Development Level

Tbio 1,761 | 11,651
Tdark 283 | 6,593
Tchem 240 | 1,388
Tclin 62 | 612

Collection

Kinase: IDG Consortium (Target... 26 | 125
Kinase: IDG Consortium (Comple... 10 | 37
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 253 | 979
preweaning lethality, incomple... 99 | 499
embryonic lethality prior to t... 68 | 278
embryonic lethality prior to o... 63 | 239
abnormal embryo size 54 | 220
abnormal behavior 46 | 298
decreased total body fat amoun... 42 | 207
decreased body weight 35 | 161
increased lean body mass 35 | 172
abnormal bone structure 33 | 187
enlarged heart 29 | 210
increased circulating alkaline... 26 | 122
decreased bone mineral content 25 | 151
decreased circulating glucose ... 25 | 126
increased startle reflex 25 | 112
male infertility 25 | 123
decreased lean body mass 24 | 135
decreased vertical activity 24 | 208
embryonic growth retardation 24 | 106
hypoactivity 24 | 132
abnormal heart morphology 23 | 162
decreased bone mineral density 22 | 126
decreased circulating choleste... 22 | 93
increased total body fat amoun... 22 | 134
decreased body length 21 | 101
decreased grip strength 20 | 116
increased mean corpuscular hem... 20 | 96
prenatal lethality prior to he... 20 | 87
decreased circulating triglyce... 19 | 79
increased mean corpuscular vol... 18 | 92
abnormal eye morphology 17 | 68
decreased circulating serum al... 17 | 82
abnormal retina morphology 16 | 71
decreased leukocyte cell numbe... 16 | 73
short tibia 16 | 97
decreased circulating HDL chol... 15 | 68
decreased erythrocyte cell num... 15 | 62
edema 15 | 59
increased circulating HDL chol... 15 | 80
hyperactivity 14 | 148
increased bone mineral content 14 | 108
abnormal neural tube closure 13 | 46
decreased caudal vertebrae num... 13 | 53
decreased lymphocyte cell numb... 13 | 83
decreased prepulse inhibition 13 | 82
improved glucose tolerance 13 | 79
increased bone mineral density 13 | 72
increased circulating choleste... 13 | 66
increased or absent threshold ... 13 | 101
abnormal coat-hair pigmentatio... 12 | 64
abnormal sleep behavior 12 | 70
abnormal spleen morphology 12 | 55
decreased circulating alkaline... 12 | 46
decreased hemoglobin content 12 | 68
decreased mean corpuscular vol... 12 | 79
hemorrhage 12 | 23
increased hematocrit 12 | 46
thrombocytopenia 12 | 56
decreased circulating LDL chol... 11 | 38
decreased circulating alanine ... 11 | 47
decreased circulating total pr... 11 | 49
decreased mean corpuscular hem... 11 | 50
decreased neutrophil cell numb... 11 | 42
impaired glucose tolerance 11 | 75
increased fasted circulating g... 11 | 76
increased leukocyte cell numbe... 11 | 47
increased monocyte cell number 11 | 63
small testis 11 | 58
abnormal bone mineralization 10 | 38
abnormal cornea morphology 10 | 31
abnormal lens morphology 10 | 81
cataract 10 | 92
decreased fasted circulating g... 10 | 65
decreased hematocrit 10 | 46
increased circulating chloride... 10 | 41
increased grip strength 10 | 41
increased heart weight 10 | 62
increased mean platelet volume 10 | 45
pallor 10 | 34
prolonged QT interval 10 | 38
small superior vagus ganglion 10 | 74
abnormal behavioral response t... 9 | 66
abnormal placenta size 9 | 20
abnormal seminal vesicle morph... 9 | 114
decreased mean corpuscular hem... 9 | 31
decreased red blood cell distr... 9 | 41
decreased startle reflex 9 | 75
increased body length 9 | 32
increased lymphocyte cell numb... 9 | 32
prolonged ST segment 9 | 36
tremors 9 | 39
abnormal cranium morphology 8 | 36
abnormal gait 8 | 69
abnormal skin coloration 8 | 25
corneal opacity 8 | 32
decreased circulating insulin ... 8 | 76
female infertility 8 | 60
abnormal kidney morphology 7 | 65
abnormal skin morphology 7 | 50
decreased circulating fructosa... 7 | 30

