Development Level

Tbio 90 | 10,625
Tdark 29 | 7,003
Tchem 17 | 1,890
Tclin 8 | 602

Collection

Eligible Kinase Proteins 2 | 134
Eligible non-olfactory GPCR Proteins 2 | 143
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 4 | 633
increased circulating alkaline... 2 | 119
prenatal lethality prior to he... 2 | 64
abnormal behavior 1 | 226
abnormal clavicle morphology 1 | 5
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 5
abnormal humerus morphology 1 | 11
abnormal iris morphology 1 | 12
abnormal iris pigmentation 1 | 3
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal radius morphology 1 | 8
abnormal response to tactile s... 1 | 16
abnormal spleen morphology 1 | 36
abnormal thoracic cage shape 1 | 3
abnormal thoracic vertebrae mo... 1 | 16
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
abnormal vertebral arch morpho... 1 | 9
abnormal zygomatic bone morpho... 1 | 3
corneal opacity 1 | 25
decreased B cell number 1 | 30
decreased CD4-positive, CD25-p... 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased NK cell number 1 | 16
decreased bone mineral content 1 | 157
decreased brain size 1 | 4
decreased caudal vertebrae num... 1 | 49
decreased circulating potassiu... 1 | 17
decreased circulating triglyce... 1 | 83
decreased effector memory T-he... 1 | 2
decreased gamma-delta T cell n... 1 | 18
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased mature B cell number 1 | 25
decreased memory CD4-positive,... 1 | 1
decreased memory-marker gamma-... 1 | 1
decreased monocyte cell number 1 | 28
decreased rib number 1 | 59
decreased spleen weight 1 | 13
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
fusion of vertebral arches 1 | 7
increased B cell number 1 | 23
increased CD4-positive, CD25-p... 1 | 18
increased CD4-positive, alpha ... 1 | 15
increased CD8-positive, alpha-... 1 | 11
increased CD8-positive, naive ... 1 | 3
increased Ly6C high monocyte n... 1 | 12
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased eosinophil cell numb... 1 | 9
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased memory-marker gamma-... 1 | 2
increased neutrophil cell numb... 1 | 15
no abnormal phenotype detected 1 | 3
polysyndactyly 1 | 2
small heart 1 | 8
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 11
small stomach 1 | 3
small thymus 1 | 11
thrombocytopenia 1 | 46
vertebral transformation 1 | 12

