Development Level

Tbio 73 | 10,625
Tdark 35 | 7,003
Tchem 11 | 1,890
Tclin 3 | 602

Collection

Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 4 | 633
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
abnormal behavior 2 | 226
abnormal behavioral response t... 2 | 52
abnormal heart morphology 2 | 51
abnormal sleep behavior 2 | 63
decreased alpha-beta T cell nu... 2 | 12
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased mean corpuscular hem... 2 | 34
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
enlarged spleen 2 | 26
hyperactivity 2 | 108
increased erythrocyte cell num... 2 | 26
increased heart weight 2 | 37
increased lean body mass 2 | 107
increased monocyte cell number 2 | 27
increased or absent threshold ... 2 | 128
abnormal QRS complex 1 | 25
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal retina morphology 1 | 100
abnormal retinal inner nuclear... 1 | 5
abnormal sensory capabilities/... 1 | 3
abnormal spleen morphology 1 | 36
abnormal vitreous body morphol... 1 | 7
absent pinna reflex 1 | 21
cardiovascular system phenotyp... 1 | 35
decreased CD4-positive, CD25-p... 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C low monocyte nu... 1 | 23
decreased NK T cell number 1 | 28
decreased T cell number 1 | 31
decreased bone mineral content 1 | 157
decreased cardiac output 1 | 2
decreased cardiac stroke volum... 1 | 3
decreased caudal vertebrae num... 1 | 49
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating sodium l... 1 | 18
decreased heart rate 1 | 10
decreased heart rate variabili... 1 | 11
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased lymphocyte cell numb... 1 | 9
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased respiratory quotient 1 | 12
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased KLRG1-positive NK ce... 1 | 9
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased cardiac muscle contr... 1 | 5
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased hemoglobin content 1 | 45
increased kidney weight 1 | 4
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased prepulse inhibition 1 | 21
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased vertical activity 1 | 18
limb grasping 1 | 35
male infertility 1 | 62
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260

