Development Level

Tbio 1,636 | 10,625
Tdark 330 | 7,003
Tchem 308 | 1,890
Tclin 63 | 602

Collection

Eligible Kinase Proteins 25 | 134
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 155 | 633
preweaning lethality, incomple... 48 | 260
decreased lean body mass 44 | 195
decreased body weight 43 | 174
embryonic lethality prior to t... 43 | 187
decreased total body fat amoun... 41 | 186
abnormal behavior 39 | 226
embryonic lethality prior to o... 39 | 148
abnormal embryo size 29 | 112
decreased body length 29 | 108
decreased bone mineral content 29 | 157
abnormal retina morphology 25 | 100
abnormal bone structure 23 | 131
decreased bone mineral density 23 | 126
increased lean body mass 23 | 107
increased or absent threshold ... 23 | 128
increased circulating alkaline... 22 | 119
increased mean corpuscular hem... 22 | 93
decreased circulating choleste... 21 | 85
decreased circulating glucose ... 21 | 121
decreased grip strength 20 | 123
decreased circulating HDL chol... 19 | 77
increased mean corpuscular vol... 19 | 91
increased bone mineral content 17 | 92
decreased circulating triglyce... 16 | 83
prenatal lethality prior to he... 16 | 64
abnormal retinal pigmentation 15 | 61
decreased circulating serum al... 15 | 79
decreased leukocyte cell numbe... 15 | 54
decreased lumbar vertebrae num... 15 | 62
increased grip strength 15 | 83
increased sacral vertebrae num... 15 | 62
enlarged heart 14 | 111
hyperactivity 14 | 108
abnormal bone mineralization 13 | 55
hypoactivity 13 | 89
abnormal neural tube closure 12 | 37
abnormal sleep behavior 12 | 63
decreased caudal vertebrae num... 12 | 49
decreased mean corpuscular vol... 12 | 50
decreased rib number 12 | 59
decreased circulating LDL chol... 11 | 37
decreased circulating total pr... 11 | 41
improved glucose tolerance 11 | 56
increased leukocyte cell numbe... 11 | 37
male infertility 11 | 62
short tibia 11 | 82
abnormal lens morphology 10 | 73
decreased circulating alanine ... 10 | 53
decreased hemoglobin content 10 | 53
decreased mean corpuscular hem... 10 | 34
increased circulating HDL chol... 10 | 63
increased circulating chloride... 10 | 43
thrombocytopenia 10 | 46
abnormal rib morphology 9 | 28
decreased CD4-positive, CD25-p... 9 | 24
decreased T cell number 9 | 31
decreased circulating alkaline... 9 | 41
increased fasted circulating g... 9 | 68
increased hematocrit 9 | 36
abnormal coat/hair pigmentatio... 8 | 54
abnormal cornea morphology 8 | 24
abnormal hindbrain development 8 | 24
abnormal spleen morphology 8 | 36
decreased circulating fructosa... 8 | 31
decreased circulating insulin ... 8 | 75
decreased erythrocyte cell num... 8 | 43
decreased mature B cell number 8 | 25
decreased prepulse inhibition 8 | 52
increased bone mineral density 8 | 52
increased circulating choleste... 8 | 53
increased circulating sodium l... 8 | 71
tremors 8 | 34
abnormal cranium morphology 7 | 32
abnormal eye morphology 7 | 38
decreased CD8-positive, alpha-... 7 | 26
decreased circulating amylase ... 7 | 24
decreased circulating calcium ... 7 | 33
decreased circulating chloride... 7 | 32
decreased effector memory CD8-... 7 | 24
decreased fasted circulating g... 7 | 49
decreased heart weight 7 | 44
decreased neutrophil cell numb... 7 | 37
hemorrhage 7 | 12
hydrops fetalis 7 | 22
impaired glucose tolerance 7 | 52
increased CD4-positive, alpha ... 7 | 15
increased body weight 7 | 42
increased circulating iron lev... 7 | 25
increased hemoglobin content 7 | 45
increased mean corpuscular hem... 7 | 25
increased monocyte cell number 7 | 27
increased total body fat amoun... 7 | 57
abnormal behavioral response t... 6 | 52
decreased circulating free fat... 6 | 39
decreased startle reflex 6 | 48
increased body length 6 | 20
increased exploration in new e... 6 | 56
increased heart weight 6 | 37
small testis 6 | 37

