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Target Filters...

Development Level

Tbio 469 | 11,445
Tchem 173 | 1,598
Tclin 121 | 613
Tdark 16 | 6,588

Collection

RFA-RM-18-021 7 | 328
Ion Channel: IDG Consortium (T... 6 | 99
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 58 | 979
preweaning lethality, incomple... 32 | 499
abnormal behavior 23 | 298
embryonic lethality prior to t... 20 | 278
increased total body fat amoun... 16 | 134
decreased total body fat amoun... 15 | 207
hyperactivity 15 | 148
decreased bone mineral content 14 | 151
embryonic lethality prior to o... 14 | 239
increased lean body mass 13 | 172
abnormal bone structure 12 | 187
decreased lean body mass 12 | 135
decreased vertical activity 12 | 208
increased circulating alkaline... 12 | 122
decreased body weight 11 | 161
enlarged heart 11 | 210
hypoactivity 11 | 132
abnormal embryo size 10 | 220
abnormal gait 9 | 69
abnormal retina morphology 9 | 71
decreased grip strength 9 | 116
increased mean corpuscular vol... 9 | 92
limb grasping 9 | 41
abnormal heart morphology 8 | 162
decreased circulating choleste... 8 | 93
embryonic growth retardation 8 | 106
increased circulating choleste... 8 | 66
increased fasted circulating g... 8 | 76
increased startle reflex 8 | 112
prenatal lethality prior to he... 8 | 87
decreased circulating HDL chol... 7 | 68
decreased circulating triglyce... 7 | 79
impaired glucose tolerance 7 | 75
increased circulating sodium l... 7 | 71
increased circulating triglyce... 7 | 42
abnormal locomotor behavior 6 | 24
abnormal seminal vesicle morph... 6 | 114
abnormal sleep behavior 6 | 70
decreased circulating alkaline... 6 | 46
decreased circulating amylase ... 6 | 28
decreased circulating serum al... 6 | 82
decreased fasted circulating g... 6 | 65
increased circulating HDL chol... 6 | 80
increased circulating chloride... 6 | 41
prolonged QT interval 6 | 38
prolonged ST segment 6 | 36
short tibia 6 | 97
tremors 6 | 39
cataract 5 | 92
decreased body length 5 | 101
decreased circulating LDL chol... 5 | 38
decreased circulating glucose ... 5 | 126
decreased erythrocyte cell num... 5 | 62
decreased lymphocyte cell numb... 5 | 83
decreased mean platelet volume 5 | 25
decreased neutrophil cell numb... 5 | 42
increased bone mineral content 5 | 108
increased erythrocyte cell num... 5 | 39
increased heart weight 5 | 62
increased monocyte cell number 5 | 63
increased red blood cell distr... 5 | 34
abnormal behavioral response t... 4 | 66
abnormal epididymis morphology 4 | 42
abnormal lens morphology 4 | 81
abnormal testis morphology 4 | 43
decreased blood urea nitrogen ... 4 | 51
decreased bone mineral density 4 | 126
decreased circulating aspartat... 4 | 34
decreased circulating fructosa... 4 | 30
decreased heart left ventricle... 4 | 28
decreased heart weight 4 | 27
decreased hemoglobin content 4 | 68
decreased prepulse inhibition 4 | 82
hemorrhage 4 | 23
improved glucose tolerance 4 | 79
increased circulating alanine ... 4 | 13
increased circulating amylase ... 4 | 25
increased circulating iron lev... 4 | 30
increased circulating phosphat... 4 | 26
increased mean platelet volume 4 | 45
male infertility 4 | 123
small superior vagus ganglion 4 | 74
thin ventricular wall 4 | 24
thrombocytopenia 4 | 56
cardiovascular system phenotyp... 3 | 36
decreased caudal vertebrae num... 3 | 53
decreased circulating bilirubi... 3 | 19
decreased circulating creatini... 3 | 39
decreased circulating insulin ... 3 | 76
decreased circulating total pr... 3 | 49
decreased spleen weight 3 | 10
decreased startle reflex 3 | 75
enlarged kidney 3 | 14
increased circulating bilirubi... 3 | 16
increased circulating potassiu... 3 | 29
increased circulating serum al... 3 | 22
increased hematocrit 3 | 46
increased hemoglobin content 3 | 45
increased prepulse inhibition 3 | 32
small testis 3 | 58

