Targets

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Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
D(2) dopamine receptor	DRD2	Tclin	GPCR	-3.24474	1775.2	248
Proto-oncogene c-Fos	FOS	Tchem	Transcription Factor	-4.11560	13094.7	961
Achaete-scute homolog 1	ASCL1	Tbio	Transcription Factor	-2.39907	258.0	359
Erythropoietin	EPO	Tbio	Non-IDG	-3.90053	8755.8	628
Apolipoprotein E	APOE	Tbio	Non-IDG	-4.17470	15380.4	788
Glial cell line-derived neurotrophic factor	GDNF	Tbio	Non-IDG	-3.30206	2301.5	303
Charged multivesicular body protein 2b	CHMP2B	Tbio	Non-IDG	-1.65708	53.0	166
Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	Tchem	Ion Channel	-1.68717	47.7	33
Monocarboxylate transporter 8	SLC16A2	Tbio	Transporter	-2.32240	230.6	103
Methyl-CpG-binding protein 2	MECP2	Tchem	Transcription Factor	-3.22710	1827.6	567

	Tbio	438 \| 10,625
	Tchem	177 \| 1,890
	Tclin	111 \| 602
	Tdark	18 \| 7,003

	Eligible Ion Channel Proteins	7 \| 117
	Eligible non-olfactory GPCR Proteins	1 \| 143

	preweaning lethality, complete...	35 \| 633
	preweaning lethality, incomple...	22 \| 260
	abnormal behavior	18 \| 226
	decreased lean body mass	15 \| 195
	embryonic lethality prior to t...	14 \| 187
	decreased bone mineral content	12 \| 157
	decreased grip strength	12 \| 123
	decreased total body fat amoun...	12 \| 186
	hyperactivity	12 \| 108
	abnormal bone structure	11 \| 131
	decreased body weight	10 \| 174
	hypoactivity	10 \| 89
	increased circulating alkaline...	10 \| 119
	decreased circulating choleste...	8 \| 85
	embryonic lethality prior to o...	8 \| 148
	increased lean body mass	8 \| 107
	increased mean corpuscular vol...	8 \| 91
	abnormal embryo size	7 \| 112
	abnormal gait	7 \| 51
	decreased circulating HDL chol...	7 \| 77
	increased circulating HDL chol...	7 \| 63
	increased circulating choleste...	7 \| 53
	increased grip strength	7 \| 83
	abnormal retina morphology	6 \| 100
	decreased bone mineral density	6 \| 126
	decreased circulating triglyce...	6 \| 83
	increased circulating sodium l...	6 \| 71
	increased or absent threshold ...	6 \| 128
	tremors	6 \| 34
	abnormal sleep behavior	5 \| 63
	decreased circulating LDL chol...	5 \| 37
	decreased circulating alkaline...	5 \| 41
	decreased fasted circulating g...	5 \| 49
	decreased heart weight	5 \| 44
	increased circulating chloride...	5 \| 43
	increased erythrocyte cell num...	5 \| 26
	increased total body fat amoun...	5 \| 57
