Development Level

Tbio 2,176 | 10,625
Tdark 1,287 | 7,003
Tchem 345 | 1,890
Tclin 54 | 602

Collection

Eligible Kinase Proteins 49 | 134
Eligible Ion Channel Proteins 14 | 117
Eligible non-olfactory GPCR Proteins 13 | 143

IMPC Term

preweaning lethality, complete... 156 | 633
preweaning lethality, incomple... 62 | 260
abnormal behavior 51 | 226
decreased body weight 47 | 174
decreased lean body mass 47 | 195
decreased bone mineral content 41 | 157
embryonic lethality prior to t... 41 | 187
decreased total body fat amoun... 36 | 186
decreased grip strength 31 | 123
increased or absent threshold ... 31 | 128
embryonic lethality prior to o... 30 | 148
abnormal bone structure 29 | 131
abnormal embryo size 25 | 112
increased grip strength 25 | 83
increased lean body mass 25 | 107
increased circulating HDL chol... 24 | 63
increased circulating alkaline... 24 | 119
male infertility 24 | 62
decreased body length 23 | 108
decreased circulating glucose ... 23 | 121
hyperactivity 23 | 108
decreased bone mineral density 22 | 126
increased bone mineral content 22 | 92
enlarged heart 21 | 111
hypoactivity 21 | 89
short tibia 21 | 82
abnormal retina morphology 20 | 100
increased mean corpuscular hem... 20 | 93
decreased circulating choleste... 19 | 85
decreased circulating serum al... 19 | 79
increased mean corpuscular vol... 19 | 91
decreased lumbar vertebrae num... 17 | 62
increased circulating choleste... 17 | 53
abnormal lens morphology 16 | 73
increased exploration in new e... 16 | 56
increased sacral vertebrae num... 16 | 62
decreased circulating triglyce... 15 | 83
decreased leukocyte cell numbe... 15 | 54
impaired glucose tolerance 15 | 52
thrombocytopenia 15 | 46
decreased circulating alanine ... 14 | 53
increased total body fat amoun... 14 | 57
prenatal lethality prior to he... 14 | 64
abnormal bone mineralization 13 | 55
abnormal gait 13 | 51
abnormal retinal pigmentation 13 | 61
decreased caudal vertebrae num... 13 | 49
decreased hemoglobin content 13 | 53
decreased mean corpuscular vol... 13 | 50
improved glucose tolerance 13 | 56
increased bone mineral density 13 | 52
increased fasted circulating g... 13 | 68
abnormal heart morphology 12 | 51
decreased circulating insulin ... 12 | 75
decreased eosinophil cell numb... 12 | 41
decreased erythrocyte cell num... 12 | 43
decreased rib number 12 | 59
abnormal spleen morphology 11 | 36
decreased circulating HDL chol... 11 | 77
decreased fasted circulating g... 11 | 49
increased hemoglobin content 11 | 45
abnormal sleep behavior 10 | 63
cardiovascular system phenotyp... 10 | 35
decreased circulating aspartat... 10 | 27
decreased mean corpuscular hem... 10 | 34
decreased prepulse inhibition 10 | 52
abnormal behavioral response t... 9 | 52
abnormal cranium morphology 9 | 32
abnormal vocalization 9 | 21
decreased B cell number 9 | 30
decreased CD4-positive, CD25-p... 9 | 24
decreased circulating free fat... 9 | 39
decreased heart weight 9 | 44
enlarged lymph nodes 9 | 27
increased circulating sodium l... 9 | 71
increased heart weight 9 | 37
increased leukocyte cell numbe... 9 | 37
polydactyly 9 | 22
small testis 9 | 37
abnormal seminal vesicle morph... 8 | 47
decreased circulating total pr... 8 | 41
decreased hematocrit 8 | 25
decreased neutrophil cell numb... 8 | 37
enlarged spleen 8 | 26
female infertility 8 | 34
increased body weight 8 | 42
increased circulating serum al... 8 | 25
limb grasping 8 | 35
abnormal coat/hair pigmentatio... 7 | 54
absent pinna reflex 7 | 21
decreased CD8-positive, alpha-... 7 | 26
decreased circulating LDL chol... 7 | 37
decreased circulating creatini... 7 | 31
decreased monocyte cell number 7 | 28
decreased threshold for audito... 7 | 32
embryonic growth retardation 7 | 28
increased body length 7 | 20
increased circulating glucose ... 7 | 16
increased rib number 7 | 41
tremors 7 | 34

