Development Level

Tbio 270 | 10,625
Tdark 98 | 7,003
Tchem 43 | 1,890
Tclin 3 | 602

Collection

GPCR: IDG Consortium (Targets) 2 | 128
Kinase: IDG Consortium (Targets) 2 | 125
Ion Channel: IDG Consortium (Targets) 1 | 102
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 20 | 633
abnormal behavior 8 | 226
decreased body weight 8 | 174
decreased circulating glucose ... 6 | 121
decreased circulating triglyce... 6 | 83
decreased lean body mass 6 | 195
embryonic lethality prior to t... 6 | 187
decreased body length 5 | 108
decreased bone mineral content 5 | 157
decreased bone mineral density 5 | 126
decreased total body fat amoun... 5 | 186
increased lean body mass 5 | 107
preweaning lethality, incomple... 5 | 260
short tibia 5 | 82
abnormal embryo size 4 | 112
decreased circulating HDL chol... 4 | 77
decreased circulating choleste... 4 | 85
enlarged heart 4 | 111
hyperactivity 4 | 108
increased grip strength 4 | 83
increased mean corpuscular hem... 4 | 93
abnormal behavioral response t... 3 | 52
abnormal bone structure 3 | 131
abnormal heart morphology 3 | 51
abnormal lens morphology 3 | 73
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular vol... 3 | 50
decreased rib number 3 | 59
embryonic lethality prior to o... 3 | 148
hypoactivity 3 | 89
increased mean corpuscular vol... 3 | 91
abnormal QRS complex 2 | 25
abnormal coat-hair pigmentatio... 2 | 54
abnormal locomotor activation 2 | 26
abnormal retina morphology 2 | 100
abnormal rib morphology 2 | 28
abnormal sleep behavior 2 | 63
corneal opacity 2 | 25
decreased Ly6C high monocyte n... 2 | 18
decreased circulating LDL chol... 2 | 37
decreased circulating iron lev... 2 | 25
decreased circulating potassiu... 2 | 17
decreased erythrocyte cell num... 2 | 43
decreased grip strength 2 | 123
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
decreased monocyte cell number 2 | 28
improved glucose tolerance 2 | 56
increased bone mineral content 2 | 92
increased circulating alkaline... 2 | 119
increased circulating aspartat... 2 | 17
increased exploration in new e... 2 | 56
increased gamma-delta T cell n... 2 | 16
increased mean corpuscular hem... 2 | 25
increased or absent threshold ... 2 | 128
increased red blood cell distr... 2 | 21
increased sacral vertebrae num... 2 | 62
vertebral transformation 2 | 12
abnormal cranium morphology 1 | 32
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal respiratory quotient 1 | 9
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
decreased CD4-positive, alpha ... 1 | 19
decreased cardiac muscle contr... 1 | 5
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased red blood cell distr... 1 | 11
decreased thoracic vertebrae n... 1 | 7
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
hydrometra 1 | 13
increased CD4-positive, CD25-p... 1 | 18
increased KLRG1+ CD4 alpha bet... 1 | 5
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased circulating HDL chol... 1 | 63
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased effector memory CD4-... 1 | 15
increased mean platelet volume 1 | 19
increased rib number 1 | 41
increased startle reflex 1 | 38
premature death 1 | 5
small thymus 1 | 11
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 246 | 8,491
osteosarcoma 204 | 7,933
psoriasis 145 | 6,685
medulloblastoma, large-cell 139 | 6,234
glioblastoma 138 | 5,572
lung cancer 131 | 4,473
atypical teratoid / rhabdoid tumor 108 | 4,369
Breast cancer 93 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 92 | 3,289
malignant mesothelioma 75 | 3,163
non-small cell lung cancer 75 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 74 | 2,988
lung adenocarcinoma 70 | 2,714
oligodendroglioma 69 | 2,849
invasive ductal carcinoma 68 | 2,950
astrocytic glioma 66 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 65 | 2,956
pancreatic cancer 65 | 2,300
Cancer 63 | 2,346
Multiple myeloma 62 | 1,327
ependymoma 62 | 2,514
group 3 medulloblastoma 62 | 2,254
primitive neuroectodermal tumor 61 | 3,031
subependymal giant cell astrocytoma 57 | 2,287
lung carcinoma 54 | 2,844
pediatric high grade glioma 54 | 2,712
ductal carcinoma in situ 53 | 1,745
pilocytic astrocytoma 53 | 3,086
breast carcinoma 52 | 1,614
adrenocortical carcinoma 50 | 1,427
group 4 medulloblastoma 48 | 1,875
pituitary cancer 48 | 1,972
astrocytoma 47 | 1,493
primary pancreatic ductal adenocarcinoma 47 | 1,271
pancreatic ductal adenocarcinoma liver metastasis 46 | 1,795
ulcerative colitis 45 | 2,087
colon cancer 44 | 1,475
diabetes mellitus 44 | 1,663
juvenile dermatomyositis 44 | 1,189
acute quadriplegic myopathy 43 | 1,157
adult high grade glioma 41 | 2,148
Pick disease 37 | 1,893
interstitial cystitis 37 | 2,299
nasopharyngeal carcinoma 36 | 1,056
Waldenstrons macroglobulinemia 35 | 764
dermatomyositis 35 | 966
non primary Sjogren syndrome sicca 34 | 840
posterior fossa group B ependymoma 34 | 1,530
Carcinoma 33 | 2,147
cystic fibrosis 33 | 1,670
posterior fossa group A ependymoma 32 | 1,511
spina bifida 32 | 1,064
tuberculosis 30 | 1,563
tuberculosis and treatment for 6 months 30 | 686
medulloblastoma 29 | 1,524
sonic hedgehog group medulloblastoma 28 | 1,482
acute myeloid leukemia 27 | 785
active Crohn's disease 25 | 918
atypical teratoid/rhabdoid tumor 24 | 1,095
esophageal adenocarcinoma 23 | 737
Duchenne muscular dystrophy 22 | 602
Amyotrophic Lateral Sclerosis 20 | 432
gastric carcinoma 20 | 832
Atopic dermatitis 18 | 944
Endometriosis 18 | 535
aldosterone-producing adenoma 18 | 664
cutaneous lupus erythematosus 18 | 1,056
gastric cancer 18 | 436
hepatocellular carcinoma 18 | 550
progressive supranuclear palsy 18 | 674
Rheumatoid Arthritis 16 | 1,170
IGA Glomerulonephritis 15 | 454
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
fibroadenoma 15 | 557
primary Sjogren syndrome 15 | 788
Alzheimer's disease 14 | 644
Mammary Neoplasms 14 | 410
Neurodegenerative disease 14 | 383
pancreatic carcinoma 14 | 567
Intellectual disability 12 | 573
interstitial lung disease 12 | 292
Hypertensive disease 11 | 193
Polycystic Ovary Syndrome 11 | 334
Prostatic Neoplasms 11 | 471
chronic rhinosinusitis 11 | 512
Acquired metabolic disease 10 | 267
Down syndrome 10 | 548
Mammary Neoplasms, Experimental 10 | 149
limb girdle muscular dystrophy 2A 10 | 156
non-small cell lung carcinoma 10 | 413
Animal Mammary Neoplasms 9 | 135
Becker muscular dystrophy 9 | 187
Crohn's disease 9 | 304
Kidney disease 9 | 397
Multiple Sclerosis 9 | 498
Myocardial Ischemia 9 | 169
mucosa-associated lymphoid tissue lymphoma 9 | 480
Schizophrenia 8 | 503
inflammatory breast cancer 8 | 404
nephrosclerosis 8 | 329

