Development Level

Tbio 226 | 11,445
Tdark 57 | 6,588
Tchem 38 | 1,598
Tclin 16 | 613

Collection

GPCR: IDG Consortium (Targets) 4 | 126
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 13 | 979
preweaning lethality, incomple... 13 | 499
abnormal behavior 11 | 298
decreased body weight 9 | 161
hypoactivity 9 | 132
increased or absent threshold ... 7 | 101
decreased vertical activity 6 | 208
enlarged heart 6 | 210
increased lean body mass 6 | 172
increased mean corpuscular hem... 6 | 96
decreased lean body mass 5 | 135
embryonic lethality prior to o... 5 | 239
increased startle reflex 5 | 112
abnormal bone structure 4 | 187
abnormal embryo size 4 | 220
abnormal heart morphology 4 | 162
decreased circulating glucose ... 4 | 126
decreased grip strength 4 | 116
decreased total body fat amoun... 4 | 207
hyperactivity 4 | 148
increased heart rate 4 | 23
increased mean corpuscular vol... 4 | 92
increased total body fat amoun... 4 | 134
decreased body length 3 | 101
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased circulating triglyce... 3 | 79
decreased leukocyte cell numbe... 3 | 73
decreased mean corpuscular hem... 3 | 31
decreased prepulse inhibition 3 | 82
embryonic lethality prior to t... 3 | 278
hydrometra 3 | 53
improved glucose tolerance 3 | 79
increased fasted circulating g... 3 | 76
prolonged PR interval 3 | 15
shortened RR interval 3 | 17
small superior vagus ganglion 3 | 74
small testis 3 | 58
abnormal bone mineralization 2 | 38
abnormal locomotor behavior 2 | 24
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
abnormal testis morphology 2 | 43
abnormal vibrissa morphology 2 | 25
absent pinna reflex 2 | 23
decreased circulating HDL chol... 2 | 68
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating free fat... 2 | 31
decreased circulating iron lev... 2 | 32
decreased exploration in new e... 2 | 11
decreased heart weight 2 | 27
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
embryonic growth retardation 2 | 106
impaired righting response 2 | 26
increased bone mineral content 2 | 108
increased circulating potassiu... 2 | 29
increased circulating sodium l... 2 | 71
increased grip strength 2 | 41
increased hematocrit 2 | 46
macrophthalmia 2 | 2
male infertility 2 | 123
short tibia 2 | 97
thrombocytopenia 2 | 56
trunk curl 2 | 16
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal liver morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
convulsive seizures 1 | 13
decreased circulating calcium ... 1 | 36
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased hematocrit 1 | 46
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
impaired pupillary reflex 1 | 26
increased blood uric acid leve... 1 | 5
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
stereotypic behavior 1 | 3
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 239 | 11,493
ovarian cancer 146 | 8,520
medulloblastoma, large-cell 140 | 6,241
osteosarcoma 136 | 7,950
psoriasis 133 | 6,694
glioblastoma 122 | 5,792
atypical teratoid / rhabdoid tumor 116 | 5,112
ependymoma 110 | 4,679
lung cancer 92 | 4,740
adult high grade glioma 91 | 3,801
group 3 medulloblastoma 89 | 4,104
primitive neuroectodermal tumor 75 | 3,035
astrocytic glioma 72 | 2,597
Astrocytoma, Pilocytic 69 | 3,081
Kidney cancer 68 | 2,613
lung carcinoma 68 | 2,843
oligodendroglioma 68 | 2,850
malignant mesothelioma 67 | 3,232
Breast cancer 60 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 57 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 55 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 54 | 2,989
pituitary cancer 51 | 1,972
invasive ductal carcinoma 49 | 2,951
lung adenocarcinoma 48 | 2,716
pancreatic cancer 47 | 2,398
subependymal giant cell astrocytoma 47 | 2,287
Autosomal recessive predisposition 44 | 1,442
Retinitis Pigmentosa 44 | 226
Pick disease 42 | 1,894
Cancer 41 | 2,499
Intellectual disability 41 | 1,016
group 4 medulloblastoma 40 | 1,855
non-small cell lung cancer 40 | 2,890
tuberculosis 39 | 2,010
interstitial cystitis 37 | 2,312
cystic fibrosis 36 | 1,696
Night Blindness 35 | 101
Nystagmus 35 | 317
Electroretinogram abnormal 33 | 95
Schizophrenia 33 | 1,160
Difficulties with night vision 31 | 87
Dull intelligence 31 | 645
Low intelligence 31 | 645
Mental Retardation 31 | 645
Mental deficiency 31 | 645
Poor school performance 31 | 645
Blindness 30 | 88
Cataract 30 | 297
Epilepsy 30 | 792
Obesity 30 | 678
Photodysphoria 30 | 121
Photophobia 30 | 121
colon cancer 30 | 1,478
diabetes mellitus 30 | 1,728
Abnormality of retinal pigmentation 29 | 111
Retinal pigment epithelial abnormality 29 | 111
astrocytoma 29 | 1,146
ductal carcinoma in situ 29 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
Glaucoma 27 | 239
Lens Opacities 27 | 231
Sensorineural Hearing Loss (disorder) 27 | 284
adrenocortical carcinoma 27 | 1,428
ulcerative colitis 26 | 1,819
Low Vision 25 | 174
Retinal Degeneration 25 | 106
Rheumatoid arthritis 25 | 1,191
Visual Impairment 25 | 174
breast carcinoma 25 | 1,638
juvenile dermatomyositis 25 | 1,187
Fundus dystrophy 24 | 83
Multiple myeloma 24 | 1,332
Seizures 24 | 596
active Crohn's disease 24 | 922
cutaneous lupus erythematosus 24 | 1,057
Optic Atrophy 23 | 242
Anteverted nostril 22 | 191
Cone dystrophy 22 | 71
Keratoconus 22 | 113
Blind Vision 21 | 111
Blindness, Legal 21 | 110
Broad flat nasal bridge 21 | 236
Congenital hypoplasia of penis 21 | 176
Melanoma 21 | 711
Nasal bridge wide 21 | 236
acute quadriplegic myopathy 21 | 1,158
dermatomyositis 21 | 966
nasopharyngeal carcinoma 21 | 1,058
primary pancreatic ductal adenocarcinoma 21 | 1,109
Abnormality of the retinal vasculature 20 | 59
Reduced visual acuity 20 | 63
spina bifida 20 | 1,074
Alzheimer's disease 19 | 658
Conductive hearing loss 19 | 123
Down syndrome 19 | 499
Hypogonadism 19 | 173
Liver Cirrhosis, Experimental 19 | 769
Muscle hypotonia 19 | 571
Ophthalmoplegia 19 | 106

