Development Level

Tbio 116 | 10,625
Tdark 41 | 7,003
Tchem 20 | 1,890
Tclin 6 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal behavior 4 | 226
decreased body length 4 | 108
decreased lean body mass 4 | 195
decreased total body fat amoun... 4 | 186
improved glucose tolerance 4 | 56
increased mean corpuscular hem... 4 | 93
preweaning lethality, incomple... 4 | 260
abnormal embryo size 3 | 112
decreased fasted circulating g... 3 | 49
decreased grip strength 3 | 123
hypoactivity 3 | 89
increased bone mineral content 3 | 92
increased total body fat amoun... 3 | 57
male infertility 3 | 62
abnormal bone structure 2 | 131
abnormal coat/hair pigmentatio... 2 | 54
abnormal cranium morphology 2 | 32
abnormal eye morphology 2 | 38
abnormal gait 2 | 51
abnormal retina morphology 2 | 100
abnormal skin morphology 2 | 23
cataract 2 | 26
decreased blood urea nitrogen ... 2 | 31
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating iron lev... 2 | 25
decreased circulating total pr... 2 | 41
decreased effector memory CD8-... 2 | 24
decreased heart weight 2 | 44
embryonic lethality prior to t... 2 | 187
enlarged heart 2 | 111
female infertility 2 | 34
increased circulating HDL chol... 2 | 63
increased circulating calcium ... 2 | 32
increased circulating iron lev... 2 | 25
increased erythrocyte cell num... 2 | 26
increased grip strength 2 | 83
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 91
increased vertical activity 2 | 18
short tibia 2 | 82
straub tail 2 | 26
tremors 2 | 34
abnormal behavioral response t... 1 | 52
abnormal cornea morphology 1 | 24
abnormal heart left ventricle ... 1 | 20
abnormal iris morphology 1 | 12
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal lung morphology 1 | 15
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal response to new envir... 1 | 8
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C low monocyte nu... 1 | 23
decreased T cell number 1 | 31
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased gamma-delta T cell n... 1 | 18
decreased hemoglobin content 1 | 53
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased vertical activity 1 | 22
edema 1 | 11
enlarged lymph nodes 1 | 27
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased CD4-positive, CD25-p... 1 | 18
increased Ly6C high monocyte n... 1 | 12
increased blood urea nitrogen ... 1 | 44
increased circulating alkaline... 1 | 119
increased circulating amylase ... 1 | 13
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 24
increased fasted circulating g... 1 | 68
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean platelet volume 1 | 19
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
thin ventricular wall 1 | 5
trunk curl 1 | 15

