Development Level

Tbio 1,057 | 11,445
Tdark 303 | 6,588
Tchem 154 | 1,598
Tclin 42 | 613

Collection

GPCR: IDG Consortium (Targets) 5 | 126
Kinase: IDG Consortium (Target... 4 | 125
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 112 | 979
preweaning lethality, incomple... 41 | 499
embryonic lethality prior to o... 38 | 239
embryonic lethality prior to t... 38 | 278
abnormal behavior 35 | 298
enlarged heart 26 | 210
abnormal embryo size 25 | 220
decreased vertical activity 23 | 208
decreased total body fat amoun... 21 | 207
decreased body weight 20 | 161
hyperactivity 18 | 148
abnormal heart morphology 17 | 162
increased lean body mass 17 | 172
cataract 16 | 92
abnormal coat-hair pigmentatio... 15 | 64
decreased bone mineral content 14 | 151
decreased circulating choleste... 14 | 93
decreased lean body mass 14 | 135
abnormal retina morphology 13 | 71
decreased body length 13 | 101
decreased circulating glucose ... 13 | 126
embryonic growth retardation 13 | 106
hypoactivity 13 | 132
increased mean corpuscular hem... 13 | 96
increased total body fat amoun... 13 | 134
abnormal bone structure 12 | 187
decreased bone mineral density 12 | 126
increased bone mineral content 12 | 108
increased bone mineral density 11 | 72
increased or absent threshold ... 11 | 101
prenatal lethality prior to he... 11 | 87
abnormal lens morphology 10 | 81
decreased startle reflex 10 | 75
short tibia 10 | 97
small superior vagus ganglion 10 | 74
abnormal behavioral response t... 9 | 66
decreased grip strength 9 | 116
increased circulating HDL chol... 9 | 80
increased mean corpuscular vol... 9 | 92
abnormal gait 8 | 69
decreased circulating HDL chol... 8 | 68
decreased erythrocyte cell num... 8 | 62
decreased hemoglobin content 8 | 68
decreased prepulse inhibition 8 | 82
hydrometra 8 | 53
abnormal spleen morphology 7 | 55
decreased circulating fructosa... 7 | 30
decreased circulating insulin ... 7 | 76
decreased circulating serum al... 7 | 82
decreased circulating total pr... 7 | 49
increased circulating choleste... 7 | 66
increased circulating phosphat... 7 | 26
increased heart weight 7 | 62
long tibia 7 | 25
abnormal epididymis morphology 6 | 42
abnormal eye morphology 6 | 68
abnormal seminal vesicle morph... 6 | 114
abnormal skin morphology 6 | 50
absent startle reflex 6 | 24
decreased caudal vertebrae num... 6 | 53
decreased neutrophil cell numb... 6 | 42
edema 6 | 59
enlarged spleen 6 | 41
improved glucose tolerance 6 | 79
increased startle reflex 6 | 112
persistence of hyaloid vascula... 6 | 33
abnormal sleep behavior 5 | 70
abnormal tail morphology 5 | 25
decreased circulating alanine ... 5 | 47
decreased circulating aspartat... 5 | 34
decreased circulating iron lev... 5 | 32
decreased circulating sodium l... 5 | 22
decreased hematocrit 5 | 46
decreased leukocyte cell numbe... 5 | 73
decreased lymphocyte cell numb... 5 | 83
decreased mean corpuscular vol... 5 | 79
enlarged epididymis 5 | 31
increased fasted circulating g... 5 | 76
increased monocyte cell number 5 | 63
pallor 5 | 34
tremors 5 | 39
abnormal cornea morphology 4 | 31
abnormal forebrain development 4 | 20
abnormal neural tube closure 4 | 46
decreased circulating chloride... 4 | 30
decreased circulating triglyce... 4 | 79
decreased eosinophil cell numb... 4 | 24
decreased fasted circulating g... 4 | 65
decreased mean corpuscular hem... 4 | 50
enlarged lymph nodes 4 | 37
increased body length 4 | 32
increased body weight 4 | 25
increased circulating alkaline... 4 | 122
increased circulating glucose ... 4 | 24
increased grip strength 4 | 41
increased prepulse inhibition 4 | 32
male infertility 4 | 123
prolonged QT interval 4 | 38
small testis 4 | 58
syndactyly 4 | 23