Disease

Carcinoma 1,817 | 11,493
ovarian cancer 1,536 | 8,520
osteosarcoma 1,398 | 7,950
medulloblastoma, large-cell 1,010 | 6,241
psoriasis 945 | 6,694
glioblastoma 910 | 5,792
lung cancer 825 | 4,740
atypical teratoid / rhabdoid tumor 785 | 5,112
group 3 medulloblastoma 689 | 4,104
ependymoma 685 | 4,679
Kidney cancer 600 | 2,613
Breast cancer 544 | 3,578
malignant mesothelioma 522 | 3,232
adult high grade glioma 520 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 502 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 478 | 2,989
primitive neuroectodermal tumor 477 | 3,035
oligodendroglioma 475 | 2,850
Cancer 469 | 2,499
non-small cell lung cancer 418 | 2,890
invasive ductal carcinoma 417 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 411 | 2,955
astrocytic glioma 390 | 2,597
subependymal giant cell astrocytoma 372 | 2,287
lung adenocarcinoma 370 | 2,716
Pick disease 369 | 1,894
Astrocytoma, Pilocytic 356 | 3,081
pancreatic cancer 344 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 317 | 1,962
Multiple myeloma 307 | 1,332
group 4 medulloblastoma 301 | 1,855
tuberculosis 301 | 2,010
lung carcinoma 279 | 2,843
acute quadriplegic myopathy 277 | 1,158
astrocytoma 276 | 1,146
juvenile dermatomyositis 264 | 1,187
ulcerative colitis 250 | 1,819
Rheumatoid arthritis 243 | 1,191
dermatomyositis 242 | 966
breast carcinoma 238 | 1,638
diabetes mellitus 238 | 1,728
interstitial cystitis 230 | 2,312
ductal carcinoma in situ 226 | 1,745
Waldenstrons macroglobulinemia 214 | 765
colon cancer 214 | 1,478
adrenocortical carcinoma 207 | 1,428
pituitary cancer 205 | 1,972
Intellectual disability 201 | 1,016
primary pancreatic ductal adenocarcinoma 196 | 1,109
pediatric high grade glioma 178 | 1,064
spina bifida 176 | 1,074
acute myeloid leukemia 163 | 783
progressive supranuclear palsy 156 | 676
Schizophrenia 155 | 1,160
cystic fibrosis 155 | 1,696
Autosomal recessive predisposition 143 | 1,442
cutaneous lupus erythematosus 138 | 1,057
Liver cancer 136 | 604
primary Sjogren syndrome 135 | 735
non primary Sjogren syndrome sicca 122 | 891
Dull intelligence 120 | 645
Low intelligence 120 | 645
Mental Retardation 120 | 645
Mental deficiency 120 | 645
Poor school performance 120 | 645
nasopharyngeal carcinoma 115 | 1,058
aldosterone-producing adenoma 113 | 665
Alzheimer's disease 110 | 658
gastric carcinoma 108 | 807
Amyotrophic lateral sclerosis 107 | 451
Atopic dermatitis 102 | 952
Short stature 102 | 531
active Crohn's disease 102 | 922
tuberculosis and treatment for 6 months 101 | 409
Cognitive delay 100 | 608
Epilepsy 100 | 792
Global developmental delay 100 | 608
Mental and motor retardation 100 | 608
Liver Cirrhosis, Experimental 99 | 769
medulloblastoma 98 | 720
esophageal adenocarcinoma 96 | 737
Muscle hypotonia 92 | 571
autosomal dominant Emery-Dreifuss muscular dystrophy 92 | 510
Breast Neoplasms 91 | 445
Down syndrome 91 | 499
pancreatic carcinoma 87 | 562
hepatocellular carcinoma 86 | 547
Small head 85 | 374
Mammary Neoplasms 84 | 425
Obesity 84 | 678
Prostatic Neoplasms 83 | 495
Seizures 83 | 596
Neurodegenerative disease 82 | 414
Endometrial cancer 80 | 311
Bipolar Disorder 79 | 666
Melanoma 79 | 711
Duchenne muscular dystrophy 78 | 601
Endometriosis 75 | 540
hereditary spastic paraplegia 75 | 318
sonic hedgehog group medulloblastoma 72 | 467

Tissue

Endocrine System 2,320 | 18,159
Female tissues 2,315 | 17,400
Digestive Tract 2,314 | 17,369
Male tissues 2,313 | 17,142
Urinary Tract 2,313 | 16,678
Blood and immune system 2,312 | 16,909
Liver and Pancreas 2,311 | 16,750
Skin and soft tissues 2,311 | 17,230
Nervous System 2,309 | 16,725
Respiratory system 2,309 | 16,393
Cardiovascular System 2,285 | 15,192

Target Family

Non-IDG 1,451 | 12,091
Enzyme 413 | 4,145
Kinase 161 | 634
Transcription Factor 154 | 1,400
Epigenetic 101 | 242
Transporter 39 | 473
TF/Epigenetic 13 | 38
Ion Channel 9 | 344
GPCR 3 | 408
Nuclear Receptor 2 | 48

Jensen-KB Tissue

T-cell chronic lymphocytic leu... 2,346 | 2,346
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Caskin-2 CASKIN2 Tdark Non-IDG -0.21450 1.97 118
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Homeobox protein SIX6 SIX6 Tbio Transcription Factor -2.23077 163.2 112
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
Eukaryotic translation initiation factor 4E transporter EIF4ENIF1 Tbio Non-IDG -1.60874 36.7 242
ETS-related transcription factor Elf-2 ELF2 Tbio Transcription Factor -2.04794 106.4 92
Chromosome alignment-maintaining phosphoprotein 1 CHAMP1 Tbio Non-IDG -0.61730 4.58 106
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
Oxidation resistance protein 1 OXR1 Tbio Non-IDG -1.67505 49.4 144