Development Level

Tbio 307 | 11,651
Tdark 86 | 6,593
Tchem 48 | 1,388
Tclin 16 | 612

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 22 | 979
preweaning lethality, incomple... 13 | 499
embryonic lethality prior to o... 6 | 239
enlarged heart 6 | 210
abnormal embryo size 5 | 220
cataract 5 | 92
decreased bone mineral content 5 | 151
decreased vertical activity 5 | 208
embryonic lethality prior to t... 5 | 278
abnormal behavior 4 | 298
abnormal lens morphology 4 | 81
cardiovascular system phenotyp... 4 | 36
decreased body weight 4 | 161
increased or absent threshold ... 4 | 101
increased startle reflex 4 | 112
abnormal bone structure 3 | 187
abnormal heart morphology 3 | 162
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
decreased grip strength 3 | 116
decreased hematocrit 3 | 46
decreased hemoglobin content 3 | 68
decreased lean body mass 3 | 135
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
embryonic growth retardation 3 | 106
hypoactivity 3 | 132
increased bone mineral content 3 | 108
increased mean corpuscular hem... 3 | 96
male infertility 3 | 123
prenatal lethality prior to he... 3 | 87
prolonged QT interval 3 | 38
short tibia 3 | 97
abnormal cornea morphology 2 | 31
abnormal eye morphology 2 | 68
abnormal heart left ventricle ... 2 | 16
abnormal limb bud morphology 2 | 17
abnormal liver size 2 | 5
abnormal placenta size 2 | 20
abnormal sleep behavior 2 | 70
abnormal tail morphology 2 | 25
abnormal testis morphology 2 | 43
decreased blood urea nitrogen ... 2 | 51
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased eosinophil cell numb... 2 | 24
decreased erythrocyte cell num... 2 | 62
decreased heart rate variabili... 2 | 13
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
edema 2 | 59
female infertility 2 | 60
hydrometra 2 | 53
improved glucose tolerance 2 | 79
increased body temperature 2 | 9
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
pale yolk sac 2 | 25
pallor 2 | 34
small liver 2 | 8
small testis 2 | 58
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal hair growth 1 | 10
abnormal heart looping 1 | 5
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
prenatal lethality 1 | 28
small thymus 1 | 16
thin ventricular wall 1 | 24
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 259 | 11,493
ovarian cancer 236 | 8,520
osteosarcoma 209 | 7,950
psoriasis 167 | 6,694
medulloblastoma, large-cell 161 | 6,241
glioblastoma 147 | 5,792
lung cancer 143 | 4,740
atypical teratoid / rhabdoid tumor 129 | 5,112
Breast cancer 125 | 3,578
ependymoma 110 | 4,679
group 3 medulloblastoma 109 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 104 | 3,291
invasive ductal carcinoma 101 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 98 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 98 | 2,989
interstitial cystitis 96 | 2,312
lung carcinoma 93 | 2,843
non-small cell lung cancer 90 | 2,890
adult high grade glioma 89 | 3,801
pancreatic cancer 89 | 2,398
lung adenocarcinoma 86 | 2,716
malignant mesothelioma 81 | 3,232
Astrocytoma, Pilocytic 75 | 3,081
oligodendroglioma 75 | 2,850
Cancer 73 | 2,499
cystic fibrosis 73 | 1,696
astrocytic glioma 72 | 2,597
primitive neuroectodermal tumor 72 | 3,035
tuberculosis 66 | 2,010
ductal carcinoma in situ 62 | 1,745
colon cancer 58 | 1,478
ulcerative colitis 58 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 56 | 1,962
pituitary cancer 56 | 1,972
breast carcinoma 53 | 1,638
subependymal giant cell astrocytoma 52 | 2,287
Pick disease 49 | 1,894
Multiple myeloma 48 | 1,332
acute quadriplegic myopathy 47 | 1,158
Kidney cancer 46 | 2,613
astrocytoma 41 | 1,146
juvenile dermatomyositis 40 | 1,187
spina bifida 40 | 1,074
diabetes mellitus 38 | 1,728
primary pancreatic ductal adenocarcinoma 38 | 1,109
adrenocortical carcinoma 35 | 1,428
dermatomyositis 34 | 966
active Crohn's disease 33 | 922
group 4 medulloblastoma 33 | 1,855
Autosomal recessive predisposition 30 | 1,442
Endometriosis 29 | 540
active ulcerative colitis 29 | 764
acute myeloid leukemia 29 | 783
pediatric high grade glioma 29 | 1,064
nasopharyngeal carcinoma 28 | 1,058
Prostatic Neoplasms 27 | 495
Rheumatoid arthritis 27 | 1,191
Schizophrenia 27 | 1,160
non primary Sjogren syndrome sicca 27 | 891
Atopic dermatitis 26 | 952
gastric carcinoma 26 | 807
pancreatic carcinoma 25 | 562
Liver Cirrhosis, Experimental 24 | 769
cutaneous lupus erythematosus 24 | 1,057
esophageal adenocarcinoma 24 | 737
medulloblastoma 23 | 720
Bipolar Disorder 22 | 666
Waldenstrons macroglobulinemia 22 | 765
fibroadenoma 22 | 559
aldosterone-producing adenoma 21 | 665
primary Sjogren syndrome 21 | 735
progressive supranuclear palsy 21 | 676
Alzheimer's disease 19 | 658
Duchenne muscular dystrophy 19 | 601
Hypertension 18 | 396
Prostate cancer 18 | 175
Intellectual disability 17 | 1,016
Multiple Sclerosis 17 | 540
Amyotrophic lateral sclerosis 16 | 451
Asthma 16 | 385
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 510
gastric cancer 16 | 459
hepatocellular carcinoma 16 | 547
Coronary artery disease 15 | 268
Kidney disease 15 | 430
chronic rhinosinusitis 15 | 512
Breast Neoplasms 14 | 445
Mammary Neoplasms 14 | 425
Obesity 14 | 678
Parkinson's disease 14 | 392
Polycystic ovary syndrome 14 | 360
hereditary spastic paraplegia 14 | 318
inflammatory breast cancer 14 | 286
posterior fossa group A ependymoma 14 | 468
sarcoidosis 14 | 370
Arthritis 13 | 290
Down syndrome 13 | 499
head and neck cancer and chronic obstructive pulmonary disease 13 | 239
Cleft Palate 12 | 271
Short stature 12 | 531

