Development Level

Tbio 1,991 | 10,625
Tdark 538 | 7,003
Tchem 412 | 1,890
Tclin 121 | 602

Collection

Eligible Kinase Proteins 13 | 134
Eligible non-olfactory GPCR Proteins 13 | 143
Eligible Ion Channel Proteins 6 | 117

IMPC Term

preweaning lethality, complete... 147 | 633
embryonic lethality prior to t... 55 | 187
abnormal behavior 54 | 226
preweaning lethality, incomple... 49 | 260
embryonic lethality prior to o... 47 | 148
decreased lean body mass 44 | 195
decreased total body fat amoun... 35 | 186
decreased bone mineral content 33 | 157
decreased bone mineral density 30 | 126
abnormal bone structure 28 | 131
abnormal embryo size 27 | 112
decreased body length 26 | 108
enlarged heart 25 | 111
abnormal retina morphology 24 | 100
decreased body weight 24 | 174
hyperactivity 24 | 108
increased bone mineral content 23 | 92
increased or absent threshold ... 23 | 128
increased circulating alkaline... 22 | 119
increased mean corpuscular vol... 21 | 91
decreased circulating insulin ... 20 | 75
increased grip strength 19 | 83
hypoactivity 18 | 89
improved glucose tolerance 18 | 56
increased lean body mass 18 | 107
increased mean corpuscular hem... 18 | 93
decreased circulating serum al... 17 | 79
decreased circulating triglyce... 17 | 83
abnormal lens morphology 16 | 73
decreased grip strength 16 | 123
decreased circulating choleste... 15 | 85
decreased circulating glucose ... 15 | 121
impaired glucose tolerance 15 | 52
increased fasted circulating g... 15 | 68
decreased leukocyte cell numbe... 14 | 54
short tibia 14 | 82
abnormal behavioral response t... 13 | 52
decreased NK T cell number 13 | 28
abnormal retinal pigmentation 12 | 61
abnormal sleep behavior 12 | 63
decreased caudal vertebrae num... 12 | 49
decreased circulating HDL chol... 12 | 77
increased circulating sodium l... 12 | 71
abnormal neural tube closure 11 | 37
decreased circulating alanine ... 11 | 53
decreased circulating fructosa... 11 | 31
decreased eosinophil cell numb... 11 | 41
decreased erythrocyte cell num... 11 | 43
decreased fasted circulating g... 11 | 49
decreased heart weight 11 | 44
decreased mean corpuscular vol... 11 | 50
enlarged lymph nodes 11 | 27
male infertility 11 | 62
decreased lumbar vertebrae num... 10 | 62
decreased rib number 10 | 59
increased body weight 10 | 42
increased exploration in new e... 10 | 56
increased total body fat amoun... 10 | 57
small testis 10 | 37
abnormal QRS complex 9 | 25
abnormal bone mineralization 9 | 55
abnormal gait 9 | 51
abnormal spleen morphology 9 | 36
decreased circulating alkaline... 9 | 41
increased bone mineral density 9 | 52
increased circulating HDL chol... 9 | 63
increased circulating potassiu... 9 | 31
increased sacral vertebrae num... 9 | 62
prenatal lethality prior to he... 9 | 64
abnormal kidney morphology 8 | 30
cardiovascular system phenotyp... 8 | 35
decreased blood urea nitrogen ... 8 | 31
decreased circulating free fat... 8 | 39
increased hematocrit 8 | 36
increased leukocyte cell numbe... 8 | 37
thrombocytopenia 8 | 46
thrombocytosis 8 | 23
abnormal epididymis morphology 7 | 31
abnormal eye morphology 7 | 38
abnormal hindbrain development 7 | 24
abnormal seminal vesicle morph... 7 | 47
absent pinna reflex 7 | 21
cataract 7 | 26
decreased CD4-positive, CD25-p... 7 | 24
decreased CD8-positive, alpha-... 7 | 26
decreased T cell number 7 | 31
decreased circulating calcium ... 7 | 33
decreased circulating creatini... 7 | 31
decreased hemoglobin content 7 | 53
decreased mean corpuscular hem... 7 | 34
decreased startle reflex 7 | 48
decreased threshold for audito... 7 | 32
increased blood urea nitrogen ... 7 | 44
increased circulating choleste... 7 | 53
increased circulating free fat... 7 | 17
increased circulating iron lev... 7 | 25
increased heart rate 7 | 17
increased monocyte cell number 7 | 27
abnormal coat/hair pigmentatio... 6 | 54
decreased circulating glycerol... 6 | 19

