Development Level

Tbio 35 | 11,445
Tchem 11 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to t... 3 | 278
embryonic lethality prior to o... 2 | 239
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal tooth morphology 1 | 24
decreased basophil cell number 1 | 16
decreased circulating magnesiu... 1 | 13
decreased hemoglobin content 1 | 68
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased prepulse inhibition 1 | 32
shortened RR interval 1 | 17
small kidney 1 | 16
small superior vagus ganglion 1 | 74

Disease

ovarian cancer 29 | 8,520
Carcinoma 28 | 11,493
osteosarcoma 21 | 7,950
glioblastoma 18 | 5,792
psoriasis 16 | 6,694
Autosomal recessive predisposition 15 | 1,442
medulloblastoma, large-cell 12 | 6,241
Intellectual disability 11 | 1,016
group 3 medulloblastoma 11 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
tuberculosis 11 | 2,010
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
lung carcinoma 10 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Breast cancer 9 | 3,578
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
astrocytic glioma 9 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
lung cancer 9 | 4,740
subependymal giant cell astrocytoma 9 | 2,287
Astrocytoma, Pilocytic 8 | 3,081
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Multiple myeloma 8 | 1,332
Muscle hypotonia 8 | 571
atypical teratoid / rhabdoid tumor 8 | 5,112
diabetes mellitus 8 | 1,728
ductal carcinoma in situ 8 | 1,745
ependymoma 8 | 4,679
invasive ductal carcinoma 8 | 2,951
non-small cell lung cancer 8 | 2,890
pancreatic cancer 8 | 2,398
Cerebellar Ataxia 6 | 304
Epilepsy 6 | 792
Galactosemia 6 | 19
Obesity 6 | 678
Seizures 6 | 596
group 4 medulloblastoma 6 | 1,855
lung adenocarcinoma 6 | 2,716
malignant mesothelioma 6 | 3,232
oligodendroglioma 6 | 2,850
Congenital disorder of glycosylation 5 | 54
Failure to gain weight 5 | 365
Hepatomegaly 5 | 285
Muscle Weakness 5 | 170
Pediatric failure to thrive 5 | 365
active ulcerative colitis 5 | 764
adult high grade glioma 5 | 3,801
astrocytoma 5 | 1,146
esophageal adenocarcinoma 5 | 737
gastric carcinoma 5 | 807
juvenile dermatomyositis 5 | 1,187
pediatric high grade glioma 5 | 1,064
Feeding difficulties 4 | 127
Icterus 4 | 82
Methemoglobinemia 4 | 17
Small head 4 | 374
Splenomegaly 4 | 190
Vomiting 4 | 116
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 922
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
interstitial cystitis 4 | 2,312
primary pancreatic ductal adenocarcinoma 4 | 1,109
primitive neuroectodermal tumor 4 | 3,035
ulcerative colitis 4 | 1,819
Adenocarcinoma of lung 3 | 142
Byzanthine arch palate 3 | 194
Cancer 3 | 2,499
Cataract 3 | 297
Coarse facial features 3 | 108
Diarrhea 3 | 253
Disease Models, Animal 3 | 155
Dysarthria 3 | 192
Gaucher's disease 3 | 26
Hyperglycemia 3 | 137
Hypoglycemia 3 | 152
Lens Opacities 3 | 231
Liver Cirrhosis, Experimental 3 | 769
Myocardial Ischemia 3 | 169
Neurodegenerative disease 3 | 414
Neuropathy 3 | 261
Peripheral Neuropathy 3 | 134
Sensorineural Hearing Loss (disorder) 3 | 284
Strabismus 3 | 270
Thickened facial skin with coarse facial features 3 | 108
adrenocortical carcinoma 3 | 1,428
dermatomyositis 3 | 966
hepatocellular carcinoma 3 | 547
mucosa-associated lymphoid tissue lymphoma 3 | 484
nasopharyngeal carcinoma 3 | 1,058
pituitary cancer 3 | 1,972
spina bifida 3 | 1,074

Tissue

Blood and immune system 48 | 16,909
Digestive Tract 48 | 17,369
Endocrine System 48 | 18,159
Female tissues 48 | 17,400
Liver and Pancreas 48 | 16,750
Male tissues 48 | 17,142
Nervous System 48 | 16,725
Respiratory system 48 | 16,393
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Cardiovascular System 47 | 15,192

Target Family

Enzyme 40 | 4,145
Kinase 8 | 634

KEGG Pathway

Amino sugar and nucleotide sug... 48 | 48
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 UAP1L1 Tdark Enzyme 0.90 0.11 70
NADH-cytochrome b5 reductase 2 CYB5R2 Tbio Enzyme -0.96076 7.49 58
NADH-cytochrome b5 reductase 1 CYB5R1 Tbio Enzyme -0.95573 7.22 142
N-acetylglucosamine-6-phosphate deacetylase AMDHD2 Tchem Enzyme -1.10834 6.96 87
Hexokinase-2 HK2 Tchem Kinase -2.64934 432.5 446
UDP-N-acetylhexosamine pyrophosphorylase UAP1 Tbio Enzyme -2.32564 204.9 178
Mannose-1-phosphate guanyltransferase alpha GMPPA Tbio Enzyme -1.64224 42.1 100
Phosphomannomutase 2 PMM2 Tchem Enzyme -2.12990 128.2 153
Cytochrome b5 reductase 4 CYB5R4 Tbio Enzyme -1.15554 17.5 107
NADH-cytochrome b5 reductase-like CYB5RL Tdark Enzyme -0.08219 0.57 22