Targets

Target Filters...

This is where graphics are reside..

Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
NACHT, LRR and PYD domains-containing protein 3	NLRP3	Tchem	Non-IDG	-3.22772	1655.7	459
Synapsin-1	SYN1	Tbio	Non-IDG	-2.85684	687.9	716
Glutamate receptor-interacting protein 1	GRIP1	Tbio	Non-IDG	-2.16287	147.6	149
Myeloid differentiation primary response protein MyD88	MYD88	Tbio	Non-IDG	-3.22244	1606.1	561
Dystrobrevin alpha	DTNA	Tbio	Non-IDG	-2.24566	173.6	138
Putative peripheral benzodiazepine receptor-related protein	TSPO	Tbio	Non-IDG	-3.04986	2078.3	186
Neurturin	NRTN	Tbio	Non-IDG	-2.19264	157.5	257
Metabotropic glutamate receptor 4	GRM4	Tchem	GPCR	-2.32485	207.4	140
Guanine nucleotide-binding protein subunit alpha-15	GNA15	Tbio	Non-IDG	-2.74618	475.0	155
Tubulin beta-3 chain	TUBB3	Tclin	Non-IDG	-2.04546	78.8	485

	Tbio	790 \| 10,625
	Tchem	420 \| 1,890
	Tclin	215 \| 602
	Tdark	17 \| 7,003

	Eligible Ion Channel Proteins	7 \| 117
	Eligible non-olfactory GPCR Proteins	7 \| 145

	preweaning lethality, complete...	61 \| 633
	preweaning lethality, incomple...	38 \| 260
	abnormal behavior	33 \| 226
	decreased lean body mass	26 \| 195
	decreased bone mineral content	24 \| 157
	embryonic lethality prior to t...	24 \| 187
	decreased total body fat amoun...	22 \| 186
	increased circulating alkaline...	20 \| 119
	decreased body weight	19 \| 174
	decreased grip strength	19 \| 123
	hyperactivity	19 \| 108
	abnormal bone structure	18 \| 131
	abnormal embryo size	17 \| 112
	hypoactivity	16 \| 89
	increased grip strength	15 \| 83
	decreased bone mineral density	14 \| 126
	decreased circulating choleste...	14 \| 85
	embryonic lethality prior to o...	14 \| 148
	increased or absent threshold ...	14 \| 128
	decreased circulating HDL chol...	13 \| 77
	increased lean body mass	13 \| 107
	decreased fasted circulating g...	12 \| 49
	enlarged heart	12 \| 111
	improved glucose tolerance	12 \| 56
	increased circulating HDL chol...	12 \| 63
	increased mean corpuscular vol...	12 \| 91
	abnormal gait	11 \| 51
	decreased body length	10 \| 108
	decreased circulating LDL chol...	10 \| 37
	decreased circulating alanine ...	10 \| 53
	decreased circulating insulin ...	10 \| 75
	decreased circulating triglyce...	10 \| 83
	increased total body fat amoun...	10 \| 57
	male infertility	10 \| 62
	abnormal neural tube closure	9 \| 37
	abnormal retina morphology	9 \| 100
