Development Level

Tbio 90 | 10,625
Tdark 29 | 7,003
Tchem 17 | 1,890
Tclin 8 | 602

Collection

GPCR: IDG Consortium (Targets) 2 | 128
Kinase: IDG Consortium (Targets) 2 | 125
Ion Channel: IDG Consortium (Targets) 1 | 102
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 4 | 633
increased circulating alkaline... 2 | 119
prenatal lethality prior to he... 2 | 64
abnormal behavior 1 | 226
abnormal clavicle morphology 1 | 5
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 5
abnormal humerus morphology 1 | 11
abnormal iris morphology 1 | 12
abnormal iris pigmentation 1 | 3
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal radius morphology 1 | 8
abnormal response to tactile s... 1 | 16
abnormal spleen morphology 1 | 36
abnormal thoracic cage shape 1 | 3
abnormal thoracic vertebrae mo... 1 | 16
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
abnormal vertebral arch morpho... 1 | 9
abnormal zygomatic bone morpho... 1 | 3
corneal opacity 1 | 25
decreased B cell number 1 | 30
decreased CD4-positive, CD25-p... 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased NK cell number 1 | 16
decreased bone mineral content 1 | 157
decreased brain size 1 | 4
decreased caudal vertebrae num... 1 | 49
decreased circulating potassiu... 1 | 17
decreased circulating triglyce... 1 | 83
decreased effector memory T-he... 1 | 2
decreased gamma-delta T cell n... 1 | 18
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased mature B cell number 1 | 25
decreased memory CD4-positive,... 1 | 1
decreased memory-marker gamma-... 1 | 1
decreased monocyte cell number 1 | 28
decreased rib number 1 | 59
decreased spleen weight 1 | 13
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
fusion of vertebral arches 1 | 7
increased B cell number 1 | 23
increased CD4-positive, CD25-p... 1 | 18
increased CD4-positive, alpha ... 1 | 15
increased CD8-positive, alpha-... 1 | 11
increased CD8-positive, naive ... 1 | 3
increased Ly6C high monocyte n... 1 | 12
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased eosinophil cell numb... 1 | 9
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased memory-marker gamma-... 1 | 2
increased neutrophil cell numb... 1 | 15
no abnormal phenotype detected 1 | 3
polysyndactyly 1 | 2
small heart 1 | 8
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 11
small stomach 1 | 3
small thymus 1 | 11
thrombocytopenia 1 | 46
vertebral transformation 1 | 12

