Development Level

Tbio 374 | 10,625
Tdark 80 | 7,003
Tchem 73 | 1,890
Tclin 16 | 602

Collection

Eligible Ion Channel Proteins 4 | 117
Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 26 | 633
abnormal embryo size 8 | 112
abnormal bone structure 7 | 131
abnormal lens morphology 7 | 73
decreased circulating glucose ... 7 | 121
abnormal retina morphology 6 | 100
decreased body weight 6 | 174
decreased bone mineral content 6 | 157
decreased lean body mass 6 | 195
increased circulating alkaline... 6 | 119
abnormal behavior 5 | 226
abnormal sleep behavior 5 | 63
decreased fasted circulating g... 5 | 49
decreased total body fat amoun... 5 | 186
embryonic lethality prior to o... 5 | 148
embryonic lethality prior to t... 5 | 187
increased bone mineral content 5 | 92
abnormal limb bud morphology 4 | 15
abnormal vocalization 4 | 21
decreased circulating choleste... 4 | 85
edema 4 | 11
enlarged heart 4 | 111
increased mean corpuscular vol... 4 | 91
increased or absent threshold ... 4 | 128
preweaning lethality, incomple... 4 | 260
abnormal behavioral response t... 3 | 52
abnormal facial morphology 3 | 9
abnormal neural tube closure 3 | 37
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 49
decreased circulating alkaline... 3 | 41
decreased circulating creatini... 3 | 31
decreased circulating serum al... 3 | 79
decreased circulating total pr... 3 | 41
decreased grip strength 3 | 123
decreased startle reflex 3 | 48
decreased vertical activity 3 | 22
hyperactivity 3 | 108
increased circulating choleste... 3 | 53
increased circulating iron lev... 3 | 25
increased erythrocyte cell num... 3 | 26
increased exploration in new e... 3 | 56
increased hematocrit 3 | 36
increased hemoglobin content 3 | 45
increased startle reflex 3 | 38
increased total body fat amoun... 3 | 57
prenatal lethality 3 | 16
shortened RR interval 3 | 19
thrombocytopenia 3 | 46
abnormal body wall morphology 2 | 7
abnormal coat/hair pigmentatio... 2 | 54
abnormal craniofacial morpholo... 2 | 12
abnormal digit morphology 2 | 13
abnormal heart morphology 2 | 51
abnormal hindbrain development 2 | 24
abnormal limb morphology 2 | 7
abnormal midbrain development 2 | 22
abnormal placenta size 2 | 10
absent vibrissae 2 | 14
anophthalmia 2 | 20
cleft palate 2 | 6
decreased T cell number 2 | 31
decreased body length 2 | 108
decreased circulating amylase ... 2 | 24
decreased circulating fructosa... 2 | 31
decreased circulating iron lev... 2 | 25
decreased eosinophil cell numb... 2 | 41
decreased neutrophil cell numb... 2 | 37
enlarged lymph nodes 2 | 27
enlarged spleen 2 | 26
facial cleft 2 | 3
hemorrhage 2 | 12
hydrops fetalis 2 | 22
hypoactivity 2 | 89
increased CD8-positive, alpha-... 2 | 11
increased Ly6C high monocyte n... 2 | 12
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased body weight 2 | 42
increased bone mineral density 2 | 52
increased circulating total pr... 2 | 20
increased heart rate 2 | 17
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 93
increased rib number 2 | 41
pallor 2 | 13
persistence of hyaloid vascula... 2 | 22
polydactyly 2 | 22
small testis 2 | 37
straub tail 2 | 26
tremors 2 | 34
trunk curl 2 | 15
abnormal embryo turning 1 | 15
abnormal neural tube morpholog... 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal testis morphology 1 | 30
corneal opacity 1 | 25
embryonic growth retardation 1 | 28
increased NK cell number 1 | 19
increased eosinophil cell numb... 1 | 9

