Development Level

Tbio 445 | 10,625
Tchem 259 | 1,890
Tclin 119 | 602
Tdark 17 | 7,003

Collection

Eligible Ion Channel Proteins 3 | 117

IMPC Term

preweaning lethality, complete... 39 | 633
preweaning lethality, incomple... 16 | 260
abnormal behavior 14 | 226
embryonic lethality prior to t... 13 | 187
decreased bone mineral content 12 | 157
abnormal bone structure 11 | 131
decreased bone mineral density 10 | 126
decreased circulating insulin ... 10 | 75
decreased lean body mass 10 | 195
decreased total body fat amoun... 10 | 186
decreased circulating triglyce... 9 | 83
hypoactivity 9 | 89
abnormal retina morphology 8 | 100
decreased circulating choleste... 8 | 85
embryonic lethality prior to o... 8 | 148
increased circulating alkaline... 8 | 119
abnormal bone mineralization 7 | 55
abnormal embryo size 7 | 112
decreased body weight 7 | 174
decreased circulating HDL chol... 7 | 77
decreased grip strength 7 | 123
abnormal lens morphology 6 | 73
increased circulating HDL chol... 6 | 63
increased circulating choleste... 6 | 53
increased circulating creatini... 6 | 29
increased grip strength 6 | 83
increased or absent threshold ... 6 | 128
decreased body length 5 | 108
decreased circulating calcium ... 5 | 33
decreased hemoglobin content 5 | 53
decreased mean corpuscular vol... 5 | 50
enlarged heart 5 | 111
increased blood urea nitrogen ... 5 | 44
increased heart weight 5 | 37
increased lean body mass 5 | 107
short tibia 5 | 82
abnormal femur morphology 4 | 14
abnormal neural tube closure 4 | 37
abnormal retinal pigmentation 4 | 61
abnormal testis morphology 4 | 30
cataract 4 | 26
decreased blood urea nitrogen ... 4 | 31
decreased circulating LDL chol... 4 | 37
decreased heart weight 4 | 44
enlarged epididymis 4 | 27
hyperactivity 4 | 108
impaired glucose tolerance 4 | 52
increased bone mineral content 4 | 92
increased circulating bilirubi... 4 | 16
increased circulating phosphat... 4 | 24
increased circulating potassiu... 4 | 31
increased circulating sodium l... 4 | 71
increased total body fat amoun... 4 | 57
male infertility 4 | 62
small testis 4 | 37
thrombocytopenia 4 | 46
tremors 4 | 34
abnormal epididymis morphology 3 | 31
abnormal forebrain development 3 | 18
abnormal gait 3 | 51
abnormal heart morphology 3 | 51
abnormal hindbrain development 3 | 24
abnormal midbrain development 3 | 22
abnormal sleep behavior 3 | 63
abnormal tooth morphology 3 | 24
decreased circulating alkaline... 3 | 41
decreased circulating amylase ... 3 | 24
decreased circulating creatini... 3 | 31
decreased circulating glucose ... 3 | 121
decreased circulating phosphat... 3 | 15
decreased circulating serum al... 3 | 79
decreased fasted circulating g... 3 | 49
decreased leukocyte cell numbe... 3 | 54
decreased mean corpuscular hem... 3 | 34
decreased monocyte cell number 3 | 28
decreased startle reflex 3 | 48
female infertility 3 | 34
increased body weight 3 | 42
increased circulating calcium ... 3 | 32
increased circulating serum al... 3 | 25
increased circulating triglyce... 3 | 24
increased erythrocyte cell num... 3 | 26
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
straub tail 3 | 26
abnormal behavioral response t... 2 | 52
abnormal cranium morphology 2 | 32
abnormal head morphology 2 | 10
abnormal kidney morphology 2 | 30
abnormal lung morphology 2 | 15
abnormal vertebrae morphology 2 | 14
cardiovascular system phenotyp... 2 | 35
decreased neutrophil cell numb... 2 | 37
decreased rib number 2 | 59
increased body length 2 | 20
increased circulating chloride... 2 | 43
increased circulating total pr... 2 | 20
increased hemoglobin content 2 | 45
increased respiratory quotient 2 | 12
persistence of hyaloid vascula... 2 | 22