Disease

osteosarcoma 71 | 7,933
ovarian cancer 61 | 8,484
psoriasis 60 | 6,685
medulloblastoma, large-cell 42 | 6,234
glioblastoma 38 | 5,572
atypical teratoid / rhabdoid tumor 34 | 4,369
lung adenocarcinoma 32 | 2,713
lung cancer 31 | 4,466
malignant mesothelioma 30 | 3,162
non-small cell lung cancer 30 | 2,798
pilocytic astrocytoma 30 | 3,086
invasive ductal carcinoma 28 | 2,950
lung carcinoma 28 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,289
ductal carcinoma in situ 24 | 1,745
oligodendroglioma 24 | 2,849
Carcinoma 23 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,795
astrocytic glioma 20 | 2,241
ependymoma 20 | 2,514
pancreatic cancer 20 | 2,300
primitive neuroectodermal tumor 20 | 3,031
Breast cancer 19 | 3,094
Cancer 19 | 2,346
breast carcinoma 19 | 1,614
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
interstitial cystitis 18 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
adult high grade glioma 17 | 2,148
pediatric high grade glioma 17 | 2,712
pituitary cancer 16 | 1,972
acute quadriplegic myopathy 15 | 1,157
adrenocortical carcinoma 14 | 1,427
colon cancer 14 | 1,475
group 4 medulloblastoma 14 | 1,875
nasopharyngeal carcinoma 14 | 1,056
subependymal giant cell astrocytoma 14 | 2,287
atypical teratoid/rhabdoid tumor 13 | 1,095
posterior fossa group B ependymoma 13 | 1,530
Hypothyroidism 12 | 89
cystic fibrosis 12 | 1,665
diabetes mellitus 12 | 1,663
group 3 medulloblastoma 12 | 2,254
juvenile dermatomyositis 12 | 1,189
spina bifida 12 | 1,064
ulcerative colitis 12 | 2,087
active Crohn's disease 11 | 918
medulloblastoma 11 | 1,524
primary pancreatic ductal adenocarcinoma 11 | 1,271
Endometriosis 10 | 535
aldosterone-producing adenoma 10 | 664
posterior fossa group A ependymoma 10 | 1,511
sonic hedgehog group medulloblastoma 10 | 1,482
Goiter 9 | 27
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 499
dermatomyositis 9 | 933
Congenital hypothyroidism 8 | 20
Pick disease 8 | 1,893
astrocytoma 8 | 1,493
non primary Sjogren syndrome sicca 8 | 840
tuberculosis 8 | 1,557
Atopic dermatitis 7 | 944
Duchenne muscular dystrophy 7 | 602
Multiple myeloma 7 | 1,327
chronic rhinosinusitis 7 | 512
primary Sjogren syndrome 7 | 789
Graves' disease 6 | 25
Papillary thyroid carcinoma 6 | 37
acute myeloid leukemia 6 | 780
fibroadenoma 6 | 557
gastric carcinoma 6 | 832
inflammatory breast cancer 6 | 404
Autoimmune thyroiditis 5 | 24
Hypertension 5 | 287
Kidney disease 5 | 396
Prostatic Neoplasms 5 | 471
Rheumatoid Arthritis 5 | 1,160
Waldenstrons macroglobulinemia 5 | 765
esophageal adenocarcinoma 5 | 737
Adenoma 4 | 165
Atherosclerosis 4 | 275
Polycystic Ovary Syndrome 4 | 332
Prostate cancer 4 | 172
Thyrotoxicosis 4 | 38
Vascular disease 4 | 281
active ulcerative colitis 4 | 477
cutaneous lupus erythematosus 4 | 1,056
cystic fibrosis and chronic rhinosinusitis 4 | 213
gastric cancer 4 | 430
hepatocellular carcinoma 4 | 532
interstitial lung disease 4 | 291
sarcoidosis 4 | 358
tuberculosis and treatment for 3 months 4 | 327
uncontrolled asthma 4 | 67
urothelial carcinoma 4 | 318
Down syndrome 3 | 548
Myocardial Ischemia 3 | 169
Schizophrenia 3 | 501
mucosa-associated lymphoid tissue lymphoma 3 | 480
progressive supranuclear palsy 3 | 674

Tissue

Digestive Tract 143 | 18,473
Endocrine System 143 | 18,512
Female tissues 142 | 18,647
Liver and Pancreas 142 | 18,136
Nervous System 142 | 18,561
Skin and soft tissues 142 | 18,115
Cardiovascular System 141 | 17,958
Urinary Tract 140 | 18,444
Blood and immune system 139 | 17,995
Male tissues 139 | 17,969
Respiratory system 139 | 17,484

Target Family

Non-IDG 68 | 11,971
Enzyme 42 | 4,146
Epigenetic 7 | 242
Transporter 7 | 473
Kinase 6 | 634
Transcription Factor 6 | 1,400
GPCR 5 | 406
Ion Channel 2 | 341
TF/Epigenetic 1 | 38

Jensen-KB Tissue

Thyroid gland 144 | 144
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Pyrroline-5-carboxylate reductase 3 PYCRL Tbio Enzyme 0.14 0.58 97
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 Tchem Enzyme -1.31042 21.3 114
Follicular dendritic cell secreted peptide FDCSP Tbio Non-IDG -0.86544 12.0 46
MICAL C-terminal-like protein MICALCL Tdark Non-IDG -0.12494 1.47 50
All-trans-retinol 13,14-reductase RETSAT Tdark Enzyme -0.66366 5.73 8
Autophagy-related protein 13 ATG13 Tbio Non-IDG -1.41149 24.1 305
A-kinase anchor protein 5 AKAP5 Tbio Enzyme -2.04275 121.6 174
Very-long-chain 3-oxoacyl-CoA reductase HSD17B12 Tbio Enzyme -1.34964 31.9 103
Nostrin NOSTRIN Tbio Non-IDG -1.03381 13.4 106