Development Level

Tbio 2,164 | 11,651
Tdark 478 | 6,593
Tchem 317 | 1,388
Tclin 120 | 612

Collection

RFA-RM-18-021 35 | 328
Kinase: IDG Consortium (Target... 15 | 125
GPCR: IDG Consortium (Targets) 13 | 126
Kinase: IDG Consortium (Comple... 9 | 37
GPCR: IDG Consortium (Complete... 4 | 25
Ion Channel: IDG Consortium (T... 4 | 99

IMPC Phenotype

preweaning lethality, complete... 223 | 979
preweaning lethality, incomple... 104 | 499
embryonic lethality prior to t... 73 | 278
embryonic lethality prior to o... 65 | 239
abnormal behavior 62 | 298
abnormal embryo size 45 | 220
enlarged heart 43 | 210
abnormal bone structure 41 | 187
decreased total body fat amoun... 36 | 207
decreased vertical activity 32 | 208
decreased bone mineral content 30 | 151
hyperactivity 30 | 148
decreased bone mineral density 29 | 126
increased lean body mass 28 | 172
decreased body weight 27 | 161
increased circulating alkaline... 25 | 122
abnormal heart morphology 24 | 162
increased bone mineral content 24 | 108
decreased lean body mass 23 | 135
increased mean corpuscular hem... 22 | 96
hypoactivity 21 | 132
increased mean corpuscular vol... 21 | 92
abnormal retina morphology 20 | 71
abnormal seminal vesicle morph... 20 | 114
cataract 20 | 92
decreased circulating serum al... 20 | 82
improved glucose tolerance 20 | 79
increased or absent threshold ... 20 | 101
decreased body length 19 | 101
male infertility 19 | 123
decreased circulating glucose ... 18 | 126
decreased circulating insulin ... 18 | 76
embryonic growth retardation 18 | 106
impaired glucose tolerance 18 | 75
increased fasted circulating g... 18 | 76
increased startle reflex 18 | 112
abnormal lens morphology 17 | 81
decreased mean corpuscular vol... 17 | 79
prenatal lethality prior to he... 17 | 87
abnormal sleep behavior 16 | 70
decreased circulating choleste... 16 | 93
decreased erythrocyte cell num... 16 | 62
increased circulating HDL chol... 16 | 80
short tibia 16 | 97
small testis 16 | 58
decreased circulating triglyce... 15 | 79
decreased circulating alkaline... 14 | 46
edema 14 | 59
enlarged lymph nodes 14 | 37
abnormal eye morphology 13 | 68
abnormal spleen morphology 13 | 55
decreased circulating HDL chol... 13 | 68
decreased fasted circulating g... 13 | 65
decreased leukocyte cell numbe... 13 | 73
increased circulating choleste... 13 | 66
increased total body fat amoun... 13 | 134
abnormal kidney morphology 12 | 65
decreased blood urea nitrogen ... 12 | 51
decreased grip strength 12 | 116
decreased lymphocyte cell numb... 12 | 83
increased bone mineral density 12 | 72
increased circulating sodium l... 12 | 71
increased leukocyte cell numbe... 12 | 47
thrombocytopenia 12 | 56
abnormal gait 11 | 69
abnormal neural tube closure 11 | 46
abnormal skin morphology 11 | 50
decreased circulating fructosa... 11 | 30
decreased startle reflex 11 | 75
abnormal behavioral response t... 10 | 66
abnormal epididymis morphology 10 | 42
corneal opacity 10 | 32
decreased circulating alanine ... 10 | 47
decreased prepulse inhibition 10 | 82
decreased red blood cell distr... 10 | 41
enlarged spleen 10 | 41
increased circulating iron lev... 10 | 30
increased circulating potassiu... 10 | 29
increased circulating triglyce... 10 | 42
increased erythrocyte cell num... 10 | 39
increased neutrophil cell numb... 10 | 46
pallor 10 | 34
small superior vagus ganglion 10 | 74
abnormal coat-hair pigmentatio... 9 | 64
abnormal cornea morphology 9 | 31
abnormal cranium morphology 9 | 36
decreased hemoglobin content 9 | 68
decreased neutrophil cell numb... 9 | 42
increased monocyte cell number 9 | 63
abnormal bone mineralization 8 | 38
abnormal liver morphology 8 | 17
cardiovascular system phenotyp... 8 | 36
decreased circulating creatini... 8 | 39
decreased circulating free fat... 8 | 31
decreased mean corpuscular hem... 8 | 50
increased hematocrit 8 | 46
increased hemoglobin content 8 | 45
increased mean platelet volume 8 | 45
prolonged QT interval 8 | 38
prolonged ST segment 8 | 36