Disease

Cancer 519 | 2,346
psoriasis 414 | 6,685
ovarian cancer 407 | 8,484
osteosarcoma 335 | 7,933
diabetes mellitus 320 | 1,663
Kidney disease 308 | 396
lung cancer 299 | 4,466
glioblastoma 297 | 5,572
medulloblastoma, large-cell 261 | 6,234
lung carcinoma 221 | 2,844
malignant mesothelioma 215 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 208 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 207 | 3,289
lung adenocarcinoma 201 | 2,713
pancreatic cancer 196 | 2,300
ulcerative colitis 194 | 2,087
Hypertension 191 | 287
non-small cell lung cancer 191 | 2,798
atypical teratoid / rhabdoid tumor 190 | 4,369
invasive ductal carcinoma 187 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 185 | 2,988
Breast cancer 179 | 3,094
pilocytic astrocytoma 173 | 3,086
cystic fibrosis 163 | 1,665
interstitial cystitis 162 | 2,299
Arthritis 156 | 248
Rheumatoid Arthritis 154 | 1,160
Carcinoma 152 | 2,147
tuberculosis 151 | 1,557
pediatric high grade glioma 150 | 2,712
subependymal giant cell astrocytoma 137 | 2,287
Hypersensitivity reaction type II disease 136 | 235
Obesity 136 | 616
oligodendroglioma 134 | 2,849
Heart disease 133 | 279
pancreatic ductal adenocarcinoma liver metastasis 133 | 1,795
Liver disease 131 | 219
Atherosclerosis 129 | 275
pituitary cancer 125 | 1,972
ductal carcinoma in situ 123 | 1,745
Vascular disease 122 | 281
Cerebrovascular disease 117 | 231
primitive neuroectodermal tumor 115 | 3,031
colon cancer 113 | 1,475
Anemia 111 | 252
breast carcinoma 111 | 1,614
astrocytoma 108 | 1,493
ependymoma 108 | 2,514
Alzheimer's disease 105 | 644
Prostatic Neoplasms 105 | 471
primary pancreatic ductal adenocarcinoma 105 | 1,271
Coronary artery disease 102 | 240
adrenocortical carcinoma 102 | 1,427
Multiple Sclerosis 101 | 498
adult high grade glioma 100 | 2,148
cutaneous lupus erythematosus 99 | 1,056
group 4 medulloblastoma 99 | 1,875
posterior fossa group A ependymoma 99 | 1,511
Mammary Neoplasms 98 | 410
Hypertensive disease 95 | 193
Asthma 91 | 349
gastric carcinoma 88 | 832
astrocytic glioma 87 | 2,241
Acquired immunodeficiency syndrome 86 | 164
Lung disease 86 | 132
acute quadriplegic myopathy 84 | 1,157
Multiple myeloma 83 | 1,327
Pick disease 82 | 1,893
Uveitis 82 | 103
juvenile dermatomyositis 82 | 1,189
group 3 medulloblastoma 78 | 2,254
Endometriosis 76 | 535
Inflammatory bowel disease 74 | 142
Diarrhea 73 | 155
Ankylosing spondylitis 72 | 138
Hyperglycemia 71 | 120
Adenoma 68 | 165
nephrosclerosis 67 | 329
posterior fossa group B ependymoma 67 | 1,530
Duchenne muscular dystrophy 66 | 602
dermatomyositis 66 | 933
medulloblastoma 66 | 1,524
esophageal adenocarcinoma 65 | 737
Juvenile rheumatoid arthritis 64 | 104
Liver carcinoma 64 | 217
Lung Neoplasms 64 | 171
Stomach Neoplasms 64 | 282
Osteoporosis 63 | 257
active Crohn's disease 62 | 918
Down syndrome 61 | 548
Atopic dermatitis 60 | 944
Schizophrenia 60 | 501
nasopharyngeal carcinoma 59 | 1,056
sonic hedgehog group medulloblastoma 59 | 1,482
Inflammation 58 | 109
Metabolic syndrome X 58 | 155
Behcet's disease 57 | 74
Toxic encephalopathy 57 | 131
autosomal dominant Emery-Dreifuss muscular dystrophy 55 | 499
primary Sjogren syndrome 55 | 789