Tissue

Endocrine System 451 | 18,159
Male tissues 448 | 17,142
Female tissues 447 | 17,400
Digestive Tract 445 | 17,369
Skin and soft tissues 445 | 17,230
Blood and immune system 443 | 16,909
Liver and Pancreas 438 | 16,750
Nervous System 438 | 16,725
Respiratory system 437 | 16,393
Urinary Tract 435 | 16,678
Cardiovascular System 419 | 15,192

Target Family

Non-IDG 256 | 12,091
Enzyme 117 | 4,145
Transcription Factor 32 | 1,400
Transporter 15 | 473
Kinase 12 | 634
GPCR 8 | 408
Epigenetic 5 | 242
Ion Channel 5 | 344
Nuclear Receptor 4 | 48
oGPCR 2 | 421
TF/Epigenetic 1 | 38

Jensen-KB Tissue

Prostate gland epithelium 457 | 457
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
60S ribosomal protein L17 RPL17 Tbio Non-IDG -1.22337 16.5 217
Transmembrane protein 11, mitochondrial TMEM11 Tdark Non-IDG -2.44072 252.5 35
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Platelet-derived growth factor C PDGFC Tbio Non-IDG -2.03910 120.6 226
Transcription initiation factor IIB GTF2B Tbio Non-IDG -2.63302 410.1 286
ATR-interacting protein ATRIP Tbio Non-IDG -1.60828 43.0 359
Interferon gamma receptor 1 IFNGR1 Tbio Non-IDG -2.23009 172.7 518
Dolichyl-phosphate beta-glucosyltransferase ALG5 Tbio Enzyme -1.03048 11.1 116
Aurora kinase A-interacting protein AURKAIP1 Tchem Enzyme -0.07918 1.93 59
Retinoic acid receptor responder protein 2 RARRES2 Tbio Non-IDG -2.41772 314.1 196