1. Home
  2. Targets
Target Filters...

Development Level

Tbio 438 | 10,625
Tchem 177 | 1,890
Tclin 111 | 602
Tdark 18 | 7,003

Collection

Eligible Ion Channel Proteins 7 | 117
Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, complete... 35 | 633
preweaning lethality, incomple... 22 | 260
abnormal behavior 18 | 226
decreased lean body mass 15 | 195
embryonic lethality prior to t... 14 | 187
decreased bone mineral content 12 | 157
decreased grip strength 12 | 123
decreased total body fat amoun... 12 | 186
hyperactivity 12 | 108
abnormal bone structure 11 | 131
decreased body weight 10 | 174
hypoactivity 10 | 89
increased circulating alkaline... 10 | 119
decreased circulating choleste... 8 | 85
embryonic lethality prior to o... 8 | 148
increased lean body mass 8 | 107
increased mean corpuscular vol... 8 | 91
abnormal embryo size 7 | 112
abnormal gait 7 | 51
decreased circulating HDL chol... 7 | 77
increased circulating HDL chol... 7 | 63
increased circulating choleste... 7 | 53
increased grip strength 7 | 83
abnormal retina morphology 6 | 100
decreased bone mineral density 6 | 126
decreased circulating triglyce... 6 | 83
increased circulating sodium l... 6 | 71
increased or absent threshold ... 6 | 128
tremors 6 | 34
abnormal sleep behavior 5 | 63
decreased circulating LDL chol... 5 | 37
decreased circulating alkaline... 5 | 41
decreased fasted circulating g... 5 | 49
decreased heart weight 5 | 44
increased circulating chloride... 5 | 43
increased erythrocyte cell num... 5 | 26
increased total body fat amoun... 5 | 57
limb grasping 5 | 35
male infertility 5 | 62
short tibia 5 | 82
thrombocytopenia 5 | 46
abnormal QRS complex 4 | 25
abnormal forebrain development 4 | 18
abnormal hindbrain development 4 | 24
abnormal locomotor activation 4 | 26
abnormal neural tube closure 4 | 37
abnormal retinal pigmentation 4 | 61
decreased circulating amylase ... 4 | 24
decreased circulating insulin ... 4 | 75
decreased rib number 4 | 59
enlarged heart 4 | 111
female infertility 4 | 34
impaired glucose tolerance 4 | 52
increased blood urea nitrogen ... 4 | 44
increased circulating phosphat... 4 | 24
increased circulating potassiu... 4 | 31
increased mean corpuscular hem... 4 | 93
persistence of hyaloid vascula... 4 | 22
straub tail 4 | 26
abnormal behavioral response t... 3 | 52
abnormal bone mineralization 3 | 55
abnormal epididymis morphology 3 | 31
abnormal midbrain development 3 | 22
abnormal tooth morphology 3 | 24
decreased body length 3 | 108
decreased circulating alanine ... 3 | 53
decreased circulating fructosa... 3 | 31
decreased circulating glucose ... 3 | 121
decreased circulating serum al... 3 | 79
decreased exploration in new e... 3 | 9
decreased prepulse inhibition 3 | 52
decreased pulmonary respirator... 3 | 4
decreased total retina thickne... 3 | 20
impaired righting response 3 | 19
improved glucose tolerance 3 | 56
increased bone mineral content 3 | 92
increased circulating alanine ... 3 | 11
increased circulating creatini... 3 | 29
increased fasted circulating g... 3 | 68
increased heart weight 3 | 37
increased startle reflex 3 | 38
lethargy 3 | 5
prenatal lethality prior to he... 3 | 64
abnormal heart left ventricle ... 2 | 20
abnormal lens morphology 2 | 73
abnormal optic disc morphology 2 | 10
cardiovascular system phenotyp... 2 | 35
decreased T cell number 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating bilirubi... 2 | 14
decreased circulating calcium ... 2 | 33
decreased hemoglobin content 2 | 53
decreased vertical activity 2 | 22
increased circulating aspartat... 2 | 17
increased circulating calcium ... 2 | 32
increased circulating iron lev... 2 | 25
increased circulating serum al... 2 | 25
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased respiratory quotient 2 | 12

