Development Level

Tbio 2,395 | 11,651
Tdark 1,180 | 6,593
Tchem 267 | 1,388
Tclin 55 | 612

Collection

RFA-RM-18-021 72 | 328
Kinase: IDG Consortium (Target... 43 | 125
Ion Channel: IDG Consortium (T... 15 | 99
GPCR: IDG Consortium (Targets) 13 | 126
Kinase: IDG Consortium (Comple... 11 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 241 | 979
preweaning lethality, incomple... 103 | 499
embryonic lethality prior to t... 67 | 278
abnormal behavior 63 | 298
embryonic lethality prior to o... 55 | 239
male infertility 51 | 123
abnormal embryo size 48 | 220
abnormal bone structure 47 | 187
enlarged heart 43 | 210
decreased body weight 42 | 161
decreased total body fat amoun... 42 | 207
decreased vertical activity 41 | 208
decreased bone mineral content 40 | 151
increased lean body mass 38 | 172
abnormal heart morphology 37 | 162
decreased lean body mass 37 | 135
increased total body fat amoun... 33 | 134
decreased bone mineral density 31 | 126
hypoactivity 29 | 132
decreased grip strength 28 | 116
increased circulating alkaline... 28 | 122
hyperactivity 27 | 148
decreased circulating glucose ... 26 | 126
embryonic growth retardation 26 | 106
increased bone mineral content 25 | 108
short tibia 25 | 97
abnormal seminal vesicle morph... 24 | 114
decreased body length 23 | 101
decreased leukocyte cell numbe... 23 | 73
increased startle reflex 23 | 112
female infertility 22 | 60
increased circulating HDL chol... 22 | 80
increased mean corpuscular hem... 22 | 96
prenatal lethality prior to he... 22 | 87
impaired glucose tolerance 21 | 75
improved glucose tolerance 20 | 79
increased or absent threshold ... 20 | 101
decreased hemoglobin content 19 | 68
decreased mean corpuscular vol... 18 | 79
increased circulating choleste... 18 | 66
thrombocytopenia 18 | 56
decreased lymphocyte cell numb... 17 | 83
decreased circulating choleste... 16 | 93
decreased prepulse inhibition 16 | 82
increased fasted circulating g... 16 | 76
increased mean corpuscular vol... 16 | 92
small superior vagus ganglion 16 | 74
small testis 16 | 58
abnormal gait 15 | 69
decreased circulating serum al... 15 | 82
decreased fasted circulating g... 15 | 65
increased bone mineral density 15 | 72
decreased blood urea nitrogen ... 14 | 51
decreased caudal vertebrae num... 14 | 53
decreased circulating alanine ... 14 | 47
decreased circulating triglyce... 14 | 79
decreased erythrocyte cell num... 14 | 62
decreased mean corpuscular hem... 14 | 50
increased grip strength 14 | 41
increased heart weight 14 | 62
abnormal spleen morphology 13 | 55
cataract 13 | 92
decreased startle reflex 13 | 75
increased circulating triglyce... 13 | 42
increased hemoglobin content 13 | 45
abnormal behavioral response t... 12 | 66
abnormal eye morphology 12 | 68
abnormal skin morphology 12 | 50
abnormal sleep behavior 12 | 70
decreased circulating insulin ... 12 | 76
decreased hematocrit 12 | 46
hydrometra 12 | 53
increased lymphocyte cell numb... 12 | 32
increased neutrophil cell numb... 12 | 46
abnormal embryo turning 11 | 31
abnormal lens morphology 11 | 81
abnormal retina morphology 11 | 71
decreased neutrophil cell numb... 11 | 42
enlarged lymph nodes 11 | 37
increased circulating sodium l... 11 | 71
increased monocyte cell number 11 | 63
abnormal epididymis morphology 10 | 42
abnormal testis morphology 10 | 43
decreased circulating HDL chol... 10 | 68
decreased circulating aspartat... 10 | 34
decreased red blood cell distr... 10 | 41
enlarged spleen 10 | 41
long tibia 10 | 25
abnormal bone mineralization 9 | 38
abnormal coat-hair pigmentatio... 9 | 64
abnormal cranium morphology 9 | 36
abnormal vocalization 9 | 21
corneal opacity 9 | 32
decreased circulating LDL chol... 9 | 38
decreased circulating total pr... 9 | 49
enlarged epididymis 9 | 31
increased leukocyte cell numbe... 9 | 47
limb grasping 9 | 41
abnormal kidney morphology 8 | 65
decreased circulating alkaline... 8 | 46