Disease

Carcinoma 554 | 11,493
glioblastoma 410 | 5,792
medulloblastoma, large-cell 403 | 6,241
atypical teratoid / rhabdoid tumor 373 | 5,112
ovarian cancer 370 | 8,520
ependymoma 347 | 4,679
osteosarcoma 331 | 7,950
psoriasis 331 | 6,694
adult high grade glioma 303 | 3,801
Astrocytoma, Pilocytic 278 | 3,081
lung cancer 278 | 4,740
Schizophrenia 270 | 1,160
Cancer 269 | 2,499
oligodendroglioma 268 | 2,850
group 3 medulloblastoma 255 | 4,104
primitive neuroectodermal tumor 229 | 3,035
astrocytic glioma 226 | 2,597
lung carcinoma 200 | 2,843
Breast cancer 194 | 3,578
Kidney cancer 192 | 2,613
subependymal giant cell astrocytoma 186 | 2,287
malignant mesothelioma 185 | 3,232
Bipolar Disorder 170 | 666
Epilepsy 165 | 792
Alzheimer's disease 162 | 658
Pick disease 153 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 153 | 2,955
pituitary cancer 153 | 1,972
intraductal papillary-mucinous neoplasm (IPMN) 150 | 3,291
Parkinson's disease 141 | 392
invasive ductal carcinoma 141 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 140 | 2,989
non-small cell lung cancer 138 | 2,890
Depressive disorder 132 | 409
Neurodegenerative disease 130 | 414
diabetes mellitus 129 | 1,728
Intellectual disability 128 | 1,016
pancreatic cancer 128 | 2,398
lung adenocarcinoma 126 | 2,716
group 4 medulloblastoma 123 | 1,855
Obesity 107 | 678
colon cancer 107 | 1,478
Seizures 105 | 596
Toxic encephalopathy 104 | 141
Mental Depression 103 | 333
interstitial cystitis 102 | 2,312
Vascular disease 100 | 319
Major Depressive Disorder 95 | 301
breast carcinoma 95 | 1,638
cystic fibrosis 95 | 1,696
astrocytoma 92 | 1,146
Autistic Disorder 91 | 364
ulcerative colitis 89 | 1,819
tuberculosis 88 | 2,010
Autosomal recessive predisposition 86 | 1,442
adrenocortical carcinoma 82 | 1,428
Dementia 81 | 175
Mood Disorders 81 | 184
Unipolar Depression 81 | 250
Alcoholic Intoxication, Chronic 80 | 289
Dull intelligence 78 | 645
Low intelligence 78 | 645
Mental Retardation 78 | 645
Mental deficiency 78 | 645
Poor school performance 78 | 645
ductal carcinoma in situ 76 | 1,745
Rheumatoid arthritis 75 | 1,191
Multiple myeloma 74 | 1,332
Melanoma 71 | 711
Cognitive delay 69 | 608
Global developmental delay 69 | 608
Mental and motor retardation 69 | 608
Liver cancer 67 | 604
Amyotrophic lateral sclerosis 66 | 451
pancreatic ductal adenocarcinoma liver metastasis 65 | 1,962
Hypertension 64 | 396
Muscle hypotonia 63 | 571
acute quadriplegic myopathy 58 | 1,158
Nerve Degeneration 57 | 121
pediatric high grade glioma 57 | 1,064
primary pancreatic ductal adenocarcinoma 57 | 1,109
Skin cancer 56 | 469
juvenile dermatomyositis 56 | 1,187
medulloblastoma 56 | 720
Down syndrome 55 | 499
Multiple Sclerosis 55 | 540
Prostatic Neoplasms 55 | 495
cutaneous lupus erythematosus 55 | 1,057
Heart disease 52 | 306
Waldenstrons macroglobulinemia 52 | 765
Breast Neoplasms 51 | 445
Kidney disease 51 | 430
Attention deficit hyperactivity disorder 49 | 278
Mammary Neoplasms 49 | 425
Neuropathy 49 | 261
Atopic dermatitis 47 | 952
Brain disease 47 | 96
Cocaine-Related Disorders 47 | 92
non primary Sjogren syndrome sicca 47 | 891
Cerebellar Ataxia 46 | 304