Disease

ovarian cancer 1,868 | 8,484
osteosarcoma 1,760 | 7,933
medulloblastoma, large-cell 1,326 | 6,234
psoriasis 1,250 | 6,685
glioblastoma 1,133 | 5,572
atypical teratoid / rhabdoid tumor 899 | 4,369
lung cancer 879 | 4,466
Breast cancer 684 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 663 | 3,289
primitive neuroectodermal tumor 662 | 3,031
malignant mesothelioma 635 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 590 | 2,956
oligodendroglioma 589 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 588 | 2,988
invasive ductal carcinoma 574 | 2,950
pilocytic astrocytoma 549 | 3,086
ependymoma 545 | 2,514
Carcinoma 519 | 2,147
non-small cell lung cancer 519 | 2,798
pediatric high grade glioma 508 | 2,712
lung adenocarcinoma 493 | 2,713
astrocytic glioma 476 | 2,241
group 3 medulloblastoma 476 | 2,254
lung carcinoma 455 | 2,844
Pick disease 450 | 1,893
adult high grade glioma 429 | 2,148
subependymal giant cell astrocytoma 415 | 2,287
group 4 medulloblastoma 412 | 1,875
pancreatic cancer 404 | 2,300
Cancer 400 | 2,346
posterior fossa group B ependymoma 386 | 1,530
pituitary cancer 380 | 1,972
ulcerative colitis 357 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 336 | 1,795
ductal carcinoma in situ 333 | 1,745
interstitial cystitis 332 | 2,299
adrenocortical carcinoma 311 | 1,427
sonic hedgehog group medulloblastoma 311 | 1,482
medulloblastoma 310 | 1,524
breast carcinoma 289 | 1,614
tuberculosis 288 | 1,557
astrocytoma 278 | 1,493
cystic fibrosis 276 | 1,665
Multiple myeloma 275 | 1,327
colon cancer 273 | 1,475
nasopharyngeal carcinoma 269 | 1,056
posterior fossa group A ependymoma 263 | 1,511
acute quadriplegic myopathy 257 | 1,157
diabetes mellitus 253 | 1,663
spina bifida 246 | 1,064
juvenile dermatomyositis 245 | 1,189
Rheumatoid Arthritis 233 | 1,160
primary pancreatic ductal adenocarcinoma 226 | 1,271
dermatomyositis 221 | 933
atypical teratoid/rhabdoid tumor 212 | 1,095
progressive supranuclear palsy 191 | 674
tuberculosis and treatment for 6 months 181 | 686
non primary Sjogren syndrome sicca 173 | 840
Atopic dermatitis 172 | 944
active Crohn's disease 164 | 918
chronic rhinosinusitis 161 | 512
Waldenstrons macroglobulinemia 159 | 765
cutaneous lupus erythematosus 151 | 1,056
acute myeloid leukemia 142 | 780
gastric carcinoma 138 | 832
primary Sjogren syndrome 137 | 789
Alzheimer's disease 135 | 644
pancreatic carcinoma 130 | 567
Intellectual disability 128 | 573
Endometriosis 123 | 535
esophageal adenocarcinoma 117 | 737
hepatocellular carcinoma 117 | 532
aldosterone-producing adenoma 115 | 664
Down syndrome 112 | 548
Duchenne muscular dystrophy 103 | 602
Obesity 102 | 616
Male infertility 99 | 170
fibroadenoma 98 | 557
Amyotrophic Lateral Sclerosis 97 | 431
Schizophrenia 96 | 501
gastric cancer 95 | 430
autosomal dominant Emery-Dreifuss muscular dystrophy 92 | 499
IGA Glomerulonephritis 91 | 454
active ulcerative colitis 86 | 477
hereditary spastic paraplegia 86 | 313
Neurodegenerative disease 79 | 383
inflammatory breast cancer 77 | 404
mucosa-associated lymphoid tissue lymphoma 73 | 480
Infertility 71 | 163
Prostatic Neoplasms 70 | 471
tuberculosis and treatment for 3 months 70 | 327
non-small cell lung carcinoma 68 | 413
Parkinson's disease 67 | 364
sarcoidosis 67 | 358
Mammary Neoplasms 65 | 410
glioblastoma multiforme 60 | 347
Polycystic Ovary Syndrome 59 | 332
urothelial carcinoma 59 | 318
Epilepsy 58 | 346
Crohn's disease 55 | 304

Tissue

Female tissues 3,765 | 18,647
Endocrine System 3,761 | 18,512
Nervous System 3,743 | 18,561
Urinary Tract 3,734 | 18,444
Digestive Tract 3,727 | 18,473
Male tissues 3,685 | 17,969
Liver and Pancreas 3,673 | 18,136
Skin and soft tissues 3,668 | 18,115
Blood and immune system 3,655 | 17,995
Cardiovascular System 3,646 | 17,958
Respiratory system 3,571 | 17,484

Target Family

Non-IDG 2,225 | 11,971
Enzyme 862 | 4,146
Transcription Factor 288 | 1,400
Kinase 159 | 634
Transporter 85 | 473
Epigenetic 80 | 242
oGPCR 70 | 421
Ion Channel 40 | 341
GPCR 34 | 406
TF/Epigenetic 10 | 38
Nuclear Receptor 9 | 48

Jensen-KB Tissue

Testis 3,862 | 3,862
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Protein THEMIS2 THEMIS2 Tbio Non-IDG -1.15987 17.5 42
Protein FAM69C FAM69C Tdark Non-IDG 0.27 0.39 3
WD repeat-containing protein 87 WDR87 Tdark Non-IDG 0.42 0.25 12
Testis-specific gene 10 protein TSGA10 Tbio Non-IDG -1.05563 13.1 82
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65