Disease

Carcinoma 2,750 | 11,493
ovarian cancer 1,885 | 8,520
osteosarcoma 1,784 | 7,950
medulloblastoma, large-cell 1,340 | 6,241
psoriasis 1,258 | 6,694
glioblastoma 1,183 | 5,792
atypical teratoid / rhabdoid tumor 1,050 | 5,112
ependymoma 1,034 | 4,679
lung cancer 945 | 4,740
group 3 medulloblastoma 886 | 4,104
Breast cancer 774 | 3,578
adult high grade glioma 744 | 3,801
Kidney cancer 695 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 668 | 3,291
primitive neuroectodermal tumor 668 | 3,035
malignant mesothelioma 647 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 593 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 591 | 2,989
oligodendroglioma 591 | 2,850
invasive ductal carcinoma 581 | 2,951
Astrocytoma, Pilocytic 545 | 3,081
non-small cell lung cancer 539 | 2,890
astrocytic glioma 529 | 2,597
lung adenocarcinoma 497 | 2,716
lung carcinoma 455 | 2,843
Pick disease 452 | 1,894
Cancer 429 | 2,499
pancreatic cancer 425 | 2,398
subependymal giant cell astrocytoma 417 | 2,287
group 4 medulloblastoma 402 | 1,855
pituitary cancer 385 | 1,972
tuberculosis 380 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 367 | 1,962
ductal carcinoma in situ 337 | 1,745
interstitial cystitis 337 | 2,312
adrenocortical carcinoma 316 | 1,428
ulcerative colitis 315 | 1,819
breast carcinoma 295 | 1,638
cystic fibrosis 281 | 1,696
Multiple myeloma 277 | 1,332
nasopharyngeal carcinoma 277 | 1,058
colon cancer 275 | 1,478
diabetes mellitus 266 | 1,728
acute quadriplegic myopathy 259 | 1,158
Autosomal recessive predisposition 251 | 1,442
spina bifida 248 | 1,074
juvenile dermatomyositis 246 | 1,187
Rheumatoid arthritis 240 | 1,191
astrocytoma 232 | 1,146
dermatomyositis 221 | 966
Intellectual disability 215 | 1,016
Schizophrenia 209 | 1,160
pediatric high grade glioma 200 | 1,064
primary pancreatic ductal adenocarcinoma 199 | 1,109
progressive supranuclear palsy 190 | 676
non primary Sjogren syndrome sicca 180 | 891
Atopic dermatitis 176 | 952
active Crohn's disease 166 | 922
chronic rhinosinusitis 165 | 512
Waldenstrons macroglobulinemia 160 | 765
cutaneous lupus erythematosus 152 | 1,057
acute myeloid leukemia 144 | 783
medulloblastoma 144 | 720
gastric carcinoma 138 | 807
Alzheimer's disease 137 | 658
Liver cancer 134 | 604
Epilepsy 133 | 792
active ulcerative colitis 132 | 764
primary Sjogren syndrome 131 | 735
Dull intelligence 129 | 645
Low intelligence 129 | 645
Mental Retardation 129 | 645
Mental deficiency 129 | 645
Poor school performance 129 | 645
pancreatic carcinoma 128 | 562
Endometriosis 124 | 540
Melanoma 124 | 711
Obesity 123 | 678
Bipolar Disorder 122 | 666
Cognitive delay 119 | 608
Global developmental delay 119 | 608
Mental and motor retardation 119 | 608
hepatocellular carcinoma 119 | 547
tuberculosis and treatment for 6 months 119 | 409
esophageal adenocarcinoma 118 | 737
aldosterone-producing adenoma 115 | 665
Male infertility 113 | 206
Muscle hypotonia 109 | 571
Short stature 105 | 531
Duchenne muscular dystrophy 104 | 601
Amyotrophic lateral sclerosis 101 | 451
Down syndrome 100 | 499
Liver Cirrhosis, Experimental 99 | 769
fibroadenoma 99 | 559
Seizures 98 | 596
gastric cancer 98 | 459
autosomal dominant Emery-Dreifuss muscular dystrophy 93 | 510
sonic hedgehog group medulloblastoma 92 | 467
posterior fossa group A ependymoma 89 | 468
posterior fossa group B ependymoma 88 | 416

Tissue

Endocrine System 3,777 | 18,159
Male tissues 3,564 | 17,142
Female tissues 3,560 | 17,400
Digestive Tract 3,526 | 17,369
Skin and soft tissues 3,523 | 17,230
Blood and immune system 3,478 | 16,909
Liver and Pancreas 3,449 | 16,750
Nervous System 3,448 | 16,725
Urinary Tract 3,437 | 16,678
Respiratory system 3,418 | 16,393
Cardiovascular System 3,188 | 15,192

Target Family

Non-IDG 2,256 | 12,091
Enzyme 863 | 4,145
Transcription Factor 288 | 1,400
Kinase 159 | 634
Transporter 85 | 473
Epigenetic 81 | 242
oGPCR 70 | 421
Ion Channel 42 | 344
GPCR 34 | 408
TF/Epigenetic 10 | 38
Nuclear Receptor 9 | 48

Jensen-KB Tissue

Testis 3,897 | 3,897
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
IQ and AAA domain-containing protein 1 IQCA1 Tbio Non-IDG -0.80618 5.26 77
Caskin-2 CASKIN2 Tdark Non-IDG -0.21450 1.97 118
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Zinc finger protein 346 ZNF346 Tbio Non-IDG -2.28393 188.7 213
Putative neuroblastoma breakpoint family member 5 NBPF5P Tdark Non-IDG 1.26 0.07 0