Disease

ovarian cancer 894 | 8,520
Carcinoma 885 | 11,493
osteosarcoma 707 | 7,950
psoriasis 564 | 6,694
glioblastoma 534 | 5,792
medulloblastoma, large-cell 531 | 6,241
lung cancer 469 | 4,740
atypical teratoid / rhabdoid tumor 397 | 5,112
ependymoma 374 | 4,679
group 3 medulloblastoma 348 | 4,104
Breast cancer 338 | 3,578
malignant mesothelioma 329 | 3,232
adult high grade glioma 308 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 299 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 266 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 261 | 2,989
Cancer 260 | 2,499
oligodendroglioma 253 | 2,850
invasive ductal carcinoma 252 | 2,951
non-small cell lung cancer 250 | 2,890
primitive neuroectodermal tumor 248 | 3,035
Astrocytoma, Pilocytic 239 | 3,081
pancreatic cancer 238 | 2,398
lung adenocarcinoma 237 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 223 | 1,962
Multiple myeloma 216 | 1,332
astrocytic glioma 212 | 2,597
subependymal giant cell astrocytoma 194 | 2,287
diabetes mellitus 172 | 1,728
interstitial cystitis 169 | 2,312
tuberculosis 169 | 2,010
ulcerative colitis 167 | 1,819
Pick disease 166 | 1,894
lung carcinoma 166 | 2,843
Kidney cancer 165 | 2,613
cystic fibrosis 158 | 1,696
ductal carcinoma in situ 153 | 1,745
group 4 medulloblastoma 153 | 1,855
pituitary cancer 153 | 1,972
breast carcinoma 149 | 1,638
colon cancer 140 | 1,478
acute quadriplegic myopathy 136 | 1,158
Autosomal recessive predisposition 135 | 1,442
astrocytoma 133 | 1,146
juvenile dermatomyositis 132 | 1,187
adrenocortical carcinoma 131 | 1,428
dermatomyositis 121 | 966
Rheumatoid arthritis 114 | 1,191
pediatric high grade glioma 114 | 1,064
primary pancreatic ductal adenocarcinoma 113 | 1,109
non primary Sjogren syndrome sicca 112 | 891
esophageal adenocarcinoma 104 | 737
Waldenstrons macroglobulinemia 101 | 765
Atopic dermatitis 97 | 952
spina bifida 96 | 1,074
Intellectual disability 94 | 1,016
active Crohn's disease 87 | 922
gastric carcinoma 86 | 807
acute myeloid leukemia 83 | 783
cutaneous lupus erythematosus 83 | 1,057
Schizophrenia 81 | 1,160
nasopharyngeal carcinoma 81 | 1,058
Liver Cirrhosis, Experimental 77 | 769
Duchenne muscular dystrophy 76 | 601
active ulcerative colitis 72 | 764
Cognitive delay 68 | 608
Global developmental delay 68 | 608
Mental and motor retardation 68 | 608
progressive supranuclear palsy 62 | 676
Epilepsy 61 | 792
Muscle hypotonia 59 | 571
Obesity 59 | 678
Melanoma 58 | 711
Short stature 58 | 531
hepatocellular carcinoma 58 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 57 | 510
Down syndrome 56 | 499
Dull intelligence 56 | 645
Low intelligence 56 | 645
Mental Retardation 56 | 645
Mental deficiency 56 | 645
Poor school performance 56 | 645
medulloblastoma 54 | 720
Alzheimer's disease 52 | 658
Prostatic Neoplasms 52 | 495
aldosterone-producing adenoma 50 | 665
primary Sjogren syndrome 49 | 735
Bipolar Disorder 48 | 666
Seizures 48 | 596
Endometriosis 47 | 540
fibroadenoma 46 | 559
gastric cancer 45 | 459
tuberculosis and treatment for 6 months 44 | 409
Neurodegenerative disease 42 | 414
pancreatic carcinoma 42 | 562
posterior fossa group A ependymoma 42 | 468
Breast Neoplasms 41 | 445
Multiple Sclerosis 41 | 540
Polycystic ovary syndrome 40 | 360
Stomach Neoplasms 40 | 300

Tissue

Female tissues 1,534 | 17,400
Skin and soft tissues 1,526 | 17,230
Endocrine System 1,525 | 18,159
Digestive Tract 1,520 | 17,369
Blood and immune system 1,511 | 16,909
Male tissues 1,507 | 17,142
Urinary Tract 1,495 | 16,678
Liver and Pancreas 1,493 | 16,750
Nervous System 1,487 | 16,725
Respiratory system 1,484 | 16,393
Cardiovascular System 1,436 | 15,192

Target Family

Non-IDG 912 | 12,091
Enzyme 438 | 4,145
Transcription Factor 83 | 1,400
Kinase 43 | 634
Transporter 31 | 473
Epigenetic 25 | 242
GPCR 12 | 408
Ion Channel 9 | 344
Nuclear Receptor 3 | 48

Jensen-KB Tissue

Skin 1,556 | 1,556
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Uncharacterized protein C2orf42 C2orf42 Tdark Non-IDG 0.95 0.09 69
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Carboxypeptidase Q CPQ Tbio Enzyme -2.51783 330.9 81
G patch domain-containing protein 8 GPATCH8 Tbio Non-IDG -0.13830 1.47 20
Exportin-6 XPO6 Tbio Non-IDG -1.53980 34.5 29
DnaJ homolog subfamily C member 15 DNAJC15 Tbio Non-IDG -1.67016 50.2 31
Transient receptor potential cation channel subfamily V member 2 TRPV2 Tchem Ion Channel -2.28525 197.9 203
Cysteine-rich hydrophobic domain-containing protein 2 CHIC2 Tbio Non-IDG -2.12710 132.1 97