Development Level

Tchem 30 | 1,598
Tbio 25 | 11,445
Tclin 11 | 613

IMPC Phenotype

preweaning lethality, complete... 9 | 979
decreased body weight 3 | 161
increased circulating alkaline... 3 | 122
abnormal bone mineralization 2 | 38
cataract 2 | 92
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased total body fat amoun... 2 | 207
increased bone mineral content 2 | 108
increased circulating LDL chol... 2 | 13
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
prenatal lethality 2 | 28
preweaning lethality, incomple... 2 | 499
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal response to tactile s... 1 | 17
abnormal skin condition 1 | 6
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased fasted circulating g... 1 | 65
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased thermal nociceptive ... 1 | 2
enlarged heart 1 | 210
female infertility 1 | 60
increased B cell number 1 | 9
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mammalian phenotype 1 | 17
short tibia 1 | 97
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Cancer 55 | 2,499
Carcinoma 53 | 11,493
ovarian cancer 41 | 8,520
osteosarcoma 38 | 7,950
psoriasis 36 | 6,694
glioblastoma 35 | 5,792
lung cancer 30 | 4,740
medulloblastoma, large-cell 29 | 6,241
atypical teratoid / rhabdoid tumor 26 | 5,112
Breast cancer 24 | 3,578
Kidney cancer 20 | 2,613
Schizophrenia 20 | 1,160
Breast Neoplasms 19 | 445
ependymoma 19 | 4,679
malignant mesothelioma 19 | 3,232
Mammary Neoplasms 18 | 425
group 3 medulloblastoma 18 | 4,104
invasive ductal carcinoma 18 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
diabetes mellitus 16 | 1,728
pancreatic cancer 16 | 2,398
subependymal giant cell astrocytoma 16 | 2,287
Astrocytoma, Pilocytic 15 | 3,081
adult high grade glioma 15 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
ulcerative colitis 15 | 1,819
Multiple myeloma 14 | 1,332
Orbital separation excessive 14 | 244
Prostatic Neoplasms 14 | 495
astrocytic glioma 14 | 2,597
Intellectual disability 13 | 1,016
Leukemia, Myelocytic, Acute 13 | 120
Leukemia, Myeloid, Acute 13 | 105
Lung Neoplasms 13 | 232
Obesity 13 | 678
Short stature 13 | 531
breast carcinoma 13 | 1,638
cystic fibrosis 13 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
juvenile dermatomyositis 13 | 1,187
lung adenocarcinoma 13 | 2,716
oligodendroglioma 13 | 2,850
primitive neuroectodermal tumor 13 | 3,035
Acquired scoliosis 12 | 281
Anemia 12 | 365
Autosomal recessive predisposition 12 | 1,442
Bipolar Disorder 12 | 666
Byzanthine arch palate 12 | 194
Cryptorchidism 12 | 296
Curvature of spine 12 | 282
Dull intelligence 12 | 645
Epilepsy 12 | 792
Immune system cancer 12 | 140
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
Rheumatoid arthritis 12 | 1,191
Vascular disease 12 | 319
cutaneous lupus erythematosus 12 | 1,057
group 4 medulloblastoma 12 | 1,855
lung carcinoma 12 | 2,843
non-small cell lung cancer 12 | 2,890
pituitary cancer 12 | 1,972
tuberculosis 12 | 2,010
Acute Promyelocytic Leukemia 11 | 40
Blepharoptosis 11 | 231
Carcinoma, Hepatocellular 11 | 228
Concave bridge of nose 11 | 195
Depressed nasal bridge 11 | 195
Depressed nasal root/bridge 11 | 195
Downward slant of palpebral fissure 11 | 158
Frontal bossing 11 | 157
High forehead 11 | 102
Hypoplastic mandible condyle 11 | 275
Liver carcinoma 11 | 240
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
Renal Cell Carcinoma 11 | 214
Seizures 11 | 596
Stomach Neoplasms 11 | 300
Strabismus 11 | 270
Tall forehead 11 | 102
astrocytoma 11 | 1,146
ductal carcinoma in situ 11 | 1,745
interstitial cystitis 11 | 2,312
Arthritis 10 | 290
Big calvaria 10 | 147
Cognitive delay 10 | 608
Delayed bone age 10 | 136
Global developmental delay 10 | 608
Increased head circumference 10 | 147
Increased size of cranium 10 | 147
Increased size of skull 10 | 147
Lymphoid leukemia 10 | 160
Mental and motor retardation 10 | 608
Muscle hypotonia 10 | 571
Pectus excavatum 10 | 100
Splenomegaly 10 | 190
Squamous cell carcinoma 10 | 129

Tissue

Blood and immune system 66 | 16,909
Endocrine System 66 | 18,159
Digestive Tract 65 | 17,369
Female tissues 65 | 17,400
Liver and Pancreas 65 | 16,750
Male tissues 65 | 17,142
Respiratory system 65 | 16,393
Skin and soft tissues 65 | 17,230
Urinary Tract 65 | 16,678
Nervous System 64 | 16,725
Cardiovascular System 63 | 15,192

Target Family

Kinase 25 | 634
Non-IDG 17 | 12,091
Transcription Factor 15 | 1,400
Enzyme 7 | 4,145
Nuclear Receptor 2 | 48

KEGG Pathway

Acute myeloid leukemia 66 | 66
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Integrin alpha-M ITGAM Tbio Non-IDG -3.63427 3939.5 2165
CCAAT/enhancer-binding protein alpha CEBPA Tbio Transcription Factor -2.94393 846.3 518
Son of sevenless homolog 2 SOS2 Tbio Non-IDG -1.62118 35.9 134
Mast/stem cell growth factor receptor Kit KIT Tclin Kinase -3.80501 6371.9 4098
Dual specificity protein phosphatase 6 DUSP6 Tbio Enzyme -2.22889 183.5 379