Development Level

Tchem 17 | 1,598
Tbio 8 | 11,445
Tclin 6 | 613

IMPC Phenotype

decreased circulating glucose ... 3 | 126
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
preweaning lethality, complete... 3 | 979
decreased circulating amylase ... 2 | 28
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
abnormal allantois morphology 1 | 8
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal left-right axis patte... 1 | 2
abnormal limb bud morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal somite shape 1 | 5
abnormal tail bud morphology 1 | 8
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased body weight 1 | 161
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased kidney weight 1 | 6
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58

Disease

Cancer 24 | 2,499
Carcinoma 21 | 11,493
osteosarcoma 18 | 7,950
Rheumatoid arthritis 17 | 1,191
non-small cell lung cancer 17 | 2,890
psoriasis 16 | 6,694
ovarian cancer 15 | 8,520
Arthritis, Rheumatoid 14 | 174
lung cancer 14 | 4,740
Colorectal Neoplasms 13 | 243
glioblastoma 13 | 5,792
malignant mesothelioma 13 | 3,232
medulloblastoma, large-cell 13 | 6,241
tuberculosis 12 | 2,010
atypical teratoid / rhabdoid tumor 11 | 5,112
ependymoma 11 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
Adverse reaction to drug 10 | 61
Breast Neoplasms 10 | 445
Drug-Related Side Effects and Adverse Reactions 10 | 62
Mammary Neoplasms 10 | 425
adult high grade glioma 10 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
Kidney cancer 9 | 2,613
diabetes mellitus 9 | 1,728
Astrocytoma, Pilocytic 8 | 3,081
Breast cancer 8 | 3,578
Chemical and Drug Induced Liver Injury 8 | 195
Colonic Neoplasms 8 | 142
Endometriosis 8 | 540
Liver Cirrhosis, Experimental 8 | 769
Nervous System Diseases 8 | 53
Schizophrenia 8 | 1,160
adrenocortical carcinoma 8 | 1,428
cystic fibrosis 8 | 1,696
interstitial cystitis 8 | 2,312
lung adenocarcinoma 8 | 2,716
nervous system disorder 8 | 53
Alcoholic Intoxication, Chronic 7 | 289
Autosomal recessive predisposition 7 | 1,442
Cholestasis 7 | 155
Hypertension 7 | 396
Malignant mesothelioma of pleura 7 | 7
Seizures 7 | 596
invasive ductal carcinoma 7 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Anemia 6 | 365
Brain Ischemia 6 | 110
Dermatologic disorders 6 | 93
Disease Models, Animal 6 | 155
Juvenile rheumatoid arthritis 6 | 111
Lung Neoplasms 6 | 232
Multiple myeloma 6 | 1,332
group 3 medulloblastoma 6 | 4,104
lung carcinoma 6 | 2,843
ulcerative colitis 6 | 1,819
Bipolar Disorder 5 | 666
Diarrhea 5 | 253
Epilepsy 5 | 792
Heat Stroke 5 | 13
Hyperglycemia 5 | 137
Hypertensive disease 5 | 292
Liver disease 5 | 237
Malaria 5 | 160
Mucositis 5 | 29
Neoplasm Metastasis 5 | 168
Obesity 5 | 678
Skin Diseases 5 | 71
Stomach Neoplasms 5 | 300
colon cancer 5 | 1,478
pancreatic cancer 5 | 2,398
primitive neuroectodermal tumor 5 | 3,035
Alzheimer's disease 4 | 658
Atherosclerosis 4 | 291
Autistic Disorder 4 | 364
Bladder Neoplasm 4 | 112
Cerebrovascular accident 4 | 63
Cerebrovascular disease 4 | 238
Coronary artery disease 4 | 268
Dementia 4 | 175
Depressive disorder 4 | 409
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Down syndrome 4 | 499
Infertility 4 | 188
Inflammatory bowel disease 4 | 151
Kidney disease 4 | 430
Liver cancer 4 | 604
Major Depressive Disorder 4 | 301
Mental Depression 4 | 333
Neoplasm Invasiveness 4 | 161
Reperfusion Injury 4 | 86
Stroke 4 | 33
Unipolar Depression 4 | 250
Urinary Bladder Neoplasms 4 | 114
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
pituitary cancer 4 | 1,972

Tissue

Blood and immune system 31 | 16,909
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Liver and Pancreas 31 | 16,750
Male tissues 31 | 17,142
Skin and soft tissues 31 | 17,230
Urinary Tract 31 | 16,678
Nervous System 30 | 16,725
Respiratory system 30 | 16,393
Cardiovascular System 28 | 15,192

Target Family

Enzyme 9 | 4,145
Non-IDG 9 | 12,091
Transporter 8 | 473
Kinase 3 | 634
Transcription Factor 2 | 1,400

KEGG Pathway

Antifolate resistance 31 | 31
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Folate receptor alpha FOLR1 Tchem Non-IDG -2.33242 206.1 303
Bifunctional purine biosynthesis protein PURH ATIC Tchem Non-IDG -2.93014 835.0 246
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Proton-coupled folate transporter SLC46A1 Tchem Transporter -2.23182 177.1 76
Folate transporter 1 SLC19A1 Tchem Transporter -2.00363 97.7 67
Folate receptor gamma FOLR3 Tbio Non-IDG -0.82047 6.26 98
Thymidylate synthase TYMS Tclin Enzyme -2.93426 732.0 733
Sperm-egg fusion protein Juno IZUMO1R Tbio Non-IDG -1.78804 57.0 212
Folate receptor beta FOLR2 Tchem Non-IDG -1.91119 88.6 222
Canalicular multispecific organic anion transporter 2 ABCC3 Tbio Transporter -2.46032 287.4 214