Disease

medulloblastoma, large-cell 384 | 6,234
glioblastoma 378 | 5,572
ovarian cancer 350 | 8,492
psoriasis 315 | 6,685
osteosarcoma 311 | 7,933
atypical teratoid / rhabdoid tumor 294 | 4,369
pilocytic astrocytoma 269 | 3,086
oligodendroglioma 256 | 2,849
lung cancer 251 | 4,473
Cancer 248 | 2,346
pediatric high grade glioma 218 | 2,712
primitive neuroectodermal tumor 217 | 3,031
lung carcinoma 194 | 2,844
subependymal giant cell astrocytoma 179 | 2,287
malignant mesothelioma 171 | 3,163
ependymoma 162 | 2,514
Carcinoma 160 | 2,147
astrocytic glioma 159 | 2,241
Alzheimer's disease 150 | 644
pituitary cancer 147 | 1,972
Breast cancer 146 | 3,099
astrocytoma 144 | 1,493
Pick disease 143 | 1,893
intraductal papillary-mucinous adenoma (IPMA) 142 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 141 | 3,289
Parkinson's disease 136 | 364
invasive ductal carcinoma 134 | 2,950
Schizophrenia 133 | 503
intraductal papillary-mucinous carcinoma (IPMC) 131 | 2,988
adult high grade glioma 129 | 2,148
Epilepsy 128 | 346
Neurodegenerative disease 123 | 383
non-small cell lung cancer 123 | 2,798
group 4 medulloblastoma 120 | 1,875
lung adenocarcinoma 119 | 2,714
medulloblastoma 119 | 1,524
diabetes mellitus 117 | 1,663
sonic hedgehog group medulloblastoma 115 | 1,482
posterior fossa group A ependymoma 114 | 1,511
pancreatic cancer 112 | 2,300
colon cancer 101 | 1,475
Toxic encephalopathy 98 | 131
interstitial cystitis 97 | 2,299
ulcerative colitis 95 | 2,087
posterior fossa group B ependymoma 92 | 1,530
Vascular disease 88 | 281
cystic fibrosis 87 | 1,670
Obesity 86 | 616
group 3 medulloblastoma 86 | 2,254
breast carcinoma 85 | 1,614
Intellectual disability 84 | 573
Autistic Disorder 81 | 320
atypical teratoid/rhabdoid tumor 81 | 1,095
ductal carcinoma in situ 76 | 1,745
adrenocortical carcinoma 74 | 1,427
Multiple myeloma 72 | 1,328
Rheumatoid Arthritis 71 | 1,171
tuberculosis 70 | 1,563
Amyotrophic Lateral Sclerosis 64 | 432
Dementia 64 | 129
Bipolar Disorder 63 | 266
Down syndrome 60 | 548
primary pancreatic ductal adenocarcinoma 58 | 1,271
acute quadriplegic myopathy 56 | 1,157
juvenile dermatomyositis 54 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 54 | 1,795
cutaneous lupus erythematosus 53 | 1,056
Multiple Sclerosis 49 | 498
Prostatic Neoplasms 49 | 471
Waldenstrons macroglobulinemia 49 | 765
Cocaine-Related Disorders 47 | 88
Kidney disease 47 | 397
Mammary Neoplasms 47 | 410
gastric carcinoma 46 | 832
non primary Sjogren syndrome sicca 45 | 840
Atopic dermatitis 43 | 944
Brain disease 42 | 84
Cerebrovascular disease 41 | 231
Nerve Degeneration 41 | 73
dermatomyositis 41 | 967
aldosterone-producing adenoma 40 | 664
Endometriosis 39 | 535
Heart disease 39 | 279
Huntington's disease 39 | 72
Hypertension 38 | 293
Seizures 38 | 95
Duchenne muscular dystrophy 37 | 602
Major Depressive Disorder 37 | 106
Neuropathy 36 | 210
active Crohn's disease 36 | 918
Pain agnosia 35 | 99
esophageal adenocarcinoma 35 | 737
progressive supranuclear palsy 35 | 674
Status Epilepticus 34 | 85
spina bifida 34 | 1,064
Alcohol dependence 33 | 107
Brain Ischemia 33 | 87
Stomach Neoplasms 33 | 282
Attention deficit hyperactivity disorder 32 | 156
hepatocellular carcinoma 32 | 550

Tissue

Nervous System 735 | 18,561
Endocrine System 734 | 18,512
Female tissues 732 | 18,647
Digestive Tract 730 | 18,473
Urinary Tract 726 | 18,444
Liver and Pancreas 719 | 18,136
Cardiovascular System 718 | 17,958
Skin and soft tissues 717 | 18,115
Male tissues 710 | 17,969
Blood and immune system 708 | 17,995
Respiratory system 689 | 17,484

