Development Level

Tbio 1,026 | 11,445
Tdark 313 | 6,588
Tchem 122 | 1,598
Tclin 32 | 613

Collection

RFA-RM-18-021 15 | 328
Kinase: IDG Consortium (Target... 8 | 125
Ion Channel: IDG Consortium (T... 6 | 99
Kinase: IDG Consortium (Comple... 3 | 37
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 132 | 979
preweaning lethality, incomple... 43 | 499
embryonic lethality prior to t... 36 | 278
embryonic lethality prior to o... 32 | 239
abnormal behavior 26 | 298
abnormal embryo size 22 | 220
decreased total body fat amoun... 21 | 207
increased startle reflex 19 | 112
prenatal lethality prior to he... 18 | 87
decreased body weight 16 | 161
decreased vertical activity 16 | 208
abnormal heart morphology 15 | 162
male infertility 15 | 123
decreased circulating glucose ... 14 | 126
embryonic growth retardation 14 | 106
enlarged heart 14 | 210
abnormal bone structure 13 | 187
edema 13 | 59
hyperactivity 13 | 148
hypoactivity 13 | 132
increased lean body mass 13 | 172
increased circulating alkaline... 12 | 122
increased fasted circulating g... 12 | 76
decreased grip strength 11 | 116
increased bone mineral content 11 | 108
small testis 11 | 58
abnormal seminal vesicle morph... 10 | 114
decreased body length 10 | 101
increased bone mineral density 10 | 72
short tibia 10 | 97
abnormal coat-hair pigmentatio... 9 | 64
abnormal kidney morphology 9 | 65
abnormal retina morphology 9 | 71
decreased bone mineral density 9 | 126
decreased prepulse inhibition 9 | 82
abnormal eye morphology 8 | 68
decreased circulating serum al... 8 | 82
increased mean corpuscular vol... 8 | 92
increased total body fat amoun... 8 | 134
abnormal craniofacial morpholo... 7 | 33
decreased bone mineral content 7 | 151
decreased circulating triglyce... 7 | 79
decreased lean body mass 7 | 135
increased mean platelet volume 7 | 45
abnormal sleep behavior 6 | 70
abnormal tail morphology 6 | 25
decreased circulating insulin ... 6 | 76
decreased circulating sodium l... 6 | 22
decreased leukocyte cell numbe... 6 | 73
decreased lymphocyte cell numb... 6 | 83
decreased mean corpuscular vol... 6 | 79
decreased startle reflex 6 | 75
increased neutrophil cell numb... 6 | 46
thrombocytopenia 6 | 56
abnormal embryo turning 5 | 31
abnormal pericardium morpholog... 5 | 26
abnormal testis morphology 5 | 43
anophthalmia 5 | 33
decreased caudal vertebrae num... 5 | 53
decreased circulating HDL chol... 5 | 68
decreased circulating aspartat... 5 | 34
decreased circulating choleste... 5 | 93
decreased erythrocyte cell num... 5 | 62
decreased fasted circulating g... 5 | 65
decreased hemoglobin content 5 | 68
decreased mean corpuscular hem... 5 | 50
decreased mean corpuscular hem... 5 | 31
impaired glucose tolerance 5 | 75
improved glucose tolerance 5 | 79
increased circulating HDL chol... 5 | 80
increased circulating chloride... 5 | 41
increased circulating choleste... 5 | 66
increased circulating creatini... 5 | 38
increased circulating phosphat... 5 | 26
increased circulating triglyce... 5 | 42
increased leukocyte cell numbe... 5 | 47
increased mean corpuscular hem... 5 | 96
increased mean corpuscular hem... 5 | 36
abnormal epididymis morphology 4 | 42
abnormal lens morphology 4 | 81
abnormal lung morphology 4 | 26
abnormal neural tube closure 4 | 46
abnormal optic disc morphology 4 | 10
abnormal skin coloration 4 | 25
abnormal skin morphology 4 | 50
abnormal vibrissa morphology 4 | 25
cataract 4 | 92
decreased circulating alanine ... 4 | 47
decreased circulating potassiu... 4 | 20
decreased hematocrit 4 | 46
enlarged lymph nodes 4 | 37
increased circulating iron lev... 4 | 30
increased eosinophil cell numb... 4 | 11
increased heart rate 4 | 23
increased heart weight 4 | 62
increased monocyte cell number 4 | 63
increased or absent threshold ... 4 | 101
persistence of hyaloid vascula... 4 | 33
small superior vagus ganglion 4 | 74
tremors 4 | 39