	abnormal sleep behavior	9 \| 63
	decreased heart weight	9 \| 44
	decreased mean corpuscular vol...	9 \| 50
	decreased prepulse inhibition	9 \| 52
	impaired glucose tolerance	9 \| 52
	increased circulating chloride...	9 \| 43
	increased circulating choleste...	9 \| 53
	short tibia	9 \| 82
	abnormal epididymis morphology	8 \| 31
	increased mean corpuscular hem...	8 \| 93
	tremors	8 \| 34
	abnormal bone mineralization	7 \| 55
	cataract	7 \| 26
	decreased circulating alkaline...	7 \| 41
	decreased circulating calcium ...	7 \| 33
	decreased circulating glucose ...	7 \| 121
	female infertility	7 \| 34
	increased blood urea nitrogen ...	7 \| 44
	increased body weight	7 \| 42
	increased bone mineral density	7 \| 52
	increased circulating sodium l...	7 \| 71
	increased fasted circulating g...	7 \| 68
	limb grasping	7 \| 35
	abnormal QRS complex	6 \| 25
	abnormal behavioral response t...	6 \| 52
	abnormal forebrain development	6 \| 18
	abnormal hindbrain development	6 \| 24
	abnormal lens morphology	6 \| 73
	abnormal retinal pigmentation	6 \| 61
	decreased circulating serum al...	6 \| 79
	decreased circulating total pr...	6 \| 41
	decreased rib number	6 \| 59
	decreased startle reflex	6 \| 48
	decreased vertical activity	6 \| 22
	enlarged epididymis	6 \| 27
	increased bone mineral content	6 \| 92
	increased circulating potassiu...	6 \| 31
	increased erythrocyte cell num...	6 \| 26
	increased startle reflex	6 \| 38
	thrombocytopenia	6 \| 46
	abnormal coat/hair pigmentatio...	5 \| 54
	abnormal heart morphology	5 \| 51
	abnormal midbrain development	5 \| 22
	abnormal testis morphology	5 \| 30
	cardiovascular system phenotyp...	5 \| 35
	decreased blood urea nitrogen ...	5 \| 31
	decreased circulating amylase ...	5 \| 24
	decreased circulating aspartat...	5 \| 27
	decreased leukocyte cell numbe...	5 \| 54
	decreased mean corpuscular hem...	5 \| 34
	increased circulating creatini...	5 \| 29
	increased circulating phosphat...	5 \| 24
	small testis	5 \| 37
	straub tail	5 \| 26
	abnormal locomotor activation	4 \| 26
	abnormal tooth morphology	4 \| 24
	corneal opacity	4 \| 25
	decreased T cell number	4 \| 31
	decreased hemoglobin content	4 \| 53
	decreased total retina thickne...	4 \| 20
	increased circulating calcium ...	4 \| 32
	increased circulating serum al...	4 \| 25
	increased heart weight	4 \| 37
	persistence of hyaloid vascula...	4 \| 22