Target Family

Non-IDG 327 | 11,969
Enzyme 115 | 4,146
Transcription Factor 87 | 1,400
Ion Channel 86 | 341
GPCR 40 | 408
Kinase 39 | 634
Transporter 35 | 473
Epigenetic 8 | 242
Nuclear Receptor 7 | 48

Jensen-TM Tissue

Neuron 744 | 744
Blood 1,867 | 1,867
Brain 1,442 | 1,442
Immune system 1,150 | 1,150
Muscle 1,110 | 1,110
Liver 1,001 | 1,001
Adult 976 | 976
Heart 881 | 881
Kidney 840 | 840
Skin 735 | 735
Intestine 626 | 626
Lung 623 | 623
Spinal cord 526 | 526
Bone marrow 494 | 494
Finger 432 | 432
Breast 429 | 429
Blood vessel 387 | 387
Hematopoietic stem cell 370 | 370
Ovary 342 | 342
Artery 327 | 327
Ganglion 322 | 322
Retina 301 | 301
Nerve 290 | 290
Urine 281 | 281
Semen 266 | 266
Fiber 263 | 263
Mesenchyme 261 | 261
Germ cell 244 | 244
BTO:0000964 243 | 243
Pancreas 239 | 239
Breast cancer cell line 228 | 228
Trophoblast 225 | 225
Breast cancer cell 222 | 222
Embryonic stem cell 218 | 218
Adrenal gland 207 | 207
Lymph node 206 | 206
Adipocyte 194 | 194
Thyroid gland 190 | 190
Cornea 186 | 186
Stromal cell 183 | 183
Stomach 179 | 179
Osteoblast 175 | 175
Marrow 169 | 169
Blood plasma 165 | 165
Mesenchymal stem cell 159 | 159
T-lymphocyte 158 | 158
Mast cell 155 | 155
Peripheral nerve 155 | 155
Cranium 141 | 141
Ectoderm 141 | 141
Filament 139 | 139
Root nodule 135 | 135
Spermatid 135 | 135
Neural crest 134 | 134
Spleen 130 | 130
Uterine cervix 124 | 124
Blood vessel endothelium 122 | 122
Prostate cancer cell line 121 | 121
Prostate gland cancer cell 121 | 121
HeLa cell 120 | 120
Neural tube 120 | 120
Vasculature 119 | 119
Blastocyst 117 | 117
HUVEC cell 116 | 116
Hepatoma cell 113 | 113
Fruit 112 | 112
Knee 112 | 112
Neural stem cell 112 | 112
NIH-3T3 cell 109 | 109
Seedling 109 | 109
Tendon 108 | 108
Lung cancer cell 107 | 107
Hip 106 | 106
Bronchoalveolar lavage 105 | 105
Primordium 104 | 104
Bud 103 | 103
Capillary 101 | 101
Myotube 101 | 101
B-lymphocyte 99 | 99
Myoblast 99 | 99
Colonic cancer cell 98 | 98
Peripheral blood 96 | 96
Vegetative cell 96 | 96
Germ 95 | 95
Somatic cell 92 | 92
Endoderm 91 | 91
Embryonic fibroblast 90 | 90
Salivary gland 90 | 90
3T3-L1 cell 88 | 88
Epididymis 88 | 88
Neonate 88 | 88
Mesoderm 87 | 87
Vagina 87 | 87
Hair cell 86 | 86
Ascites 85 | 85
Parenchyma 85 | 85
Saliva 84 | 84
Synovial tissue 83 | 83
Carcass 82 | 82
Spike 80 | 80

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Synapsin-1 SYN1 Tbio Non-IDG -2.85684 687.9 716
Glutamate receptor-interacting protein 1 GRIP1 Tbio Non-IDG -2.16287 147.6 149
Neurturin NRTN Tbio Non-IDG -2.19264 157.5 257
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.03835 107.4 139
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.32485 207.4 140
Myocyte-specific enhancer factor 2D MEF2D Tbio Transcription Factor -1.92983 79.1 279
Tubulin beta-3 chain TUBB3 Tclin Non-IDG -2.04546 78.8 485
Short transient receptor potential channel 3 TRPC3 Tchem Ion Channel -2.43407 268.0 184
Dipeptidyl aminopeptidase-like protein 6 DPP6 Tbio Enzyme -2.02374 108.0 115
Plexin-A4 PLXNA4 Tbio Non-IDG -1.39542 24.7 96