Disease

Carcinoma 1,946 | 11,493
ovarian cancer 1,821 | 8,520
osteosarcoma 1,532 | 7,950
psoriasis 1,196 | 6,694
medulloblastoma, large-cell 1,142 | 6,241
glioblastoma 1,115 | 5,792
lung cancer 994 | 4,740
atypical teratoid / rhabdoid tumor 896 | 5,112
ependymoma 768 | 4,679
group 3 medulloblastoma 749 | 4,104
Breast cancer 730 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 705 | 3,291
malignant mesothelioma 690 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 664 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 664 | 2,989
non-small cell lung cancer 620 | 2,890
adult high grade glioma 615 | 3,801
invasive ductal carcinoma 606 | 2,951
Cancer 585 | 2,499
lung adenocarcinoma 584 | 2,716
pancreatic cancer 569 | 2,398
Astrocytoma, Pilocytic 561 | 3,081
lung carcinoma 522 | 2,843
primitive neuroectodermal tumor 495 | 3,035
pancreatic ductal adenocarcinoma liver metastasis 487 | 1,962
oligodendroglioma 481 | 2,850
interstitial cystitis 468 | 2,312
Kidney cancer 435 | 2,613
subependymal giant cell astrocytoma 429 | 2,287
tuberculosis 421 | 2,010
astrocytic glioma 408 | 2,597
ulcerative colitis 379 | 1,819
Multiple myeloma 376 | 1,332
cystic fibrosis 361 | 1,696
group 4 medulloblastoma 360 | 1,855
ductal carcinoma in situ 359 | 1,745
pituitary cancer 355 | 1,972
diabetes mellitus 354 | 1,728
Pick disease 343 | 1,894
breast carcinoma 332 | 1,638
Autosomal recessive predisposition 315 | 1,442
juvenile dermatomyositis 314 | 1,187
adrenocortical carcinoma 301 | 1,428
acute quadriplegic myopathy 294 | 1,158
colon cancer 290 | 1,478
astrocytoma 281 | 1,146
spina bifida 257 | 1,074
primary pancreatic ductal adenocarcinoma 252 | 1,109
Rheumatoid arthritis 249 | 1,191
pediatric high grade glioma 234 | 1,064
dermatomyositis 233 | 966
Intellectual disability 223 | 1,016
cutaneous lupus erythematosus 220 | 1,057
Waldenstrons macroglobulinemia 214 | 765
nasopharyngeal carcinoma 208 | 1,058
Liver Cirrhosis, Experimental 200 | 769
gastric carcinoma 185 | 807
Schizophrenia 184 | 1,160
active Crohn's disease 183 | 922
esophageal adenocarcinoma 177 | 737
Atopic dermatitis 176 | 952
Duchenne muscular dystrophy 167 | 601
acute myeloid leukemia 164 | 783
aldosterone-producing adenoma 163 | 665
non primary Sjogren syndrome sicca 155 | 891
Obesity 153 | 678
active ulcerative colitis 153 | 764
primary Sjogren syndrome 150 | 735
Cognitive delay 149 | 608
Global developmental delay 149 | 608
Mental and motor retardation 149 | 608
Dull intelligence 147 | 645
Low intelligence 147 | 645
Mental Retardation 147 | 645
Mental deficiency 147 | 645
Poor school performance 147 | 645
Epilepsy 145 | 792
pancreatic carcinoma 141 | 562
medulloblastoma 136 | 720
Muscle hypotonia 134 | 571
Short stature 133 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 133 | 510
progressive supranuclear palsy 132 | 676
Prostatic Neoplasms 129 | 495
Down syndrome 127 | 499
hepatocellular carcinoma 127 | 547
Alzheimer's disease 125 | 658
fibroadenoma 123 | 559
Breast Neoplasms 121 | 445
Seizures 119 | 596
Endometriosis 118 | 540
Melanoma 118 | 711
Mammary Neoplasms 116 | 425
Bipolar Disorder 115 | 666
gastric cancer 111 | 459
Amyotrophic lateral sclerosis 105 | 451
Hypertension 104 | 396
Liver cancer 97 | 604
mucosa-associated lymphoid tissue lymphoma 96 | 484
posterior fossa group A ependymoma 96 | 468

Tissue

Endocrine System 3,028 | 18,159
Female tissues 3,021 | 17,400
Digestive Tract 3,011 | 17,369
Skin and soft tissues 3,010 | 17,230
Blood and immune system 2,992 | 16,909
Male tissues 2,991 | 17,142
Liver and Pancreas 2,981 | 16,750
Urinary Tract 2,973 | 16,678
Respiratory system 2,964 | 16,393
Nervous System 2,951 | 16,725
Cardiovascular System 2,875 | 15,192

Target Family

Non-IDG 1,707 | 12,091
Enzyme 799 | 4,145
Transcription Factor 204 | 1,400
Kinase 122 | 634
Transporter 90 | 473
GPCR 71 | 408
Epigenetic 41 | 242
Ion Channel 27 | 344
Nuclear Receptor 12 | 48
TF/Epigenetic 5 | 38
oGPCR 1 | 421

Jensen-KB Tissue

Placenta 3,079 | 3,079
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Caskin-2 CASKIN2 Tdark Non-IDG -0.21450 1.97 118
Zinc finger protein 346 ZNF346 Tbio Non-IDG -2.28393 188.7 213
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Carbonyl reductase family member 4 CBR4 Tbio Enzyme -1.69083 48.5 128