Disease

ovarian cancer 1,811 | 8,484
osteosarcoma 1,524 | 7,933
psoriasis 1,195 | 6,685
medulloblastoma, large-cell 1,136 | 6,234
glioblastoma 1,079 | 5,572
lung cancer 966 | 4,466
atypical teratoid / rhabdoid tumor 768 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 702 | 3,289
malignant mesothelioma 673 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 660 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 659 | 2,956
Breast cancer 645 | 3,094
invasive ductal carcinoma 605 | 2,950
non-small cell lung cancer 597 | 2,798
lung adenocarcinoma 584 | 2,713
pilocytic astrocytoma 563 | 3,086
pancreatic cancer 553 | 2,300
Cancer 548 | 2,346
pediatric high grade glioma 522 | 2,712
lung carcinoma 520 | 2,844
primitive neuroectodermal tumor 491 | 3,031
oligodendroglioma 478 | 2,849
interstitial cystitis 469 | 2,299
ulcerative colitis 440 | 2,087
group 3 medulloblastoma 437 | 2,254
pancreatic ductal adenocarcinoma liver metastasis 427 | 1,795
subependymal giant cell astrocytoma 427 | 2,287
ependymoma 421 | 2,514
Multiple myeloma 371 | 1,327
group 4 medulloblastoma 370 | 1,875
ductal carcinoma in situ 358 | 1,745
pituitary cancer 354 | 1,972
cystic fibrosis 353 | 1,665
astrocytic glioma 344 | 2,241
Pick disease 342 | 1,893
astrocytoma 339 | 1,493
diabetes mellitus 339 | 1,663
Carcinoma 334 | 2,147
tuberculosis 332 | 1,557
breast carcinoma 325 | 1,614
adult high grade glioma 323 | 2,148
juvenile dermatomyositis 312 | 1,189
primary pancreatic ductal adenocarcinoma 307 | 1,271
adrenocortical carcinoma 302 | 1,427
acute quadriplegic myopathy 293 | 1,157
colon cancer 291 | 1,475
sonic hedgehog group medulloblastoma 286 | 1,482
posterior fossa group A ependymoma 285 | 1,511
spina bifida 253 | 1,064
Rheumatoid Arthritis 244 | 1,160
medulloblastoma 234 | 1,524
dermatomyositis 232 | 933
cutaneous lupus erythematosus 219 | 1,056
posterior fossa group B ependymoma 218 | 1,530
Waldenstrons macroglobulinemia 215 | 765
nasopharyngeal carcinoma 208 | 1,056
atypical teratoid/rhabdoid tumor 192 | 1,095
gastric carcinoma 191 | 832
active Crohn's disease 182 | 918
Atopic dermatitis 177 | 944
esophageal adenocarcinoma 176 | 737
Duchenne muscular dystrophy 167 | 602
aldosterone-producing adenoma 162 | 664
primary Sjogren syndrome 161 | 789
acute myeloid leukemia 160 | 780
pancreatic carcinoma 144 | 567
non primary Sjogren syndrome sicca 142 | 840
Obesity 139 | 616
Down syndrome 138 | 548
tuberculosis and treatment for 6 months 138 | 686
progressive supranuclear palsy 132 | 674
autosomal dominant Emery-Dreifuss muscular dystrophy 128 | 499
Alzheimer's disease 126 | 644
hepatocellular carcinoma 125 | 532
Prostatic Neoplasms 123 | 471
fibroadenoma 123 | 557
Intellectual disability 121 | 573
Endometriosis 115 | 535
Mammary Neoplasms 113 | 410
IGA Glomerulonephritis 108 | 454
Amyotrophic Lateral Sclerosis 102 | 431
gastric cancer 102 | 430
mucosa-associated lymphoid tissue lymphoma 96 | 480
active ulcerative colitis 90 | 477
inflammatory breast cancer 90 | 404
Kidney disease 85 | 396
Neurodegenerative disease 83 | 383
Polycystic Ovary Syndrome 81 | 332
Multiple Sclerosis 79 | 498
Vascular disease 78 | 281
Schizophrenia 77 | 501
hereditary spastic paraplegia 77 | 313
non-small cell lung carcinoma 77 | 413
Hypertension 75 | 287
Asthma 73 | 349
interstitial lung disease 72 | 291
tuberculosis and treatment for 3 months 72 | 327
chronic rhinosinusitis 71 | 512
sarcoidosis 71 | 358
Stomach Neoplasms 70 | 282

Tissue

Female tissues 3,026 | 18,647
Nervous System 3,026 | 18,561
Endocrine System 3,020 | 18,512
Digestive Tract 3,015 | 18,473
Urinary Tract 3,015 | 18,444
Cardiovascular System 3,007 | 17,958
Liver and Pancreas 3,007 | 18,136
Skin and soft tissues 2,999 | 18,115
Blood and immune system 2,997 | 17,995
Male tissues 2,995 | 17,969
Respiratory system 2,976 | 17,484

Target Family

Non-IDG 1,695 | 11,971
Enzyme 797 | 4,146
Transcription Factor 203 | 1,400
Kinase 121 | 634
Transporter 90 | 473
GPCR 71 | 406
Epigenetic 40 | 242
Ion Channel 27 | 341
Nuclear Receptor 12 | 48
TF/Epigenetic 5 | 38
oGPCR 1 | 421

Jensen-KB Tissue

Placenta 3,062 | 3,062
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
NADH-ubiquinone oxidoreductase chain 6 MT-ND6 Tclin Enzyme -2.74395 585.6 62
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60