Development Level

Tbio 31 | 11,445
Tchem 12 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 17 | 979
embryonic lethality prior to o... 5 | 239
decreased grip strength 3 | 116
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
decreased fasted circulating g... 2 | 65
impaired glucose tolerance 2 | 75
increased total body fat amoun... 2 | 134
abnormal QT variability 1 | 10
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal spinal cord morpholog... 1 | 9
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating sodium l... 1 | 22
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
decreased urine magnesium leve... 1 | 3
embryonic growth retardation 1 | 106
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased red blood cell distr... 1 | 34
increased thermal nociceptive ... 1 | 9

Disease

Carcinoma 41 | 11,493
ovarian cancer 29 | 8,520
Autosomal recessive predisposition 16 | 1,442
lung cancer 16 | 4,740
osteosarcoma 16 | 7,950
medulloblastoma, large-cell 14 | 6,241
psoriasis 14 | 6,694
Multiple myeloma 12 | 1,332
Neurodegenerative disease 10 | 414
atypical teratoid / rhabdoid tumor 10 | 5,112
glioblastoma 10 | 5,792
Myositis 9 | 30
Epilepsy 8 | 792
diabetes mellitus 8 | 1,728
Cognitive delay 7 | 608
Distal sensory impairment 7 | 52
Global developmental delay 7 | 608
Leigh disease 7 | 100
Mental and motor retardation 7 | 608
Neuropathy 7 | 261
malignant mesothelioma 7 | 3,232
tuberculosis 7 | 2,010
Cancer 6 | 2,499
Charcot-Marie-Tooth disease 6 | 62
Muscle hypotonia 6 | 571
Nystagmus 6 | 317
dermatomyositis 6 | 966
group 3 medulloblastoma 6 | 4,104
primitive neuroectodermal tumor 6 | 3,035
Anemia 5 | 365
Breast cancer 5 | 3,578
Failure to gain weight 5 | 365
Kidney cancer 5 | 2,613
Pediatric failure to thrive 5 | 365
Pick disease 5 | 1,894
Small head 5 | 374
Waldenstrons macroglobulinemia 5 | 765
astrocytoma 5 | 1,146
ependymoma 5 | 4,679
juvenile dermatomyositis 5 | 1,187
non-small cell lung cancer 5 | 2,890
sonic hedgehog group medulloblastoma 5 | 467
Alpers syndrome 4 | 9
Autosomal recessive Robinow syndrome 4 | 27
Cerebral atrophy 4 | 178
Combined oxidative phosphorylation deficiency 4 | 14
Congenital pes cavus 4 | 88
Decreased tendon reflex 4 | 122
Degenerative brain disorder 4 | 100
Hemoglobin low 4 | 124
Highly variable severity 4 | 157
Hypoplasia of corpus callosum 4 | 90
Progressive disorder 4 | 142
Supratentorial atrophy 4 | 94
Variable expressivity 4 | 157
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
astrocytic glioma 4 | 2,597
colon cancer 4 | 1,478
interstitial lung disease 4 | 298
lung adenocarcinoma 4 | 2,716
oligodendroglioma 4 | 2,850
pediatric high grade glioma 4 | 1,064
Absent reflex 3 | 92
Absent tendon reflex 3 | 92
Acidosis, Lactic 3 | 97
Acquired scoliosis 3 | 281
Axonal neuropathy 3 | 27
CNS hypomyelination 3 | 17
Curvature of spine 3 | 282
Distal limb muscle weakness due to peripheral neuropathy 3 | 62
Distal muscle weakness 3 | 62
Foot dorsiflexor weakness 3 | 27
Foot-drop 3 | 27
Gait, Drop Foot 3 | 24
Hammer Toe 3 | 23
Hyperreflexia 3 | 209
Hypomyelination 3 | 17
Infantile onset 3 | 238
Intellectual disability 3 | 1,016
Lactic acidemia 3 | 95
Motor delay 3 | 147
Muscle Spasticity 3 | 195
No development of motor milestones 3 | 147
Peripheral axonal neuropathy 3 | 18
Perrault syndrome 3 | 19
Reflex, Deep Tendon, Absent 3 | 92
Seizures 3 | 596
Sensorineural Hearing Loss (disorder) 3 | 284
Slow progression 3 | 89
adult high grade glioma 3 | 3,801
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Atrophy of cerebellum 2 | 103
Cerebellar degeneration 2 | 103
posterior fossa group B ependymoma 2 | 416

Tissue

Blood and immune system 44 | 16,909
Cardiovascular System 44 | 15,192
Digestive Tract 44 | 17,369
Endocrine System 44 | 18,159
Female tissues 44 | 17,400
Liver and Pancreas 44 | 16,750
Male tissues 44 | 17,142
Nervous System 44 | 16,725
Respiratory system 44 | 16,393
Skin and soft tissues 44 | 17,230
Urinary Tract 44 | 16,678

Target Family

Enzyme 43 | 4,145
Kinase 1 | 634

KEGG Pathway

Aminoacyl-tRNA biosynthesis 44 | 44
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Isoleucine--tRNA ligase, cytoplasmic IARS Tchem Enzyme -3.11190 1198.0 95
Tyrosine--tRNA ligase, cytoplasmic YARS Tchem Enzyme -2.45633 272.6 180
Glycine--tRNA ligase GARS Tbio Enzyme -2.62899 412.8 178
O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS Tbio Enzyme -2.11362 120.5 120
Aspartate--tRNA ligase, cytoplasmic DARS Tbio Enzyme -1.93573 78.1 128
Alanine--tRNA ligase, cytoplasmic AARS Tbio Enzyme -2.49617 295.2 140
Cysteine--tRNA ligase, cytoplasmic CARS Tbio Enzyme -3.00492 954.7 154
L-seryl-tRNA(Sec) kinase PSTK Tdark Kinase -1.27559 18.1 37
Tryptophan--tRNA ligase, cytoplasmic WARS Tbio Enzyme -2.74520 518.6 163
Threonine--tRNA ligase, cytoplasmic TARS Tchem Enzyme -2.61174 405.9 120