Tissue

Digestive Tract 775 | 18,473
Urinary Tract 772 | 18,444
Female tissues 771 | 18,647
Nervous System 771 | 18,561
Endocrine System 769 | 18,512
Liver and Pancreas 769 | 18,136
Blood and immune system 762 | 17,995
Skin and soft tissues 759 | 18,115
Cardiovascular System 755 | 17,958
Male tissues 752 | 17,969
Respiratory system 750 | 17,484

Target Family

Non-IDG 412 | 11,971
Enzyme 186 | 4,146
Transporter 78 | 473
Kinase 50 | 634
Transcription Factor 42 | 1,400
Ion Channel 30 | 341
GPCR 26 | 406
Nuclear Receptor 10 | 48
Epigenetic 5 | 242
TF/Epigenetic 1 | 38

Jensen-TM Tissue

Kidney 840 | 840
Blood 1,867 | 1,867
Brain 1,442 | 1,442
Immune system 1,150 | 1,150
Muscle 1,110 | 1,110
Liver 1,001 | 1,001
Adult 976 | 976
Heart 881 | 881
Neuron 744 | 744
Skin 735 | 735
Intestine 626 | 626
Lung 623 | 623
Spinal cord 526 | 526
Bone marrow 494 | 494
Finger 432 | 432
Breast 429 | 429
Blood vessel 387 | 387
Hematopoietic stem cell 370 | 370
Ovary 342 | 342
Artery 327 | 327
Ganglion 322 | 322
Retina 301 | 301
Nerve 290 | 290
Urine 281 | 281
Semen 266 | 266
Fiber 263 | 263
Mesenchyme 261 | 261
Germ cell 244 | 244
BTO:0000964 243 | 243
Pancreas 239 | 239
Breast cancer cell line 228 | 228
Trophoblast 225 | 225
Breast cancer cell 222 | 222
Embryonic stem cell 218 | 218
Adrenal gland 207 | 207
Lymph node 206 | 206
Adipocyte 194 | 194
Thyroid gland 190 | 190
Cornea 186 | 186
Stromal cell 183 | 183
Stomach 179 | 179
Osteoblast 175 | 175
Marrow 169 | 169
Blood plasma 165 | 165
Mesenchymal stem cell 159 | 159
T-lymphocyte 158 | 158
Mast cell 155 | 155
Peripheral nerve 155 | 155
Cranium 141 | 141
Ectoderm 141 | 141
Filament 139 | 139
Root nodule 135 | 135
Spermatid 135 | 135
Neural crest 134 | 134
Spleen 130 | 130
Uterine cervix 124 | 124
Blood vessel endothelium 122 | 122
Prostate cancer cell line 121 | 121
Prostate gland cancer cell 121 | 121
HeLa cell 120 | 120
Neural tube 120 | 120
Vasculature 119 | 119
Blastocyst 117 | 117
HUVEC cell 116 | 116
Hepatoma cell 113 | 113
Fruit 112 | 112
Knee 112 | 112
Neural stem cell 112 | 112
NIH-3T3 cell 109 | 109
Seedling 109 | 109
Tendon 108 | 108
Lung cancer cell 107 | 107
Hip 106 | 106
Bronchoalveolar lavage 105 | 105
Primordium 104 | 104
Bud 103 | 103
Capillary 101 | 101
Myotube 101 | 101
B-lymphocyte 99 | 99
Myoblast 99 | 99
Colonic cancer cell 98 | 98
Peripheral blood 96 | 96
Vegetative cell 96 | 96
Germ 95 | 95
Somatic cell 92 | 92
Endoderm 91 | 91
Embryonic fibroblast 90 | 90
Salivary gland 90 | 90
3T3-L1 cell 88 | 88
Epididymis 88 | 88
Neonate 88 | 88
Mesoderm 87 | 87
Vagina 87 | 87
Hair cell 86 | 86
Ascites 85 | 85
Parenchyma 85 | 85
Saliva 84 | 84
Synovial tissue 83 | 83
Carcass 82 | 82
Spike 80 | 80

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748