Development Level

Tbio 92 | 11,445
Tdark 27 | 6,588
Tchem 17 | 1,598
Tclin 8 | 613

Collection

GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Target... 2 | 125
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
decreased bone mineral content 3 | 151
decreased red blood cell distr... 3 | 41
embryonic lethality prior to t... 3 | 278
abnormal bone structure 2 | 187
abnormal epididymis morphology 2 | 42
abnormal seminal vesicle morph... 2 | 114
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased lean body mass 2 | 135
decreased mean corpuscular hem... 2 | 50
decreased total body fat amoun... 2 | 207
enlarged epididymis 2 | 31
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
prenatal lethality prior to he... 2 | 87
thrombocytopenia 2 | 56
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal eyelid morphology 1 | 7
abnormal femur morphology 1 | 14
abnormal hair growth 1 | 10
abnormal head morphology 1 | 10
abnormal humerus morphology 1 | 11
abnormal iris pigmentation 1 | 4
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal male genitalia morpho... 1 | 3
abnormal radius morphology 1 | 8
abnormal response to tactile s... 1 | 17
abnormal retinal blood vessel ... 1 | 26
abnormal sensory capabilities-... 1 | 8
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vertebral arch morpho... 1 | 9
absent pinna reflex 1 | 23
cataract 1 | 92
corneal opacity 1 | 32
decreased brain size 1 | 4
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating potassiu... 1 | 20
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased food intake 1 | 13
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
fusion of vertebral arches 1 | 7
impaired righting response 1 | 26
increased body length 1 | 32
increased body weight 1 | 25
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
pale yolk sac 1 | 25
pallor 1 | 34
polysyndactyly 1 | 2
prolonged QRS complex duration 1 | 8
small heart 1 | 10
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
small stomach 1 | 3
small thymus 1 | 16
unresponsive to tactile stimul... 1 | 8
vertebral transformation 1 | 12

Disease

Carcinoma 94 | 11,493
osteosarcoma 71 | 7,950
ovarian cancer 61 | 8,520
psoriasis 60 | 6,694
atypical teratoid / rhabdoid tumor 43 | 5,112
medulloblastoma, large-cell 42 | 6,241
glioblastoma 40 | 5,792
ependymoma 37 | 4,679
lung adenocarcinoma 32 | 2,716
lung cancer 32 | 4,740
malignant mesothelioma 31 | 3,232
Astrocytoma, Pilocytic 30 | 3,081
non-small cell lung cancer 30 | 2,890
invasive ductal carcinoma 28 | 2,951
lung carcinoma 28 | 2,843
Breast cancer 27 | 3,578
Kidney cancer 27 | 2,613
adult high grade glioma 27 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
group 3 medulloblastoma 25 | 4,104
ductal carcinoma in situ 24 | 1,745
oligodendroglioma 24 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
astrocytic glioma 22 | 2,597
Cancer 20 | 2,499
pancreatic cancer 20 | 2,398
primitive neuroectodermal tumor 20 | 3,035
breast carcinoma 19 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
interstitial cystitis 18 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
pituitary cancer 16 | 1,972
acute quadriplegic myopathy 15 | 1,158
Autosomal recessive predisposition 14 | 1,442
adrenocortical carcinoma 14 | 1,428
colon cancer 14 | 1,478
nasopharyngeal carcinoma 14 | 1,058
subependymal giant cell astrocytoma 14 | 2,287
diabetes mellitus 13 | 1,728
Hypothyroidism 12 | 122
cystic fibrosis 12 | 1,696
group 4 medulloblastoma 12 | 1,855
juvenile dermatomyositis 12 | 1,187
spina bifida 12 | 1,074
Intellectual disability 11 | 1,016
active Crohn's disease 11 | 922
Endometriosis 10 | 540
aldosterone-producing adenoma 10 | 665
Congenital hypothyroidism 9 | 26
Constipation 9 | 181
Goiter 9 | 38
Muscle hypotonia 9 | 571
Short stature 9 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
dermatomyositis 9 | 966
primary pancreatic ductal adenocarcinoma 9 | 1,109
tuberculosis 9 | 2,010
Cognitive delay 8 | 608
Duchenne muscular dystrophy 8 | 601
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Multiple myeloma 8 | 1,332
Pick disease 8 | 1,894
active ulcerative colitis 8 | 764
non primary Sjogren syndrome sicca 8 | 891
ulcerative colitis 8 | 1,819
Atopic dermatitis 7 | 952
Dull intelligence 7 | 645
Dyschezia 7 | 135
Fatigue 7 | 182
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
chronic rhinosinusitis 7 | 512
medulloblastoma 7 | 720
pediatric high grade glioma 7 | 1,064
primary Sjogren syndrome 7 | 735
Abdomen distended 6 | 43
Autoimmune thyroiditis 6 | 27
Coarse facial features 6 | 108
Graves' disease 6 | 24
Hypersomnia 6 | 8
Icterus 6 | 82
Kidney disease 6 | 430
Large bregma sutures 6 | 46
Large fontanelle 6 | 46
Large, late-closing fontanelle 6 | 46
Liver Cirrhosis, Experimental 6 | 769
Macroglossia 6 | 65
Papillary thyroid carcinoma 6 | 43
Prostatic Neoplasms 6 | 495
Schizophrenia 6 | 1,160
Thickened facial skin with coarse facial features 6 | 108
Thyroid Dyshormonogenesis 1 6 | 6
Wide bregma sutures 6 | 46
acute myeloid leukemia 6 | 783
astrocytoma 6 | 1,146
fibroadenoma 6 | 559
Rheumatoid arthritis 5 | 1,191

Tissue

Digestive Tract 142 | 17,369
Endocrine System 142 | 18,159
Female tissues 142 | 17,400
Skin and soft tissues 141 | 17,230
Liver and Pancreas 140 | 16,750
Blood and immune system 139 | 16,909
Male tissues 136 | 17,142
Urinary Tract 135 | 16,678
Respiratory system 134 | 16,393
Cardiovascular System 133 | 15,192
Nervous System 131 | 16,725

Target Family

Non-IDG 68 | 12,091
Enzyme 42 | 4,145
Epigenetic 7 | 242
Transporter 7 | 473
Kinase 6 | 634
Transcription Factor 6 | 1,400
GPCR 5 | 408
Ion Channel 2 | 344
TF/Epigenetic 1 | 38

Jensen-KB Tissue

Thyroid gland 144 | 144
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exportin-6 XPO6 Tbio Non-IDG -1.53980 34.5 29
Poly(ADP-ribose) glycohydrolase ARH3 ADPRHL2 Tbio Enzyme -0.95745 8.60 94
Pyridoxine-5'-phosphate oxidase PNPO Tchem Enzyme -1.95803 90.7 200
Dipeptidyl peptidase 1 CTSC Tchem Enzyme -3.27566 1855.5 168
Protein FAM83A FAM83A Tbio Non-IDG -0.95889 9.55 63
Zinc finger protein 385A ZNF385A Tbio Non-IDG -0.03141 1.24 99
Probable E3 ubiquitin-protein ligase DTX2 DTX2 Tbio Enzyme -1.74890 58.1 123
Uridine diphosphate glucose pyrophosphatase NUDT14 Tdark Enzyme -0.67608 5.47 45
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase PKMYT1 Tchem Kinase -1.27237 19.2 364
Sigma non-opioid intracellular receptor 1 SIGMAR1 Tclin Non-IDG -2.28907 210.0 143