Disease

ovarian cancer 1,528 | 8,484
osteosarcoma 1,389 | 7,933
medulloblastoma, large-cell 1,009 | 6,234
psoriasis 945 | 6,685
glioblastoma 881 | 5,572
lung cancer 786 | 4,466
atypical teratoid / rhabdoid tumor 677 | 4,369
malignant mesothelioma 505 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 498 | 3,289
Carcinoma 487 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 476 | 2,988
primitive neuroectodermal tumor 475 | 3,031
oligodendroglioma 474 | 2,849
Breast cancer 460 | 3,094
ependymoma 455 | 2,514
Cancer 444 | 2,346
pediatric high grade glioma 427 | 2,712
invasive ductal carcinoma 416 | 2,950
non-small cell lung cancer 413 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 410 | 2,956
group 3 medulloblastoma 397 | 2,254
subependymal giant cell astrocytoma 374 | 2,287
Pick disease 369 | 1,893
lung adenocarcinoma 368 | 2,713
pilocytic astrocytoma 360 | 3,086
astrocytoma 333 | 1,493
astrocytic glioma 331 | 2,241
pancreatic cancer 325 | 2,300
Multiple myeloma 309 | 1,327
group 4 medulloblastoma 301 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 287 | 1,795
lung carcinoma 279 | 2,844
acute quadriplegic myopathy 278 | 1,157
ulcerative colitis 270 | 2,087
adult high grade glioma 269 | 2,148
juvenile dermatomyositis 264 | 1,189
Rheumatoid Arthritis 247 | 1,160
dermatomyositis 241 | 933
tuberculosis 237 | 1,557
diabetes mellitus 232 | 1,663
breast carcinoma 230 | 1,614
interstitial cystitis 229 | 2,299
medulloblastoma 229 | 1,524
sonic hedgehog group medulloblastoma 228 | 1,482
primary pancreatic ductal adenocarcinoma 225 | 1,271
ductal carcinoma in situ 224 | 1,745
Waldenstrons macroglobulinemia 216 | 765
colon cancer 214 | 1,475
adrenocortical carcinoma 207 | 1,427
pituitary cancer 206 | 1,972
posterior fossa group A ependymoma 179 | 1,511
spina bifida 174 | 1,064
acute myeloid leukemia 160 | 780
tuberculosis and treatment for 6 months 160 | 686
progressive supranuclear palsy 157 | 674
atypical teratoid/rhabdoid tumor 156 | 1,095
cystic fibrosis 152 | 1,665
primary Sjogren syndrome 145 | 789
cutaneous lupus erythematosus 139 | 1,056
posterior fossa group B ependymoma 139 | 1,530
Intellectual disability 125 | 573
Alzheimer's disease 115 | 644
nasopharyngeal carcinoma 115 | 1,056
aldosterone-producing adenoma 114 | 664
non primary Sjogren syndrome sicca 114 | 840
gastric carcinoma 111 | 832
Amyotrophic Lateral Sclerosis 105 | 431
Atopic dermatitis 100 | 944
active Crohn's disease 100 | 918
IGA Glomerulonephritis 98 | 454
Down syndrome 97 | 548
esophageal adenocarcinoma 96 | 737
autosomal dominant Emery-Dreifuss muscular dystrophy 91 | 499
pancreatic carcinoma 88 | 567
hepatocellular carcinoma 83 | 532
Mammary Neoplasms 81 | 410
Neurodegenerative disease 79 | 383
Duchenne muscular dystrophy 77 | 602
Endometriosis 75 | 535
Prostatic Neoplasms 75 | 471
Obesity 74 | 616
hereditary spastic paraplegia 74 | 313
Schizophrenia 65 | 501
Parkinson's disease 63 | 364
Gaucher disease type 1 62 | 171
gastric cancer 58 | 430
Polycystic Ovary Syndrome 57 | 332
Chronic Lymphocytic Leukemia 53 | 242
Crohn's disease 53 | 304
inflammatory breast cancer 53 | 404
tuberculosis and treatment for 3 months 52 | 327
Multiple Sclerosis 48 | 498
fibroadenoma 48 | 557
sarcoidosis 48 | 358
interstitial lung disease 46 | 291
Renal Cell Carcinoma 45 | 199
Stomach Neoplasms 45 | 282
Peripheral Neuropathy 43 | 303
glioblastoma multiforme 41 | 347
Autistic Disorder 40 | 320

Tissue

Nervous System 2,325 | 18,561
Blood and immune system 2,324 | 17,995
Digestive Tract 2,324 | 18,473
Endocrine System 2,324 | 18,512
Female tissues 2,324 | 18,647
Liver and Pancreas 2,324 | 18,136
Male tissues 2,324 | 17,969
Cardiovascular System 2,322 | 17,958
Urinary Tract 2,318 | 18,444
Respiratory system 2,311 | 17,484
Skin and soft tissues 2,303 | 18,115

Target Family

Non-IDG 1,447 | 11,971
Enzyme 411 | 4,146
Kinase 160 | 634
Transcription Factor 153 | 1,400
Epigenetic 100 | 242
Transporter 39 | 473
TF/Epigenetic 13 | 38
Ion Channel 9 | 341
GPCR 3 | 406
Nuclear Receptor 2 | 48

Jensen-KB Tissue

T-cell chronic lymphocytic leu... 2,337 | 2,337
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
HEAT repeat-containing protein 6 HEATR6 Tdark Non-IDG -1.48236 11.6 38
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.40380 284.9 546
Sex comb on midleg-like protein 2 SCML2 Tbio Epigenetic -1.13986 13.7 93
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269