Development Level

Tbio 69 | 11,445
Tchem 41 | 1,598
Tclin 10 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 6 | 499
abnormal bone structure 5 | 187
decreased bone mineral density 4 | 126
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular vol... 4 | 79
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
increased total body fat amoun... 4 | 134
abnormal behavior 3 | 298
abnormal retinal vasculature m... 3 | 27
decreased body weight 3 | 161
decreased circulating LDL chol... 3 | 38
decreased lean body mass 3 | 135
decreased leukocyte cell numbe... 3 | 73
decreased mean platelet volume 3 | 25
decreased vertical activity 3 | 208
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
increased circulating choleste... 3 | 66
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
increased mean platelet volume 3 | 45
thrombocytopenia 3 | 56
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal locomotor behavior 2 | 24
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
decreased bone mineral content 2 | 151
decreased circulating calcium ... 2 | 36
decreased circulating chloride... 2 | 30
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased erythrocyte cell num... 2 | 62
decreased heart weight 2 | 27
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
enlarged spleen 2 | 41
impaired glucose tolerance 2 | 75
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 34
increased circulating phosphat... 2 | 26
increased circulating total pr... 2 | 28
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased lymphocyte cell numb... 2 | 32
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased red blood cell distr... 2 | 34
limb grasping 2 | 41
male infertility 2 | 123
abnormal heart left ventricle ... 1 | 16
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
embryonic lethality prior to o... 1 | 239
enlarged thymus 1 | 5
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased cardiac muscle contr... 1 | 8
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
short tibia 1 | 97
small superior vagus ganglion 1 | 74
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 91 | 11,493
ovarian cancer 73 | 8,520
psoriasis 69 | 6,694
osteosarcoma 68 | 7,950
medulloblastoma, large-cell 54 | 6,241
Cancer 49 | 2,499
glioblastoma 49 | 5,792
atypical teratoid / rhabdoid tumor 45 | 5,112
diabetes mellitus 42 | 1,728
Obesity 40 | 678
lung cancer 40 | 4,740
Breast cancer 37 | 3,578
ependymoma 36 | 4,679
adult high grade glioma 34 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
group 3 medulloblastoma 28 | 4,104
invasive ductal carcinoma 28 | 2,951
subependymal giant cell astrocytoma 27 | 2,287
breast carcinoma 26 | 1,638
ductal carcinoma in situ 26 | 1,745
non-small cell lung cancer 25 | 2,890
Autosomal recessive predisposition 24 | 1,442
Kidney cancer 24 | 2,613
group 4 medulloblastoma 24 | 1,855
malignant mesothelioma 24 | 3,232
Hyperglycemia 23 | 137
lung adenocarcinoma 23 | 2,716
Fatty liver disease 22 | 103
astrocytic glioma 21 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
pancreatic cancer 20 | 2,398
primitive neuroectodermal tumor 20 | 3,035
Astrocytoma, Pilocytic 19 | 3,081
Epilepsy 19 | 792
Insulin Resistance 19 | 72
Schizophrenia 19 | 1,160
Polycystic ovary syndrome 18 | 360
Diabetes Mellitus, Experimental 17 | 108
Liver carcinoma 17 | 240
Seizures 17 | 596
lung carcinoma 17 | 2,843
pituitary cancer 17 | 1,972
ulcerative colitis 17 | 1,819
Carcinoma, Hepatocellular 16 | 228
Hyperinsulinism 16 | 133
Pick disease 16 | 1,894
adrenocortical carcinoma 16 | 1,428
colon cancer 16 | 1,478
interstitial cystitis 16 | 2,312
oligodendroglioma 16 | 2,850
Alzheimer's disease 15 | 658
Lipid metabolism disorder 15 | 114
Atopic dermatitis 14 | 952
Breast Neoplasms 14 | 445
Diabetes Mellitus, Non-Insulin-Dependent 14 | 145
Hypoglycemia 14 | 152
Intellectual disability 14 | 1,016
Mammary Neoplasms 14 | 425
Multiple myeloma 14 | 1,332
acute quadriplegic myopathy 14 | 1,158
astrocytoma 14 | 1,146
Diabetes Mellitus, Type 2 13 | 142
Liver Cirrhosis, Experimental 13 | 769
cystic fibrosis 13 | 1,696
tuberculosis 13 | 2,010
Bipolar Disorder 12 | 666
Hypertension 12 | 396
Prostatic Neoplasms 12 | 495
Rheumatoid arthritis 12 | 1,191
dermatomyositis 12 | 966
Cognitive delay 11 | 608
Dull intelligence 11 | 645
Global developmental delay 11 | 608
Hypertensive disease 11 | 292
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental and motor retardation 11 | 608
Mental deficiency 11 | 645
Parkinson's disease 11 | 392
Poor school performance 11 | 645
spina bifida 11 | 1,074
Atherosclerosis 10 | 291
Heart disease 10 | 306
Heart failure 10 | 162
Waldenstrons macroglobulinemia 10 | 765
fibroadenoma 10 | 559
juvenile dermatomyositis 10 | 1,187
Glycogen storage disease 9 | 39
Kidney disease 9 | 430
Lipodystrophy 9 | 40
Stomach Neoplasms 9 | 300
active ulcerative colitis 9 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
cutaneous lupus erythematosus 9 | 1,057
non primary Sjogren syndrome sicca 9 | 891
pediatric high grade glioma 9 | 1,064
acute myeloid leukemia 8 | 783
gastric carcinoma 8 | 807

Tissue

Digestive Tract 120 | 17,369
Endocrine System 120 | 18,159
Female tissues 119 | 17,400
Skin and soft tissues 119 | 17,230
Liver and Pancreas 118 | 16,750
Blood and immune system 117 | 16,909
Nervous System 117 | 16,725
Urinary Tract 117 | 16,678
Male tissues 116 | 17,142
Cardiovascular System 114 | 15,192
Respiratory system 113 | 16,393

Target Family

Enzyme 46 | 4,145
Kinase 32 | 634
Non-IDG 26 | 12,091
Transcription Factor 10 | 1,400
Nuclear Receptor 2 | 48
Epigenetic 1 | 242
GPCR 1 | 408
Ion Channel 1 | 344
Transporter 1 | 473

KEGG Pathway

AMPK signaling pathway 120 | 120
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glucose-6-phosphatase 3 G6PC3 Tbio Enzyme -1.55249 37.2 54
Malonyl-CoA decarboxylase, mitochondrial MLYCD Tchem Enzyme -1.70434 46.1 67
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.47825 30.5 103
Calcium/calmodulin-dependent protein kinase kinase 2 CAMKK2 Tchem Kinase -2.09841 125.5 257
Cyclic AMP-responsive element-binding protein 3-like protein 2 CREB3L2 Tbio Transcription Factor -2.52262 324.1 178
Alpha-1A adrenergic receptor ADRA1A Tclin GPCR -2.18682 155.5 236
Elongation factor 2 EEF2 Tchem Non-IDG -2.95619 938.4 363