	limb grasping	5 \| 35
	male infertility	5 \| 62
	short tibia	5 \| 82
	thrombocytopenia	5 \| 46
	abnormal QRS complex	4 \| 25
	abnormal forebrain development	4 \| 18
	abnormal hindbrain development	4 \| 24
	abnormal locomotor activation	4 \| 26
	abnormal neural tube closure	4 \| 37
	abnormal retinal pigmentation	4 \| 61
	decreased circulating amylase ...	4 \| 24
	decreased circulating insulin ...	4 \| 75
	decreased rib number	4 \| 59
	enlarged heart	4 \| 111
	female infertility	4 \| 34
	impaired glucose tolerance	4 \| 52
	increased blood urea nitrogen ...	4 \| 44
	increased circulating phosphat...	4 \| 24
	increased circulating potassiu...	4 \| 31
	increased mean corpuscular hem...	4 \| 93
	persistence of hyaloid vascula...	4 \| 22
	straub tail	4 \| 26
	abnormal behavioral response t...	3 \| 52
	abnormal bone mineralization	3 \| 55
	abnormal epididymis morphology	3 \| 31
	abnormal midbrain development	3 \| 22
	abnormal tooth morphology	3 \| 24
	decreased body length	3 \| 108
	decreased circulating alanine ...	3 \| 53
	decreased circulating fructosa...	3 \| 31
	decreased circulating glucose ...	3 \| 121
	decreased circulating serum al...	3 \| 79
	decreased exploration in new e...	3 \| 9
	decreased prepulse inhibition	3 \| 52
	decreased pulmonary respirator...	3 \| 4
	decreased total retina thickne...	3 \| 20
	impaired righting response	3 \| 19
	improved glucose tolerance	3 \| 56
	increased bone mineral content	3 \| 92
	increased circulating alanine ...	3 \| 11
	increased circulating creatini...	3 \| 29
	increased fasted circulating g...	3 \| 68
	increased heart weight	3 \| 37
	increased startle reflex	3 \| 38
	lethargy	3 \| 5
	prenatal lethality prior to he...	3 \| 64
	abnormal heart left ventricle ...	2 \| 20
	abnormal lens morphology	2 \| 73
	abnormal optic disc morphology	2 \| 10
	cardiovascular system phenotyp...	2 \| 35
	decreased T cell number	2 \| 31
	decreased caudal vertebrae num...	2 \| 49
	decreased circulating bilirubi...	2 \| 14
	decreased circulating calcium ...	2 \| 33
	decreased hemoglobin content	2 \| 53
	decreased vertical activity	2 \| 22
	increased circulating aspartat...	2 \| 17
	increased circulating calcium ...	2 \| 32
	increased circulating iron lev...	2 \| 25
	increased circulating serum al...	2 \| 25
	increased hematocrit	2 \| 36
	increased hemoglobin content	2 \| 45
	increased respiratory quotient	2 \| 12

