Development Level

Tbio 31 | 10,625
Tchem 14 | 1,890
Tdark 3 | 7,003

IMPC Phenotype

embryonic lethality prior to t... 3 | 187
embryonic lethality prior to o... 2 | 148
preweaning lethality, complete... 2 | 633
abnormal bone mineralization 1 | 55
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal lens morphology 1 | 73
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 35
decreased CD4-positive NK T ce... 1 | 4
decreased CD4-positive, CD25-p... 1 | 24
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased CD8-positive, naive ... 1 | 5
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased basophil cell number 1 | 11
decreased circulating glucose ... 1 | 121
decreased dendritic cell numbe... 1 | 3
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased hemoglobin content 1 | 53
decreased macrophage cell numb... 1 | 4
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
decreased total body fat amoun... 1 | 186
enlarged lymph nodes 1 | 27
increased B cell number 1 | 23
increased CD4-negative NK T ce... 1 | 4
increased CD4-positive, alpha ... 1 | 15
increased CD5-positive Ly6C-po... 1 | 4
increased CD8-positive, alpha-... 1 | 11
increased Ly6C high monocyte n... 1 | 12
increased NK T cell number 1 | 11
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased blood urea nitrogen ... 1 | 44
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating iron lev... 1 | 25
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased granulocyte number 1 | 8
increased mature B cell number 1 | 12
increased neutrophil cell numb... 1 | 15
increased prepulse inhibition 1 | 21
increased rib number 1 | 41
short tibia 1 | 82
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

ovarian cancer 29 | 8,491
osteosarcoma 21 | 7,933
glioblastoma 18 | 5,572
psoriasis 16 | 6,685
medulloblastoma, large-cell 12 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
group 3 medulloblastoma 10 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
lung carcinoma 10 | 2,844
Breast cancer 9 | 3,098
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
lung cancer 9 | 4,473
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
subependymal giant cell astrocytoma 9 | 2,287
Multiple myeloma 8 | 1,327
astrocytoma 8 | 1,493
diabetes mellitus 8 | 1,663
ductal carcinoma in situ 8 | 1,745
invasive ductal carcinoma 8 | 2,950
non-small cell lung cancer 8 | 2,798
pancreatic cancer 8 | 2,300
pediatric high grade glioma 8 | 2,712
pilocytic astrocytoma 8 | 3,086
tuberculosis 7 | 1,563
ulcerative colitis 7 | 2,087
Galactosemia 6 | 20
astrocytic glioma 6 | 2,241
lung adenocarcinoma 6 | 2,714
malignant mesothelioma 6 | 3,163
oligodendroglioma 6 | 2,849
Congenital disorder of glycosylation 5 | 53
Obesity 5 | 616
atypical teratoid/rhabdoid tumor 5 | 1,095
ependymoma 5 | 2,514
esophageal adenocarcinoma 5 | 737
gastric carcinoma 5 | 832
group 4 medulloblastoma 5 | 1,875
juvenile dermatomyositis 5 | 1,189
primary pancreatic ductal adenocarcinoma 5 | 1,271
Intellectual disability 4 | 573
Methemoglobinemia 4 | 17
Waldenstrons macroglobulinemia 4 | 764
active Crohn's disease 4 | 918
atypical teratoid / rhabdoid tumor 4 | 4,369
breast carcinoma 4 | 1,614
colon cancer 4 | 1,475
cystic fibrosis 4 | 1,670
interstitial cystitis 4 | 2,299
primitive neuroectodermal tumor 4 | 3,031
Cancer 3 | 2,346
Galactosemias 3 | 3
Gaucher's disease 3 | 25
Hyperglycemia 3 | 120
IGA Glomerulonephritis 3 | 454
Myocardial Ischemia 3 | 169
Neurodegenerative disease 3 | 383
adrenocortical carcinoma 3 | 1,427
dermatomyositis 3 | 966
hepatocellular carcinoma 3 | 550
medulloblastoma 3 | 1,524
mucosa-associated lymphoid tissue lymphoma 3 | 480
nasopharyngeal carcinoma 3 | 1,056
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 1,511
spina bifida 3 | 1,064
tuberculosis and treatment for 3 months 3 | 327
Acquired metabolic disease 2 | 267
Barrett's esophagus 2 | 185
Cataract 2 | 104
Congenital myasthenic syndrome 2 | 28
Diabetes Mellitus, Experimental 2 | 106
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
Exocrine pancreatic insufficiency 2 | 21
Gangliosidosis 2 | 17
Gestational Diabetes 2 | 17
Glaucoma 2 | 135
Neuropathy 2 | 210
Pancreatic steatorrhea 2 | 6
Pick disease 2 | 1,893
Rheumatoid Arthritis 2 | 1,170
Sandhoff disease 2 | 3
Schizophrenia 2 | 503
Steatorrhea 2 | 20
Type 2 diabetes mellitus 2 | 192
Typhoid fever 2 | 22
active ulcerative colitis 2 | 477
adult high grade glioma 2 | 2,148
gastric cancer 2 | 436
non diabetic and post-ischemic heart failure 2 | 200
non-small cell lung carcinoma 2 | 413
pancreatic carcinoma 2 | 567
primary Sjogren syndrome 2 | 788
sarcoidosis 2 | 368
sonic hedgehog group medulloblastoma 2 | 1,482
triple-A syndrome 2 | 18
Breast giant fibroadenoma 1 | 4
Hypervitaminosis A 1 | 8
Omenn syndrome 1 | 14
Tinea cruris 1 | 12
permanent neonatal diabetes mellitus 1 | 6

Tissue

Blood and immune system 48 | 17,994
Cardiovascular System 48 | 17,957
Digestive Tract 48 | 18,472
Endocrine System 48 | 18,511
Female tissues 48 | 18,646
Liver and Pancreas 48 | 18,135
Nervous System 48 | 18,560
Respiratory system 48 | 17,483
Skin and soft tissues 48 | 18,114
Urinary Tract 48 | 18,443
Male tissues 47 | 17,968

Target Family

Enzyme 40 | 4,146
Kinase 8 | 634

KEGG Pathway

Amino sugar and nucleotide sug... 48 | 48
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hexokinase-2 HK2 Tchem Kinase -2.60415 391.1 373
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 Tbio Enzyme -2.68162 450.4 121
Phosphoacetylglucosamine mutase PGM3 Tbio Enzyme -2.19929 160.2 141
Galactose-1-phosphate uridylyltransferase GALT Tbio Enzyme -2.32448 208.9 205
UDP-glucose 4-epimerase GALE Tchem Enzyme -2.41033 251.8 165
UDP-glucose 6-dehydrogenase UGDH Tbio Enzyme -2.37672 243.7 199
Sialic acid synthase NANS Tbio Enzyme -1.88529 76.2 108
Chitotriosidase-1 CHIT1 Tchem Enzyme -2.55683 356.5 127
Phosphoglucomutase-1 PGM1 Tbio Enzyme -2.68147 478.5 119
Glucokinase GCK Tchem Kinase -2.88674 738.6 291