Development Level

Tbio 34 | 11,445
Tchem 26 | 1,598
Tclin 8 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
increased circulating alkaline... 4 | 122
increased circulating choleste... 4 | 66
increased total body fat amoun... 4 | 134
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased vertical activity 3 | 208
increased circulating HDL chol... 3 | 80
increased circulating bilirubi... 3 | 16
increased mean platelet volume 3 | 45
abnormal bone mineralization 2 | 38
abnormal lens morphology 2 | 81
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating HDL chol... 2 | 68
decreased circulating amylase ... 2 | 28
decreased circulating chloride... 2 | 30
decreased circulating triglyce... 2 | 79
decreased heart weight 2 | 27
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
enlarged spleen 2 | 41
increased circulating LDL chol... 2 | 13
increased circulating phosphat... 2 | 26
increased hematocrit 2 | 46
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
increased red blood cell distr... 2 | 34
limb grasping 2 | 41
small testis 2 | 58
thrombocytopenia 2 | 56
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal locomotor behavior 1 | 24
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
enlarged thymus 1 | 5
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased glycosylated hemoglo... 1 | 1
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased startle reflex 1 | 112
male infertility 1 | 123
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 51 | 11,493
ovarian cancer 40 | 8,520
Obesity 34 | 678
osteosarcoma 34 | 7,950
medulloblastoma, large-cell 33 | 6,241
Cancer 32 | 2,499
diabetes mellitus 32 | 1,728
psoriasis 32 | 6,694
glioblastoma 26 | 5,792
lung cancer 25 | 4,740
ependymoma 22 | 4,679
Hyperglycemia 21 | 137
atypical teratoid / rhabdoid tumor 21 | 5,112
adult high grade glioma 18 | 3,801
Breast cancer 17 | 3,578
Fatty liver disease 17 | 103
Kidney cancer 17 | 2,613
Schizophrenia 17 | 1,160
group 4 medulloblastoma 17 | 1,855
invasive ductal carcinoma 17 | 2,951
Diabetes Mellitus, Non-Insulin-Dependent 16 | 145
Diabetes Mellitus, Type 2 16 | 142
group 3 medulloblastoma 16 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Astrocytoma, Pilocytic 14 | 3,081
Diabetes Mellitus, Experimental 14 | 108
Hypertension 14 | 396
Rheumatoid arthritis 14 | 1,191
breast carcinoma 14 | 1,638
lung adenocarcinoma 14 | 2,716
lung carcinoma 14 | 2,843
subependymal giant cell astrocytoma 14 | 2,287
Hyperinsulinism 13 | 133
Insulin Resistance 13 | 72
Liver Cirrhosis, Experimental 13 | 769
ductal carcinoma in situ 13 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Hypertensive disease 12 | 292
astrocytoma 12 | 1,146
colon cancer 12 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
malignant mesothelioma 12 | 3,232
pituitary cancer 12 | 1,972
primitive neuroectodermal tumor 12 | 3,035
tuberculosis 12 | 2,010
ulcerative colitis 12 | 1,819
Arthritis 11 | 290
Autosomal recessive predisposition 11 | 1,442
Breast Neoplasms 11 | 445
Depressive disorder 11 | 409
Epilepsy 11 | 792
Heart disease 11 | 306
Hypoglycemia 11 | 152
Kidney disease 11 | 430
Mammary Neoplasms 11 | 425
Polycystic ovary syndrome 11 | 360
cystic fibrosis 11 | 1,696
interstitial cystitis 11 | 2,312
oligodendroglioma 11 | 2,850
pancreatic cancer 11 | 2,398
Alzheimer's disease 10 | 658
Asthma 10 | 385
Cardiomegaly 10 | 116
Liver carcinoma 10 | 240
Liver disease 10 | 237
Pick disease 10 | 1,894
Seizures 10 | 596
non-small cell lung cancer 10 | 2,890
Atopic dermatitis 9 | 952
Brain Ischemia 9 | 110
Carcinoma, Hepatocellular 9 | 228
Hepatomegaly 9 | 285
Inflammatory bowel disease 9 | 151
Myocardial Ischemia 9 | 169
Prostatic Neoplasms 9 | 495
adrenocortical carcinoma 9 | 1,428
astrocytic glioma 9 | 2,597
Atherosclerosis 8 | 291
Coronary artery disease 8 | 268
Lipid metabolism disorder 8 | 114
Mental Depression 8 | 333
Osteoporosis 8 | 363
Stomach Neoplasms 8 | 300
Vascular disease 8 | 319
Arthritis, Experimental 7 | 39
Cerebrovascular disease 7 | 238
Heart failure 7 | 162
Inflammation 7 | 120
Intellectual disability 7 | 1,016
Kidney Failure, Chronic 7 | 46
Pneumonia 7 | 174
Reperfusion Injury 7 | 86
Anorexia nervosa 6 | 80
Bipolar Disorder 6 | 666
Crohn's disease 6 | 321
cutaneous lupus erythematosus 6 | 1,057
dermatomyositis 6 | 966
pancreatic carcinoma 6 | 562
primary Sjogren syndrome 6 | 735

Tissue

Digestive Tract 69 | 17,369
Endocrine System 69 | 18,159
Female tissues 68 | 17,400
Skin and soft tissues 68 | 17,230
Male tissues 67 | 17,142
Nervous System 67 | 16,725
Blood and immune system 66 | 16,909
Urinary Tract 66 | 16,678
Liver and Pancreas 65 | 16,750
Cardiovascular System 63 | 15,192
Respiratory system 63 | 16,393

Target Family

Non-IDG 22 | 12,091
Kinase 20 | 634
Enzyme 18 | 4,145
Nuclear Receptor 4 | 48
Transcription Factor 3 | 1,400
Transporter 2 | 473

KEGG Pathway

Adipocytokine signaling pathwa... 69 | 69
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glucose-6-phosphatase 3 G6PC3 Tbio Enzyme -1.55249 37.2 54
Long-chain-fatty-acid--CoA ligase 5 ACSL5 Tbio Enzyme -1.98202 97.3 170
Calcium/calmodulin-dependent protein kinase kinase 2 CAMKK2 Tchem Kinase -2.09841 125.5 257
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.86749 73.8 139
Pro-neuropeptide Y NPY Tbio Non-IDG -3.83401 7433.3 432
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615
Retinoic acid receptor RXR-beta RXRB Tclin Nuclear Receptor -1.72557 49.3 274
Carnitine O-palmitoyltransferase 1, muscle isoform CPT1B Tchem Enzyme -2.33657 211.9 299
Acetyl-CoA carboxylase 2 ACACB Tchem Enzyme -2.25387 171.9 125
Long-chain-fatty-acid--CoA ligase 4 ACSL4 Tbio Enzyme -1.88239 83.9 249