	medulloblastoma, large-cell	384 \| 6,234
	glioblastoma	378 \| 5,572
	ovarian cancer	349 \| 8,484
	psoriasis	315 \| 6,685
	osteosarcoma	311 \| 7,933
	atypical teratoid / rhabdoid tumor	294 \| 4,369
	pilocytic astrocytoma	269 \| 3,086
	oligodendroglioma	256 \| 2,849
	lung cancer	249 \| 4,466
	Cancer	248 \| 2,346
	pediatric high grade glioma	218 \| 2,712
	primitive neuroectodermal tumor	217 \| 3,031
	lung carcinoma	194 \| 2,844
	subependymal giant cell astrocytoma	179 \| 2,287
	malignant mesothelioma	171 \| 3,162
	ependymoma	162 \| 2,514
	Carcinoma	160 \| 2,147
	astrocytic glioma	159 \| 2,241
	Alzheimer's disease	150 \| 644
	pituitary cancer	147 \| 1,972
	Breast cancer	145 \| 3,094
	astrocytoma	144 \| 1,493
	Pick disease	143 \| 1,893
	intraductal papillary-mucinous adenoma (IPMA)	142 \| 2,956
	intraductal papillary-mucinous neoplasm (IPMN)	141 \| 3,289
	Parkinson's disease	136 \| 364
	invasive ductal carcinoma	134 \| 2,950
	Schizophrenia	133 \| 501
	intraductal papillary-mucinous carcinoma (IPMC)	131 \| 2,988
	adult high grade glioma	129 \| 2,148
	Epilepsy	128 \| 346
	Neurodegenerative disease	123 \| 383
	non-small cell lung cancer	123 \| 2,798
	group 4 medulloblastoma	120 \| 1,875
	lung adenocarcinoma	119 \| 2,713
	medulloblastoma	119 \| 1,524
	diabetes mellitus	117 \| 1,663
	sonic hedgehog group medulloblastoma	115 \| 1,482
	posterior fossa group A ependymoma	114 \| 1,511
	pancreatic cancer	112 \| 2,300
	colon cancer	101 \| 1,475
	Toxic encephalopathy	98 \| 131
	interstitial cystitis	97 \| 2,299
	ulcerative colitis	95 \| 2,087
	posterior fossa group B ependymoma	92 \| 1,530
	Vascular disease	88 \| 281
	Obesity	86 \| 616
	cystic fibrosis	86 \| 1,665
	group 3 medulloblastoma	86 \| 2,254
	breast carcinoma	85 \| 1,614
	Intellectual disability	84 \| 573
	Autistic Disorder	81 \| 320
	atypical teratoid/rhabdoid tumor	81 \| 1,095
	ductal carcinoma in situ	76 \| 1,745
	adrenocortical carcinoma	74 \| 1,427
	Multiple myeloma	72 \| 1,327
	Rheumatoid Arthritis	71 \| 1,160
	tuberculosis	69 \| 1,557
	Amyotrophic Lateral Sclerosis	64 \| 431
	Dementia	64 \| 129
	Bipolar Disorder	63 \| 266
	Down syndrome	60 \| 548
	primary pancreatic ductal adenocarcinoma	58 \| 1,271
	acute quadriplegic myopathy	56 \| 1,157
	juvenile dermatomyositis	54 \| 1,189
	pancreatic ductal adenocarcinoma liver metastasis	54 \| 1,795
	cutaneous lupus erythematosus	53 \| 1,056
	Multiple Sclerosis	49 \| 498
	Prostatic Neoplasms	49 \| 471
	Waldenstrons macroglobulinemia	49 \| 765
	Cocaine-Related Disorders	47 \| 88
	Kidney disease	47 \| 396
	Mammary Neoplasms	47 \| 410
	gastric carcinoma	46 \| 832
	non primary Sjogren syndrome sicca	45 \| 840
	Atopic dermatitis	43 \| 944
	Brain disease	42 \| 83
	Cerebrovascular disease	41 \| 231
	Nerve Degeneration	41 \| 73
	dermatomyositis	41 \| 933
	aldosterone-producing adenoma	40 \| 664
	Endometriosis	39 \| 535
	Heart disease	39 \| 279
	Huntington's disease	39 \| 72
	Seizures	38 \| 95
	Duchenne muscular dystrophy	37 \| 602
	Hypertension	37 \| 287
	Major Depressive Disorder	37 \| 106
	Neuropathy	36 \| 210
	active Crohn's disease	36 \| 918
	Pain agnosia	35 \| 99
	esophageal adenocarcinoma	35 \| 737
	progressive supranuclear palsy	35 \| 674
	Status Epilepticus	34 \| 85
	spina bifida	34 \| 1,064
	Alcohol dependence	33 \| 107
	Brain Ischemia	33 \| 87
	Stomach Neoplasms	33 \| 282
	Attention deficit hyperactivity disorder	32 \| 156
	Asthma	31 \| 349