	ovarian cancer	724 \| 8,492
	psoriasis	692 \| 6,685
	medulloblastoma, large-cell	678 \| 6,234
	glioblastoma	676 \| 5,572
	Cancer	631 \| 2,346
	osteosarcoma	629 \| 7,933
	lung cancer	552 \| 4,473
	atypical teratoid / rhabdoid tumor	497 \| 4,369
	pilocytic astrocytoma	468 \| 3,086
	oligodendroglioma	435 \| 2,849
	malignant mesothelioma	377 \| 3,163
	lung carcinoma	375 \| 2,844
	primitive neuroectodermal tumor	375 \| 3,031
	pediatric high grade glioma	366 \| 2,712
	intraductal papillary-mucinous neoplasm (IPMN)	337 \| 3,289
	intraductal papillary-mucinous adenoma (IPMA)	328 \| 2,956
	invasive ductal carcinoma	328 \| 2,950
	Breast cancer	323 \| 3,099
	diabetes mellitus	316 \| 1,663
	intraductal papillary-mucinous carcinoma (IPMC)	313 \| 2,988
	subependymal giant cell astrocytoma	307 \| 2,287
	ependymoma	303 \| 2,514
	Carcinoma	300 \| 2,147
	lung adenocarcinoma	290 \| 2,714
	non-small cell lung cancer	289 \| 2,798
	interstitial cystitis	276 \| 2,299
	astrocytic glioma	271 \| 2,241
	pancreatic cancer	271 \| 2,300
	ulcerative colitis	271 \| 2,087
	pituitary cancer	259 \| 1,972
	astrocytoma	251 \| 1,493
	Alzheimer's disease	242 \| 644
	adult high grade glioma	239 \| 2,148
	cystic fibrosis	235 \| 1,670
	Pick disease	225 \| 1,893
	group 4 medulloblastoma	219 \| 1,875
	Schizophrenia	214 \| 503
	medulloblastoma	213 \| 1,524
	colon cancer	208 \| 1,475
	Obesity	206 \| 616
	breast carcinoma	206 \| 1,614
	posterior fossa group A ependymoma	205 \| 1,511
	ductal carcinoma in situ	199 \| 1,745
	tuberculosis	192 \| 1,563
	group 3 medulloblastoma	188 \| 2,254
	Epilepsy	185 \| 346
	adrenocortical carcinoma	174 \| 1,427
	Kidney disease	173 \| 397
	Neurodegenerative disease	173 \| 383
	pancreatic ductal adenocarcinoma liver metastasis	173 \| 1,795
	Parkinson's disease	169 \| 364
	sonic hedgehog group medulloblastoma	166 \| 1,482
	Hypertension	163 \| 293
	Vascular disease	163 \| 281
	Rheumatoid Arthritis	162 \| 1,171
	Autistic Disorder	159 \| 320
	atypical teratoid/rhabdoid tumor	157 \| 1,095
	posterior fossa group B ependymoma	157 \| 1,530
	Cerebrovascular disease	153 \| 231
	cutaneous lupus erythematosus	151 \| 1,056
	primary pancreatic ductal adenocarcinoma	149 \| 1,271
	Heart disease	146 \| 279
	Intellectual disability	144 \| 573
	Multiple myeloma	138 \| 1,328
	Mammary Neoplasms	137 \| 410
	acute quadriplegic myopathy	133 \| 1,157
	juvenile dermatomyositis	127 \| 1,189
	Prostatic Neoplasms	126 \| 471
	Down syndrome	124 \| 548
	Asthma	121 \| 349
	Atherosclerosis	121 \| 275
	Multiple Sclerosis	121 \| 498
	Toxic encephalopathy	118 \| 131
	gastric carcinoma	117 \| 832
	dermatomyositis	115 \| 967
	Coronary artery disease	109 \| 240
	Bipolar Disorder	108 \| 266
	Arthritis	106 \| 248
	Atopic dermatitis	106 \| 944
	Dementia	105 \| 129
	Duchenne muscular dystrophy	104 \| 602
	Endometriosis	103 \| 535
	Waldenstrons macroglobulinemia	98 \| 765
	nasopharyngeal carcinoma	94 \| 1,056
	Hypertensive disease	92 \| 193
	Amyotrophic Lateral Sclerosis	86 \| 432
	Liver disease	86 \| 219
	spina bifida	86 \| 1,064
	Lung disease	85 \| 136
	aldosterone-producing adenoma	85 \| 664
	Liver carcinoma	84 \| 217
	Neuropathy	84 \| 210
	esophageal adenocarcinoma	84 \| 737
	Stomach Neoplasms	82 \| 282
	active Crohn's disease	82 \| 918
	fibroadenoma	78 \| 557
	Adenoma	77 \| 165
	autosomal dominant Emery-Dreifuss muscular dystrophy	77 \| 499
	non primary Sjogren syndrome sicca	77 \| 840
	Hypersensitivity reaction type II disease	76 \| 235