Disease

Carcinoma 946 | 11,493
ovarian cancer 899 | 8,520
osteosarcoma 742 | 7,950
psoriasis 559 | 6,694
medulloblastoma, large-cell 549 | 6,241
glioblastoma 534 | 5,792
lung cancer 466 | 4,740
atypical teratoid / rhabdoid tumor 450 | 5,112
ependymoma 390 | 4,679
group 3 medulloblastoma 365 | 4,104
Breast cancer 345 | 3,578
malignant mesothelioma 343 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 308 | 3,291
adult high grade glioma 302 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 285 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 276 | 2,955
invasive ductal carcinoma 267 | 2,951
primitive neuroectodermal tumor 261 | 3,035
lung adenocarcinoma 244 | 2,716
non-small cell lung cancer 241 | 2,890
oligodendroglioma 237 | 2,850
pancreatic cancer 226 | 2,398
astrocytic glioma 224 | 2,597
Astrocytoma, Pilocytic 222 | 3,081
Cancer 211 | 2,499
Kidney cancer 204 | 2,613
lung carcinoma 203 | 2,843
subependymal giant cell astrocytoma 197 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 187 | 1,962
Pick disease 183 | 1,894
tuberculosis 177 | 2,010
breast carcinoma 172 | 1,638
Multiple myeloma 171 | 1,332
group 4 medulloblastoma 169 | 1,855
interstitial cystitis 154 | 2,312
pituitary cancer 151 | 1,972
colon cancer 143 | 1,478
cystic fibrosis 140 | 1,696
adrenocortical carcinoma 135 | 1,428
diabetes mellitus 135 | 1,728
ductal carcinoma in situ 135 | 1,745
juvenile dermatomyositis 135 | 1,187
ulcerative colitis 135 | 1,819
primary pancreatic ductal adenocarcinoma 132 | 1,109
acute quadriplegic myopathy 130 | 1,158
astrocytoma 128 | 1,146
dermatomyositis 127 | 966
Autosomal recessive predisposition 112 | 1,442
pediatric high grade glioma 104 | 1,064
spina bifida 99 | 1,074
Rheumatoid arthritis 98 | 1,191
Intellectual disability 88 | 1,016
Waldenstrons macroglobulinemia 87 | 765
Schizophrenia 86 | 1,160
acute myeloid leukemia 82 | 783
non primary Sjogren syndrome sicca 82 | 891
active Crohn's disease 81 | 922
Duchenne muscular dystrophy 74 | 601
hepatocellular carcinoma 74 | 547
nasopharyngeal carcinoma 72 | 1,058
medulloblastoma 71 | 720
Atopic dermatitis 69 | 952
primary Sjogren syndrome 66 | 735
Liver Cirrhosis, Experimental 65 | 769
progressive supranuclear palsy 65 | 676
cutaneous lupus erythematosus 64 | 1,057
gastric carcinoma 63 | 807
aldosterone-producing adenoma 62 | 665
esophageal adenocarcinoma 57 | 737
Epilepsy 56 | 792
pancreatic carcinoma 56 | 562
Dull intelligence 55 | 645
Low intelligence 55 | 645
Mental Retardation 55 | 645
Mental deficiency 55 | 645
Poor school performance 55 | 645
autosomal dominant Emery-Dreifuss muscular dystrophy 55 | 510
gastric cancer 55 | 459
Cognitive delay 54 | 608
Global developmental delay 54 | 608
Mental and motor retardation 54 | 608
fibroadenoma 53 | 559
sonic hedgehog group medulloblastoma 52 | 467
Alzheimer's disease 50 | 658
Muscle hypotonia 50 | 571
posterior fossa group A ependymoma 49 | 468
active ulcerative colitis 48 | 764
tuberculosis and treatment for 6 months 48 | 409
Obesity 47 | 678
Breast Neoplasms 46 | 445
Endometriosis 46 | 540
Seizures 46 | 596
Prostatic Neoplasms 45 | 495
Down syndrome 44 | 499
Mammary Neoplasms 43 | 425
Short stature 43 | 531
Bipolar Disorder 41 | 666
Amyotrophic lateral sclerosis 40 | 451
Neurodegenerative disease 40 | 414
hereditary spastic paraplegia 40 | 318

Tissue

Endocrine System 1,467 | 18,159
Skin and soft tissues 1,464 | 17,230
Digestive Tract 1,462 | 17,369
Female tissues 1,462 | 17,400
Urinary Tract 1,457 | 16,678
Male tissues 1,456 | 17,142
Blood and immune system 1,455 | 16,909
Liver and Pancreas 1,455 | 16,750
Respiratory system 1,455 | 16,393
Nervous System 1,447 | 16,725
Cardiovascular System 1,434 | 15,192

Target Family

Non-IDG 892 | 12,091
Enzyme 337 | 4,145
Transcription Factor 126 | 1,400
Kinase 50 | 634
Epigenetic 35 | 242
Transporter 18 | 473
Ion Channel 14 | 344
GPCR 11 | 408
Nuclear Receptor 5 | 48
TF/Epigenetic 4 | 38
oGPCR 1 | 421

Jensen-KB Tissue

Uterus 1,493 | 1,493
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Heterogeneous nuclear ribonucleoprotein H3 HNRNPH3 Tbio Non-IDG -1.80776 63.4 80
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
E3 SUMO-protein ligase KIAA1586 KIAA1586 Tdark Non-IDG 0.70 0.13 60
Ribonucleoprotein PTB-binding 2 RAVER2 Tdark Non-IDG -0.31876 3.20 38
Protein pelota homolog PELO Tbio Non-IDG -1.33842 18.2 100
ATP-dependent DNA helicase Q5 RECQL5 Tbio Enzyme -1.67373 56.2 148