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Development Level

Tbio 348 | 11,651
Tdark 113 | 6,593
Tchem 46 | 1,388
Tclin 18 | 612

Collection

RFA-RM-18-021 11 | 328
Kinase: IDG Consortium (Target... 7 | 125
Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 34 | 979
preweaning lethality, incomple... 15 | 499
abnormal behavior 12 | 298
abnormal heart morphology 9 | 162
embryonic lethality prior to t... 9 | 278
enlarged heart 9 | 210
increased total body fat amoun... 9 | 134
abnormal embryo size 8 | 220
decreased hematocrit 8 | 46
hypoactivity 8 | 132
abnormal bone structure 7 | 187
abnormal lens morphology 7 | 81
decreased hemoglobin content 7 | 68
decreased lymphocyte cell numb... 7 | 83
decreased total body fat amoun... 7 | 207
decreased vertical activity 7 | 208
embryonic lethality prior to o... 7 | 239
increased lean body mass 7 | 172
increased startle reflex 7 | 112
cataract 6 | 92
decreased body weight 6 | 161
decreased bone mineral density 6 | 126
decreased erythrocyte cell num... 6 | 62
decreased prepulse inhibition 6 | 82
increased bone mineral content 6 | 108
increased circulating HDL chol... 6 | 80
increased mean corpuscular vol... 6 | 92
abnormal spleen morphology 5 | 55
decreased circulating glucose ... 5 | 126
decreased lean body mass 5 | 135
decreased mean corpuscular hem... 5 | 50
decreased mean corpuscular vol... 5 | 79
abnormal seminal vesicle morph... 4 | 114
abnormal skin morphology 4 | 50
decreased bone mineral content 4 | 151
decreased caudal vertebrae num... 4 | 53
decreased leukocyte cell numbe... 4 | 73
embryonic growth retardation 4 | 106
enlarged spleen 4 | 41
hydrometra 4 | 53
increased monocyte cell number 4 | 63
limb grasping 4 | 41
male infertility 4 | 123
abnormal coat-hair pigmentatio... 3 | 64
abnormal eye morphology 3 | 68
abnormal liver morphology 3 | 17
abnormal locomotor activation 3 | 16
abnormal retina morphology 3 | 71
decreased circulating insulin ... 3 | 76
decreased circulating iron lev... 3 | 32
decreased circulating triglyce... 3 | 79
decreased fasted circulating g... 3 | 65
decreased startle reflex 3 | 75
hyperactivity 3 | 148
impaired glucose tolerance 3 | 75
increased blood urea nitrogen ... 3 | 48
increased bone mineral density 3 | 72
increased circulating alkaline... 3 | 122
increased circulating amylase ... 3 | 25
increased circulating creatini... 3 | 38
increased circulating phosphat... 3 | 26
increased erythrocyte cell num... 3 | 39
increased hematocrit 3 | 46
increased leukocyte cell numbe... 3 | 47
increased lymphocyte cell numb... 3 | 32
increased neutrophil cell numb... 3 | 46
small superior vagus ganglion 3 | 74
abnormal coat appearance 2 | 31
abnormal epididymis morphology 2 | 42
abnormal startle reflex 2 | 15
decreased IgE level 2 | 6
decreased body length 2 | 101
decreased circulating creatini... 2 | 39
decreased circulating free fat... 2 | 31
decreased circulating phosphat... 2 | 27
decreased circulating serum al... 2 | 82
decreased circulating sodium l... 2 | 22
decreased circulating total pr... 2 | 49
decreased grip strength 2 | 116
decreased mean platelet volume 2 | 25
edema 2 | 59
enlarged epididymis 2 | 31
enlarged lymph nodes 2 | 37
enlarged urinary bladder 2 | 8
female infertility 2 | 60
increased body length 2 | 32
increased cardiac muscle contr... 2 | 8
increased circulating chloride... 2 | 41
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased heart rate variabili... 2 | 7
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased or absent threshold ... 2 | 101
pale yolk sac 2 | 25
short tibia 2 | 97
thin ventricular wall 2 | 24
thrombocytosis 2 | 27
tremors 2 | 39
vertebral fusion 2 | 23