Disease

ovarian cancer 275 | 8,484
osteosarcoma 228 | 7,933
psoriasis 209 | 6,685
medulloblastoma, large-cell 183 | 6,234
glioblastoma 171 | 5,572
lung cancer 145 | 4,466
atypical teratoid / rhabdoid tumor 138 | 4,369
Breast cancer 116 | 3,094
invasive ductal carcinoma 106 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 104 | 3,289
non-small cell lung cancer 100 | 2,798
primitive neuroectodermal tumor 99 | 3,031
acute quadriplegic myopathy 97 | 1,157
lung adenocarcinoma 97 | 2,713
ependymoma 96 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 95 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 94 | 2,956
pilocytic astrocytoma 94 | 3,086
malignant mesothelioma 93 | 3,162
Carcinoma 82 | 2,147
lung carcinoma 80 | 2,844
oligodendroglioma 79 | 2,849
pediatric high grade glioma 79 | 2,712
group 3 medulloblastoma 78 | 2,254
astrocytic glioma 77 | 2,241
ductal carcinoma in situ 75 | 1,745
pancreatic cancer 73 | 2,300
adult high grade glioma 71 | 2,148
pituitary cancer 71 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 70 | 1,795
Multiple myeloma 68 | 1,327
subependymal giant cell astrocytoma 62 | 2,287
breast carcinoma 61 | 1,614
diabetes mellitus 61 | 1,663
group 4 medulloblastoma 59 | 1,875
Cancer 58 | 2,346
Pick disease 58 | 1,893
colon cancer 58 | 1,475
ulcerative colitis 58 | 2,087
dermatomyositis 57 | 933
interstitial cystitis 53 | 2,299
medulloblastoma 53 | 1,524
cystic fibrosis 50 | 1,665
adrenocortical carcinoma 49 | 1,427
juvenile dermatomyositis 46 | 1,189
Duchenne muscular dystrophy 45 | 602
astrocytoma 45 | 1,493
primary pancreatic ductal adenocarcinoma 43 | 1,271
sonic hedgehog group medulloblastoma 43 | 1,482
posterior fossa group B ependymoma 41 | 1,530
atypical teratoid/rhabdoid tumor 40 | 1,095
tuberculosis 40 | 1,557
spina bifida 39 | 1,064
Rheumatoid Arthritis 38 | 1,160
Myopathy 36 | 128
Waldenstrons macroglobulinemia 36 | 765
posterior fossa group A ependymoma 33 | 1,511
gastric carcinoma 30 | 832
hereditary spastic paraplegia 30 | 313
Obesity 29 | 616
Heart disease 28 | 279
cutaneous lupus erythematosus 27 | 1,056
esophageal adenocarcinoma 27 | 737
Atopic dermatitis 26 | 944
non primary Sjogren syndrome sicca 26 | 840
Alzheimer's disease 25 | 644
Amyotrophic Lateral Sclerosis 25 | 431
aldosterone-producing adenoma 25 | 664
fibroadenoma 24 | 557
progressive supranuclear palsy 24 | 674
nasopharyngeal carcinoma 23 | 1,056
tuberculosis and treatment for 6 months 23 | 686
Cardiomyopathy 22 | 110
acute myeloid leukemia 22 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 21 | 499
active Crohn's disease 20 | 918
Down syndrome 18 | 548
mucosa-associated lymphoid tissue lymphoma 18 | 480
primary Sjogren syndrome 18 | 789
pancreatic carcinoma 17 | 567
Coronary artery disease 16 | 240
Dilated cardiomyopathy 16 | 50
Endometriosis 16 | 535
active ulcerative colitis 16 | 477
non diabetic and post-ischemic heart failure 16 | 200
Hypertrophic Cardiomyopathy 15 | 56
Schizophrenia 15 | 501
Vascular disease 15 | 281
hepatocellular carcinoma 15 | 532
IGA Glomerulonephritis 14 | 454
chronic rhinosinusitis 14 | 512
Intellectual disability 13 | 573
Multiple Sclerosis 13 | 498
Neurodegenerative disease 13 | 383
gastric cancer 13 | 430
non-small cell lung carcinoma 13 | 413
Distal arthrogryposis 12 | 45
Parkinson's disease 12 | 364
limb girdle muscular dystrophy 2A 12 | 156
limb-girdle muscular dystrophy 12 | 36

Tissue

Blood and immune system 539 | 17,995
Cardiovascular System 539 | 17,958
Digestive Tract 539 | 18,473
Female tissues 539 | 18,647
Endocrine System 538 | 18,512
Nervous System 538 | 18,561
Liver and Pancreas 536 | 18,136
Male tissues 535 | 17,969
Skin and soft tissues 534 | 18,115
Urinary Tract 534 | 18,444
Respiratory system 529 | 17,484

Target Family

Non-IDG 335 | 11,971
Enzyme 116 | 4,146
Kinase 22 | 634
Transcription Factor 21 | 1,400
Transporter 20 | 473
Ion Channel 15 | 341
Epigenetic 7 | 242
Nuclear Receptor 5 | 48
GPCR 1 | 406
TF/Epigenetic 1 | 38

Jensen-KB Tissue

Skeletal muscle 543 | 543
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Sialidase-3 NEU3 Tbio Enzyme -1.97558 109.4 23
39S ribosomal protein L37, mitochondrial MRPL37 Tdark Non-IDG -0.30103 2.00 47
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Myosin light chain 6B MYL6B Tdark Non-IDG -0.43175 2.57 113
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901
Apolipoprotein C-II APOC2 Tbio Non-IDG -2.49982 337.4 18
Apolipoprotein A-II APOA2 Tbio Non-IDG -2.80284 593.9 352