499
group 3 medulloblastoma 45 | 4,104
adult high grade glioma 43 | 3,801
primitive neuroectodermal tumor 41 | 3,035
Kidney cancer 39 | 2,613
Astrocytoma, Pilocytic 36 | 3,081
subependymal giant cell astrocytoma 35 | 2,287
oligodendroglioma 34 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
lung carcinoma 33 | 2,843
invasive ductal carcinoma 32 | 2,951
malignant mesothelioma 32 | 3,232
astrocytic glioma 30 | 2,597
diabetes mellitus 30 | 1,728
pancreatic cancer 30 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,989
ulcerative colitis 28 | 1,819
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
non-small cell lung cancer 27 | 2,890
lung adenocarcinoma 26 | 2,716
Pick disease 25 | 1,894
Obesity 24 | 678
Heart disease 23 | 306
Hypertension 22 | 396
Schizophrenia 22 | 1,160
breast carcinoma 22 | 1,638
colon cancer 21 | 1,478
pituitary cancer 21 | 1,972
Epilepsy 20 | 792
interstitial cystitis 20 | 2,312
Seizures 19 | 596
group 4 medulloblastoma 19 | 1,855
Intellectual disability 18 | 1,016
cystic fibrosis 18 | 1,696
Autosomal recessive predisposition 17 | 1,442
Hypertensive disease 17 | 292
Kidney disease 17 | 430
acute quadriplegic myopathy 17 | 1,158
tuberculosis 17 | 2,010
Breast Neoplasms 16 | 445
Mammary Neoplasms 16 | 425
juvenile dermatomyositis 16 | 1,187
Depressive disorder 15 | 409
Lung Neoplasms 15 | 232
pediatric high grade glioma 15 | 1,064
primary pancreatic ductal adenocarcinoma 15 | 1,109
Liver cancer 14 | 604
Melanoma 14 | 711
Multiple myeloma 14 | 1,332
Orbital separation excessive 14 | 244
Stomach Neoplasms 14 | 300
Vascular disease 14 | 319
ductal carcinoma in situ 14 | 1,745
Coronary artery disease 13 | 268
Dull intelligence 13 | 645
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Muscle hypotonia 13 | 571
Poor school performance 13 | 645
Bipolar Disorder 12 | 666
Brain Ischemia 12 | 110
Cerebrovascular disease 12 | 238
Endometrial cancer 12 | 311
adrenocortical carcinoma 12 | 1,428
Acquired scoliosis 11 | 281
Alzheimer's disease 11 | 658
Byzanthine arch palate 11 | 194
Curvature of spine 11 | 282
Duchenne muscular dystrophy 11 | 601
Heart failure 11 | 162
Mental Depression 11 | 333
Myocardial Infarction 11 | 151
Prostatic Neoplasms 11 | 495
Rheumatoid arthritis 11 | 1,191
Short stature 11 | 531
Skin cancer 11 | 469
astrocytoma 11 | 1,146
nasopharyngeal carcinoma 11 | 1,058
Atherosclerosis 10 | 291
Cardiomegaly 10 | 116
Colorectal Neoplasms 10 | 243
Concave bridge of nose 10 | 195
Cryptorchidism 10 | 296
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Hypertrophic Cardiomyopathy 10 | 117
dermatomyositis 10 | 966
gastric carcinoma 10 | 807
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962

Tissue

Endocrine System 135 | 18,159
Digestive Tract 134 | 17,369
Female tissues 133 | 17,400
Male tissues 133 | 17,142
Blood and immune system 132 | 16,909
Skin and soft tissues 132 | 17,230
Liver and Pancreas 131 | 16,750
Nervous System 129 | 16,725
Urinary Tract 128 | 16,678
Cardiovascular System 127 | 15,192
Respiratory system 126 | 16,393

Target Family

Non-IDG 50 | 12,091
Enzyme 31 | 4,145
Kinase 30 | 634
Transcription Factor 11 | 1,400
Ion Channel 6 | 344
Transporter 4 | 473
Epigenetic 2 | 242
GPCR 2 | 408

KEGG Pathway

Apelin signaling pathway 136 | 136
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beclin-2 BECN2 Tbio Non-IDG 0.00000 87
Krueppel-like factor 2 KLF2 Tbio Transcription Factor -2.30630 216.2 308
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Adenylate cyclase type 10 ADCY10 Tchem Enzyme -3.13751 1324.4 108
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104