Development Level

Tchem 54 | 1,598
Tbio 33 | 11,445
Tclin 12 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
increased circulating alkaline... 4 | 122
decreased body weight 3 | 161
decreased erythrocyte cell num... 3 | 62
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
increased lean body mass 3 | 172
increased neutrophil cell numb... 3 | 46
male infertility 3 | 123
preweaning lethality, incomple... 3 | 499
short tibia 3 | 97
abnormal bone mineralization 2 | 38
abnormal embryo size 2 | 220
abnormal gait 2 | 69
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased mean corpuscular vol... 2 | 79
edema 2 | 59
embryonic lethality prior to o... 2 | 239
enlarged lymph nodes 2 | 37
female infertility 2 | 60
increased bone mineral content 2 | 108
increased circulating choleste... 2 | 66
increased erythrocyte cell num... 2 | 39
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
decreased IgG3 level 1 | 1
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased spleen weight 1 | 10
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased thermal nociceptive ... 1 | 9
microphthalmia 1 | 26
pale yolk sac 1 | 25
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27

Disease

Carcinoma 78 | 11,493
Cancer 73 | 2,499
ovarian cancer 68 | 8,520
lung cancer 64 | 4,740
glioblastoma 59 | 5,792
psoriasis 56 | 6,694
osteosarcoma 53 | 7,950
ependymoma 46 | 4,679
atypical teratoid / rhabdoid tumor 45 | 5,112
medulloblastoma, large-cell 45 | 6,241
Breast cancer 44 | 3,578
adult high grade glioma 42 | 3,801
malignant mesothelioma 41 | 3,232
Astrocytoma, Pilocytic 40 | 3,081
diabetes mellitus 38 | 1,728
lung adenocarcinoma 37 | 2,716
group 3 medulloblastoma 36 | 4,104
Kidney disease 35 | 430
interstitial cystitis 34 | 2,312
invasive ductal carcinoma 34 | 2,951
lung carcinoma 34 | 2,843
Schizophrenia 33 | 1,160
ulcerative colitis 33 | 1,819
Hypertensive disease 30 | 292
Kidney cancer 30 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,955
Heart disease 29 | 306
Hypertension 29 | 396
cystic fibrosis 29 | 1,696
non-small cell lung cancer 29 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,989
pituitary cancer 27 | 1,972
primitive neuroectodermal tumor 27 | 3,035
pancreatic cancer 26 | 2,398
tuberculosis 25 | 2,010
Breast Neoplasms 24 | 445
Liver Cirrhosis, Experimental 24 | 769
Mammary Neoplasms 24 | 425
ductal carcinoma in situ 24 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
Atherosclerosis 23 | 291
Hyperglycemia 23 | 137
Stomach Neoplasms 23 | 300
subependymal giant cell astrocytoma 23 | 2,287
Arthritis 22 | 290
Coronary artery disease 22 | 268
Lung disease 22 | 142
Obesity 22 | 678
oligodendroglioma 22 | 2,850
Cerebrovascular disease 21 | 238
Asthma 20 | 385
Autosomal recessive predisposition 20 | 1,442
Prostatic Neoplasms 20 | 495
Reperfusion Injury 20 | 86
breast carcinoma 20 | 1,638
colon cancer 20 | 1,478
nasopharyngeal carcinoma 20 | 1,058
juvenile dermatomyositis 19 | 1,187
Brain Ischemia 18 | 110
Diabetes Mellitus, Experimental 18 | 108
Hypersensitivity reaction type II disease 18 | 253
Inflammatory bowel disease 18 | 151
Liver disease 18 | 237
Rheumatoid arthritis 18 | 1,191
Vascular disease 18 | 319
group 4 medulloblastoma 18 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Depressive disorder 17 | 409
Lung Neoplasms 17 | 232
Myocardial Ischemia 17 | 169
adrenocortical carcinoma 17 | 1,428
Alzheimer's disease 16 | 658
Bipolar Disorder 16 | 666
Cell Transformation, Neoplastic 16 | 97
Colonic Neoplasms 16 | 142
Inflammation 16 | 120
Liver Cirrhosis 16 | 181
Neoplastic Cell Transformation 16 | 89
Pulmonary Fibrosis 16 | 106
Seizures 16 | 596
Anemia 15 | 365
Carcinoma, Hepatocellular 15 | 228
Epilepsy 15 | 792
Hyperalgesia 15 | 83
Liver carcinoma 15 | 240
Neoplasm Metastasis 15 | 168
Orbital separation excessive 15 | 244
astrocytoma 15 | 1,146
cutaneous lupus erythematosus 15 | 1,057
dermatomyositis 15 | 966
gastric carcinoma 15 | 807
Adenocarcinoma 14 | 122
Cardiomegaly 14 | 116
Colorectal Neoplasms 14 | 243
Endometriosis 14 | 540
Heart failure 14 | 162
Multiple Sclerosis 14 | 540
Squamous cell carcinoma 14 | 129
Hypoplastic mandible condyle 13 | 275
Multiple myeloma 13 | 1,332

Tissue

Blood and immune system 99 | 16,909
Digestive Tract 99 | 17,369
Endocrine System 99 | 18,159
Female tissues 99 | 17,400
Liver and Pancreas 99 | 16,750
Male tissues 99 | 17,142
Respiratory system 99 | 16,393
Skin and soft tissues 99 | 17,230
Urinary Tract 99 | 16,678
Nervous System 98 | 16,725
Cardiovascular System 96 | 15,192

Target Family

Non-IDG 35 | 12,091
Kinase 26 | 634
Enzyme 23 | 4,145
Transcription Factor 13 | 1,400
GPCR 1 | 408
Ion Channel 1 | 344

KEGG Pathway

AGE-RAGE signaling pathway in ... 99 | 99
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Collagen alpha-1(IV) chain COL4A1 Tbio Non-IDG -2.28595 186.9 391
Cytochrome b-245 heavy chain CYBB Tchem Ion Channel -3.09698 1276.8 315
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 PLCD1 Tchem Enzyme -2.17969 140.9 120
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733