	Nervous System	735 \| 18,561
	Endocrine System	734 \| 18,512
	Female tissues	732 \| 18,647
	Digestive Tract	730 \| 18,473
	Urinary Tract	726 \| 18,444
	Liver and Pancreas	719 \| 18,136
	Cardiovascular System	718 \| 17,958
	Skin and soft tissues	717 \| 18,115
	Male tissues	710 \| 17,969
	Blood and immune system	708 \| 17,995
	Respiratory system	689 \| 17,484

Development Level

Collection

IMPC Term

Disease

Tissue

Target Family

Jensen-TM Tissue

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Grant Funding IC

Grant Activity

Data Source

	Non-IDG	327 \| 11,971
	Enzyme	115 \| 4,146
	Transcription Factor	87 \| 1,400
	Ion Channel	86 \| 341
	GPCR	40 \| 406
	Kinase	39 \| 634
	Transporter	35 \| 473
	Epigenetic	8 \| 242
	Nuclear Receptor	7 \| 48

	Neuron	744 \| 744
	Blood	1,867 \| 1,867
	Brain	1,442 \| 1,442
	Immune system	1,150 \| 1,150
	Muscle	1,110 \| 1,110
	Liver	1,001 \| 1,001
	Adult	976 \| 976
	Heart	881 \| 881
	Kidney	840 \| 840
	Skin	735 \| 735
	Intestine	626 \| 626
	Lung	623 \| 623
	Spinal cord	526 \| 526
	Bone marrow	494 \| 494
	Finger	432 \| 432
	Breast	429 \| 429
	Blood vessel	387 \| 387
	Hematopoietic stem cell	370 \| 370
	Ovary	342 \| 342
	Artery	327 \| 327
	Ganglion	322 \| 322
	Retina	301 \| 301
	Nerve	290 \| 290
	Urine	281 \| 281
	Semen	266 \| 266
	Fiber	263 \| 263
	Mesenchyme	261 \| 261
	Germ cell	244 \| 244
	BTO:0000964	243 \| 243
	Pancreas	239 \| 239
	Breast cancer cell line	228 \| 228
	Trophoblast	225 \| 225
	Breast cancer cell	222 \| 222
	Embryonic stem cell	218 \| 218
	Adrenal gland	207 \| 207
	Lymph node	206 \| 206
	Adipocyte	194 \| 194
	Thyroid gland	190 \| 190
	Cornea	186 \| 186
	Stromal cell	183 \| 183
	Stomach	179 \| 179
	Osteoblast	175 \| 175
	Marrow	169 \| 169
	Blood plasma	165 \| 165
	Mesenchymal stem cell	159 \| 159
	T-lymphocyte	158 \| 158
	Mast cell	155 \| 155
	Peripheral nerve	155 \| 155
	Cranium	141 \| 141
	Ectoderm	141 \| 141
	Filament	139 \| 139
	Root nodule	135 \| 135
	Spermatid	135 \| 135
	Neural crest	134 \| 134
	Spleen	130 \| 130
	Uterine cervix	124 \| 124
	Blood vessel endothelium	122 \| 122
	Prostate cancer cell line	121 \| 121
	Prostate gland cancer cell	121 \| 121
	HeLa cell	120 \| 120
	Neural tube	120 \| 120
	Vasculature	119 \| 119
	Blastocyst	117 \| 117
	HUVEC cell	116 \| 116
	Hepatoma cell	113 \| 113
	Fruit	112 \| 112
	Knee	112 \| 112
	Neural stem cell	112 \| 112
	NIH-3T3 cell	109 \| 109
	Seedling	109 \| 109
	Tendon	108 \| 108
	Lung cancer cell	107 \| 107
	Hip	106 \| 106
	Bronchoalveolar lavage	105 \| 105
	Primordium	104 \| 104
	Bud	103 \| 103
	Capillary	101 \| 101
	Myotube	101 \| 101
	B-lymphocyte	99 \| 99
	Myoblast	99 \| 99
	Colonic cancer cell	98 \| 98
	Peripheral blood	96 \| 96
	Vegetative cell	96 \| 96
	Germ	95 \| 95
	Somatic cell	92 \| 92
	Endoderm	91 \| 91
	Embryonic fibroblast	90 \| 90
	Salivary gland	90 \| 90
	3T3-L1 cell	88 \| 88
	Epididymis	88 \| 88
	Neonate	88 \| 88
	Mesoderm	87 \| 87
	Vagina	87 \| 87
	Hair cell	86 \| 86
	Ascites	85 \| 85
	Parenchyma	85 \| 85
	Saliva	84 \| 84
	Synovial tissue	83 \| 83
	Carcass	82 \| 82
	Spike	80 \| 80