Tissue

Endocrine System 744 | 18,159
Nervous System 725 | 16,725
Female tissues 712 | 17,400
Digestive Tract 711 | 17,369
Skin and soft tissues 692 | 17,230
Male tissues 679 | 17,142
Blood and immune system 670 | 16,909
Liver and Pancreas 665 | 16,750
Urinary Tract 660 | 16,678
Respiratory system 641 | 16,393
Cardiovascular System 585 | 15,192

Target Family

Non-IDG 342 | 12,091
Enzyme 123 | 4,145
Ion Channel 93 | 344
Transcription Factor 93 | 1,400
GPCR 39 | 408
Kinase 39 | 634
Transporter 34 | 473
Epigenetic 9 | 242
Nuclear Receptor 7 | 48

Jensen-TM Tissue

Neuron 779 | 779
Blood 1,962 | 1,962
Brain 1,516 | 1,516
Immune system 1,205 | 1,205
Muscle 1,170 | 1,170
Liver 1,045 | 1,045
Adult 1,013 | 1,013
Heart 914 | 914
Kidney 888 | 888
Skin 763 | 763
Intestine 665 | 665
Lung 663 | 663
Spinal cord 549 | 549
Bone marrow 513 | 513
Breast 450 | 450
Finger 438 | 438
Blood vessel 398 | 398
Hematopoietic stem cell 379 | 379
Artery 356 | 356
Ovary 353 | 353
Ganglion 334 | 334
Retina 330 | 330
Urine 298 | 298
Nerve 290 | 290
Semen 285 | 285
Mesenchyme 275 | 275
Fiber 274 | 274
Germ cell 264 | 264
BTO:0000964 256 | 256
Pancreas 250 | 250
Breast cancer cell line 246 | 246
Breast cancer cell 235 | 235
Trophoblast 228 | 228
Embryonic stem cell 226 | 226
Adrenal gland 212 | 212
Adipocyte 199 | 199
Lymph node 198 | 198
Thyroid gland 196 | 196
Stromal cell 195 | 195
Cornea 194 | 194
Stomach 185 | 185
Osteoblast 180 | 180
Marrow 169 | 169
Mesenchymal stem cell 167 | 167
Blood plasma 163 | 163
T-lymphocyte 161 | 161
Mast cell 159 | 159
Peripheral nerve 157 | 157
Cranium 149 | 149
Filament 144 | 144
Ectoderm 143 | 143
Root nodule 140 | 140
Spermatid 138 | 138
Neural crest 134 | 134
Blood vessel endothelium 133 | 133
Uterine cervix 132 | 132
Prostate cancer cell line 129 | 129
Spleen 129 | 129
HeLa cell 128 | 128
Hepatoma cell 126 | 126
Vasculature 123 | 123
Neural tube 122 | 122
Prostate gland cancer cell 121 | 121
Knee 120 | 120
Lung cancer cell 119 | 119
Seedling 119 | 119
Neural stem cell 117 | 117
HUVEC cell 115 | 115
Blastocyst 114 | 114
Fruit 113 | 113
Tendon 111 | 111
Bronchoalveolar lavage 108 | 108
Hip 108 | 108
NIH-3T3 cell 106 | 106
Myotube 105 | 105
Capillary 104 | 104
Salivary gland 104 | 104
Primordium 102 | 102
Somatic cell 102 | 102
Colonic cancer cell 101 | 101
Myoblast 101 | 101
Germ 99 | 99
B-lymphocyte 98 | 98
Vegetative cell 98 | 98
Bud 96 | 96
Peripheral blood 96 | 96
Endoderm 93 | 93
Hair cell 93 | 93
Vagina 93 | 93
Epididymis 92 | 92
Neonate 92 | 92
Spike 92 | 92
3T3-L1 cell 91 | 91
dr9 90 | 90
Ascites 88 | 88
Embryonic fibroblast 88 | 88
Parenchyma 88 | 88
Saliva 87 | 87
Synovial tissue 86 | 86
Cancer stem cell 84 | 84

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
Choline O-acetyltransferase CHAT Tchem Enzyme -3.40175 2597.2 436
Potassium voltage-gated channel subfamily C member 2 KCNC2 Tclin Ion Channel -1.45272 28.7 178
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.30964 186.9 274
RNA binding protein fox-1 homolog 3 RBFOX3 Tbio Non-IDG -3.23341 1462.9 208
Roundabout homolog 2 ROBO2 Tbio Non-IDG -1.89275 74.1 161
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 Tclin Ion Channel -2.48671 270.6 121