Disease

Carcinoma 388 | 11,493
ovarian cancer 318 | 8,520
osteosarcoma 291 | 7,950
psoriasis 214 | 6,694
medulloblastoma, large-cell 203 | 6,241
glioblastoma 198 | 5,792
atypical teratoid / rhabdoid tumor 169 | 5,112
lung cancer 167 | 4,740
ependymoma 163 | 4,679
Breast cancer 140 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 140 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 138 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 122 | 2,989
adult high grade glioma 121 | 3,801
non-small cell lung cancer 117 | 2,890
malignant mesothelioma 115 | 3,232
invasive ductal carcinoma 112 | 2,951
group 3 medulloblastoma 109 | 4,104
lung adenocarcinoma 107 | 2,716
oligodendroglioma 105 | 2,850
interstitial cystitis 104 | 2,312
Astrocytoma, Pilocytic 102 | 3,081
lung carcinoma 102 | 2,843
pancreatic cancer 101 | 2,398
Kidney cancer 93 | 2,613
primitive neuroectodermal tumor 93 | 3,035
astrocytic glioma 92 | 2,597
subependymal giant cell astrocytoma 82 | 2,287
Cancer 80 | 2,499
group 4 medulloblastoma 80 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 79 | 1,962
pituitary cancer 78 | 1,972
cystic fibrosis 75 | 1,696
tuberculosis 75 | 2,010
Pick disease 73 | 1,894
ductal carcinoma in situ 70 | 1,745
ulcerative colitis 69 | 1,819
juvenile dermatomyositis 60 | 1,187
acute quadriplegic myopathy 59 | 1,158
spina bifida 56 | 1,074
nasopharyngeal carcinoma 54 | 1,058
breast carcinoma 53 | 1,638
adrenocortical carcinoma 52 | 1,428
diabetes mellitus 51 | 1,728
colon cancer 50 | 1,478
Multiple myeloma 48 | 1,332
Rheumatoid arthritis 48 | 1,191
primary pancreatic ductal adenocarcinoma 42 | 1,109
astrocytoma 41 | 1,146
cutaneous lupus erythematosus 41 | 1,057
pediatric high grade glioma 39 | 1,064
active Crohn's disease 38 | 922
chronic rhinosinusitis 36 | 512
active ulcerative colitis 34 | 764
Atopic dermatitis 33 | 952
Autosomal recessive predisposition 33 | 1,442
Schizophrenia 33 | 1,160
hepatocellular carcinoma 33 | 547
Waldenstrons macroglobulinemia 32 | 765
acute myeloid leukemia 32 | 783
aldosterone-producing adenoma 32 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 31 | 510
dermatomyositis 31 | 966
primary Sjogren syndrome 31 | 735
Intellectual disability 29 | 1,016
gastric carcinoma 29 | 807
progressive supranuclear palsy 29 | 676
fibroadenoma 26 | 559
medulloblastoma 26 | 720
pancreatic carcinoma 26 | 562
esophageal adenocarcinoma 25 | 737
gastric cancer 24 | 459
mucosa-associated lymphoid tissue lymphoma 24 | 484
Duchenne muscular dystrophy 23 | 601
Liver Cirrhosis, Experimental 23 | 769
Alzheimer's disease 22 | 658
Down syndrome 22 | 499
Bipolar Disorder 21 | 666
Melanoma 21 | 711
non primary Sjogren syndrome sicca 21 | 891
Dull intelligence 20 | 645
Low intelligence 20 | 645
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Poor school performance 20 | 645
head and neck cancer 20 | 271
tuberculosis and treatment for 6 months 20 | 409
Obesity 19 | 678
Amyotrophic lateral sclerosis 18 | 451
Endometriosis 18 | 540
Hypertension 18 | 396
Muscle hypotonia 18 | 571
non-small cell lung carcinoma 18 | 317
sonic hedgehog group medulloblastoma 18 | 467
Epilepsy 17 | 792
hereditary spastic paraplegia 17 | 318
Asthma 16 | 385
Osteoporosis 16 | 363
posterior fossa group B ependymoma 16 | 416
sarcoidosis 16 | 370

Tissue

Female tissues 521 | 17,400
Digestive Tract 518 | 17,369
Endocrine System 517 | 18,159
Skin and soft tissues 517 | 17,230
Male tissues 516 | 17,142
Liver and Pancreas 513 | 16,750
Blood and immune system 512 | 16,909
Respiratory system 512 | 16,393
Urinary Tract 512 | 16,678
Nervous System 504 | 16,725
Cardiovascular System 486 | 15,192

Target Family

Non-IDG 297 | 12,091
Enzyme 118 | 4,145
Transcription Factor 39 | 1,400
Transporter 22 | 473
Kinase 20 | 634
Ion Channel 9 | 344
Epigenetic 8 | 242
GPCR 8 | 408
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38

Jensen-KB Tissue

Trachea 525 | 525
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Zinc finger protein 561 ZNF561 Tdark Transcription Factor 0.00000 36
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Nephronectin NPNT Tbio Non-IDG -1.54450 37.2 104
Cysteine-rich secretory protein 3 CRISP3 Tbio Non-IDG -1.58618 43.2 129
Dual oxidase 1 DUOX1 Tbio Enzyme -2.50131 279.5 85
Protein crumbs homolog 3 CRB3 Tbio Non-IDG -1.22596 16.1 79