	Nervous System	1,429 \| 18,561
	Endocrine System	1,426 \| 18,512
	Female tissues	1,424 \| 18,647
	Digestive Tract	1,422 \| 18,473
	Urinary Tract	1,416 \| 18,444
	Skin and soft tissues	1,407 \| 18,115
	Liver and Pancreas	1,406 \| 18,136
	Cardiovascular System	1,401 \| 17,958
	Blood and immune system	1,390 \| 17,995
	Male tissues	1,387 \| 17,969
	Respiratory system	1,366 \| 17,484

Development Level

Collection

IMPC Term

Disease

Tissue

Target Family

Jensen-TM Tissue

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Grant Funding IC

Grant Activity

Data Source

	Non-IDG	644 \| 11,969
	Enzyme	310 \| 4,146
	Transcription Factor	115 \| 1,400
	GPCR	103 \| 408
	Ion Channel	90 \| 341
	Kinase	89 \| 634
	Transporter	57 \| 473
	Epigenetic	16 \| 242
	Nuclear Receptor	16 \| 48
	TF/Epigenetic	2 \| 38

	Brain	1,442 \| 1,442
	Blood	1,867 \| 1,867
	Immune system	1,150 \| 1,150
	Muscle	1,110 \| 1,110
	Liver	1,001 \| 1,001
	Adult	976 \| 976
	Heart	881 \| 881
	Kidney	840 \| 840
	Neuron	744 \| 744
	Skin	735 \| 735
	Intestine	626 \| 626
	Lung	623 \| 623
	Spinal cord	526 \| 526
	Bone marrow	494 \| 494
	Finger	432 \| 432
	Breast	429 \| 429
	Blood vessel	387 \| 387
	Hematopoietic stem cell	370 \| 370
	Ovary	342 \| 342
	Artery	327 \| 327
	Ganglion	322 \| 322
	Retina	301 \| 301
	Nerve	290 \| 290
	Urine	281 \| 281
	Semen	266 \| 266
	Fiber	263 \| 263
	Mesenchyme	261 \| 261
	Germ cell	244 \| 244
	BTO:0000964	243 \| 243
	Pancreas	239 \| 239
	Breast cancer cell line	228 \| 228
	Trophoblast	225 \| 225
	Breast cancer cell	222 \| 222
	Embryonic stem cell	218 \| 218
	Adrenal gland	207 \| 207
	Lymph node	206 \| 206
	Adipocyte	194 \| 194
	Thyroid gland	190 \| 190
	Cornea	186 \| 186
	Stromal cell	183 \| 183
	Stomach	179 \| 179
	Osteoblast	175 \| 175
	Marrow	169 \| 169
	Blood plasma	165 \| 165
	Mesenchymal stem cell	159 \| 159
	T-lymphocyte	158 \| 158
	Mast cell	155 \| 155
	Peripheral nerve	155 \| 155
	Cranium	141 \| 141
	Ectoderm	141 \| 141
	Filament	139 \| 139
	Root nodule	135 \| 135
	Spermatid	135 \| 135
	Neural crest	134 \| 134
	Spleen	130 \| 130
	Uterine cervix	124 \| 124
	Blood vessel endothelium	122 \| 122
	Prostate cancer cell line	121 \| 121
	Prostate gland cancer cell	121 \| 121
	HeLa cell	120 \| 120
	Neural tube	120 \| 120
	Vasculature	119 \| 119
	Blastocyst	117 \| 117
	HUVEC cell	116 \| 116
	Hepatoma cell	113 \| 113
	Fruit	112 \| 112
	Knee	112 \| 112
	Neural stem cell	112 \| 112
	NIH-3T3 cell	109 \| 109
	Seedling	109 \| 109
	Tendon	108 \| 108
	Lung cancer cell	107 \| 107
	Hip	106 \| 106
	Bronchoalveolar lavage	105 \| 105
	Primordium	104 \| 104
	Bud	103 \| 103
	Capillary	101 \| 101
	Myotube	101 \| 101
	B-lymphocyte	99 \| 99
	Myoblast	99 \| 99
	Colonic cancer cell	98 \| 98
	Peripheral blood	96 \| 96
	Vegetative cell	96 \| 96
	Germ	95 \| 95
	Somatic cell	92 \| 92
	Endoderm	91 \| 91
	Embryonic fibroblast	90 \| 90
	Salivary gland	90 \| 90
	3T3-L1 cell	88 \| 88
	Epididymis	88 \| 88
	Neonate	88 \| 88
	Mesoderm	87 \| 87
	Vagina	87 \| 87
	Hair cell	86 \| 86
	Ascites	85 \| 85
	Parenchyma	85 \| 85
	Saliva	84 \| 84
	Synovial tissue	83 \| 83
	Carcass	82 \| 82
	Spike	80 \| 80