Disease

osteosarcoma 71 | 7,933
ovarian cancer 61 | 8,491
psoriasis 60 | 6,685
medulloblastoma, large-cell 42 | 6,234
glioblastoma 38 | 5,572
atypical teratoid / rhabdoid tumor 34 | 4,369
lung adenocarcinoma 32 | 2,714
lung cancer 31 | 4,473
malignant mesothelioma 30 | 3,163
non-small cell lung cancer 30 | 2,798
pilocytic astrocytoma 30 | 3,086
invasive ductal carcinoma 28 | 2,950
lung carcinoma 28 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,289
ductal carcinoma in situ 24 | 1,745
oligodendroglioma 24 | 2,849
Carcinoma 23 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,795
astrocytic glioma 20 | 2,241
ependymoma 20 | 2,514
pancreatic cancer 20 | 2,300
primitive neuroectodermal tumor 20 | 3,031
Breast cancer 19 | 3,098
Cancer 19 | 2,346
breast carcinoma 19 | 1,614
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
interstitial cystitis 18 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
adult high grade glioma 17 | 2,148
pediatric high grade glioma 17 | 2,712
pituitary cancer 16 | 1,972
acute quadriplegic myopathy 15 | 1,157
adrenocortical carcinoma 14 | 1,427
colon cancer 14 | 1,475
group 4 medulloblastoma 14 | 1,875
nasopharyngeal carcinoma 14 | 1,056
subependymal giant cell astrocytoma 14 | 2,287
atypical teratoid/rhabdoid tumor 13 | 1,095
posterior fossa group B ependymoma 13 | 1,530
Hypothyroidism 12 | 89
cystic fibrosis 12 | 1,670
diabetes mellitus 12 | 1,663
group 3 medulloblastoma 12 | 2,254
juvenile dermatomyositis 12 | 1,189
spina bifida 12 | 1,064
ulcerative colitis 12 | 2,087
active Crohn's disease 11 | 918
medulloblastoma 11 | 1,524
primary pancreatic ductal adenocarcinoma 11 | 1,271
Endometriosis 10 | 535
aldosterone-producing adenoma 10 | 664
posterior fossa group A ependymoma 10 | 1,511
sonic hedgehog group medulloblastoma 10 | 1,482
Goiter 9 | 27
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 499
dermatomyositis 9 | 966
Congenital hypothyroidism 8 | 20
Pick disease 8 | 1,893
astrocytoma 8 | 1,493
non primary Sjogren syndrome sicca 8 | 840
tuberculosis 8 | 1,563
Atopic dermatitis 7 | 944
Duchenne muscular dystrophy 7 | 602
Multiple myeloma 7 | 1,327
chronic rhinosinusitis 7 | 512
primary Sjogren syndrome 7 | 788
Graves' disease 6 | 25
Papillary thyroid carcinoma 6 | 37
Thyroid Dyshormonogenesis 1 6 | 6
acute myeloid leukemia 6 | 785
fibroadenoma 6 | 557
gastric carcinoma 6 | 832
inflammatory breast cancer 6 | 404
Autoimmune thyroiditis 5 | 24
Hypertension 5 | 293
Kidney disease 5 | 397
Prostatic Neoplasms 5 | 471
Rheumatoid Arthritis 5 | 1,170
Waldenstrons macroglobulinemia 5 | 764
esophageal adenocarcinoma 5 | 737
Adenoma 4 | 165
Atherosclerosis 4 | 275
Polycystic Ovary Syndrome 4 | 334
Prostate cancer 4 | 172
Thyrotoxicosis 4 | 38
Vascular disease 4 | 281
active ulcerative colitis 4 | 477
cutaneous lupus erythematosus 4 | 1,056
cystic fibrosis and chronic rhinosinusitis 4 | 213
gastric cancer 4 | 436
hepatocellular carcinoma 4 | 550
interstitial lung disease 4 | 292
sarcoidosis 4 | 368
tuberculosis and treatment for 3 months 4 | 327
uncontrolled asthma 4 | 67
urothelial carcinoma 4 | 318
Down syndrome 3 | 548
Myocardial Ischemia 3 | 169
Schizophrenia 3 | 503
mucosa-associated lymphoid tissue lymphoma 3 | 480

Tissue

Digestive Tract 143 | 18,472
Endocrine System 143 | 18,511
Female tissues 142 | 18,646
Liver and Pancreas 142 | 18,135
Nervous System 142 | 18,560
Skin and soft tissues 142 | 18,114
Cardiovascular System 141 | 17,957
Urinary Tract 140 | 18,443
Blood and immune system 139 | 17,994
Male tissues 139 | 17,968
Respiratory system 139 | 17,483

Target Family

Non-IDG 68 | 11,969
Enzyme 42 | 4,146
Epigenetic 7 | 242
Transporter 7 | 473
Kinase 6 | 634
Transcription Factor 6 | 1,400
GPCR 5 | 408
Ion Channel 2 | 341
TF/Epigenetic 1 | 38

Jensen-KB Tissue

Thyroid gland 144 | 144
Brain 7,307 | 7,307
Liver 4,987 | 4,987
Cervical carcinoma cell 4,914 | 4,914
Erythroleukemia cell 4,273 | 4,273
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,281 | 2,281
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 827 | 827
Muscle 721 | 721
Pronephros 714 | 714
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 569 | 569
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 225 | 225
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein fosB FOSB Tbio Transcription Factor -2.64139 409.7 306
Actin-binding protein IPP IPP Tdark Non-IDG -2.89711 782.9 29
Pyridoxine-5'-phosphate oxidase PNPO Tchem Enzyme -1.92404 83.6 160
Dipeptidyl peptidase 1 CTSC Tchem Enzyme -3.24582 1740.5 143
Cystatin-S CST4 Tbio Non-IDG -1.82088 50.6 143
Pendrin SLC26A4 Tbio Transporter -2.65903 426.8 96
A-kinase anchor protein 13 AKAP13 Tbio Enzyme -2.43559 267.5 129
X-ray repair cross-complementing protein 5 XRCC5 Tbio Non-IDG -2.67147 456.7 712
Histatin-3 HTN3 Tbio Non-IDG -2.65588 410.6 7
Calcyphosin CAPS Tbio Non-IDG -1.21228 16.6 74