Tissue

Endocrine System 325 | 18,159
Nervous System 310 | 16,725
Digestive Tract 309 | 17,369
Skin and soft tissues 308 | 17,230
Blood and immune system 305 | 16,909
Female tissues 305 | 17,400
Male tissues 299 | 17,142
Urinary Tract 290 | 16,678
Liver and Pancreas 288 | 16,750
Respiratory system 284 | 16,393
Cardiovascular System 266 | 15,192

Target Family

Non-IDG 182 | 12,091
Enzyme 77 | 4,145
Transcription Factor 24 | 1,400
Ion Channel 15 | 344
GPCR 13 | 408
Kinase 11 | 634
Transporter 11 | 473
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

Jensen-KB Tissue

Retina 337 | 337
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protocadherin-15 PCDH15 Tbio Non-IDG -1.83877 74.3 42
SCAN domain-containing protein 3 ZBED9 Tdark Non-IDG -0.98652 9.59 50
Protein Shroom2 SHROOM2 Tbio Non-IDG -1.07032 11.9 112
Huntingtin HTT Tchem Non-IDG -3.36282 2294.8 599
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
Neural retina-specific leucine zipper protein NRL Tbio Transcription Factor -2.46080 279.4 74
Sodium bicarbonate cotransporter 3 SLC4A7 Tbio Transporter -1.82039 64.7 133
Myocilin MYOC Tbio Non-IDG -2.65916 482.8 169
39S ribosomal protein L22, mitochondrial MRPL22 Tdark Non-IDG 0.70 0.21 64
Cone-rod homeobox protein CRX Tbio Transcription Factor -2.44826 272.0 185