Development Level

Tbio 69 | 11,445
Tclin 55 | 613
Tchem 36 | 1,598
Tdark 11 | 6,588

IMPC Phenotype

preweaning lethality, complete... 24 | 979
abnormal embryo size 9 | 220
embryonic lethality prior to t... 8 | 278
pallor 6 | 34
embryonic lethality prior to o... 5 | 239
abnormal behavior 4 | 298
embryonic growth retardation 4 | 106
cataract 3 | 92
decreased bone mineral content 3 | 151
hemorrhage 3 | 23
increased bone mineral content 3 | 108
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal lens morphology 2 | 81
abnormal limb bud morphology 2 | 17
abnormal midbrain development 2 | 20
abnormal neural tube closure 2 | 46
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
cyanosis 2 | 7
decreased body weight 2 | 161
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased lactate dehydrogenas... 2 | 16
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
edema 2 | 59
hypoactivity 2 | 132
increased circulating alkaline... 2 | 122
increased heart weight 2 | 62
increased lean body mass 2 | 172
male infertility 2 | 123
pale yolk sac 2 | 25
prenatal lethality 2 | 28
respiratory system phenotype 2 | 2
small superior vagus ganglion 2 | 74
abnormal allantois morphology 1 | 8
abnormal chorioallantoic fusio... 1 | 8
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal embryonic autopod pla... 1 | 2
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal locomotor behavior 1 | 24
abnormal neural tube morpholog... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal placenta morphology 1 | 5
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal vocalization 1 | 21
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased total retina thickne... 1 | 17
hydrometra 1 | 53
hyperactivity 1 | 148
increased blood urea nitrogen ... 1 | 48
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
polycystic kidney 1 | 15
premature death 1 | 5
syndactyly 1 | 23
unresponsive to tactile stimul... 1 | 8

Disease

ovarian cancer 97 | 8,520
Carcinoma 71 | 11,493
osteosarcoma 66 | 7,950
psoriasis 62 | 6,694
glioblastoma 59 | 5,792
lung cancer 54 | 4,740
medulloblastoma, large-cell 54 | 6,241
Multiple myeloma 50 | 1,332
atypical teratoid / rhabdoid tumor 48 | 5,112
ependymoma 44 | 4,679
Schizophrenia 42 | 1,160
Cancer 41 | 2,499
Diabetes mellitus type 2 39 | 69
Treatment Refractory Type 2 Diabetes Mellitus 39 | 53
Autosomal recessive predisposition 38 | 1,442
Breast cancer 38 | 3,578
Epilepsy 37 | 792
Alzheimer's disease 36 | 658
astrocytic glioma 36 | 2,597
adult high grade glioma 35 | 3,801
Astrocytoma, Pilocytic 34 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
oligodendroglioma 33 | 2,850
diabetes mellitus 32 | 1,728
Seizures 31 | 596
Cognitive delay 30 | 608
Global developmental delay 30 | 608
Mental and motor retardation 30 | 608
Cerebellar Ataxia 27 | 304
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
subependymal giant cell astrocytoma 27 | 2,287
Toxic encephalopathy 26 | 141
Leigh disease 25 | 100
Pick disease 25 | 1,894
group 3 medulloblastoma 25 | 4,104
lung carcinoma 25 | 2,843
Parkinson's disease 24 | 392
primitive neuroectodermal tumor 24 | 3,035
Acidosis, Lactic 23 | 97
Bipolar Disorder 23 | 666
Intellectual disability 23 | 1,016
Kidney cancer 23 | 2,613
Lactic acidemia 23 | 95
Muscle hypotonia 23 | 571
malignant mesothelioma 23 | 3,232
Mitochondrial complex I deficiency 22 | 46
Sensorineural Hearing Loss (disorder) 22 | 284
Dull intelligence 21 | 645
Low intelligence 21 | 645
Mental Retardation 21 | 645
Mental deficiency 21 | 645
Nystagmus 21 | 317
Poor school performance 21 | 645
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
Blepharoptosis 20 | 231
Dementia 20 | 175
Hyperreflexia 20 | 209
lung adenocarcinoma 20 | 2,716
Failure to gain weight 19 | 365
Pediatric failure to thrive 19 | 365
Waldenstrons macroglobulinemia 19 | 765
non-small cell lung cancer 19 | 2,890
Depressive disorder 18 | 409
Muscle Spasticity 18 | 195
Neurodegenerative disease 18 | 414
colon cancer 18 | 1,478
invasive ductal carcinoma 18 | 2,951
pancreatic cancer 18 | 2,398
Strabismus 17 | 270
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
CSF lactate increased 16 | 33
Developmental regression 16 | 95
Highly variable clinical phenotype 16 | 150
Highly variable phenotype and severity 16 | 150
Highly variable phenotype, even within families 16 | 150
Hypoglycemia 16 | 152
Loss of developmental milestones 16 | 95
Mental deterioration in childhood 16 | 95
Neurodevelopmental regression 16 | 95
Phenotypic variability 16 | 150
Psychomotor regression 16 | 95
Psychomotor regression beginning in infancy 16 | 95
Psychomotor regression in infants 16 | 95
Psychomotor regression, progressive 16 | 95
Rheumatoid arthritis 16 | 1,191
group 4 medulloblastoma 16 | 1,855
pituitary cancer 16 | 1,972
ulcerative colitis 16 | 1,819
Cerebrovascular disease 15 | 238
Heart failure 15 | 162
Hypertrophic Cardiomyopathy 15 | 117
Increased serum lactate 15 | 60
Mitochondrial Complex 1 Deficiency 15 | 28
Muscle Weakness 15 | 170
Obesity 15 | 678
Optic Atrophy 15 | 242
Respiratory Failure 15 | 104
breast carcinoma 15 | 1,638
non primary Sjogren syndrome sicca 14 | 891
tuberculosis 14 | 2,010

Tissue

Endocrine System 170 | 18,159
Skin and soft tissues 169 | 17,230
Blood and immune system 168 | 16,909
Digestive Tract 168 | 17,369
Female tissues 168 | 17,400
Liver and Pancreas 167 | 16,750
Male tissues 167 | 17,142
Nervous System 167 | 16,725
Urinary Tract 165 | 16,678
Respiratory system 164 | 16,393
Cardiovascular System 161 | 15,192

Target Family

Enzyme 108 | 4,145
Non-IDG 40 | 12,091
Ion Channel 13 | 344
Kinase 6 | 634
Transporter 3 | 473
Transcription Factor 1 | 1,400

KEGG Pathway

Alzheimer's disease 171 | 171
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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