Disease

ovarian cancer 86 | 8,484
osteosarcoma 80 | 7,933
psoriasis 75 | 6,685
medulloblastoma, large-cell 69 | 6,234
glioblastoma 57 | 5,572
atypical teratoid / rhabdoid tumor 51 | 4,369
lung cancer 50 | 4,466
invasive ductal carcinoma 45 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 44 | 2,956
lung adenocarcinoma 43 | 2,713
pilocytic astrocytoma 43 | 3,086
Breast cancer 41 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,988
non-small cell lung cancer 37 | 2,798
oligodendroglioma 34 | 2,849
primitive neuroectodermal tumor 34 | 3,031
malignant mesothelioma 33 | 3,162
lung carcinoma 32 | 2,844
adult high grade glioma 31 | 2,148
Carcinoma 30 | 2,147
breast carcinoma 30 | 1,614
subependymal giant cell astrocytoma 29 | 2,287
pituitary cancer 28 | 1,972
group 3 medulloblastoma 27 | 2,254
ependymoma 26 | 2,514
pediatric high grade glioma 26 | 2,712
Pick disease 25 | 1,893
pancreatic cancer 25 | 2,300
adrenocortical carcinoma 24 | 1,427
colon cancer 24 | 1,475
group 4 medulloblastoma 24 | 1,875
Cancer 23 | 2,346
ductal carcinoma in situ 23 | 1,745
primary pancreatic ductal adenocarcinoma 21 | 1,271
atypical teratoid/rhabdoid tumor 20 | 1,095
interstitial cystitis 20 | 2,299
acute quadriplegic myopathy 19 | 1,157
astrocytic glioma 19 | 2,241
cystic fibrosis 19 | 1,665
ulcerative colitis 19 | 2,087
astrocytoma 18 | 1,493
juvenile dermatomyositis 18 | 1,189
gastric carcinoma 17 | 832
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,795
posterior fossa group A ependymoma 17 | 1,511
Multiple myeloma 16 | 1,327
medulloblastoma 15 | 1,524
posterior fossa group B ependymoma 15 | 1,530
tuberculosis 15 | 1,557
sonic hedgehog group medulloblastoma 14 | 1,482
dermatomyositis 13 | 933
diabetes mellitus 13 | 1,663
Atopic dermatitis 12 | 944
Down syndrome 12 | 548
Duchenne muscular dystrophy 12 | 602
aldosterone-producing adenoma 12 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 499
Rheumatoid Arthritis 11 | 1,160
acute myeloid leukemia 10 | 780
fibroadenoma 10 | 557
primary Sjogren syndrome 10 | 789
progressive supranuclear palsy 10 | 674
Parkinson's disease 9 | 364
active ulcerative colitis 9 | 477
nasopharyngeal carcinoma 9 | 1,056
Becker muscular dystrophy 8 | 187
active Crohn's disease 8 | 918
cutaneous lupus erythematosus 8 | 1,056
limb girdle muscular dystrophy 2A 8 | 156
non primary Sjogren syndrome sicca 8 | 840
Amyotrophic Lateral Sclerosis 7 | 431
Neurodegenerative disease 7 | 383
Neuropathy 7 | 210
Waldenstrons macroglobulinemia 7 | 765
hepatocellular carcinoma 7 | 532
spina bifida 7 | 1,064
Endometriosis 6 | 535
IGA Glomerulonephritis 6 | 454
Intellectual disability 6 | 573
Obesity 6 | 616
Peripheral Neuropathy 6 | 303
Prostatic Neoplasms 6 | 471
esophageal adenocarcinoma 6 | 737
inflammatory breast cancer 6 | 404
Animal Mammary Neoplasms 5 | 136
Crohn's disease 5 | 304
Hydrolethalus syndrome 5 | 128
Mammary Neoplasms 5 | 410
Mammary Neoplasms, Experimental 5 | 150
Osteoporosis 5 | 257
Polycystic Ovary Syndrome 5 | 332
X-linked cerebral adrenoleukodystrophy 5 | 115
chronic rhinosinusitis 5 | 512
glioblastoma multiforme 5 | 347
head and neck cancer 5 | 270
interstitial lung disease 5 | 291
non-inflammatory breast cancer 5 | 208
urothelial carcinoma 5 | 318
mucosa-associated lymphoid tissue lymphoma 4 | 480

Tissue

Blood and immune system 180 | 17,995
Cardiovascular System 180 | 17,958
Digestive Tract 180 | 18,473
Endocrine System 180 | 18,512
Female tissues 180 | 18,647
Liver and Pancreas 180 | 18,136
Male tissues 180 | 17,969
Nervous System 180 | 18,561
Respiratory system 180 | 17,484
Skin and soft tissues 180 | 18,115
Urinary Tract 180 | 18,444

Target Family

Non-IDG 120 | 11,971
Enzyme 27 | 4,146
Transcription Factor 13 | 1,400
Epigenetic 7 | 242
Kinase 6 | 634
Transporter 5 | 473
GPCR 2 | 406
Ion Channel 2 | 341
Nuclear Receptor 1 | 48

Jensen-KB Tissue

Peripheral nervous system 183 | 183
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Homeobox protein Hox-D8 HOXD8 Tbio Transcription Factor -1.03632 9.95 167
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B MGAT4B Tdark Enzyme -0.75856 4.88 37
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
SURP and G-patch domain-containing protein 1 SUGP1 Tbio Non-IDG -2.08366 122.0 109
ERC protein 2 ERC2 Tbio Non-IDG -1.59613 39.1 32
Cytochrome b561 CYB561 Tbio Non-IDG -1.41910 20.4 45
Bromodomain-containing protein 2 BRD2 Tchem Epigenetic -2.42927 0.00000 306
Transmembrane protein 267 TMEM267 Tdark Non-IDG 0.00000 4
Trinucleotide repeat-containing gene 6A protein TNRC6A Tbio Non-IDG -2.03159 112.3 66