Development Level

Tbio 35 | 11,178
Tdark 3 | 6,569
Tchem 2 | 1,885
Tclin 2 | 612

Collection

Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

increased or absent threshold ... 6 | 101
absent startle reflex 5 | 24
decreased body weight 4 | 161
decreased prepulse inhibition 4 | 82
decreased startle reflex 4 | 75
abnormal behavior 3 | 298
absent pinna reflex 3 | 23
decreased circulating amylase ... 3 | 28
decreased circulating triglyce... 3 | 79
increased lean body mass 3 | 172
tremors 3 | 39
trunk curl 3 | 16
abnormal bone structure 2 | 187
abnormal ear morphology 2 | 9
abnormal locomotor activation 2 | 16
abnormal locomotor behavior 2 | 24
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
impaired righting response 2 | 26
increased blood urea nitrogen ... 2 | 48
increased circulating chloride... 2 | 41
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased thermal nociceptive ... 2 | 9
increased vertical activity 2 | 24
limb grasping 2 | 41
stereotypic behavior 2 | 3
abnormal bone mineralization 1 | 38
abnormal coping response 1 | 1
abnormal digestive system phys... 1 | 1
abnormal gait 1 | 69
abnormal response to tactile s... 1 | 17
abnormal startle reflex 1 | 15
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
head bobbing 1 | 5
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased heart weight 1 | 62
increased kidney weight 1 | 6
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979
prolonged PR interval 1 | 15
short tibia 1 | 97
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
thrombocytopenia 1 | 56

Disease

Carcinoma 33 | 11,192
Nonsyndromic deafness 28 | 137
Sensorineural hearing loss 17 | 102
psoriasis 16 | 6,514
group 3 medulloblastoma 14 | 4,002
medulloblastoma, large-cell 14 | 6,086
osteosarcoma 14 | 7,766
ovarian cancer 14 | 8,297
Autosomal recessive predisposition 13 | 1,407
Usher syndrome 12 | 32
atypical teratoid / rhabdoid tumor 12 | 4,971
Breast cancer 11 | 3,469
glioblastoma 11 | 5,635
Kidney cancer 10 | 2,548
Retinitis Pigmentosa 10 | 223
Blindness 9 | 86
adult high grade glioma 9 | 3,701
pituitary cancer 9 | 1,915
ependymoma 8 | 4,559
invasive ductal carcinoma 8 | 2,867
lung cancer 8 | 4,607
lung carcinoma 8 | 2,755
Astrocytoma, Pilocytic 7 | 3,006
Deafness 7 | 193
Intellectual disability 7 | 998
Melanoma 7 | 689
hearing impairment 7 | 194
lung adenocarcinoma 7 | 2,627
pancreatic cancer 7 | 2,322
Abnormal vision 6 | 51
Cataract 6 | 290
Difficulties with night vision 6 | 85
Dull intelligence 6 | 634
Electroretinogram abnormal 6 | 94
Hemianopsia 6 | 15
Hodgkin's lymphoma, nodular sclerosis 6 | 22
Lens Opacities 6 | 227
Liver cancer 6 | 589
Low intelligence 6 | 634
Mental Retardation 6 | 634
Mental deficiency 6 | 634
Night Blindness 6 | 99
Pigmentary iris degeneration 6 | 20
Poor school performance 6 | 634
Retinal blind spot 6 | 11
Scotoma 6 | 22
Sensorineural Hearing Loss (disorder) 6 | 281
Skin cancer 6 | 451
Usher Syndrome, Type 1 6 | 7
oligodendroglioma 6 | 2,768
primitive neuroectodermal tumor 6 | 2,957
Cognitive delay 5 | 596
Congenital deafness 5 | 180
Global developmental delay 5 | 596
Hearing Loss, Partial 5 | 180
Mental and motor retardation 5 | 596
Pick disease 5 | 1,856
Schizophrenia 5 | 1,136
Usher Syndrome, Type I 5 | 6
Usher Syndrome, Type II 5 | 5
Usher syndrome type 2 5 | 5
astrocytic glioma 5 | 2,530
breast carcinoma 5 | 1,589
non-small cell lung cancer 5 | 2,799
tuberculosis 5 | 1,963
Abnormality of cochlea 4 | 6
Cancer 4 | 2,388
Cerebellar Ataxia 4 | 302
Endometrial cancer 4 | 301
Epilepsy 4 | 775
High-grade hypermetropia 4 | 24
Prenatal onset 4 | 137
Vestibular hypofunction 4 | 7
adrenocortical carcinoma 4 | 1,385
aldosterone-producing adenoma 4 | 646
cystic fibrosis 4 | 1,629
ductal carcinoma in situ 4 | 1,686
group 4 medulloblastoma 4 | 1,806
interstitial cystitis 4 | 2,237
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,204
malignant mesothelioma 4 | 3,135
spina bifida 4 | 1,053
subependymal giant cell astrocytoma 4 | 2,230
Bipolar Disorder 3 | 646
Cerebellar hypoplasia and atrophy 3 | 39
Congenital hypoplasia of penis 3 | 168
Down syndrome 3 | 480
Motor delay 3 | 144
Myopia 3 | 175
No development of motor milestones 3 | 144
Perrault syndrome 3 | 19
Sensorineural hearing loss, bilateral 3 | 18
acute quadriplegic myopathy 3 | 1,133
medulloblastoma 3 | 702
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,911
Endometriosis 2 | 521
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 492
nasopharyngeal carcinoma 2 | 1,024