Tissue

Blood and immune system 408 | 17,994
Female tissues 408 | 18,646
Nervous System 408 | 18,560
Cardiovascular System 407 | 17,957
Digestive Tract 407 | 18,472
Endocrine System 407 | 18,511
Liver and Pancreas 407 | 18,135
Male tissues 407 | 17,968
Urinary Tract 407 | 18,443
Respiratory system 404 | 17,483
Skin and soft tissues 404 | 18,114

Target Family

Non-IDG 258 | 11,969
Enzyme 97 | 4,146
Transcription Factor 24 | 1,400
Kinase 12 | 634
Epigenetic 10 | 242
Transporter 8 | 473
Ion Channel 3 | 341
GPCR 2 | 408

Jensen-KB Tissue

Uterine cervix 414 | 414
Brain 7,307 | 7,307
Liver 4,987 | 4,987
Cervical carcinoma cell 4,914 | 4,914
Erythroleukemia cell 4,273 | 4,273
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,281 | 2,281
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 827 | 827
Muscle 721 | 721
Pronephros 714 | 714
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 569 | 569
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 225 | 225
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.7 122
Interferon-induced transmembrane protein 3 IFITM3 Tbio Non-IDG -1.87958 126.0 172
TELO2-interacting protein 1 homolog TTI1 Tbio Non-IDG -0.83395 6.09 63
Putative nuclear envelope pore membrane protein POM 121B POM121B Tdark Non-IDG 0.00000 0
Tumor suppressor p53-binding protein 1 TP53BP1 Tbio Epigenetic -2.65153 422.5 514
Metalloproteinase inhibitor 1 TIMP1 Tbio Enzyme -3.55219 3513.4 673
Histone lysine demethylase PHF8 PHF8 Tchem Epigenetic -1.45177 33.5 70
Cytochrome P450 1A1 CYP1A1 Tchem Non-IDG -3.53853 3553.5 340
Probable ATP-dependent RNA helicase DDX49 DDX49 Tdark Enzyme 1.11 0.08 78
Probable ATP-dependent RNA helicase DDX56 DDX56 Tbio Enzyme -0.74504 5.47 166