Development Level

Tbio 39 | 11,445
Tchem 33 | 1,598
Tclin 24 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 4 | 125

IMPC Phenotype

abnormal behavior 5 | 298
abnormal bone structure 5 | 187
abnormal embryo size 5 | 220
increased heart weight 5 | 62
increased startle reflex 5 | 112
preweaning lethality, incomple... 5 | 499
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
preweaning lethality, complete... 3 | 979
decreased circulating amylase ... 2 | 28
decreased prepulse inhibition 2 | 82
edema 2 | 59
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased circulating choleste... 2 | 66
male infertility 2 | 123
small heart 2 | 10
small liver 2 | 8
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal gallbladder morpholog... 1 | 1
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal locomotor behavior 1 | 24
abnormal neural tube closure 1 | 46
abnormal pancreas morphology 1 | 13
abnormal placenta vasculature 1 | 2
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
absent vibrissae 1 | 12
cardiovascular system phenotyp... 1 | 36
cyanosis 1 | 7
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased brain size 1 | 4
decreased cardiac muscle contr... 1 | 11
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased circulating unsatura... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating iron lev... 1 | 30
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
prolonged PQ interval 1 | 5
prolonged PR interval 1 | 15
prolonged QT interval 1 | 38
respiratory system phenotype 1 | 2
short tibia 1 | 97
small epididymis 1 | 3
small lung 1 | 5
small spleen 1 | 19
small stomach 1 | 3
small superior vagus ganglion 1 | 74
small thymus 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 79 | 11,493
glioblastoma 53 | 5,792
osteosarcoma 51 | 7,950
ovarian cancer 51 | 8,520
medulloblastoma, large-cell 48 | 6,241
atypical teratoid / rhabdoid tumor 46 | 5,112
adult high grade glioma 44 | 3,801
psoriasis 44 | 6,694
ependymoma 43 | 4,679
group 3 medulloblastoma 41 | 4,104
primitive neuroectodermal tumor 37 | 3,035
Astrocytoma, Pilocytic 36 | 3,081
Kidney cancer 31 | 2,613
lung cancer 30 | 4,740
Breast cancer 28 | 3,578
astrocytic glioma 28 | 2,597
oligodendroglioma 28 | 2,850
subependymal giant cell astrocytoma 27 | 2,287
lung carcinoma 26 | 2,843
lung adenocarcinoma 23 | 2,716
invasive ductal carcinoma 22 | 2,951
Cancer 21 | 2,499
non-small cell lung cancer 21 | 2,890
pituitary cancer 21 | 1,972
ulcerative colitis 21 | 1,819
Hypertension 20 | 396
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
Pick disease 19 | 1,894
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
Hypertensive disease 18 | 292
pancreatic cancer 18 | 2,398
Bipolar Disorder 17 | 666
Obesity 17 | 678
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
Epilepsy 16 | 792
Schizophrenia 16 | 1,160
diabetes mellitus 16 | 1,728
malignant mesothelioma 16 | 3,232
Autosomal recessive predisposition 15 | 1,442
Polycystic ovary syndrome 15 | 360
Depressive disorder 14 | 409
astrocytoma 14 | 1,146
tuberculosis 14 | 2,010
Adenoma 13 | 167
Liver cancer 13 | 604
ductal carcinoma in situ 13 | 1,745
group 4 medulloblastoma 13 | 1,855
Atrial Fibrillation 12 | 124
Hyperaldosteronism 12 | 35
colon cancer 12 | 1,478
Melanoma 11 | 711
Rheumatoid arthritis 11 | 1,191
breast carcinoma 11 | 1,638
interstitial cystitis 11 | 2,312
Conn's syndrome 10 | 22
Cushing's syndrome 10 | 48
Heart disease 10 | 306
adrenocortical carcinoma 10 | 1,428
cystic fibrosis 10 | 1,696
Chronic heart failure 9 | 46
Major Depressive Disorder 9 | 301
Mental Depression 9 | 333
Skin cancer 9 | 469
primary Sjogren syndrome 9 | 735
Congenital adrenal hyperplasia 8 | 73
Congestive heart failure 8 | 113
Kidney disease 8 | 430
Parkinson's disease 8 | 392
Substance Withdrawal Syndrome 8 | 55
Unipolar Depression 8 | 250
aldosterone-producing adenoma 8 | 665
cutaneous lupus erythematosus 8 | 1,057
Adrenal gland cancer 7 | 12
Alcoholic Intoxication, Chronic 7 | 289
Alzheimer's disease 7 | 658
Carney complex 7 | 25
Increase in blood pressure 7 | 119
Intellectual disability 7 | 1,016
Mood Disorders 7 | 184
Osteoporosis 7 | 363
Poisoning by digitalis glycoside 7 | 8
Primary pigmented nodular adrenocortical disease 7 | 13
Prostatic Neoplasms 7 | 495
Waldenstrons macroglobulinemia 7 | 765
juvenile dermatomyositis 7 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
primary pancreatic ductal adenocarcinoma 7 | 1,109
Adrenal cortical adenoma 6 | 19
Angina Pectoris 6 | 32
Cerebrovascular disease 6 | 238
Cocaine-Related Disorders 6 | 92
Hyperandrogenism 6 | 34
Hypertensive disorder 6 | 56
McCune Albright syndrome 6 | 19
Seizures 6 | 596
chronic rhinosinusitis 6 | 512
medulloblastoma 6 | 720
pediatric high grade glioma 6 | 1,064
progressive supranuclear palsy 6 | 676
spina bifida 6 | 1,074

Tissue

Endocrine System 96 | 18,159
Digestive Tract 94 | 17,369
Female tissues 93 | 17,400
Male tissues 92 | 17,142
Nervous System 92 | 16,725
Skin and soft tissues 92 | 17,230
Liver and Pancreas 90 | 16,750
Blood and immune system 88 | 16,909
Urinary Tract 87 | 16,678
Respiratory system 85 | 16,393
Cardiovascular System 80 | 15,192

Target Family

Enzyme 21 | 4,145
Kinase 19 | 634
Non-IDG 18 | 12,091
Ion Channel 14 | 344
Transporter 12 | 473
Transcription Factor 11 | 1,400
GPCR 2 | 408
Nuclear Receptor 2 | 48

KEGG Pathway

Aldosterone synthesis and secr... 99 | 99
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adrenocorticotropic hormone receptor MC2R Tclin GPCR -2.22640 172.4 223
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1 Tchem Enzyme -2.62147 370.7 267
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Scavenger receptor class B member 1 SCARB1 Tchem Non-IDG -2.93920 915.7 378
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Sn1-specific diacylglycerol lipase alpha DAGLA Tchem Enzyme -1.11500 11.4 129