Tissue

Endocrine System 39 | 18,159
Digestive Tract 37 | 17,369
Female tissues 37 | 17,400
Male tissues 37 | 17,142
Nervous System 37 | 16,725
Skin and soft tissues 37 | 17,230
Urinary Tract 36 | 16,678
Liver and Pancreas 35 | 16,750
Respiratory system 33 | 16,393
Blood and immune system 32 | 16,909
Cardiovascular System 31 | 15,192

Target Family

Non-IDG 25 | 12,091
Enzyme 5 | 4,145
Ion Channel 5 | 344
Transcription Factor 5 | 1,400
GPCR 1 | 408
Transporter 1 | 473

Jensen-TM Tissue

Cochlear hair cell 42 | 42
Blood 1,962 | 1,962
Brain 1,516 | 1,516
Immune system 1,205 | 1,205
Muscle 1,170 | 1,170
Liver 1,045 | 1,045
Adult 1,013 | 1,013
Heart 914 | 914
Kidney 888 | 888
Neuron 779 | 779
Skin 763 | 763
Intestine 665 | 665
Lung 663 | 663
Spinal cord 549 | 549
Bone marrow 513 | 513
Breast 450 | 450
Finger 438 | 438
Blood vessel 398 | 398
Hematopoietic stem cell 379 | 379
Artery 356 | 356
Ovary 353 | 353
Ganglion 334 | 334
Retina 330 | 330
Urine 298 | 298
Nerve 290 | 290
Semen 285 | 285
Mesenchyme 275 | 275
Fiber 274 | 274
Germ cell 264 | 264
BTO:0000964 256 | 256
Pancreas 250 | 250
Breast cancer cell line 246 | 246
Breast cancer cell 235 | 235
Trophoblast 228 | 228
Embryonic stem cell 226 | 226
Adrenal gland 212 | 212
Adipocyte 199 | 199
Lymph node 198 | 198
Thyroid gland 196 | 196
Stromal cell 195 | 195
Cornea 194 | 194
Stomach 185 | 185
Osteoblast 180 | 180
Marrow 169 | 169
Mesenchymal stem cell 167 | 167
Blood plasma 163 | 163
T-lymphocyte 161 | 161
Mast cell 159 | 159
Peripheral nerve 157 | 157
Cranium 149 | 149
Filament 144 | 144
Ectoderm 143 | 143
Root nodule 140 | 140
Spermatid 138 | 138
Neural crest 134 | 134
Blood vessel endothelium 133 | 133
Uterine cervix 132 | 132
Prostate cancer cell line 129 | 129
Spleen 129 | 129
HeLa cell 128 | 128
Hepatoma cell 126 | 126
Vasculature 123 | 123
Neural tube 122 | 122
Prostate gland cancer cell 121 | 121
Knee 120 | 120
Lung cancer cell 119 | 119
Seedling 119 | 119
Neural stem cell 117 | 117
HUVEC cell 115 | 115
Blastocyst 114 | 114
Fruit 113 | 113
Tendon 111 | 111
Bronchoalveolar lavage 108 | 108
Hip 108 | 108
NIH-3T3 cell 106 | 106
Myotube 105 | 105
Capillary 104 | 104
Salivary gland 104 | 104
Primordium 102 | 102
Somatic cell 102 | 102
Colonic cancer cell 101 | 101
Myoblast 101 | 101
Germ 99 | 99
B-lymphocyte 98 | 98
Vegetative cell 98 | 98
Bud 96 | 96
Peripheral blood 96 | 96
Endoderm 93 | 93
Hair cell 93 | 93
Vagina 93 | 93
Epididymis 92 | 92
Neonate 92 | 92
Spike 92 | 92
3T3-L1 cell 91 | 91
dr9 90 | 90
Ascites 88 | 88
Embryonic fibroblast 88 | 88
Parenchyma 88 | 88
Saliva 87 | 87
Synovial tissue 86 | 86
Cancer stem cell 84 | 84

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A STT3A Tbio Enzyme -1.76110 54.3 68
Transmembrane channel-like protein 2 TMC2 Tbio Ion Channel -1.19934 15.1 35
Transmembrane channel-like protein 1 TMC1 Tbio Ion Channel -1.99724 101.1 20
Kinocilin KNCN Tdark Non-IDG -0.30103 2.00 8
Whirlin WHRN Tbio Non-IDG -1.74958 54.1 123
POU domain, class 4, transcription factor 3 POU4F3 Tbio Transcription Factor -1.80543 58.9 168
Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 Tclin Ion Channel -2.04030 109.2 258
Espin ESPN Tbio Non-IDG -2.01425 100.4 63
Inactive ubiquitin carboxyl-terminal hydrolase 53 USP53 Tdark Enzyme 0.02 1.54 61
Calcium-binding protein 2 CABP2 Tbio Non-IDG -0.79747 6.72 76