Disease

osteosarcoma 71 | 7,933
ovarian cancer 71 | 8,484
medulloblastoma, large-cell 53 | 6,234
glioblastoma 48 | 5,572
atypical teratoid / rhabdoid tumor 43 | 4,369
psoriasis 39 | 6,685
lung cancer 38 | 4,466
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,289
Breast cancer 31 | 3,094
pilocytic astrocytoma 30 | 3,086
pediatric high grade glioma 28 | 2,712
primitive neuroectodermal tumor 28 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,956
invasive ductal carcinoma 26 | 2,950
Carcinoma 25 | 2,147
ependymoma 25 | 2,514
pancreatic cancer 25 | 2,300
astrocytic glioma 24 | 2,241
malignant mesothelioma 24 | 3,162
oligodendroglioma 24 | 2,849
lung carcinoma 23 | 2,844
ulcerative colitis 23 | 2,087
Cancer 22 | 2,346
juvenile dermatomyositis 22 | 1,189
group 3 medulloblastoma 19 | 2,254
primary pancreatic ductal adenocarcinoma 19 | 1,271
subependymal giant cell astrocytoma 19 | 2,287
adult high grade glioma 18 | 2,148
Pick disease 17 | 1,893
medulloblastoma 17 | 1,524
astrocytoma 16 | 1,493
breast carcinoma 16 | 1,614
interstitial cystitis 16 | 2,299
adrenocortical carcinoma 15 | 1,427
gastric carcinoma 15 | 832
group 4 medulloblastoma 15 | 1,875
diabetes mellitus 14 | 1,663
pituitary cancer 14 | 1,972
sonic hedgehog group medulloblastoma 14 | 1,482
tuberculosis 14 | 1,557
Rheumatoid Arthritis 13 | 1,160
cystic fibrosis 13 | 1,665
dermatomyositis 13 | 933
lung adenocarcinoma 13 | 2,713
non-small cell lung cancer 13 | 2,798
acute quadriplegic myopathy 12 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
colon cancer 11 | 1,475
ductal carcinoma in situ 11 | 1,745
spina bifida 11 | 1,064
Duchenne muscular dystrophy 10 | 602
sarcoidosis 10 | 358
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 499
posterior fossa group A ependymoma 9 | 1,511
Atopic dermatitis 8 | 944
Multiple Sclerosis 8 | 498
Neurodegenerative disease 8 | 383
active Crohn's disease 8 | 918
atypical teratoid/rhabdoid tumor 8 | 1,095
nasopharyngeal carcinoma 8 | 1,056
primary Sjogren syndrome 8 | 789
Endometriosis 7 | 535
Mammary Neoplasms 7 | 410
Multiple myeloma 7 | 1,327
glioblastoma multiforme 7 | 347
Alzheimer's disease 6 | 644
Down syndrome 6 | 548
Intellectual disability 6 | 573
cutaneous lupus erythematosus 6 | 1,056
gastric cancer 6 | 430
pancreatic carcinoma 6 | 567
posterior fossa group B ependymoma 6 | 1,530
systemic lupus erythematosus 6 | 156
tuberculosis and treatment for 6 months 6 | 686
Amyotrophic Lateral Sclerosis 5 | 431
Osteoporosis 5 | 257
aldosterone-producing adenoma 5 | 664
hepatocellular carcinoma 5 | 532
hereditary spastic paraplegia 5 | 313
progressive supranuclear palsy 5 | 674
Becker muscular dystrophy 4 | 187
Chronic obstructive pulmonary disease 4 | 146
Colorectal Neoplasms 4 | 217
Neuropathy 4 | 210
Paraplegia 4 | 71
Polycystic Ovary Syndrome 4 | 332
Prostatic Neoplasms 4 | 471
Waldenstrons macroglobulinemia 4 | 765
acute myeloid leukemia 4 | 780
fascioscapulohumeral muscular dystrophy 4 | 100
limb girdle muscular dystrophy 2A 4 | 156
non diabetic and post-ischemic heart failure 4 | 200
Crohn's disease 3 | 304
Hypertensive disease 3 | 193
IGA Glomerulonephritis 3 | 454
fibroadenoma 3 | 557
head and neck cancer 3 | 270
nephrosclerosis 3 | 329
non-small cell lung carcinoma 3 | 413

Tissue

Cardiovascular System 122 | 17,958
Digestive Tract 122 | 18,473
Endocrine System 122 | 18,512
Female tissues 122 | 18,647
Liver and Pancreas 122 | 18,136
Male tissues 122 | 17,969
Nervous System 122 | 18,561
Urinary Tract 122 | 18,444
Blood and immune system 121 | 17,995
Respiratory system 121 | 17,484
Skin and soft tissues 121 | 18,115

Target Family

Non-IDG 71 | 11,971
Enzyme 28 | 4,146
Transcription Factor 13 | 1,400
Epigenetic 2 | 242
GPCR 2 | 406
Kinase 2 | 634
Nuclear Receptor 2 | 48
Transporter 2 | 473

Jensen-KB Tissue

Uterine endometrium 122 | 122
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HEAT repeat-containing protein 6 HEATR6 Tdark Non-IDG -1.48236 11.6 38
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Fibronectin FN1 Tchem Non-IDG -3.04098 1121.3 1253
Zinc finger protein 280D ZNF280D Tdark Transcription Factor 0.41 0.29 43
UPF0544 protein C5orf45 MRNIP Tdark Non-IDG 0.30 0.80 68
Calcium-transporting ATPase type 2C member 2 ATP2C2 Tbio Transporter -1.20730 18.2 29
Protein PRRC2A PRRC2A Tbio Non-IDG -1.88933 77.7 7
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OGT Tchem Enzyme -2.92944 916.6 217
Lung adenoma susceptibility protein 2 C18orf54 Tbio Non-IDG -0.78414 10.7 58
Glycogen [starch] synthase, muscle GYS1 Tchem Enzyme -2.17524 150.6 211